KEGG   Panthera tigris altaica (Amur tiger): 102956086
Entry
102956086         CDS       T02988                                 
Symbol
ARAF
Name
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg01521  EGFR tyrosine kinase inhibitor resistance
ptg01522  Endocrine resistance
ptg04010  MAPK signaling pathway
ptg04012  ErbB signaling pathway
ptg04068  FoxO signaling pathway
ptg04270  Vascular smooth muscle contraction
ptg04650  Natural killer cell mediated cytotoxicity
ptg04720  Long-term potentiation
ptg04726  Serotonergic synapse
ptg04730  Long-term depression
ptg04810  Regulation of actin cytoskeleton
ptg04910  Insulin signaling pathway
ptg04914  Progesterone-mediated oocyte maturation
ptg04928  Parathyroid hormone synthesis, secretion and action
ptg05010  Alzheimer disease
ptg05022  Pathways of neurodegeneration - multiple diseases
ptg05034  Alcoholism
ptg05160  Hepatitis C
ptg05161  Hepatitis B
ptg05200  Pathways in cancer
ptg05205  Proteoglycans in cancer
ptg05208  Chemical carcinogenesis - reactive oxygen species
ptg05210  Colorectal cancer
ptg05211  Renal cell carcinoma
ptg05212  Pancreatic cancer
ptg05213  Endometrial cancer
ptg05214  Glioma
ptg05215  Prostate cancer
ptg05218  Melanoma
ptg05219  Bladder cancer
ptg05220  Chronic myeloid leukemia
ptg05221  Acute myeloid leukemia
ptg05223  Non-small cell lung cancer
ptg05224  Breast cancer
ptg05225  Hepatocellular carcinoma
ptg05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102956086 (ARAF)
   04012 ErbB signaling pathway
    102956086 (ARAF)
   04068 FoxO signaling pathway
    102956086 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102956086 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102956086 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102956086 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    102956086 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    102956086 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102956086 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    102956086 (ARAF)
   04720 Long-term potentiation
    102956086 (ARAF)
   04730 Long-term depression
    102956086 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102956086 (ARAF)
   05205 Proteoglycans in cancer
    102956086 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    102956086 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102956086 (ARAF)
   05212 Pancreatic cancer
    102956086 (ARAF)
   05225 Hepatocellular carcinoma
    102956086 (ARAF)
   05226 Gastric cancer
    102956086 (ARAF)
   05214 Glioma
    102956086 (ARAF)
   05221 Acute myeloid leukemia
    102956086 (ARAF)
   05220 Chronic myeloid leukemia
    102956086 (ARAF)
   05218 Melanoma
    102956086 (ARAF)
   05211 Renal cell carcinoma
    102956086 (ARAF)
   05219 Bladder cancer
    102956086 (ARAF)
   05215 Prostate cancer
    102956086 (ARAF)
   05213 Endometrial cancer
    102956086 (ARAF)
   05224 Breast cancer
    102956086 (ARAF)
   05223 Non-small cell lung cancer
    102956086 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102956086 (ARAF)
   05160 Hepatitis C
    102956086 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102956086 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    102956086 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    102956086 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102956086 (ARAF)
   01522 Endocrine resistance
    102956086 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ptg01001]
    102956086 (ARAF)
Enzymes [BR:ptg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102956086 (ARAF)
Protein kinases [BR:ptg01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102956086 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 102956086
NCBI-ProteinID: XP_015392812
LinkDB
Position
Un
AA seq 614 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQVYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSRTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTSAPMDSSLLQVGGAGVS
HGGHRAEGGASRPSSSSSLPRGSPSPSVPSGRKSPHSKSPSEQREPRERKSLADDKKKVK
NLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFK
NEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGPSLYHHLHVADTRFDMVQLIDVARQ
TAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLW
LAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSVPYSHIGSRDQIIFMVGRGYLSPDLS
KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQAD
ELPACLLSAARLVP
NT seq 1845 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtcttaatcaggattgctgtgtg
gtctaccggctgattgaggggcgaaagacagtcactgcttgggacacagccattgccccc
ctggatggagaggagctcatcgtagaggtccttgaagatgtgccattgaccatgcacaat
tttgtacggaagacgttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcactgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacaggtctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcccgcacccagcaccgcgaccctgagcactttcccttcccc
gcccctgccaacgccccactccagcgcatccgctccacatccactcccaacgtgcacatg
gtcagcacctcggcccccatggactccagcctcctccaggttggtggtgcgggtgtcagt
cacggagggcaccgggcggaggggggagcctcccgtccctcttcctccagctcactgccc
agggggagccccagccccagcgtgccctcggggaggaagtccccacattccaaatcccca
tcggagcagcgtgagccacgggagcggaagtccttggctgatgacaagaagaaagtgaag
aatctagggtaccgggactcgggctattactgggaggtgccgcccagcgaggtgcagctg
ctgaagaggatcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggcgac
gtggccgtgaaggtgctcaaggtggcccagcccacagcggagcaggcgcaggccttcaag
aacgagatgcaggtgctcaggaagacgcgtcatgtcaacatcttgctgttcatgggcttc
atgacccggccgggatttgccatcatcacacagtggtgtgagggccccagcctgtaccac
cacctacatgtggccgacacacgcttcgacatggtccagctcatcgacgtggcccggcag
actgcccagggcatggactacctccatgccaagaacatcatccaccgagatctcaagtct
aacaacatcttcctacacgaggggctcacagtgaagattggtgactttggcctggccacg
gtgaagacacggtggagcggggcccagcccttggaacagccctcgggctctgtgctatgg
ctggcggctgaggtgatccgtatgcaggacccgaacccctacagcttccagtcggatgtc
tacgcctacggggttgtgctctatgagctcatgacaggctctgtgccttacagccacatt
ggcagccgtgaccagattatcttcatggtgggccgtggctatctgtccccggacctcagc
aaaatctccagcaactgccctaaggccatgcggcgcctgctgtctgactgcctcaagttc
cagcgagaggaacgtcccctcttcccccagatcctggccacgattgagctgctgcagcgg
tcactccccaagattgagcggagtgcctccgaaccctccttgcaccgcacccaggctgat
gagttgcctgcctgcctcctcagcgcggcccgccttgtgccttag

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