KEGG   Panthera tigris altaica (Amur tiger): 102955852
Entry
102955852         CDS       T02988                                 
Symbol
RAF1
Name
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg01521  EGFR tyrosine kinase inhibitor resistance
ptg01522  Endocrine resistance
ptg04010  MAPK signaling pathway
ptg04012  ErbB signaling pathway
ptg04014  Ras signaling pathway
ptg04015  Rap1 signaling pathway
ptg04022  cGMP-PKG signaling pathway
ptg04024  cAMP signaling pathway
ptg04062  Chemokine signaling pathway
ptg04068  FoxO signaling pathway
ptg04071  Sphingolipid signaling pathway
ptg04072  Phospholipase D signaling pathway
ptg04140  Autophagy - animal
ptg04150  mTOR signaling pathway
ptg04151  PI3K-Akt signaling pathway
ptg04210  Apoptosis
ptg04218  Cellular senescence
ptg04270  Vascular smooth muscle contraction
ptg04360  Axon guidance
ptg04370  VEGF signaling pathway
ptg04371  Apelin signaling pathway
ptg04510  Focal adhesion
ptg04540  Gap junction
ptg04550  Signaling pathways regulating pluripotency of stem cells
ptg04613  Neutrophil extracellular trap formation
ptg04625  C-type lectin receptor signaling pathway
ptg04630  JAK-STAT signaling pathway
ptg04650  Natural killer cell mediated cytotoxicity
ptg04660  T cell receptor signaling pathway
ptg04662  B cell receptor signaling pathway
ptg04664  Fc epsilon RI signaling pathway
ptg04666  Fc gamma R-mediated phagocytosis
ptg04720  Long-term potentiation
ptg04722  Neurotrophin signaling pathway
ptg04726  Serotonergic synapse
ptg04730  Long-term depression
ptg04810  Regulation of actin cytoskeleton
ptg04910  Insulin signaling pathway
ptg04912  GnRH signaling pathway
ptg04914  Progesterone-mediated oocyte maturation
ptg04915  Estrogen signaling pathway
ptg04916  Melanogenesis
ptg04917  Prolactin signaling pathway
ptg04919  Thyroid hormone signaling pathway
ptg04921  Oxytocin signaling pathway
ptg04926  Relaxin signaling pathway
ptg04928  Parathyroid hormone synthesis, secretion and action
ptg04929  GnRH secretion
ptg04935  Growth hormone synthesis, secretion and action
ptg05010  Alzheimer disease
ptg05022  Pathways of neurodegeneration - multiple diseases
ptg05034  Alcoholism
ptg05132  Salmonella infection
ptg05152  Tuberculosis
ptg05160  Hepatitis C
ptg05161  Hepatitis B
ptg05163  Human cytomegalovirus infection
ptg05164  Influenza A
ptg05165  Human papillomavirus infection
ptg05167  Kaposi sarcoma-associated herpesvirus infection
ptg05170  Human immunodeficiency virus 1 infection
ptg05200  Pathways in cancer
ptg05205  Proteoglycans in cancer
ptg05206  MicroRNAs in cancer
ptg05207  Chemical carcinogenesis - receptor activation
ptg05208  Chemical carcinogenesis - reactive oxygen species
ptg05210  Colorectal cancer
ptg05211  Renal cell carcinoma
ptg05212  Pancreatic cancer
ptg05213  Endometrial cancer
ptg05214  Glioma
ptg05215  Prostate cancer
ptg05218  Melanoma
ptg05219  Bladder cancer
ptg05220  Chronic myeloid leukemia
ptg05221  Acute myeloid leukemia
ptg05223  Non-small cell lung cancer
ptg05224  Breast cancer
ptg05225  Hepatocellular carcinoma
ptg05226  Gastric cancer
ptg05230  Central carbon metabolism in cancer
ptg05231  Choline metabolism in cancer
ptg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102955852 (RAF1)
   04012 ErbB signaling pathway
    102955852 (RAF1)
   04014 Ras signaling pathway
    102955852 (RAF1)
   04015 Rap1 signaling pathway
    102955852 (RAF1)
   04370 VEGF signaling pathway
    102955852 (RAF1)
   04371 Apelin signaling pathway
    102955852 (RAF1)
   04630 JAK-STAT signaling pathway
    102955852 (RAF1)
   04068 FoxO signaling pathway
    102955852 (RAF1)
   04072 Phospholipase D signaling pathway
    102955852 (RAF1)
   04071 Sphingolipid signaling pathway
    102955852 (RAF1)
   04024 cAMP signaling pathway
    102955852 (RAF1)
   04022 cGMP-PKG signaling pathway
    102955852 (RAF1)
   04151 PI3K-Akt signaling pathway
    102955852 (RAF1)
   04150 mTOR signaling pathway
    102955852 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102955852 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    102955852 (RAF1)
   04218 Cellular senescence
    102955852 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102955852 (RAF1)
   04540 Gap junction
    102955852 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102955852 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102955852 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102955852 (RAF1)
   04625 C-type lectin receptor signaling pathway
    102955852 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    102955852 (RAF1)
   04660 T cell receptor signaling pathway
    102955852 (RAF1)
   04662 B cell receptor signaling pathway
    102955852 (RAF1)
   04664 Fc epsilon RI signaling pathway
    102955852 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    102955852 (RAF1)
   04062 Chemokine signaling pathway
    102955852 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102955852 (RAF1)
   04929 GnRH secretion
    102955852 (RAF1)
   04912 GnRH signaling pathway
    102955852 (RAF1)
   04915 Estrogen signaling pathway
    102955852 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    102955852 (RAF1)
   04917 Prolactin signaling pathway
    102955852 (RAF1)
   04921 Oxytocin signaling pathway
    102955852 (RAF1)
   04926 Relaxin signaling pathway
    102955852 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    102955852 (RAF1)
   04919 Thyroid hormone signaling pathway
    102955852 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    102955852 (RAF1)
   04916 Melanogenesis
    102955852 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102955852 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    102955852 (RAF1)
   04720 Long-term potentiation
    102955852 (RAF1)
   04730 Long-term depression
    102955852 (RAF1)
   04722 Neurotrophin signaling pathway
    102955852 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    102955852 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102955852 (RAF1)
   05206 MicroRNAs in cancer
    102955852 (RAF1)
   05205 Proteoglycans in cancer
    102955852 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    102955852 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102955852 (RAF1)
   05230 Central carbon metabolism in cancer
    102955852 (RAF1)
   05231 Choline metabolism in cancer
    102955852 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102955852 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102955852 (RAF1)
   05212 Pancreatic cancer
    102955852 (RAF1)
   05225 Hepatocellular carcinoma
    102955852 (RAF1)
   05226 Gastric cancer
    102955852 (RAF1)
   05214 Glioma
    102955852 (RAF1)
   05221 Acute myeloid leukemia
    102955852 (RAF1)
   05220 Chronic myeloid leukemia
    102955852 (RAF1)
   05218 Melanoma
    102955852 (RAF1)
   05211 Renal cell carcinoma
    102955852 (RAF1)
   05219 Bladder cancer
    102955852 (RAF1)
   05215 Prostate cancer
    102955852 (RAF1)
   05213 Endometrial cancer
    102955852 (RAF1)
   05224 Breast cancer
    102955852 (RAF1)
   05223 Non-small cell lung cancer
    102955852 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102955852 (RAF1)
   05161 Hepatitis B
    102955852 (RAF1)
   05160 Hepatitis C
    102955852 (RAF1)
   05164 Influenza A
    102955852 (RAF1)
   05163 Human cytomegalovirus infection
    102955852 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102955852 (RAF1)
   05165 Human papillomavirus infection
    102955852 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102955852 (RAF1)
   05152 Tuberculosis
    102955852 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102955852 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    102955852 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    102955852 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102955852 (RAF1)
   01522 Endocrine resistance
    102955852 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ptg01001]
    102955852 (RAF1)
Enzymes [BR:ptg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102955852 (RAF1)
Protein kinases [BR:ptg01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102955852 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 102955852
NCBI-ProteinID: XP_007075502
UniProt: A0A8C9KE60
LinkDB
Position
Un
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQPFGFQRRASDDGKLADSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDATS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSPIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacaaggggcctggaagacgatcagcaatggctttggattcaaagatgca
gtgtttgatggccccagctgcatctcccctacaatagttcagccatttggctttcagcgt
cgggcatcagatgatggcaaacttgcggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgagaaatggaatgagcttgcatgat
tgccttatgaaagcactcaaggtgaggggcctgcagccggagtgctgtgcagtgttcaga
cttctccatgaacataaaggtaaaaaagcgcgtttagattggaatactgatgccacctcg
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagaccttcctgaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgttcccaaattctcct
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagaatct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aactcttccagcccttcctctgaaggttccctctcccagaggcagaggtcaacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccagcacagagagagagggcacca
ggatccgggacccaggagaaaaacaaaatcaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctttccactcggattggatcaggctcattt
ggaacggtgtataagggcaagtggcatggagatgttgcagtgaaaattctaaaagttgtc
gaccccacgccagagcagttccaggccttcaggaatgaggtggctgtcctacgcaaaaca
cggcacgtgaacatcctgctcttcatgggctacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagactaagttc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcgcgctggagcggttctcag
caggtcgaacaacccactggctctgtcctgtggatggcccccgaggtgatccggatgcag
gataataacccattcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggggagcttccttactcccacatcaataaccgcgaccagatcatcttcatg
gtgggccgagggtatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagctgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagcttctccaacactctctgccgaaaatcaaccggagtgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacattgacc
acatcccctagactgcctgtcttctag

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