Panthera tigris altaica (Amur tiger): 102961931 Help Entry 102961931         CDS       T02988                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg04020   Calcium signaling pathway ptg04371   Apelin signaling pathway ptg04713   Circadian entrainment ptg04921   Oxytocin signaling pathway ptg04970   Salivary secretion ptg05010   Alzheimer disease ptg05012   Parkinson disease ptg05020   Prion disease ptg05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:ptg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102961931 (RYR3)    04020 Calcium signaling pathway     102961931 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102961931 (RYR3)   09154 Digestive system    04970 Salivary secretion     102961931 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     102961931 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102961931 (RYR3)    05012 Parkinson disease     102961931 (RYR3)    05020 Prion disease     102961931 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     102961931 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ptg04040]     102961931 (RYR3) Ion channels [BR:ptg04040]  Voltage-gated cation channels   Ryanodine receptor    102961931 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  102961931 NCBI-ProteinID:  XP_007097695 LinkDB All DBs Position Un AA seq 4890 aa AA seqDB search MYLHPLTPPQSSEYSGEVFSTAICSPFLYHAQKYVSLGEDEVVLQCIANIHKEQRKFCLA AEGLGNRLCFLEPTSEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGG HRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQR SEGEKVRIGDDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLL GGHVVRLFHGHDECLTIPSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIR WGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIE GMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQR CQCEESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQH EDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRL LYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEG HIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDV TSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEG WGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRING QPVQGMFENFNTDGLFFPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKM RLEPVKEYKRDAEGVRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHEL WGMNKIELGWTFGKTRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAH VNPAAGEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRI KQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELA DPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQ AFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFA DYEIENGFVPICSLGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSK RLPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYLRLSMPVECHSS FSHSPCLDSDAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKF DLSKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAM GMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEE KNPVPQCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEE NRCVDVLELCEQEDLMQFHYHTLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLP GLLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRT CLKPGFRFSTPCFVVTSEEHQKQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVE FQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGETENRAEKEEVTQVEEKAV EAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQA NQKFRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDF HEDLLIHCGVPLEEEEEEEEDTSWAGKLRALVYKIKGPPKPAKEQPTEEEERCPTTLKEL ISQTMIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLA ALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGT EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDV AASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFL RFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLP SQGYKREVTEDGEYEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSIL RSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTF LLHLLEVGFLPDLRASASLDTVSLSTTEAALSLNRYLCSAVLPLLTRCAPLFAGAEHYTS LIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYC KMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPELFR MALPCLSAIAGALPPDYLDTRISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTK YAEHSHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTML AVGWSVERTKEGEALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVA ENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSR GMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFA KVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGS DSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSR TQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGK NIYVERQRPALGECLPPRPPAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEM CPDIPQLEGLMKEISDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPW CTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLE KLKKKAVKTVQEEEQLKADTKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNW LKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQ VKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYR DTDEEVKEHVRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFH LEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETE EYSFEEKLVQDLAKCPKVEEEEEEETDKHPDPLHQIILHFSRNALTERSKLEDDPLYTSY SSMMAKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGE MSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFER QNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGN TTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYI QGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSNQIELLKELLDLLQDMVVMLLS LLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIIS KKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTN LSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQ VKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSAERPEEEEEDEDS SYMLEIEGEEEDDKSFESASAFAMACASVKKNVANFLKKATLKNFRKQYRKVKKMTVKEL VKVFFSFFWMLFVGLFQLFFTILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQ FGIHDDAMEAERAEVTEPGITPELVHFVKGEKGDADIMSDLFGFRSKKEGGLKHGPEVGL GDLSEIIGKDEPPTLESTVQKKRRAQAAEMKASHEAEGKVEPEKTDMEDGEKEGTAKEEE QADTLWAEVTKKKKRRRGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFV AFAINFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPALRAL AIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVI NTPSFPSNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSW LSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTIL SSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHM YVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVVVILLAIIQGLIIDAFGELRDQQ EQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQE SYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14673 nt NT seq  +upstreamnt  +downstreamnt atgtacctgcacccactgaccccaccccagagttcagagtactcaggggaggtgttcagt actgccatatgttctccttttctgtatcatgctcaaaagtacgtgtctctcggtgaggat gaagtggttctccagtgcatcgcaaacattcacaaggagcagaggaagttctgcctggca gccgagggcctgggaaaccgcctgtgcttcctggaacccacttcagaagccaagtatgtt cctccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagctctg caggaaatgcttgccaatacaggtgaaaatggcggcgaaggggcagcacaagggggtggc cacaggaccctgctatatggccacgcgattctcctgcggcactccttcagcggaatgtat ctaacatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtcta cgggaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagaga tccgagggagagaaagttcgaattggtgatgacctcatccttgtcagcgtgtcctctgaa agataccttcatctctccgtatcaaatgggaacatacaagtggatgcctcttttatgcaa acactctggaatgtacatcccacgtgctcaggaagtagcatcgaagaaggttacctactt ggtgggcatgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctaca gaccagaatgactcccagcacaggaggatattctatgaagctgggggagctgggacacga gccagatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcaga tggggccaggctttccgcctccggcatctcaccacaggccactacctggccttgacagag gaccaaggccttatactgcaggaccgggcaaagtcagacaccaagtccacagccttctct ttccgggcttccaaggaaatcaaggagaaattggattctagtcacaagcgggatatagaa ggcatgggagttccagaaatcaaatacggagattccgtctgctttgtccagcacatagcc agtggtctgtgggtgacctacaaagcacaagatgccaagacttcccgccttggacctctg aaaagaaaggtcatactccatcaggaaggccacatggatgacgggctaacactgcagaga tgccagtgcgaggagtcccaggctgctcggatcatccggaacacgacagccttattcagc cagtttgtaagtggaaacaatcgtacggcggcccccatcaccctgccgatagaagaggtc ctgcagaccttacaggacctgatcgcctacttccagcccccggaggaggagatgcaacac gaagacaaacagaacaagctccgctcacttaagaacagacagaatcttttcaaggaagaa ggaatgttggcccttgtgttaaactgcatcgatcgcttaaacatctacaacagcgtggcg cactttgcaggaattgcaagggaggagagtggcatggcttggaaagagatcctgcgcctg ctatacaaactgctggctgctctcattcgtggaaacagaaacaactgtgctcaattctct aataaccttgattggctaatcagcaaattggatagactagaatcttcctcaggtatcttg gaagttttgcactgcatcttgactgaaagcccagaagccttaaatctgatagcagagggt cacatcaagtctatcatctccctgttggataagcatgggcggaatcacaaggttctggat gtgctgtgctccctctgtctctgcaatggggtagccgtgagagccaaccagaatctgatt tgtgacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaacgacgtg acaagcattcggccaaacatcttcctgggagttgctgagggctcagcacagtacaagaag tggtactttgagctgatcatagaccaagtggaccccttcctaacagctgagcccacacac ctacgggtgggctgggcctcttcctcaggctatgctccgtaccctggaggtggagaagga tggggaggcaacggtgttggagacgacctgtattcctatggctttgatggccttcacctt tggtcaggccgcatacccagagccgtggcctccatcaaccagcacctcctgagatcagac gacgtggtaagctgttgcctcgacctcggggtgcccagcatctctttccgcatcaacggg cagcctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtg agcttctcagcaggtgtcaaagtgcgttttttgatgggtggacgtcatggagaatttaag ttcctgcctccctctggctatgccccttgctatgaagccttactgccaaaagaaaagatg agattggagcccgtcaaagaatataaacgcgatgctgaaggagttagagatctgttgggt accacccagttcctctctcaagcctctttcatcccatgccccatagacaccagtcaggtg gttttgccacctcacctagagaagatccgagacaggctggctgaaaacatccacgaactt tggggaatgaataaaatagagcttggctggacttttggcaagacacgggatgacaataaa agacaacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataac ctacaaatgtcaacggaaaccttaaaaacccttctggccctggggtgccacattgctcat gttaatccagctgctggggaggatctcaagaaagtcaagttgcccaaaaactatatgatg tccaatggctacaagccagcccctttggatttgtctgatgtgaagctattacctcctcaa gaaattttggtggataagcttgcagaaaatgcacataatgtttgggccaaagacagaata aaacaaggatggacctatggcatccaacaggatttgaagaacaagagaaatccccggctg gtgccgtacgcattactggatgagcgtacgaagaagtccaatagggacagccttcgtgaa gctgttcgcacatttgttggttatggctataacattgagccgtcagaccaagaactagct gacccagctgtggagaaagtcagcatagataaaattcgatttttccgggtagagcggtct tacgcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatg cgcgttggctgggccaggccgggctgtcggcccgacgttgagctgggagccgatgatcaa gcctttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttgga cgtacgtggcagccaggagatgtggttggatgtatgattaaccttgatgatgcttcaatg atcttcacactgaatggggagctgctgattaccaacaaaggctctgaacttgccttcgct gattatgagattgagaatggcttcgtgcccatctgctctctgggactgtctcagatcggc cgcatgaatcttgggatggatgccagtaccttcaagttttataccatgtgcggcctccaa gagggctttgagccttttgctgtcaacatgaaccgagacgtggcgatgtggttcagcaag cgcctcccgacatttgtcaacgtgccaaaggatcatccgcacatagaggttgtgaggata gatggcactatggacagccctccatgcctcaaggtgacccacaagacattcggcacacag aatagcaatgccaacatgatctacctacgcctgagcatgcccgtcgaatgccactcctcc ttcagccacagcccctgcttggacagtgacgcattccagaaaaggaaacagatgcaagaa atactctctcatacaacaacacagtgctactatgcaatccgcatcttcgctggacaggac ccctcctgcgtctgggtcggatgggtgactccggactatcacttgtacagcgaaaagttt gacctgagtaaaaactgcacagtgactgttactctaggagatgaaagaggccgggtccac gaaagcgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacttcg caaagatcaagccggagcaacgtggacctggagatcggctgcctcgtggatctggcgatg ggcatgttgtctttctcagccaatgggagagagctcggtacctgctatcaggtggagccc aataccaaagtgtttccagcagtcttcctgcagcccacgagcacttcattgtttcagttt gaacttgggaagctgaagaatgcgatgcccttgtcggcggccatatttaagagtgaagag aagaacccagttccgcagtgtccacctcggctggacgtccaaaccatccagcccgtgctc tggagccgcatgcccagcagcttcctgaaggtggagacggaacgggtgagcgagcgccat ggctgggtggtgcagtgcttggagcccctgcagatgatggcactccacatccctgaggag aacaggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccattac cacacgctgcgactctacagtgcagtgtgcgccctgggaaacagccgcgtggcctacgcc ctatgcggccacgtggatctctcccagctgttctacgccattgacaacaagtacctccct ggcctccttcgttctggtttctatgacctgctcatcagcatccatctggccaatgctaag gagaggaagctaatgatgaagaatgagtacatcatccccatcaccagcaccaccagaaaa atccgcctgtatccagatgagtccaagaggcacgggctgcctggggtgggcctgagaacg tgcctcaagccagggttcaggttctccaccccttgctttgtcgtgaccagtgaggagcac cagaagcagagccctgagatccccttggagattctcaagacgaaggcactgagcatgctg acggaggcagtgcagcacagcggggctcacatccgggaccctgtcggtgggtctgtagag ttccagtttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgat gacgatgacgtcaggcagatcctcctcctgatcgatccctctgtgtttggggagcacagt ggggagactgagaacagagcagagaaggaggaagtgacccaggtggaagagaaggcagtg gaggccggagaaaaggccggcaaggaggctccagtcaaaggcttactgcagacccgactg ccagagtctgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctg cagcatcgagtggaggccattgtggcatttggcgacatttatgtctctaagctccaggca aatcagaagttccgctacaacgagctcatgcaggccttgaacatgtctgcagccctgact gcccggaaaaccagggagttccgctcacccccccaggagcagatcaacatgcttcttaac tttcaactgggagagaattgcccctgcccagaagagatccgagaggagctatatgacttc catgaggaccttctcattcactgtggtgttcccctggaggaggaagaagaggaggaggaa gacacatcctgggctgggaaactccgtgccttggtgtataaaatcaaaggccctcccaag cctgcaaaggaacagccaacagaggaggaagagagatgccctacgaccttgaaggagctc atctcacagaccatgatccgctgggctcaggaggaccagatccaggatgcggagttggtc cggatgatgttcaacctcctccggaggcagtacgacagcatcggggagctgctgcaggcg ctgcggaagacctacaccatcagtcaggcctccgtgagcgacaccatcagcctgctggct gccctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctc atgatcaatgggctgggagacattatgaacaacaaggtgttctaccagcatcccaacctc atgcgagtccttggcatgcacgagacagtgatggaggtgatggtgaacgtgttggggaca gagaagtctcagattgcctttccaaaaatggttgctagctgttgccgcttcctctgctac ttctgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttacctgttg gagaacagcagtgttggcctagcttccccttcgatgaggggatctaccccgctggatgtg gcagcttcctctgtgatggacaacaacgagttagccctgggcttagaggaaccagacctt gagaaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagcc aaagggtaccctgacgtcggctggaaccccatcgaaggggagcgctacctgtccttcctg aggtttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaag ctgctcatcagacgcccagagtgcttcggcccagccttgcgaggtgaaggaggaaacggt ctattggcagccatgcagggtgccattaagatctctgagaacccagctctcgacctcccc tctcagggatataagagagaagtcacggaggacggtgaatatgaagaagagatcgtgcac atgggcaatgcaattatgtctttctattcagcccttatagatctcctgggccgctgtgct cctgaaatgcatcttatccagacaggaaagggggaagccatccggatcaggtcaatcctg cgctccctggtccccactgaggacctggttgggatcatcagcatccccttgaagctgcct tccctgaacaaagatgggtcggtcagcgagccagatatggcagccaacttctgccctgac cacaaggcacccatggtgctgttcttggatcgtgtttatggcattaaggatcaaactttc ctgctccacttgctagaggttggatttttacctgacttaagagcctctgcctctctagat acagtttccctaagcaccacagaggctgcactctcactaaataggtatctatgttctgct gtgcttccgctcctcacaagatgtgcccctctctttgccggagcagaacactacacctct ttgatcgattctacactccagacaatatataggctttccaagggacgttccctcaccaaa gcccagagggacaccatagaagaatgtttgcttgccatttgcaatcacttgaggccttcg atgttacagcaactcttgcgacgtcttgtctttgatgtgccgcagctcaacgaatactgc aaaatgcctcttaagcttctgacaaatcactatgaacagtgctggaagtattactgtctg ccttcaggatgggggagctacgggctagctgtggaggaggaattgcacctgacggagaag ctcttctgggggattttcgactccctctcccataagaagtatgacccagagcttttccga atggcccttccttgtctcagtgctatagctggggcgctaccaccggattacttagatacc agaatctcagccacgttggagaaacagatctcagtggatgcagatggcaactttgacccc aaacccatcaacaccatgaatttttccttgcctgaaaaatgggagtacatcgtcaccaag tacgcggagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatat ggaatttccctggatgaaaatgtgaagacccatccactgataaggcctttcaagacatta acagaaaaggagaaggaaatttaccgctggcctgctagagagtccctgaaaaccatgctg gctgtgggctggtctgtggagaggaccaaagagggagaggccctggtgcaacagcgggaa aatgagaagcttcggagtgtgtcccaggccagccagggcaacagctacagtcctgctccc ctggacctctccaacgttgtgctctccagggagctccagggaatggtggaggtcgtggcc gagaactatcacaacatctgggccaagaagaagaagctggagctggagagcaaaggtggc ggcagtcaccctctgttggtaccatatgacaccttgacagccaaggagaagttcagggac cgagaaaaggcacaggacctgtttaaattcctccaggtgaacggcatcgtggtttctaga ggtatgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaattt ttgaagaagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagcc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccgctggttgaccagtacttcaccaatcaccgcctctacttcctgtca tcccctctaaaacccctcagcagcagtggctatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaactcgctgctcttgttcgacacaggatttccctctttggaagt gattctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggact gtcatgaagtcaggctcagagctggtgaaggctgggttacgagctttctttgaaaatgcg gcggaagacttagagaagacttcggaaaatctgaagcttgggaagtttacgcattccaga acacagattaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatc ctgacgtccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggt gatgtgcagatttcatgctaccacatactctgcagcctctactcccttgggaccggaaag aacatctacgttgaaaggcaacgtcctgcccttggagaatgtctgcccccccggccccct gccataccggtggcattcttggaacccactcttaaccgctacaatccactctcagtcttc aacaccaaaacccccagagagaggtctattctggggatgccagacacagtggaagagatg tgtcctgacatccctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtca ggggcccggtacacggagatgccccacgtcatcgaagtgatcttgcccatgctgtgcaac tacctgtcctactggtgggagcgggggccggagcacctgccccccagcacggggccctgg tgcaccaaggtcacctctgaacacctcagtgtcatcctgggaaacattctgaaaatcatc aacaacaacctgggcatcgacgaggcatcctggatgaagcgcatcgcagtgtatgcccag ccaatcatcagcaaagccaggccggacctgctgaaaagccacttcatcccaactctggag aagctgaagaaaaaggctgtgaagactgtgcaggaggaggagcagctgaaggccgacacc aaaggagacactcaggaggcggagctcctcatcctggatgagtttgcagtcctctgcaga gacctctacgccttctaccccatgctcatccgctacgtggacaacaacagatcgaactgg ctcaaaagtcccgatgctgattctgaccagctcttccgcatggtggcagaggtcttcatc ctgtggtgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaa gtaaagtctggaggacaggaccaggaacggaagaagaccaagcggaggggagacttgtac tccatccagacctctctcatcgtggctgcgctcaagaaaatgctgcccattggtttgaat atgtgcacgccaggcgatcaggagctaatctcccttgcaaagtcacgatacagctatagg gataccgatgaagaggtgaaagaacatgtgcggaataacttgcacctgcaggaaaagtcg gatgacccagcagtaaagtggcagctgaacctctacaaagatgttttgaagagtgaagaa ccttccaatccagaaaagaccgtagagcgtgtacagagaatttccgcagctgtcttccat ctggagcaggtcgaacagcctttgaggtccaagaaggcagtctggcacaaactgttatca aagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctgtacaacttgccc aggcaccgctccattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggacttggctaaatgccccaaggtggaagag gaggaggaggaggagacagacaagcacccagacccacttcatcagatcattctccatttt agccgcaatgctctcacggagaggagcaaattggaagacgaccccttgtacacctcctat tccagcatgatggccaagagttgtcagagtggggaggacgaagaagaagaggaagacaag gaaaagacatttgaagagaaggaaatggaaaagcagaaaaccctctaccaacaagctcga ctgcatgagcgtggggctgcagagatggtcctccagatgataagtgccagcaaaggtgag atgagccccatggtggttgagactctgaagctggggatcgccattctgaatgggggcaac gctggtgtacaacagaaaatgctagattacctaaaggagaaaaaggatgctggattcttt caaagcctttccggccttatgcagtcttgcagtgtccttgatttgaatgcatttgagagg cagaataaagctgaaggcctggggatggttactgaggaaggaacactcattgtccgtgag cgtggtgaaaaagtactccagaatgacgagtttacacgagatctctttagattcctgcag ttactttgtgaaggacataacagtgacttccagaacttcctgcggactcagatgggcaac accaccactgtcaatgtcatcatcagtaccgtggactacctcctgcgtctgcaggaatca atcagtgatttctactggtattattcagggaaggacatcattgatgaatctggacagcac aacttttccaaagctctggcagtcacgaagcagattttcaattctcttacagaatacatc cagggcccttgcattgggaaccaacagagcctggctcacagcaggctgtgggatgcagtg gtcggcttcctgcacgtatttgctaatatgcagatgaaactctctcaggattccaatcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggaactattggcaagcagatggttgacacgctggta gagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaa gacctaaccagctcagacaccttcaaagaatatgacccagatggtaaagggattatctcc aaaaaagaattccagaaggccatggaagggcaaaaacagtacacacagtcagagatcgac tttctcctttcatgtgcagaagctgatgagaatgatatgtttaattacattgattttgta gaccggtttcatgagccggccaaggacatagggtttaatgtggcagtgttattgacaaat ctctccgaacacatgccaaatgattctcgccttaagtgcctattggacccagcagaaagt gtactaaattacttcgaaccctacctaggacgtattgagatcatgggtggggccaagaaa attgagcgcgtttattttgagatcagtgaatccagtcgaacccagtgggagaagccccag gtgaaggaatctaagcggcagttcatctttgatgtggtcaatgaaggtggagagcaagaa aagatggaactgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcatct cagatctctgaatctgactcagccgaaaggccagaagaggaggaggaagatgaagattct tcttacatgttagaaattgagggggaagaggaggatgacaagtcttttgagtctgcctct gcatttgccatggcctgtgcctcagtgaagaaaaacgttgccaacttcctgaagaaggca accctgaagaacttcaggaagcagtacaggaaggtgaagaagatgaccgtgaaggagctg gtgaaggtgttcttctctttcttctggatgttatttgtggggctattccagttgttcttc accatattgggaggaatctttcagatcctctggagcacagtgtttggagggggcctagtg gaaggggcaaagaacatcagagtgaccaagatcctgggtgacatgcctgacccaacccag tttggtatccatgacgatgccatggaggctgagcgggcagaggtgactgagccaggtatt acaccggaactagtccacttcgtcaagggtgagaaaggagatgcagatatcatgtcagat ctctttggattccgctcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttg ggtgatctctctgagattattggcaaggatgaaccccctacactagagagtactgtacag aagaaaaggagagcacaggcagcagaaatgaaagcatcacatgaagcagaaggaaaagtg gagcctgagaagacagacatggaagatggggagaaggagggtacggccaaggaggaagag caagctgacaccctgtgggcagaagtgacaaagaagaagaagcggcgacggggccagaaa gttgagaagcctgaagccttcatggctaatttcttcaaagggctggaaatctatcagacc aagttactgcattacctggccaggaatttctacaacctgaggttcctcgctctgtttgta gccttcgctatcaacttcatcctgctcttttacaaggtcactgaagagcctttggaagaa gagacagaggacgttgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcg atggtgttcttcgtcctacaggagagcactgggtatatggcgccagcactgcgggccttg gccattatccacaccatcatctctttggtctgtgtggtgggctattactgcctgaaggtc cctttggtggtgttcaaaagagaaaaagaaattgccaggaagctggagttcgatggcctg tatatcactgaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtaatc aacacaccatcttttcctagtaactactgggacaagtttgtaaagagaaaggtgattaac aagtatggtgatctctacggagcagaacgcattgctgaactcctaggtttggacaaaaat gcccttgatttcagcccagtagaagaaagcaaagcagaggcggcctctctggtgtcatgg ctgagttccatcgacatgaagtaccatatctggaagctgggagttgtttttactgataac tcttttctctaccttgcctggtatacaaccatgtcgatcctgggccactacaacaacttc ttctttgctgcccatctgctagacattgcaatgggcttcaagacgctgaggactattctg tcatctgtaactcacaacggcaaacagctggttctgactgtgggtctcctggctgtggtg gtttacctctacaccgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaa gatgacgatgagcctgatatgaagtgtgacgacatgatgacgtgttacctattccacatg tatgtgggagtaagagcaggaggcggcattggcgacgaaattgaagaccctgctggtgat ccttacgaaatgtaccgcattgtctttgacatcacgttcttcttctttgtcgttgtcatc ttgctggccatcattcaaggtcttattattgatgcttttggagagttaagagaccagcag gaacaggtgcgagaagatatggagactaaatgtttcatctgcgggattggcaatgactac tttgacacgacccctcatggttttgaaacacacaccttacaggagcacaacttagccaac tatttgttcttcctgatgtatctgattaacaaagatgaaacagaacacacgggtcaggaa tcttatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgc tttcggaaacaatatgaagatcagcttggataa

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