Panthera tigris altaica (Amur tiger): 102967516 Help Entry 102967516         CDS       T02988                                  Symbol NOS3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg00220   Arginine biosynthesis ptg00330   Arginine and proline metabolism ptg01100   Metabolic pathways ptg04020   Calcium signaling pathway ptg04022   cGMP-PKG signaling pathway ptg04066   HIF-1 signaling pathway ptg04071   Sphingolipid signaling pathway ptg04151   PI3K-Akt signaling pathway ptg04370   VEGF signaling pathway ptg04371   Apelin signaling pathway ptg04611   Platelet activation ptg04915   Estrogen signaling pathway ptg04921   Oxytocin signaling pathway ptg04926   Relaxin signaling pathway ptg04931   Insulin resistance ptg04933   AGE-RAGE signaling pathway in diabetic complications ptg05415   Diabetic cardiomyopathy ptg05417   Lipid and atherosclerosis ptg05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:ptg00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     102967516 (NOS3)    00330 Arginine and proline metabolism     102967516 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     102967516 (NOS3)    04371 Apelin signaling pathway     102967516 (NOS3)    04066 HIF-1 signaling pathway     102967516 (NOS3)    04020 Calcium signaling pathway     102967516 (NOS3)    04071 Sphingolipid signaling pathway     102967516 (NOS3)    04022 cGMP-PKG signaling pathway     102967516 (NOS3)    04151 PI3K-Akt signaling pathway     102967516 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102967516 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     102967516 (NOS3)    04921 Oxytocin signaling pathway     102967516 (NOS3)    04926 Relaxin signaling pathway     102967516 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102967516 (NOS3)    05418 Fluid shear stress and atherosclerosis     102967516 (NOS3)    05415 Diabetic cardiomyopathy     102967516 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     102967516 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     102967516 (NOS3) Enzymes [BR:ptg01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      102967516 (NOS3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  102967516 NCBI-ProteinID:  XP_015395458 LinkDB All DBs Position Un AA seq 1181 aa AA seqDB search MGNLKSVGQEPGPPCGLGLGLGLGLWGQQGPASPTAEPGRAPAPAPPPAPDRSSPPLTKP PEGPKFPRVKNWEVGSITYDTLSAQAQQEGPCTPRRCLGSLVFPRKLQSRPSQDPPPTEQ LLSQARDFINQYYSSIKRSGSQAHEQSLQXAAGTYQLRESELVFGAKQAWRNAPRCVGRI QWGKLQVFDARDCNSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQL VRYAGYRQQDAPVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFALPPE LVLEVPLEHPTLEWFAALGLPWYALPAGRNMLLEMGGAESPVRPLATLAPPTPSSPLHLV PTNAMHPCSQDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHHAATASF MKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFHYQPDPWRGSGSKG AGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFD PRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHR SYKMRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAV DTRLAELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAARDIFSAK RSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQAAILSVENLQSSKSTXXXXXXXXXTGG QDGLRYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGPPPSWVRD PRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESGEQQELESLSQDPRRYEEWKWFR CPTLLEALEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDG LGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQE RLHDIDSKGEAGGQGNDWKAGGGKGTETGRQKPGRQEGRQGTGHRGEQKLSRSTRGRCPV HLAPWCQTQSRQSNRIKDKGTGGTGSLERMGLGLKWPKCTWDCPRAHPAVSKTQGSYRMF RLDMGCAGHPVKQKEGAVTETRQRVRKLRVWKNMGVEQGPC NT seq 3546 nt NT seq  +upstreamnt  +downstreamnt atgggcaatttgaagagtgtgggccaggagccggggcctccctgcggcctggggctgggg ctgggcctgggcctgtggggtcagcagggcccagcctccccgacagcagagcccggcagg gcaccggcacccgcacccccacccgcgccagaccgcagcagtccccccctcaccaagccc ccggaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcacttacgac accctgagtgcccaggctcagcaggaggggccctgcacccctagacgctgcctgggctcc ctggtttttccacggaaactgcagagccggccctcccaggacccaccacccactgagcag ctgctgagccaggccagggacttcatcaaccagtactacagctccatcaagaggagtggc tcccaggcccatgagcagagcctgcagnnggccgcaggcacataccagcttcgggagagc gagctggtgttcggggctaagcaggcttggagaaatgcaccccgctgcgtgggccggatc cagtgggggaagctgcaggtgtttgatgcccgggattgcaactctgcccaggagatgttc acctacatctgcaaccacatcaagtacgccaccaaccggggcaacctccgctcggccatc acagtgttcccccagcgcgccccaggccgcggagacttccgaatctggaacagccaactg gtgcgttacgcggggtacaggcagcaggatgcccccgtgcggggggacccagccaatgtg gagatcactgagctctgcatccagcacggctggaccccgggaaacggccgctttgacgta ctgcccctactgctccaggccccagatgagcccccggaactctttgccctgccccccgag ctggtcctcgaggtgcccctggagcaccccacgctggagtggtttgcggccctgggcctg ccctggtacgccctcccggcggggaggaacatgctgctggaaatggggggggcggagtca ccagtcaggcctctggccaccctcgcgcctcctactccgtcctctcccctacaccttgtc cctaccaacgctatgcacccctgctcccaggatgtggccgtctgcatggacttggatacc cggaccacctcatccctgtggaaagacaaggcagccgtggaaatcaacttggccgtgctg cacagttaccagttggccaaagtgaccattgtggaccaccatgctgccacggcctccttc atgaagcacctggagaatgagcagaaggctagggggggctgccctgccgactgggcctgg atcgtgccccccatctccggcagcctcacccctgtgttccatcaggagatggtcaactat gtcctgtcccctgccttccactatcagccagacccgtggaggggaagtgggtccaagggt gccggcatcaccaggaagaagacctttaaggaagtggccaatgcggtgaagatctctgcc tcactcatgggcaccgtgatggcaaagcgagtaaaggcaacaatcctgtatggctccgag accggccgggcccagagctatgcacagcagctggggagactcttccggaaggctttcgat ccccgggtcctgtgcatggatgagtatgatgtcgtgtccctcgagcatgagacgctagtg ctggtcgtgaccagcacattcgggaatggtgatcccccagagaatggagagagttttgcg gcagccctgatggaaatgtctggtccctacaacagctcccctcggccagaacaacacagg agttacaaaatgcgcttcaacagtgtctcctgctcagacccgctggtgtcctcctggagg cggaagagaaaggagtccagtaacacagacagtgcaggggcactgggtaccctcaggttc tgtgtgttcgggctgggctcccgggcgtacccccacttctgtgccttcgcccgtgcggtg gacacacggctggcggagctggggggcgagcggctgctgcagctgggccagggagacgag ctgtgtggccaggaggaggccttccgtggctgggcccaggccgccttccaggcctcctgt gagactttctgcgtgggagaggacgccaaggctgccgcccgggacatattcagcgccaaa cggagctggaagcgccaaaggtaccggctcagcacccaggcggagggcctccagctgctg ccaggcctgatccatgtgcacaggaggaagatgttccaggctgccatcctctcagtcgaa aacctgcaaagcagcaagtccacnnnnnnnnnnnnnnnnnnnnnnnnnnncactggaggc caggacggcctgcggtaccagccgggggaccacataggcatctgcccgcccaaccgaccg ggcctcgtggaggcgctgctgagccgtgtggaggacccgcctccgccaggagagcccgtg gccgtggagcagctggagaagggcagccctggtggcccaccccccagctgggttcgggac ccccggctgcccccctgcacgctgcgccaggctctcaccttcttcctggacatcacctcc ccgcccagcccgcaactccttcgactgctcagcaccctggcggaagagtccggtgaacag caggagctggagagcctcagccaggacccccggcgctacgaggagtggaagtggttccgg tgccccacgctgctggaggcgctggaacagttcccgtccgtggcgctgcctgcccccctg ctcctcacccagctgcccctgctccagccccggtactactccgtcagctcggcgcccagc gcccacccgggagagattcacctcacggtggccgtgctggcgtacaggacccaggatgga ctgggccccctgcactatggagtctgctccacatggctgagccagctgaaggccggagat cccgtaccttgcttcatcaggggggctccctccttccggctgccgcctgatcccagcttg ccctgcatcctagtgggccctggcacaggtattgcccccttccggggattttggcaggag cggctgcacgacattgacagcaaaggtgaggctgggggccaagggaatgactggaaggca ggaggggggaaagggacagagactggaagacagaaacctggaagacaggaaggaaggcaa ggaacaggccacagaggtgaacagaaacttagtagatcaaccagagggcggtgccctgtt cacttggctccctggtgccagacacaaagtaggcagtcgaaccggattaaagacaagggt acagggggaactggaagtctggagagaatggggctaggactcaaatggccaaagtgtact tgggactgccccagagctcacccagctgtgtccaagacccaaggaagctacaggatgttc aggttggacatggggtgtgcagggcacccggtaaaacaaaaggagggggctgtgacggag acaaggcagagagtgcggaaactgagggtgtggaagaatatgggggtggagcagggaccg tgctag

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