Panthera tigris altaica (Amur tiger): 102967370 Help Entry 102967370         CDS       T02988                                  Symbol EGFR Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg01521   EGFR tyrosine kinase inhibitor resistance ptg01522   Endocrine resistance ptg03272   Virion - Hepatitis viruses ptg04010   MAPK signaling pathway ptg04012   ErbB signaling pathway ptg04014   Ras signaling pathway ptg04015   Rap1 signaling pathway ptg04020   Calcium signaling pathway ptg04066   HIF-1 signaling pathway ptg04068   FoxO signaling pathway ptg04072   Phospholipase D signaling pathway ptg04144   Endocytosis ptg04151   PI3K-Akt signaling pathway ptg04510   Focal adhesion ptg04520   Adherens junction ptg04540   Gap junction ptg04630   JAK-STAT signaling pathway ptg04810   Regulation of actin cytoskeleton ptg04912   GnRH signaling pathway ptg04915   Estrogen signaling pathway ptg04921   Oxytocin signaling pathway ptg04926   Relaxin signaling pathway ptg04928   Parathyroid hormone synthesis, secretion and action ptg04934   Cushing syndrome ptg05160   Hepatitis C ptg05163   Human cytomegalovirus infection ptg05165   Human papillomavirus infection ptg05171   Coronavirus disease - COVID-19 ptg05200   Pathways in cancer ptg05205   Proteoglycans in cancer ptg05206   MicroRNAs in cancer ptg05207   Chemical carcinogenesis - receptor activation ptg05208   Chemical carcinogenesis - reactive oxygen species ptg05210   Colorectal cancer ptg05212   Pancreatic cancer ptg05213   Endometrial cancer ptg05214   Glioma ptg05215   Prostate cancer ptg05218   Melanoma ptg05219   Bladder cancer ptg05223   Non-small cell lung cancer ptg05224   Breast cancer ptg05225   Hepatocellular carcinoma ptg05226   Gastric cancer ptg05230   Central carbon metabolism in cancer ptg05231   Choline metabolism in cancer ptg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ptg00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     102967370 (EGFR)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102967370 (EGFR)    04012 ErbB signaling pathway     102967370 (EGFR)    04014 Ras signaling pathway     102967370 (EGFR)    04015 Rap1 signaling pathway     102967370 (EGFR)    04630 JAK-STAT signaling pathway     102967370 (EGFR)    04066 HIF-1 signaling pathway     102967370 (EGFR)    04068 FoxO signaling pathway     102967370 (EGFR)    04020 Calcium signaling pathway     102967370 (EGFR)    04072 Phospholipase D signaling pathway     102967370 (EGFR)    04151 PI3K-Akt signaling pathway     102967370 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     102967370 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     102967370 (EGFR)    04520 Adherens junction     102967370 (EGFR)    04540 Gap junction     102967370 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     102967370 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     102967370 (EGFR)    04915 Estrogen signaling pathway     102967370 (EGFR)    04921 Oxytocin signaling pathway     102967370 (EGFR)    04926 Relaxin signaling pathway     102967370 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     102967370 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102967370 (EGFR)    05206 MicroRNAs in cancer     102967370 (EGFR)    05205 Proteoglycans in cancer     102967370 (EGFR)    05207 Chemical carcinogenesis - receptor activation     102967370 (EGFR)    05208 Chemical carcinogenesis - reactive oxygen species     102967370 (EGFR)    05230 Central carbon metabolism in cancer     102967370 (EGFR)    05231 Choline metabolism in cancer     102967370 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102967370 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     102967370 (EGFR)    05212 Pancreatic cancer     102967370 (EGFR)    05225 Hepatocellular carcinoma     102967370 (EGFR)    05226 Gastric cancer     102967370 (EGFR)    05214 Glioma     102967370 (EGFR)    05218 Melanoma     102967370 (EGFR)    05219 Bladder cancer     102967370 (EGFR)    05215 Prostate cancer     102967370 (EGFR)    05213 Endometrial cancer     102967370 (EGFR)    05224 Breast cancer     102967370 (EGFR)    05223 Non-small cell lung cancer     102967370 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     102967370 (EGFR)    05171 Coronavirus disease - COVID-19     102967370 (EGFR)    05163 Human cytomegalovirus infection     102967370 (EGFR)    05165 Human papillomavirus infection     102967370 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102967370 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102967370 (EGFR)    01522 Endocrine resistance     102967370 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ptg01001]     102967370 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ptg04147]     102967370 (EGFR) Enzymes [BR:ptg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102967370 (EGFR) Protein kinases [BR:ptg01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    102967370 (EGFR) Exosome [BR:ptg04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    102967370 (EGFR)   Exosomal proteins of pancreatic cancer cells    102967370 (EGFR)   Exosomal proteins of bladder cancer cells    102967370 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr GF_recep_IV Recep_L_domain Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 Motif Other DBs NCBI-GeneID:  102967370 NCBI-ProteinID:  XP_015398711 LinkDB All DBs Position Un AA seq 1170 aa AA seqDB search FPFCSFAVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYMQRNYDLSFLKTI QEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALSVLSNYGTNKTGLRELPMRNLHE ILQAIQWRDIVDNDFISNMSMDFQNHVGNCQKCDPGCPNGSCWGPGKENCQKLTKIICAQ QCSGRCRGRAPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQM DVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVC NGIGIGEFKDTLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPKELDILKT VKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEIS DGDVIVSGNQKLCYANTINWKKLFGTSSQKTKIINNKDEKGCKAIGHVCHPLCSSEGCWG PEPKDCVSCQNVTRGKECVEKCNVLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPD SCVQCAHYIDGPHCVKTCPAGIMGENNTLVWKFADANRMCHLCHSNCTYGCSGPGLEGCA TDGPKIPSIATGIVGGLLLVVVVALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGE APNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK EILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNW CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVP IKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPP ICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNF YRALMDEEDMEDIVDADEYLIPQQGFFHSPSTSRTPLLSSLSATSNNSTVTCIDRNGSCP LKEDSFLQRYSSDPTGTLTEDNMDDTFLPAPEYINQAVPKRPAGSVQNPVYHNQPLNPAP GRDPHYQNPHSNAVDNPEYLNTHPTCVNSVLDGPTLWAQKGNHQISLDNPDYQQDFFPKE AKSNGIFKGPAAENADYLRVAPPSSEFIGA NT seq 3513 nt NT seq  +upstreamnt  +downstreamnt tttcccttttgttcttttgcagtttgccaaggcacaagtaaccggctcacccagttgggc acttttgaggaccactttctcagcctgcagaggatgtttaataactgtgaggtggtcctt gggaatttggaaatcacctacatgcaaaggaattatgacctttccttcttaaaaaccatc caagaggttgccggctatgtactcattgccctcaacacagtggagaagattcctttggaa aacctgcagatcatccgaggaaatgtgctctatgaaaacacccatgccttatccgtctta tccaactatggcacaaataaaaccggactgcgggagctgcccatgagaaacttacatgaa atcctgcaagccatccagtggcgggatatcgttgacaacgatttcataagcaacatgtcg atggacttccagaaccacgtgggcaactgccaaaagtgtgatccaggatgtcccaatgga agctgctggggtccgggaaaggagaattgccagaaattgaccaaaatcatctgcgcccag cagtgttccgggcgctgccgcggccgggcccccagcgactgctgccataaccagtgtgct gccggctgcacggggccccgagagagcgactgcctggtctgccgcaagttccgggatgaa gccacatgcaaggacacctgcccaccactcatgctctacaaccctaccacctaccagatg gacgtcaacccagagggaaaatacagctttggtgccacctgtgtgaagaaatgcccccgt aactatgtggtgacagaccacggttcgtgtgtccgtgcctgcagttctgacagctacgaa gtggaggaagatggcgtccgcaagtgtaaaaagtgtgaggggccttgccgtaaagtttgt aatggaataggaattggtgaatttaaagacacactttccatcaatgctacaaatattaaa cacttcaaaaattgcacctcgatcagtggagatcttcatatcctgccagtagcatttaga ggtgactccttcacgcatactccacctctagatccaaaggaactggatattctaaaaact gtaaaggaaattacagggtttttgctgattcaggcctggcctgaaaacaggactgacctc catgctttcgagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttct cttgcggttgtcggcctggacataacgtccttgggattacgctccctcaaggagataagt gatggagatgtgatcgtttcaggaaaccaaaaattgtgctatgcaaatacaataaactgg aaaaaactgtttgggacttcaagtcagaaaaccaaaattataaacaacaaagatgaaaaa ggctgcaaggccataggccatgtctgtcatccattatgctcgtcagagggatgctggggc ccggagccgaaagactgcgtgtcctgccaaaacgtcacccgtggcaaggaatgtgtggag aagtgcaatgttctggagggggagccaagggagtttgtggagaattccgagtgcatacag tgccatccagaatgcctgccccaggccatgaatatcacctgcacaggacgaggaccagac agctgcgtgcagtgtgcacactacatcgacggccctcactgcgtcaagacctgcccggct ggcatcatgggagaaaacaacaccctggtctggaagtttgcggacgccaatcgcatgtgt cacctgtgccattcaaactgtacctacggctgttctgggccaggtcttgaaggctgtgca acagatgggcccaagatcccatccatcgccactgggattgttgggggcctcctcttggtg gtggtggtggcccttggggtgggcctctttctgcgccgacgccacatcgtccgcaagcgc acacttcgcagactgctgcaggaaagagagcttgttgagcctcttacgcccagcggagaa gctcccaaccaagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtg ctgggctctggagcatttggcacagtgtacaagggactctggatcccagaaggtgagaag gttaaaattcccgtggccatcaaggagttacgagaagccacatctccaaaagccaacaag gaaatccttgatgaagcttacgtgatggccagtgtggacaatccccacgtgtgccgcctc ctgggcatctgcctgacgtccacggtccagctcatcacacagctcatgcccttcggctgc ctcctggactatgtccgagagcacaaggacaacattggctcccagtacctgctcaactgg tgtgtgcagattgcgaagggcatgaactacctggaagaccggcgcttggtgcaccgtgac ctggcagccaggaatgtcctggtgaagacgccacagcatgtcaagatcacagattttggg ctggccaaactgcttggcgccgaggagaaagaataccacgcggaaggaggcaaagtgcct atcaagtggatggctttggaatcaattttacaccgaatttacacccaccaaagtgacgtc tggagctatggagtcaccgtttgggagttgatgacctttgggtctaaaccttacgacgga atccccgcaagtgagatctcgaccatcctggagaaaggagagcgcctcccgcagccaccc atatgcaccatcgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagc cgcccgaaattccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgc taccttgtcatccagggagatgagagaatgcatctgccaagccctacagactccaatttt taccgcgccctgatggacgaagaagacatggaagacatcgtagatgccgatgagtacctc atcccccagcaaggcttcttccacagcccctccacatcccggacccccctcctgagttct ctgagtgccaccagcaacaattccactgtgacttgcatcgatagaaatgggagctgcccc ctcaaggaagacagcttcttgcagcggtacagctcagaccccactggcaccttgactgag gacaacatggatgacactttcctcccggcacctgaatacataaaccaggctgttcccaaa aggcctgcgggttccgtccagaaccccgtctatcacaatcagcctctaaatccagctcct ggcagagaccctcactaccaaaatccccacagcaatgcagtggacaaccctgagtatctc aacacccaccccacttgcgtcaacagtgtgctcgacggccccaccctctgggcccagaaa ggcaaccaccagattagcctggacaaccctgactaccagcaggacttctttcccaaggaa gccaagtcaaatggcatctttaagggtcctgcagctgaaaatgcagactacctaagggta gcaccgcccagcagtgaatttattggagcatga

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