KEGG   Panthera tigris altaica (Amur tiger): 102972487
Entry
102972487         CDS       T02988                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00562  Inositol phosphate metabolism
ptg01100  Metabolic pathways
ptg01521  EGFR tyrosine kinase inhibitor resistance
ptg01522  Endocrine resistance
ptg01524  Platinum drug resistance
ptg04012  ErbB signaling pathway
ptg04014  Ras signaling pathway
ptg04015  Rap1 signaling pathway
ptg04024  cAMP signaling pathway
ptg04062  Chemokine signaling pathway
ptg04066  HIF-1 signaling pathway
ptg04068  FoxO signaling pathway
ptg04070  Phosphatidylinositol signaling system
ptg04071  Sphingolipid signaling pathway
ptg04072  Phospholipase D signaling pathway
ptg04081  Hormone signaling
ptg04140  Autophagy - animal
ptg04150  mTOR signaling pathway
ptg04151  PI3K-Akt signaling pathway
ptg04152  AMPK signaling pathway
ptg04210  Apoptosis
ptg04211  Longevity regulating pathway
ptg04213  Longevity regulating pathway - multiple species
ptg04218  Cellular senescence
ptg04360  Axon guidance
ptg04370  VEGF signaling pathway
ptg04380  Osteoclast differentiation
ptg04510  Focal adhesion
ptg04550  Signaling pathways regulating pluripotency of stem cells
ptg04611  Platelet activation
ptg04613  Neutrophil extracellular trap formation
ptg04620  Toll-like receptor signaling pathway
ptg04625  C-type lectin receptor signaling pathway
ptg04630  JAK-STAT signaling pathway
ptg04650  Natural killer cell mediated cytotoxicity
ptg04660  T cell receptor signaling pathway
ptg04662  B cell receptor signaling pathway
ptg04664  Fc epsilon RI signaling pathway
ptg04666  Fc gamma R-mediated phagocytosis
ptg04668  TNF signaling pathway
ptg04670  Leukocyte transendothelial migration
ptg04722  Neurotrophin signaling pathway
ptg04725  Cholinergic synapse
ptg04750  Inflammatory mediator regulation of TRP channels
ptg04810  Regulation of actin cytoskeleton
ptg04910  Insulin signaling pathway
ptg04914  Progesterone-mediated oocyte maturation
ptg04915  Estrogen signaling pathway
ptg04917  Prolactin signaling pathway
ptg04919  Thyroid hormone signaling pathway
ptg04923  Regulation of lipolysis in adipocytes
ptg04926  Relaxin signaling pathway
ptg04929  GnRH secretion
ptg04930  Type II diabetes mellitus
ptg04931  Insulin resistance
ptg04932  Non-alcoholic fatty liver disease
ptg04933  AGE-RAGE signaling pathway in diabetic complications
ptg04935  Growth hormone synthesis, secretion and action
ptg04960  Aldosterone-regulated sodium reabsorption
ptg04973  Carbohydrate digestion and absorption
ptg05010  Alzheimer disease
ptg05017  Spinocerebellar ataxia
ptg05020  Prion disease
ptg05100  Bacterial invasion of epithelial cells
ptg05132  Salmonella infection
ptg05135  Yersinia infection
ptg05142  Chagas disease
ptg05146  Amoebiasis
ptg05160  Hepatitis C
ptg05161  Hepatitis B
ptg05162  Measles
ptg05163  Human cytomegalovirus infection
ptg05164  Influenza A
ptg05165  Human papillomavirus infection
ptg05166  Human T-cell leukemia virus 1 infection
ptg05167  Kaposi sarcoma-associated herpesvirus infection
ptg05168  Herpes simplex virus 1 infection
ptg05169  Epstein-Barr virus infection
ptg05170  Human immunodeficiency virus 1 infection
ptg05171  Coronavirus disease - COVID-19
ptg05200  Pathways in cancer
ptg05203  Viral carcinogenesis
ptg05205  Proteoglycans in cancer
ptg05206  MicroRNAs in cancer
ptg05207  Chemical carcinogenesis - receptor activation
ptg05208  Chemical carcinogenesis - reactive oxygen species
ptg05210  Colorectal cancer
ptg05211  Renal cell carcinoma
ptg05212  Pancreatic cancer
ptg05213  Endometrial cancer
ptg05214  Glioma
ptg05215  Prostate cancer
ptg05218  Melanoma
ptg05220  Chronic myeloid leukemia
ptg05221  Acute myeloid leukemia
ptg05222  Small cell lung cancer
ptg05223  Non-small cell lung cancer
ptg05224  Breast cancer
ptg05225  Hepatocellular carcinoma
ptg05226  Gastric cancer
ptg05230  Central carbon metabolism in cancer
ptg05231  Choline metabolism in cancer
ptg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ptg05415  Diabetic cardiomyopathy
ptg05417  Lipid and atherosclerosis
ptg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102972487 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102972487 (PIK3CB)
   04014 Ras signaling pathway
    102972487 (PIK3CB)
   04015 Rap1 signaling pathway
    102972487 (PIK3CB)
   04370 VEGF signaling pathway
    102972487 (PIK3CB)
   04630 JAK-STAT signaling pathway
    102972487 (PIK3CB)
   04668 TNF signaling pathway
    102972487 (PIK3CB)
   04066 HIF-1 signaling pathway
    102972487 (PIK3CB)
   04068 FoxO signaling pathway
    102972487 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    102972487 (PIK3CB)
   04072 Phospholipase D signaling pathway
    102972487 (PIK3CB)
   04071 Sphingolipid signaling pathway
    102972487 (PIK3CB)
   04024 cAMP signaling pathway
    102972487 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    102972487 (PIK3CB)
   04152 AMPK signaling pathway
    102972487 (PIK3CB)
   04150 mTOR signaling pathway
    102972487 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102972487 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102972487 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    102972487 (PIK3CB)
   04218 Cellular senescence
    102972487 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102972487 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    102972487 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102972487 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102972487 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    102972487 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    102972487 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    102972487 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    102972487 (PIK3CB)
   04660 T cell receptor signaling pathway
    102972487 (PIK3CB)
   04662 B cell receptor signaling pathway
    102972487 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    102972487 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    102972487 (PIK3CB)
   04670 Leukocyte transendothelial migration
    102972487 (PIK3CB)
   04062 Chemokine signaling pathway
    102972487 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102972487 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    102972487 (PIK3CB)
   04929 GnRH secretion
    102972487 (PIK3CB)
   04915 Estrogen signaling pathway
    102972487 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    102972487 (PIK3CB)
   04917 Prolactin signaling pathway
    102972487 (PIK3CB)
   04926 Relaxin signaling pathway
    102972487 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    102972487 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    102972487 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102972487 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102972487 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    102972487 (PIK3CB)
   04722 Neurotrophin signaling pathway
    102972487 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102972487 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    102972487 (PIK3CB)
   04380 Osteoclast differentiation
    102972487 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    102972487 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    102972487 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102972487 (PIK3CB)
   05206 MicroRNAs in cancer
    102972487 (PIK3CB)
   05205 Proteoglycans in cancer
    102972487 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    102972487 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    102972487 (PIK3CB)
   05203 Viral carcinogenesis
    102972487 (PIK3CB)
   05230 Central carbon metabolism in cancer
    102972487 (PIK3CB)
   05231 Choline metabolism in cancer
    102972487 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102972487 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102972487 (PIK3CB)
   05212 Pancreatic cancer
    102972487 (PIK3CB)
   05225 Hepatocellular carcinoma
    102972487 (PIK3CB)
   05226 Gastric cancer
    102972487 (PIK3CB)
   05214 Glioma
    102972487 (PIK3CB)
   05221 Acute myeloid leukemia
    102972487 (PIK3CB)
   05220 Chronic myeloid leukemia
    102972487 (PIK3CB)
   05218 Melanoma
    102972487 (PIK3CB)
   05211 Renal cell carcinoma
    102972487 (PIK3CB)
   05215 Prostate cancer
    102972487 (PIK3CB)
   05213 Endometrial cancer
    102972487 (PIK3CB)
   05224 Breast cancer
    102972487 (PIK3CB)
   05222 Small cell lung cancer
    102972487 (PIK3CB)
   05223 Non-small cell lung cancer
    102972487 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102972487 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    102972487 (PIK3CB)
   05161 Hepatitis B
    102972487 (PIK3CB)
   05160 Hepatitis C
    102972487 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    102972487 (PIK3CB)
   05164 Influenza A
    102972487 (PIK3CB)
   05162 Measles
    102972487 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    102972487 (PIK3CB)
   05163 Human cytomegalovirus infection
    102972487 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102972487 (PIK3CB)
   05169 Epstein-Barr virus infection
    102972487 (PIK3CB)
   05165 Human papillomavirus infection
    102972487 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102972487 (PIK3CB)
   05135 Yersinia infection
    102972487 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    102972487 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102972487 (PIK3CB)
   05142 Chagas disease
    102972487 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102972487 (PIK3CB)
   05017 Spinocerebellar ataxia
    102972487 (PIK3CB)
   05020 Prion disease
    102972487 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102972487 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    102972487 (PIK3CB)
   05415 Diabetic cardiomyopathy
    102972487 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102972487 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    102972487 (PIK3CB)
   04931 Insulin resistance
    102972487 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102972487 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102972487 (PIK3CB)
   01524 Platinum drug resistance
    102972487 (PIK3CB)
   01522 Endocrine resistance
    102972487 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptg04131]
    102972487 (PIK3CB)
Enzymes [BR:ptg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102972487 (PIK3CB)
Membrane trafficking [BR:ptg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102972487 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 102972487
NCBI-ProteinID: XP_007087499
UniProt: A0A8C9JRR5
LinkDB
Position
Un
AA seq 1070 aa
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINICDLPRMARLCFAIYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIKEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEVLKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaaggctctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaagaaaagatt
cagtcacttgtgggattgtcttggatggattggctaaaacagacgtatccaccagaacat
gaaccatccatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagcccgtatgactatgtgttacaagtcagtgggcgagtagaatatgtgtttggtgat
cacccactaattcagttccagtatatccggaactgtgtaatgaataggaccttgcctcat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaatgattgccata
gaagctgccataaatagaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
accgaactcctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatatttgtgacctgccacgaatggctcgatta
tgttttgctatttatgcagttttggataaagtgaaaacgaaaaaatcgactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtaaatacaatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatacagaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataaaggagaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcaactgtgtgagaacgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcgatc
aagtggaataaacttgaagatgttgctcagcttcaagccctacttcagatttggcctaaa
ctgcccccccgggaggccttggagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcaatatctttta
caactggtgcaagttttgaaatacgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttgctaaccgcaggatagggcagtttctattttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagtgtagggcatatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtca
cctctgaatccgtgtgtcatcctctcagaactctatgttgaaaaatgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtttttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgttg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcatcgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgcagcagcggccttcaacaaagacgcc
cttctgaactggcttaaagaatacaactctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaagaaaaccggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgagtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cgtttccgccagtgttgtgaggatgcatatctgattttacgacgtcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagtgctaaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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