KEGG   Panthera tigris altaica (Amur tiger): 102965070
Entry
102965070         CDS       T02988                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00562  Inositol phosphate metabolism
ptg01100  Metabolic pathways
ptg01521  EGFR tyrosine kinase inhibitor resistance
ptg01522  Endocrine resistance
ptg01524  Platinum drug resistance
ptg04012  ErbB signaling pathway
ptg04014  Ras signaling pathway
ptg04015  Rap1 signaling pathway
ptg04024  cAMP signaling pathway
ptg04062  Chemokine signaling pathway
ptg04066  HIF-1 signaling pathway
ptg04068  FoxO signaling pathway
ptg04070  Phosphatidylinositol signaling system
ptg04071  Sphingolipid signaling pathway
ptg04072  Phospholipase D signaling pathway
ptg04081  Hormone signaling
ptg04140  Autophagy - animal
ptg04150  mTOR signaling pathway
ptg04151  PI3K-Akt signaling pathway
ptg04152  AMPK signaling pathway
ptg04210  Apoptosis
ptg04211  Longevity regulating pathway
ptg04213  Longevity regulating pathway - multiple species
ptg04218  Cellular senescence
ptg04360  Axon guidance
ptg04370  VEGF signaling pathway
ptg04380  Osteoclast differentiation
ptg04510  Focal adhesion
ptg04550  Signaling pathways regulating pluripotency of stem cells
ptg04611  Platelet activation
ptg04613  Neutrophil extracellular trap formation
ptg04620  Toll-like receptor signaling pathway
ptg04625  C-type lectin receptor signaling pathway
ptg04630  JAK-STAT signaling pathway
ptg04650  Natural killer cell mediated cytotoxicity
ptg04660  T cell receptor signaling pathway
ptg04662  B cell receptor signaling pathway
ptg04664  Fc epsilon RI signaling pathway
ptg04666  Fc gamma R-mediated phagocytosis
ptg04668  TNF signaling pathway
ptg04670  Leukocyte transendothelial migration
ptg04722  Neurotrophin signaling pathway
ptg04725  Cholinergic synapse
ptg04750  Inflammatory mediator regulation of TRP channels
ptg04810  Regulation of actin cytoskeleton
ptg04910  Insulin signaling pathway
ptg04914  Progesterone-mediated oocyte maturation
ptg04915  Estrogen signaling pathway
ptg04917  Prolactin signaling pathway
ptg04919  Thyroid hormone signaling pathway
ptg04923  Regulation of lipolysis in adipocytes
ptg04926  Relaxin signaling pathway
ptg04929  GnRH secretion
ptg04930  Type II diabetes mellitus
ptg04931  Insulin resistance
ptg04932  Non-alcoholic fatty liver disease
ptg04933  AGE-RAGE signaling pathway in diabetic complications
ptg04935  Growth hormone synthesis, secretion and action
ptg04960  Aldosterone-regulated sodium reabsorption
ptg04973  Carbohydrate digestion and absorption
ptg05010  Alzheimer disease
ptg05017  Spinocerebellar ataxia
ptg05020  Prion disease
ptg05100  Bacterial invasion of epithelial cells
ptg05132  Salmonella infection
ptg05135  Yersinia infection
ptg05142  Chagas disease
ptg05146  Amoebiasis
ptg05160  Hepatitis C
ptg05161  Hepatitis B
ptg05162  Measles
ptg05163  Human cytomegalovirus infection
ptg05164  Influenza A
ptg05165  Human papillomavirus infection
ptg05166  Human T-cell leukemia virus 1 infection
ptg05167  Kaposi sarcoma-associated herpesvirus infection
ptg05168  Herpes simplex virus 1 infection
ptg05169  Epstein-Barr virus infection
ptg05170  Human immunodeficiency virus 1 infection
ptg05171  Coronavirus disease - COVID-19
ptg05200  Pathways in cancer
ptg05203  Viral carcinogenesis
ptg05205  Proteoglycans in cancer
ptg05206  MicroRNAs in cancer
ptg05207  Chemical carcinogenesis - receptor activation
ptg05208  Chemical carcinogenesis - reactive oxygen species
ptg05210  Colorectal cancer
ptg05211  Renal cell carcinoma
ptg05212  Pancreatic cancer
ptg05213  Endometrial cancer
ptg05214  Glioma
ptg05215  Prostate cancer
ptg05218  Melanoma
ptg05220  Chronic myeloid leukemia
ptg05221  Acute myeloid leukemia
ptg05222  Small cell lung cancer
ptg05223  Non-small cell lung cancer
ptg05224  Breast cancer
ptg05225  Hepatocellular carcinoma
ptg05226  Gastric cancer
ptg05230  Central carbon metabolism in cancer
ptg05231  Choline metabolism in cancer
ptg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ptg05415  Diabetic cardiomyopathy
ptg05417  Lipid and atherosclerosis
ptg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102965070 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102965070 (PIK3CA)
   04014 Ras signaling pathway
    102965070 (PIK3CA)
   04015 Rap1 signaling pathway
    102965070 (PIK3CA)
   04370 VEGF signaling pathway
    102965070 (PIK3CA)
   04630 JAK-STAT signaling pathway
    102965070 (PIK3CA)
   04668 TNF signaling pathway
    102965070 (PIK3CA)
   04066 HIF-1 signaling pathway
    102965070 (PIK3CA)
   04068 FoxO signaling pathway
    102965070 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102965070 (PIK3CA)
   04072 Phospholipase D signaling pathway
    102965070 (PIK3CA)
   04071 Sphingolipid signaling pathway
    102965070 (PIK3CA)
   04024 cAMP signaling pathway
    102965070 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102965070 (PIK3CA)
   04152 AMPK signaling pathway
    102965070 (PIK3CA)
   04150 mTOR signaling pathway
    102965070 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102965070 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102965070 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    102965070 (PIK3CA)
   04218 Cellular senescence
    102965070 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102965070 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102965070 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102965070 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102965070 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    102965070 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102965070 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    102965070 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102965070 (PIK3CA)
   04660 T cell receptor signaling pathway
    102965070 (PIK3CA)
   04662 B cell receptor signaling pathway
    102965070 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102965070 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102965070 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102965070 (PIK3CA)
   04062 Chemokine signaling pathway
    102965070 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102965070 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    102965070 (PIK3CA)
   04929 GnRH secretion
    102965070 (PIK3CA)
   04915 Estrogen signaling pathway
    102965070 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102965070 (PIK3CA)
   04917 Prolactin signaling pathway
    102965070 (PIK3CA)
   04926 Relaxin signaling pathway
    102965070 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    102965070 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102965070 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102965070 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102965070 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    102965070 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102965070 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102965070 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    102965070 (PIK3CA)
   04380 Osteoclast differentiation
    102965070 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    102965070 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    102965070 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102965070 (PIK3CA)
   05206 MicroRNAs in cancer
    102965070 (PIK3CA)
   05205 Proteoglycans in cancer
    102965070 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    102965070 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    102965070 (PIK3CA)
   05203 Viral carcinogenesis
    102965070 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102965070 (PIK3CA)
   05231 Choline metabolism in cancer
    102965070 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102965070 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102965070 (PIK3CA)
   05212 Pancreatic cancer
    102965070 (PIK3CA)
   05225 Hepatocellular carcinoma
    102965070 (PIK3CA)
   05226 Gastric cancer
    102965070 (PIK3CA)
   05214 Glioma
    102965070 (PIK3CA)
   05221 Acute myeloid leukemia
    102965070 (PIK3CA)
   05220 Chronic myeloid leukemia
    102965070 (PIK3CA)
   05218 Melanoma
    102965070 (PIK3CA)
   05211 Renal cell carcinoma
    102965070 (PIK3CA)
   05215 Prostate cancer
    102965070 (PIK3CA)
   05213 Endometrial cancer
    102965070 (PIK3CA)
   05224 Breast cancer
    102965070 (PIK3CA)
   05222 Small cell lung cancer
    102965070 (PIK3CA)
   05223 Non-small cell lung cancer
    102965070 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102965070 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    102965070 (PIK3CA)
   05161 Hepatitis B
    102965070 (PIK3CA)
   05160 Hepatitis C
    102965070 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    102965070 (PIK3CA)
   05164 Influenza A
    102965070 (PIK3CA)
   05162 Measles
    102965070 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    102965070 (PIK3CA)
   05163 Human cytomegalovirus infection
    102965070 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102965070 (PIK3CA)
   05169 Epstein-Barr virus infection
    102965070 (PIK3CA)
   05165 Human papillomavirus infection
    102965070 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102965070 (PIK3CA)
   05135 Yersinia infection
    102965070 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    102965070 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102965070 (PIK3CA)
   05142 Chagas disease
    102965070 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102965070 (PIK3CA)
   05017 Spinocerebellar ataxia
    102965070 (PIK3CA)
   05020 Prion disease
    102965070 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102965070 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    102965070 (PIK3CA)
   05415 Diabetic cardiomyopathy
    102965070 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102965070 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    102965070 (PIK3CA)
   04931 Insulin resistance
    102965070 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102965070 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102965070 (PIK3CA)
   01524 Platinum drug resistance
    102965070 (PIK3CA)
   01522 Endocrine resistance
    102965070 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptg04131]
    102965070 (PIK3CA)
Enzymes [BR:ptg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102965070 (PIK3CA)
Membrane trafficking [BR:ptg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102965070 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 102965070
NCBI-ProteinID: XP_007094649
UniProt: A0A8C9JLN8
LinkDB
Position
Un
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPEMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgtatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagaaatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacacgctacaccagtgg
ctcaaagacaagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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