Panthera tigris altaica (Amur tiger): 102963653 Help Entry 102963653         CDS       T02988                                  Symbol PLCG2 Name (RefSeq) phospholipase C gamma 2   KO K05859   phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg00562   Inositol phosphate metabolism ptg01100   Metabolic pathways ptg01521   EGFR tyrosine kinase inhibitor resistance ptg04012   ErbB signaling pathway ptg04014   Ras signaling pathway ptg04020   Calcium signaling pathway ptg04062   Chemokine signaling pathway ptg04064   NF-kappa B signaling pathway ptg04066   HIF-1 signaling pathway ptg04070   Phosphatidylinositol signaling system ptg04072   Phospholipase D signaling pathway ptg04360   Axon guidance ptg04370   VEGF signaling pathway ptg04380   Osteoclast differentiation ptg04611   Platelet activation ptg04613   Neutrophil extracellular trap formation ptg04625   C-type lectin receptor signaling pathway ptg04650   Natural killer cell mediated cytotoxicity ptg04662   B cell receptor signaling pathway ptg04664   Fc epsilon RI signaling pathway ptg04666   Fc gamma R-mediated phagocytosis ptg04670   Leukocyte transendothelial migration ptg04722   Neurotrophin signaling pathway ptg04750   Inflammatory mediator regulation of TRP channels ptg04919   Thyroid hormone signaling pathway ptg04933   AGE-RAGE signaling pathway in diabetic complications ptg04935   Growth hormone synthesis, secretion and action ptg05167   Kaposi sarcoma-associated herpesvirus infection ptg05169   Epstein-Barr virus infection ptg05170   Human immunodeficiency virus 1 infection ptg05171   Coronavirus disease - COVID-19 ptg05200   Pathways in cancer ptg05205   Proteoglycans in cancer ptg05206   MicroRNAs in cancer ptg05214   Glioma ptg05223   Non-small cell lung cancer ptg05225   Hepatocellular carcinoma Module ptg_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:ptg00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102963653 (PLCG2)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102963653 (PLCG2)    04014 Ras signaling pathway     102963653 (PLCG2)    04370 VEGF signaling pathway     102963653 (PLCG2)    04064 NF-kappa B signaling pathway     102963653 (PLCG2)    04066 HIF-1 signaling pathway     102963653 (PLCG2)    04020 Calcium signaling pathway     102963653 (PLCG2)    04070 Phosphatidylinositol signaling system     102963653 (PLCG2)    04072 Phospholipase D signaling pathway     102963653 (PLCG2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102963653 (PLCG2)    04613 Neutrophil extracellular trap formation     102963653 (PLCG2)    04625 C-type lectin receptor signaling pathway     102963653 (PLCG2)    04650 Natural killer cell mediated cytotoxicity     102963653 (PLCG2)    04662 B cell receptor signaling pathway     102963653 (PLCG2)    04664 Fc epsilon RI signaling pathway     102963653 (PLCG2)    04666 Fc gamma R-mediated phagocytosis     102963653 (PLCG2)    04670 Leukocyte transendothelial migration     102963653 (PLCG2)    04062 Chemokine signaling pathway     102963653 (PLCG2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     102963653 (PLCG2)    04919 Thyroid hormone signaling pathway     102963653 (PLCG2)   09156 Nervous system    04722 Neurotrophin signaling pathway     102963653 (PLCG2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102963653 (PLCG2)   09158 Development and regeneration    04360 Axon guidance     102963653 (PLCG2)    04380 Osteoclast differentiation     102963653 (PLCG2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102963653 (PLCG2)    05206 MicroRNAs in cancer     102963653 (PLCG2)    05205 Proteoglycans in cancer     102963653 (PLCG2)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102963653 (PLCG2)    05214 Glioma     102963653 (PLCG2)    05223 Non-small cell lung cancer     102963653 (PLCG2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102963653 (PLCG2)    05171 Coronavirus disease - COVID-19     102963653 (PLCG2)    05167 Kaposi sarcoma-associated herpesvirus infection     102963653 (PLCG2)    05169 Epstein-Barr virus infection     102963653 (PLCG2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102963653 (PLCG2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102963653 (PLCG2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ptg04131]     102963653 (PLCG2) Enzymes [BR:ptg01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102963653 (PLCG2) Membrane trafficking [BR:ptg04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102963653 (PLCG2)  Endocytosis   Macropinocytosis    Phospholipase C     102963653 (PLCG2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 PH_14 SH3_2 GDPD Motif Other DBs NCBI-GeneID:  102963653 NCBI-ProteinID:  XP_007082895 UniProt:  A0A8C9M2P9 LinkDB All DBs Position Un AA seq 1265 aa AA seqDB search MTAMVNMDTLPEYEKSQIKRTLELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK IEGFLDIMEIKEIRPGKNSKDFERAKAARQKEDCCFTILYGTQFVLSTLSLAADSKEDAT KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSITLRELKTILPLVNFKVNSA KFLKDKFVEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA VYLHDFQRFLLHEQQEVWAQDLNKVRERMTKFIDDTLRETAEPFLFVDEFLTYLFSRENS IWDEKYDVVDIQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR TNAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSVMEGGTMKYF LTDNIMFTSIYDLIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY KAKRNDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTVDVEELEKQII EDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF QSIREITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY MQMNQALFSLNGRTGYVLQPESMRTEKYDPMPPEAQRKILMTLTVKVLGARHLPKLGRSI ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN SRFYS NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt atgaccgccatggtcaacatggacacccttcctgaatatgagaagagtcagatcaagaga accctggagctgggcacggtgatgaccgtgttcagctttcgtaagtctacccccgagcgg aggactgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggctgacaag attgaaggcttcttggatatcatggaaatcaaggaaatccgccccgggaagaactccaag gattttgagcgcgcgaaggcagcccgccagaaggaggactgctgtttcaccatcttgtac ggcacccagttcgtcctgagcactctgagtttggcagctgattctaaagaagacgccact aagtggctctctggcttgaaaatcttacaccaggaagcgatgagtgcgtctacgcccacc attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc atcaccctccgggagctgaagaccatcttgcccttggtcaacttcaaagtgaacagtgcc aagttcctcaaagataagtttgtggaaatcggcgctcacaaagatgaactcagctttgag cagttccaccttttctataaaaatcttatgtttgagcagcaaaagtcgattcttgatgaa ttcaaaaaagattcttccgtgttcatcttgggcaacaccgaccggccggatgcctccgct gtttacctgcacgacttccagcggtttctcctacacgaacagcaggaggtttgggctcag gatctgaacaaagtccgcgagcggatgacaaagtttatcgatgacaccctgagggagacc gccgagcccttcttgtttgttgatgagttcctcacgtacctgttttcgcgggagaacagc atctgggacgagaagtacgacgtcgtggacatacaggacatgaacaaccccttgtcccat tactggatctcctcctcacataacacgtacctcaccggtgaccagctgcggagtgagtcg tccacggaggcatacatccgctgcctgcgcatgggctgtcgctgcatcgagctggactgc tgggacgggcccgatgggaagcccatcatctaccacggctggacgcggaccaccaagatc aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacctcaagcttcccg gtgatcctgtccatcgaagagcactgctgtgtggagcagcagcgccacatggccagggtg ttcaaggaggtgtttggcgacctgctgttgacaaagcccacggaggccagtgctgaccag ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc cgaggcgatgtggatgtcaacgtggaagataagaaagatgagcacaagcaacagggtgaa ctgtacatgtgggattccattgaccagaaatggacccggcactactgtgccatcgctgat gccaagctgtcgttcagcgatgacattgagcagactgcagaggaggagctgccccaggat ataccccccacggagctgcattttggggaggagtggttccacaagaaggtggagaagaga acaaatgccgagaagctgcttcaggaatactgtgccgagacggggggcaaagatgggacc ttcttggtgcgggagagcaagaccttccccaacgactacaccctgtccttctggcggtcc ggccgggtccagcactgccggatccgctccgtcatggagggcgggaccatgaagtacttc ctgactgacaacatcatgttcaccagcatctatgacctcatccagcactaccgtgagacg cacctgcgctgtgccgagttcgagctccggctcaccgaccccgtgcccaaccccaacccc cacgagtcaaagccgtggtactatgatggcctgagccgcggggaagcagaggacatgctg atgagagttccccgggacggggccttcctgatccggaggcgggaaggtaccgactcctac gccatcaccttcagggccaggggcaaagtaaagcattgccgcatccatcgggacggccgg cactttgtgctggggacctctgcctacttcgagagcctcgtcgagctggtcagttactac gagaagcacgcgctgtaccggaagatgcggctgcgctatcccgtgacgcctgagctgctg gagcgctacaatatggaacgagatatcaactccctctatgacgtcagcaggatgtatgtg gatcccagtgaaatcaacccgtccatgcctcagaggaccgtcaaagctctgtatgactac aaagccaagcgaaacgatgagctgagcttctgccgtggggccctcattcacaacgtctcc aaggagccctggggctggtggaaaggagactatgggaccaggatccagcaatactttcca tccaactacgttgaggacatttcaacggtcgatgtggaagaactggaaaagcagattatt gaagacaatcccttagggtctctttgcagaggaatactggatctcaacacctataacgtc gtgaaagccccgcaggggaaaaaccagaaggcgttcgtgttcatcctggagcccaagaag caaggcgaccctccggtggagtttgccacagacagggtcgaggagctctttgagtggttt cagagcatccgggagatcacctggaagatggacaccaaggagaacaacatgaagtactgg gagaagaaccagtccatcgccatcgagctctcggacctggtagtctactgcaagccgacc agcaagaccaaggacaatttagaaaaccccgacttccgagaaatccgctccttcgtggag acgaaggctgacagtgtcgtcagacagaaaccggtcgacctcctcaagtacaatcagaag ggcctgacccgtgtctacccgaagggacagagggtggactcctccaactacgaccccttt cgcctctggctgtgtggctcccagatggtggcactcaatttccagactccagacaagtac atgcagatgaatcaagccttgttctcactcaacgggcggacaggctacgtcctgcagccc gagagcatgaggacggagaagtacgaccccatgccgcccgaagcccagcggaagattttg atgactctgacagtcaaggttctcggggctcgccatctccccaaacttggccgaagcatc gcatgtccctttgtggaggtggaaatctgcggggctgaatatgacaacaacaagtttaag accacagttgtgaatgacaatggcctaagccccgtttgggctccgacacaggagaaggtg acctttgaaatttatgacccaaacctcgcgtttctgcgctttgtggtctacgaggaagat atgttcagcgatcctaacttcctcgctcatgccacttaccccatcaaaggaatcaaatca ggattcagatctgttcctctgaagaacgggtacagtgaagatatcgagctggcttccctc ctggtgttctgtgagatgcagccagtcctggagagtgaagaggaactctactcctcctgc cgccagctgcgaaggcggcaggaagagctgaacaaccagctgttcctgtacgacacgcac cagaatctgcgcaatgccaaccgggatgccctcgtgaaagagttcaacgtcaacgagaac cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagttagcaac agtaggttttactcatag

DBGET integrated database retrieval system