Panthera tigris altaica (Amur tiger): 102963018 Help Entry 102963018         CDS       T02988                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg04020   Calcium signaling pathway ptg04024   cAMP signaling pathway ptg04260   Cardiac muscle contraction ptg04261   Adrenergic signaling in cardiomyocytes ptg04371   Apelin signaling pathway ptg04713   Circadian entrainment ptg04911   Insulin secretion ptg04921   Oxytocin signaling pathway ptg04972   Pancreatic secretion ptg05020   Prion disease ptg05022   Pathways of neurodegeneration - multiple diseases ptg05410   Hypertrophic cardiomyopathy ptg05412   Arrhythmogenic right ventricular cardiomyopathy ptg05414   Dilated cardiomyopathy ptg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ptg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102963018 (RYR2)    04020 Calcium signaling pathway     102963018 (RYR2)    04024 cAMP signaling pathway     102963018 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     102963018 (RYR2)    04921 Oxytocin signaling pathway     102963018 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     102963018 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102963018 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     102963018 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     102963018 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     102963018 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     102963018 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     102963018 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     102963018 (RYR2)    05414 Dilated cardiomyopathy     102963018 (RYR2)    05415 Diabetic cardiomyopathy     102963018 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ptg04040]     102963018 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ptg04990]     102963018 (RYR2) Ion channels [BR:ptg04040]  Voltage-gated cation channels   Ryanodine receptor    102963018 (RYR2) Domain-containing proteins not elsewhere classified [BR:ptg04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102963018 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  102963018 NCBI-ProteinID:  XP_015394711 LinkDB All DBs Position Un AA seq 4860 aa AA seqDB search MMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSG SEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETL RVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDV GVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMD DGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLI GYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGR EGGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLV ESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGR DLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWAST EGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLD LSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYA PCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLER IREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETL KTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLA ENAHNVWARDRIRQGWTYGIQQDVKNKRNPXXXXLDDRTKKSNKDSLREAVRTLLGYGYH LEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQ PDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILL DDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNT NRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYR LSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDK EATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQT STYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRS NCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAA FAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQF LKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSA VCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNS EFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEFP LDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNDDLKHIL QLIEPSVFKEAATPEEDTEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVK LQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTK EFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDL TIRGRLLSLVEKVTYLKKKQAEKPVESGSKKSSTLQQLISETMVRWAQESVIEDPELVRA MFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMI RGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYF CRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLE KVVRYLAGCGLQSCPMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRL LIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEQEEDDTIH MGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMP TIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLD TAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTK AQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCL PGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMES NYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIY GEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNR SRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESK GGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAY SFLQQLIRYVDEAHQYILEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFL SAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDAR TVMKTGLESVKSALRTFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLP MLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFA GAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAE SGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKI IYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAE ARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVF IYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQT SLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPA IRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQR KRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEE EGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFE VTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILN GGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGE KVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISD FYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGF LHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESS NNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLL SCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLN YFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKME LFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTVKSALFA LRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASVSRGFFR IICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSEDLTDLK ELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKVKEE EKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAY QQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGNAKVSSL DSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVA RKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRIS ELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMT MSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN FFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFET HTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14583 nt NT seq  +upstreamnt  +downstreamnt atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtatctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgacgttggcttgcaagaggacacaacaggtgaggcttgttggtgg accattcatcctgcctccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagcagcccaagggtatctaattggtggtgacgtcctcaggttgctgcacggacac atggatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccgatcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacatataaatactggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gacggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agcactgtcttccttttcaacaggtttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccacagtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagtgcggcgcatttcgcggacgtggcggggaga gaaggaggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaaatccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgc catggagtagcggtccgttccaaccagcatctcatctgcgacaatctgctgccgggaaga gatctgcttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtactatgagctgatggtggac cacacggagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagttggagac gatctcttttcctacggatttgatggccttcacctctggtcaggttgtattgcacgtact gtaagctcaccgaatcaacatctcttgagaactgacgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacatggagaatttaaattccttcctccacctgggtatgct ccttgttatgaagctgttctgccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccctgtggacaccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttgcagatgtcgcttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccctctcaggaagcgatggtggacaagttggcg gagaacgcgcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacaaaagaaaccctnnnnnnnncnttctagatgaccgcaccaag aagtccaacaaggacagcctccgcgaggccgtgcgcacgctgctgggatatggctatcat ctggaggcgccagatcaagatcatgctgcccgagccgaagtgtgtagcggcaccggggag aggttccgaatcttccgcgctgagaaaacctatgccgtcaaggcaggaaggtggtatttt gaatttgaggctgtcactgctggagacatgagagttggatggagcaggccaggttgtcaa cctgaccaagagctgggctcagacgaacgtgcctttgcttttgacggcttcaaggcccag cggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgatgttgtggga tgcatggtggacatgacagagcacaccatgatgttcacactgaatggcgaaatccttctg gatgactcgggctcggaactggcgttcaaggacttcgatgttggtgacggattcattcct gtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggatgtcagcacc ttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgctgtgaacacg aacagggatattaccatgtggctaagcaagaggcttcctcagtttctccaggtcccttca aaccatgagcacatcgaggtgaccagaatagatggcaccatcgacagttctccgtgttta aaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatgttctatcgc ctgagcatgccaatcgagtgtgccgaggttttctccaagacggtggcaggcgggctccca ggcgccggcctctttgggcccaagaatgatctggaggattacgatgcagattctgacttt gaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgacaaagacaag gaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaagccctctcgt ctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagccattctgca aggctcaccgaagatgtccttgcagatgatcgggatgattatgattacttgatgcaaacg tccacgtactattactcagtgagaatctttcccggccaagaacctgctaacgtctgggtg ggctggattacatcagatttccatcagtatgatacaggctttgacttggacagagttcgt acagtaaccgttactctaggagatgaaaagggaaaagtacacgaaagcatcaaacgcagc aactgctatatggtgtgcgcgggcgagagcatgagcccagggcaaggacgcaacaataat ggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacattcaccgccaac ggcaaggagctgagcacctactaccaggtggagccaagtacgaaattatttcctgcagct tttgcccaagctacaagtcccaatgttttccagtttgagctgggaagaatcaagaatgtg atgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgccacagtgtccc ccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgcccaaccagttc ctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcagtgtttggat cctctgcagttcatgtctctccatatcccggaggagaacagatctgtggacatactggag ctgacagagcaggaagagctgctgaaattccactaccacacgctccggctttactccgcc gtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtggacgaaccc cagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggccggctactat gacctgctgattgacatccacctgagctcctacgccactgccaggctcatgatgaacagt gagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccctgatgagaac aaaaagcacggcctccccgggattggcctcagcacctccctcaggccacggatacagttc tcctcccccagttttgtgagcatcaataacgaatgctaccaatacagtccagagttcccg ctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaagagggcagc ctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacctctcatcaag cttttctatactctgctcatcatggggatcttccacaatgacgacttaaaacacatcttg cagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagacactgaggct ctggagaaagagccctccatggaagactccaagccagaaggagctggagaagaagaagcc aaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgagccagttaaa ttgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacaccggatagaa gccatcgtggccttttcagatgactttgtagccaagctccaagacaatcagcgcttccgt tacaacgaagttatgcaagctttaaacatgtcggccgcgctcactgccaggaagacaaag gaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaaggatgacaaa agtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcacgaagatttg atgacacattgtggaattgagctggatgaagatgggtctcttgatggaaacagtgactta acaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaagaagaaacaa gccgaaaaaccagttgagagtggctccaagaagtcctctactcttcagcagttgatttct gagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactggtgagggcc atgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgggctctgcca aagacctacactataaatggtgtctccgtggaggataccatcaacctgctggcatctctc ggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaagcttatgatt cgtggattaggggatatcatgaataataaagtattttaccagcaccctaatctcatgagg gcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttggaggtggagag tccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctttgttacttc tgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctatttattggag aacagcagtgttggtcttgcctcaccagcaatgagaggttcaacaccattggatgtggca gccgcatcagtgatggataataatgaactggccttagctctgcgtgagccagatttggaa aaggtagttcgatatttggctggttgtggactgcagagttgcccgatgctggtatctaag ggttacccagatattgggtggaatccagttgaaggagagagataccttgactttctccga tttgctgtcttctgtaatggggagagtgtggaggagaatgctaatgttgtggtgaggttg ctcatccggaggcccgagtgtttcggtcctgctttgagaggggaaggtgggaacggtctt cttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagatggtccctca ccaactagcggatccagtaaaacacttgagacagaacaggaggaggatgacactatccac atggggaatgccatcatgacgttttatgcagctttgattgacctcttaggacgctgtgct cctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccggtcaattctg agatccctaattccactgggagatttggtgggagtaatcagcattgcttttcagatgcca acaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttttgcccagat cacaaggcagccatggttttgttccttgacagggtctatggcattgaggttcaagatttc ctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgcttctttagat acggctgctttgagtgccacagacatggccctggccctcaatcggtacctttgcacagcc gtgttgcctttgttaacaagatgtgcccctctttttgcgggcacagaacaccacgcttct ctcattgactcgttactgcacactgtgtacagactttcgaagggctgctcacttaccaaa gctcagcgggattccatagaagtttgtttgctctctatttgtggccaattgagaccttct atgatgcagcacttgctccgaagattagtgtttgacgtcccattattaaatgaacatgcg aagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatattactgcctg cctggagggtgggggaacttcggagctgcctcagaagaagaacttcatttatcaagaaag ttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaacttttcaaa ctggcactgccttgcctgagtgccgttgcgggagctttgcctccagactacatggagtca aattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaactttaaccca caacctgttgatacctcaaacattacaattcctgagaagttggaatacttcattaacaaa tatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatggatggatttat ggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatataaactatta tctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaaaccatgctg gcatggggttggagggttgagagaacacgggagggagacagcatggccctctacaaccgt tctcgtcgtatttcgcagacaagccaggtttctgttgatgctgcgcatggttatagcccc cgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatggcagaaatg atggctgaaaactaccataatatatgggcaaagaaaaagaaaatggagctggagtccaaa ggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaagagaaagcc aaggatagggaaaaagcacaggacatcctcaagttcttacagatcaatggatatgctgta tccaggggattcaaggacctggaattggacacaccttccattgagaaacgatttgcctat agtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatcctggagttt gatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatcaagttcttt gctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgtttatacttctta tctgcagcaagcagacccctctgttctggaggacatgcgtcaaacaaggagaaagaaatg gtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttcactatttgga aatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttggatgcaagg accgtcatgaagactggcctggagagtgttaaaagtgcgctcagaacgtttctggacaat gcggcagaagatctggagaagacgatggagaatctcaagcagggccagttcacccacacc cgaaaccaacccaaaggtgttactcagattatcaattataccacggtggctctgttgcca atgctgtcatcattatttgagcatattggccagcatcagttcggagaagatctaatattg gaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttgggaaccagc aaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtcttgctgcttttgct ggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacatctactctatc tacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactaacgtggaagat gtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaattagcggag tccggcattcgctacacgcagatgccacacgtcatggaagtcatactgcccatgctttgc agctacatgtctcgttggtgggagcacggacctgaaaataatccagaaagggctgaaatg tgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatatattgaaaatc atatataataacctgggaattgatgagggagcctggatgaagaggttagcagtattttca cagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttgccattaatg gagaaactcaagaaaaaagcagcgatggtggtgtcggaggaggaccatctgaaagctgag gccaggggggatatgtccgaggcagagcttctcattcttgatgagttcaccactctggcc agagacctctatgccttctacccgctcttgattagatttgtggactataacagggcaaag tggctaaaagaacctaacccagaagcagaggaccttttccgcatggtggccgaagtgttt atctactggtcaaaatcccacaatttcaaaagagaagagcagaacttcgtggtacagaat gaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtcaaaggccgct gtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactccacgcagacc tctctcattgtggcagctctgaagcggttgctgcccattgggttgaacatctgtgcccct ggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagacactgaggat gaagtacgagatataatccgcagtaatattcatttacaaggcaagttggaggatcctgct atcagatggcaaatggctctttacaaagacttaccgaacaggactgaagatacatcagat ccagagaagaccgtagagagagtattagatatagcaaatgtgctttttcatcttgagcag gtggagcacccacagagatcgaagaaagctgtatggcacaaacttctgtccaagcagagg aagagggcagtggtggcctgcttccgaatggctcctttatataatctgccaaggcaccgg gccgttaacctctttcttcagggatacgaaaagtcttggattgaaacagaagaacactac tttgaagataagctgatagaagatttagcaaaacctggagcagaccctccagaggaagag gaaggcacgaagagagtcgaccccctccatcagctcatccttctgtttagtcgaacagct ttaacagagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatg gcaaagagttgtcatgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaa gtcacaggatcccaacgcagcaaggaaaaagaaatggagaagcagaagcttctgtaccag caagccaggctccatgaccgcggggctgctgagatggtgctacagaccatcagtgccagc aaaggtgatactggaccaatggtagcggcgactttgaaacttggaattgcaatcttaaat ggcgggaactccacagttcagcagaaaatgcttgactatctcaaggagaagaaggacgtg ggtttctttcagagccttgccggcctgatgcagtcgtgcagcgtcctcgacctaaatgca tttgagcggcagaacaaagctgaaggacttggaatggtcacggaagaaggatcaggagaa aaggttctccaagatgacgagttcacgtgtgacctcttccgtttcctccagctgctttgt gagggacacaactcagattttcaaaattatctgagaactcagactggcaataacacaact gtcaacatcatcatctctaccgtagactacctactcagagtccaggaatccattagtgat ttctattggtattactctgggaaagatgttattgatgaacaaggacaacggaatttctcc aaagcaattcaagtagcaaaacaagtctttaacacgctcacagagtatattcagggtcct tgcactgggaatcagcagagcttggcccacagcaggctatgggacgcagttgtgggcttc cttcacgtattcgcccacatgcagatgaagctgtctcaggattccagtcaaatcgagcta ttaaaagaattaatggatcttcagaaggatatggtggtcatgttgctgtccatgctagaa ggtaatgttgtcaatggaaccattggcaaacagatggtcgatatgcttgtggagtcttcc aacaacgtggagatgattctcaagttttttgacatgttcttaaaactaaaggatttgacc tcttctgacacatttaaagaatacgaccctgacggcaagggagtcatttccaagagggac ttccataaagcgatggagagccataaacactacacgcaatcagaaaccgagtttcttctg tcctgtgcagagacggatgaaaacgaaaccctggactatgaagagtttgtcaaaaggttt cacgagcccgcaaaggacatcggcttcaacgtggccgttcttctgaccaacctttcggag cacatgcccaatgacacgcgactgcagactttcctggagttggcagagagcgtgctgaat tacttccagccctttctgggccgcatcgagatcatgggaagtgccaaacgcatcgagagg gtgtattttgaaatcagtgagtccagccgaacccagtgggagaagccccaggtcaaggag tccaaaaggcagttcatatttgacgtggtcaacgaagggggagaaaaggagaaaatggaa ctttttgtcaacttctgtgaggacaccatattcgaaatgcagctggcagcgcagatctca gagtcggatttgaatgagaggtcagcgaataaagaagagagtgagaaggagaagccagaa gagcaggggcccagaatgggtttcttttccatcgtgacggtcaagtcggccctgtttgct ctcaggtataatatcttgaccctcatgagaatgctcagcctgaagagcctgaagaaacag atgaaaaaggtgaagaagatgacgatgaaggatatggtcacggccgccttttcgtcctac tggagtattttcatgagcctcctgcactttgtggccagcgtttccagaggcttcttccgc atcatttgcagcctgctgcttggcgggagcctagtagaaggagcaaaaaagatccgagtg gcagagctcttagccaacatgccagaccccactcaggatgaggtgagaggggatggagaa gagggggacaggaggcccatggaggccgccctgccctcggaagatctgacagacctgaag gaactgacagaggaaagcgaccttctttcggacatatttggcttggatctgaagagagaa ggaggacagtacaaacttattcctcataatccaaacgctggcctcagcgatctaatgagc aacccggtccctatccctgacgtgcaagaaaaatttcaggaacagaaggtgaaagaggaa gaaaaggaggagaaagaagaaagcaaatctgaacctgaaaaggccgagggagaagatgga gaaaaagaagaaaaagccaaagaagataagggtaaacagaagttgaggcagctccacaca cacagatacggagagccagaagttcccgagtcggcattctggaagaaaatcatcgcatat caacagaaacttctaaactattttgctcgcaacttttacaacatgagaatgttagcctta ttcgtcgcgtttgcaatcaatttcatcttgctcttttataaggtctccacttcttctgtg gttgaaggaaaggagccccccactcgcagttcaagtggaaatgccaaagttagcagcctg gacagtggctcgcctagaatcatcgcggttcactacgtcctggaggagagcagcggctac atggagcccacgctgcggatcttagccattcttcacacggtcatttctttcttctgcatc atcggctactactgcttgaaagtcccattggttatttttaagcgagaaaaggaagtagct cgaaaattggaatttgatgggctttatattacagaacagccttcagaagatgatattaaa ggccagtgggatagactcgtaatcaacacacagtcatttcccaacaactactgggacaaa tttgttaaaagaaaggttatggataaatatggggagttctatggccgggacagaatcagc gagctccttggtatggacaaagccgccctagatttcagcgatgcccgggaaaagaagaag ccaaagaaagacagctccctgtcagccgtactgaactctattgatgtgaagtatcagatg tggaaactaggagtcgtcttcacggacaactctttcctctacctggcctggtatatgact atgtccgttctgggacactataacaactttttttttgctgctcatcttcttgacattgcc atgggattcaagacactgagaaccatcttgtcatcggtaactcacaatggcaagcagctt gtattaactgttggcttgttagctgttgttgtatacctatatactgttgtggcattcaac tttttccgaaaattctacaataaaagtgaagatggtgacacaccggatatgaaatgtgat gatatgctaacgtgctacatgttccacatgtacgtcggggtacgtgccggagggggtatc ggcgatgaaatcgaagacccagcaggcgacgaatatgagatctatcgaatcatctttgac atcaccttcttcttcttcgtgattgtcatcctcttggccataattcaaggtttaattatt gatgcttttggagagctaagagaccaacaggagcaagtcaaagaagacatggagaccaaa tgtttcatctgtgggataggcaacgattacttcgacacagtgccacatggctttgaaacc cacactttacaggaacacaacctggccaattacctgttttttctgatgtatctcataaac aaagatgaaacagagcacacgggacaggaatcttatgtctggaagatgtatcaagaaaga tgctgggaattcttcccagcaggggattgtttccggaaacagtatgaagaccagctaaat taa

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