Panthera tigris altaica (Amur tiger): 102954757 Help Entry 102954757         CDS       T02988                                  Symbol AKT2 Name (RefSeq) AKT serine/threonine kinase 2   KO K04456   RAC serine/threonine-protein kinase [EC:2.7.11.1] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg01521   EGFR tyrosine kinase inhibitor resistance ptg01522   Endocrine resistance ptg01524   Platinum drug resistance ptg04010   MAPK signaling pathway ptg04012   ErbB signaling pathway ptg04014   Ras signaling pathway ptg04015   Rap1 signaling pathway ptg04022   cGMP-PKG signaling pathway ptg04024   cAMP signaling pathway ptg04062   Chemokine signaling pathway ptg04066   HIF-1 signaling pathway ptg04068   FoxO signaling pathway ptg04071   Sphingolipid signaling pathway ptg04072   Phospholipase D signaling pathway ptg04140   Autophagy - animal ptg04150   mTOR signaling pathway ptg04151   PI3K-Akt signaling pathway ptg04152   AMPK signaling pathway ptg04210   Apoptosis ptg04211   Longevity regulating pathway ptg04213   Longevity regulating pathway - multiple species ptg04218   Cellular senescence ptg04261   Adrenergic signaling in cardiomyocytes ptg04370   VEGF signaling pathway ptg04371   Apelin signaling pathway ptg04380   Osteoclast differentiation ptg04510   Focal adhesion ptg04550   Signaling pathways regulating pluripotency of stem cells ptg04611   Platelet activation ptg04613   Neutrophil extracellular trap formation ptg04620   Toll-like receptor signaling pathway ptg04625   C-type lectin receptor signaling pathway ptg04630   JAK-STAT signaling pathway ptg04660   T cell receptor signaling pathway ptg04662   B cell receptor signaling pathway ptg04664   Fc epsilon RI signaling pathway ptg04666   Fc gamma R-mediated phagocytosis ptg04668   TNF signaling pathway ptg04722   Neurotrophin signaling pathway ptg04725   Cholinergic synapse ptg04728   Dopaminergic synapse ptg04810   Regulation of actin cytoskeleton ptg04910   Insulin signaling pathway ptg04914   Progesterone-mediated oocyte maturation ptg04915   Estrogen signaling pathway ptg04917   Prolactin signaling pathway ptg04919   Thyroid hormone signaling pathway ptg04920   Adipocytokine signaling pathway ptg04922   Glucagon signaling pathway ptg04923   Regulation of lipolysis in adipocytes ptg04926   Relaxin signaling pathway ptg04929   GnRH secretion ptg04931   Insulin resistance ptg04932   Non-alcoholic fatty liver disease ptg04933   AGE-RAGE signaling pathway in diabetic complications ptg04935   Growth hormone synthesis, secretion and action ptg04936   Alcoholic liver disease ptg04973   Carbohydrate digestion and absorption ptg05010   Alzheimer disease ptg05017   Spinocerebellar ataxia ptg05132   Salmonella infection ptg05135   Yersinia infection ptg05142   Chagas disease ptg05145   Toxoplasmosis ptg05152   Tuberculosis ptg05160   Hepatitis C ptg05161   Hepatitis B ptg05162   Measles ptg05163   Human cytomegalovirus infection ptg05164   Influenza A ptg05165   Human papillomavirus infection ptg05166   Human T-cell leukemia virus 1 infection ptg05167   Kaposi sarcoma-associated herpesvirus infection ptg05168   Herpes simplex virus 1 infection ptg05169   Epstein-Barr virus infection ptg05170   Human immunodeficiency virus 1 infection ptg05200   Pathways in cancer ptg05205   Proteoglycans in cancer ptg05207   Chemical carcinogenesis - receptor activation ptg05208   Chemical carcinogenesis - reactive oxygen species ptg05210   Colorectal cancer ptg05211   Renal cell carcinoma ptg05212   Pancreatic cancer ptg05213   Endometrial cancer ptg05214   Glioma ptg05215   Prostate cancer ptg05218   Melanoma ptg05220   Chronic myeloid leukemia ptg05221   Acute myeloid leukemia ptg05222   Small cell lung cancer ptg05223   Non-small cell lung cancer ptg05224   Breast cancer ptg05225   Hepatocellular carcinoma ptg05226   Gastric cancer ptg05230   Central carbon metabolism in cancer ptg05231   Choline metabolism in cancer ptg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ptg05415   Diabetic cardiomyopathy ptg05417   Lipid and atherosclerosis ptg05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:ptg00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102954757 (AKT2)    04012 ErbB signaling pathway     102954757 (AKT2)    04014 Ras signaling pathway     102954757 (AKT2)    04015 Rap1 signaling pathway     102954757 (AKT2)    04370 VEGF signaling pathway     102954757 (AKT2)    04371 Apelin signaling pathway     102954757 (AKT2)    04630 JAK-STAT signaling pathway     102954757 (AKT2)    04668 TNF signaling pathway     102954757 (AKT2)    04066 HIF-1 signaling pathway     102954757 (AKT2)    04068 FoxO signaling pathway     102954757 (AKT2)    04072 Phospholipase D signaling pathway     102954757 (AKT2)    04071 Sphingolipid signaling pathway     102954757 (AKT2)    04024 cAMP signaling pathway     102954757 (AKT2)    04022 cGMP-PKG signaling pathway     102954757 (AKT2)    04151 PI3K-Akt signaling pathway     102954757 (AKT2)    04152 AMPK signaling pathway     102954757 (AKT2)    04150 mTOR signaling pathway     102954757 (AKT2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102954757 (AKT2)   09143 Cell growth and death    04210 Apoptosis     102954757 (AKT2)    04218 Cellular senescence     102954757 (AKT2)   09144 Cellular community - eukaryotes    04510 Focal adhesion     102954757 (AKT2)    04550 Signaling pathways regulating pluripotency of stem cells     102954757 (AKT2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     102954757 (AKT2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102954757 (AKT2)    04613 Neutrophil extracellular trap formation     102954757 (AKT2)    04620 Toll-like receptor signaling pathway     102954757 (AKT2)    04625 C-type lectin receptor signaling pathway     102954757 (AKT2)    04660 T cell receptor signaling pathway     102954757 (AKT2)    04662 B cell receptor signaling pathway     102954757 (AKT2)    04664 Fc epsilon RI signaling pathway     102954757 (AKT2)    04666 Fc gamma R-mediated phagocytosis     102954757 (AKT2)    04062 Chemokine signaling pathway     102954757 (AKT2)   09152 Endocrine system    04910 Insulin signaling pathway     102954757 (AKT2)    04922 Glucagon signaling pathway     102954757 (AKT2)    04923 Regulation of lipolysis in adipocytes     102954757 (AKT2)    04920 Adipocytokine signaling pathway     102954757 (AKT2)    04929 GnRH secretion     102954757 (AKT2)    04915 Estrogen signaling pathway     102954757 (AKT2)    04914 Progesterone-mediated oocyte maturation     102954757 (AKT2)    04917 Prolactin signaling pathway     102954757 (AKT2)    04926 Relaxin signaling pathway     102954757 (AKT2)    04935 Growth hormone synthesis, secretion and action     102954757 (AKT2)    04919 Thyroid hormone signaling pathway     102954757 (AKT2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102954757 (AKT2)   09154 Digestive system    04973 Carbohydrate digestion and absorption     102954757 (AKT2)   09156 Nervous system    04725 Cholinergic synapse     102954757 (AKT2)    04728 Dopaminergic synapse     102954757 (AKT2)    04722 Neurotrophin signaling pathway     102954757 (AKT2)   09158 Development and regeneration    04380 Osteoclast differentiation     102954757 (AKT2)   09149 Aging    04211 Longevity regulating pathway     102954757 (AKT2)    04213 Longevity regulating pathway - multiple species     102954757 (AKT2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102954757 (AKT2)    05205 Proteoglycans in cancer     102954757 (AKT2)    05207 Chemical carcinogenesis - receptor activation     102954757 (AKT2)    05208 Chemical carcinogenesis - reactive oxygen species     102954757 (AKT2)    05230 Central carbon metabolism in cancer     102954757 (AKT2)    05231 Choline metabolism in cancer     102954757 (AKT2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102954757 (AKT2)   09162 Cancer: specific types    05210 Colorectal cancer     102954757 (AKT2)    05212 Pancreatic cancer     102954757 (AKT2)    05225 Hepatocellular carcinoma     102954757 (AKT2)    05226 Gastric cancer     102954757 (AKT2)    05214 Glioma     102954757 (AKT2)    05221 Acute myeloid leukemia     102954757 (AKT2)    05220 Chronic myeloid leukemia     102954757 (AKT2)    05218 Melanoma     102954757 (AKT2)    05211 Renal cell carcinoma     102954757 (AKT2)    05215 Prostate cancer     102954757 (AKT2)    05213 Endometrial cancer     102954757 (AKT2)    05224 Breast cancer     102954757 (AKT2)    05222 Small cell lung cancer     102954757 (AKT2)    05223 Non-small cell lung cancer     102954757 (AKT2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102954757 (AKT2)    05170 Human immunodeficiency virus 1 infection     102954757 (AKT2)    05161 Hepatitis B     102954757 (AKT2)    05160 Hepatitis C     102954757 (AKT2)    05164 Influenza A     102954757 (AKT2)    05162 Measles     102954757 (AKT2)    05168 Herpes simplex virus 1 infection     102954757 (AKT2)    05163 Human cytomegalovirus infection     102954757 (AKT2)    05167 Kaposi sarcoma-associated herpesvirus infection     102954757 (AKT2)    05169 Epstein-Barr virus infection     102954757 (AKT2)    05165 Human papillomavirus infection     102954757 (AKT2)   09171 Infectious disease: bacterial    05132 Salmonella infection     102954757 (AKT2)    05135 Yersinia infection     102954757 (AKT2)    05152 Tuberculosis     102954757 (AKT2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102954757 (AKT2)    05142 Chagas disease     102954757 (AKT2)   09164 Neurodegenerative disease    05010 Alzheimer disease     102954757 (AKT2)    05017 Spinocerebellar ataxia     102954757 (AKT2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102954757 (AKT2)    05418 Fluid shear stress and atherosclerosis     102954757 (AKT2)    05415 Diabetic cardiomyopathy     102954757 (AKT2)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     102954757 (AKT2)    04932 Non-alcoholic fatty liver disease     102954757 (AKT2)    04931 Insulin resistance     102954757 (AKT2)    04933 AGE-RAGE signaling pathway in diabetic complications     102954757 (AKT2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102954757 (AKT2)    01524 Platinum drug resistance     102954757 (AKT2)    01522 Endocrine resistance     102954757 (AKT2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ptg01001]     102954757 (AKT2) Enzymes [BR:ptg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      102954757 (AKT2) Protein kinases [BR:ptg01001]  Serine/threonine kinases: AGC group   AKT/PKB family    102954757 (AKT2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like ABC1 Seadorna_VP7 Motif Other DBs NCBI-GeneID:  102954757 NCBI-ProteinID:  XP_007087285 LinkDB All DBs Position Un AA seq 478 aa AA seqDB search MNEVSVIKEGWLHKRGEYIKTWRPRLKSDGSFIGYKERPGAPDQTLPPLNNFSVAECQLM KTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPMDYK CGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAMKIL RKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAREVMEHRFFLSVNWQDVVQKKLL PPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIRE NT seq 1437 nt NT seq  +upstreamnt  +downstreamnt atgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag acctggagaccccggctgaagagtgacggctccttcatcggatacaaggagcggcctggt gccccagaccagaccctgccccccctaaacaacttctctgtcgcagagtgccagctgatg aagactgagagaccacggcccaacaccttcgtcatacgctgcctacagtggaccactgtc atcgagaggaccttccacgtagactctccagacgagagggaggagtggatgcgggccatt cagatggtcgccaacagccttaagcagcggggcccaggtgaggaccccatggactataag tgtggctcccccagtgacccttctgcggccgaggagatggaagtggcagttagcaaggct cgggccaaggtgaccatgaatgacttcgactatctcaaacttctgggcaagggcaccttt ggcaaagtgattctggtgcgggagaaagccagcggccgctactacgccatgaagatcctg cggaaggaagttatcattgccaaggatgaagttgcccacacagtcaccgagagccgggtc ctccagaacaccaggcacccattcctcactgcactgaagtatgccttccagacccacgac cgcctgtgcttcgtgatggaatacgccaacggtggtgagctgtttttccacctgtcccgg gaacgtgtcttcacggaggagcgagcccgcttctatggtgcagagatcgtctctgccctt gagtatttgcattcgcgggacgtggtgtaccgcgacatcaagctggaaaacctcatgctg gacaaagatggccacatcaagatcactgacttcggactgtgcaaagagggcatcagtgac ggggctaccatgaaaaccttctgtgggacgcccgagtacctggcacccgaggtgctggag gacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatgtacgagatg atgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgagctcatcctc atggaggagatccgtttcccacgcacactgagccctgaggccaagtccctgcttgctggg ctgcttaagaaggaccccaagcagaggctcggcggggggcccagcgatgccagggaggtc atggagcacaggttcttcctcagcgtcaactggcaggacgtggtgcagaagaagctcctg ccacccttcaaacctcaggtcacctctgaggttgacacaaggtactttgacgacgagttc accgcccagtccattacaatcacacccccggaccgctatgacagcctgggctccctcgaa ctggaccagcggacccacttcccccagttctcctactcagccagcatccgcgagtga

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