Panthera uncia (snow leopard): 125908838 Help Entry 125908838         CDS       T08832                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism puc  Panthera uncia (snow leopard) Pathway puc04020   Calcium signaling pathway puc04371   Apelin signaling pathway puc04713   Circadian entrainment puc04921   Oxytocin signaling pathway puc04970   Salivary secretion puc05010   Alzheimer disease puc05012   Parkinson disease puc05020   Prion disease puc05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:puc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125908838    04020 Calcium signaling pathway     125908838  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     125908838   09154 Digestive system    04970 Salivary secretion     125908838   09159 Environmental adaptation    04713 Circadian entrainment     125908838  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     125908838    05012 Parkinson disease     125908838    05020 Prion disease     125908838    05022 Pathways of neurodegeneration - multiple diseases     125908838  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:puc04040]     125908838 Ion channels [BR:puc04040]  Voltage-gated cation channels   Ryanodine receptor    125908838 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 DUF2281 Motif Other DBs NCBI-GeneID:  125908838 NCBI-ProteinID:  XP_049467607 LinkDB All DBs Position B3 Genome browser AA seq 4886 aa AA seqDB search MVESELDALCMVLGLQCSDYMRMETQSKLISVHNEDEVVLQCIANIHKEQRKFCLAAEGL GNRLCFLEPTSEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTL LYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGE KVRIGDDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHV VRLFHGHDECLTIPSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQA FRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGV PEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQCE ESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQ NKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRLLYKL LAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKS IISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIR PNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGN GVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQ GMFENFNTDGLFFPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEP IKEYKRDAEGVRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKVRDRLAENIHELWGMN KIELGWTFGKTRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPA AGEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGW TYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAV EKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVF EGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEI ENGFVPICSLGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPT FVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYLRLSMPVECHSSFSHS PCLDSDAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLSK NCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLS FSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPV PQCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCV DVLELCEQEDLMQFHYHTLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLR SGFYDLLISIHLANAKERKLMMRNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLKP GFRFSTPCFVVTSEEHQKQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFV PVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGETENRAEKEEVTQVEEKAVEAGE KAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKF RYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDL LIHCGVPLEEEEEEEEDTSWAGKLRTLVYKIKGPPKPAKEQPTEEEERCPTTLKELISQT MIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQ IRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQ IAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASS VMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAV FVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGY KREVTEDGEYEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLV PTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHL LEVGFLPDLRASASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGAEHYTSLIDS TLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPL KLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALP CLSAIAGALPPDYLDTRISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEH SHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGW SVERTKEGEALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYH NIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKD MELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLL PLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTT MVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIK GVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYV ERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDI PQLEGLMKEISDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKV TSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKK KAVKTVQEEEQLKADTKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSP DADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSG GQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDE EVKEHVRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQV EQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSF EEKLVQDLAKCPKVEEEEEEETDKHPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMM AKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPM VVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKA EGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTV NVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPC IGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSNQIELLKELLDLLQDMVVMLLSLLEG NVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEF QKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEH MPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSAERPEEEEEDEDSSYTL EIEGEEEDDKSFESASAFAMACASVKKNVANFLKKATLKNFRKQYRKVKKMTVKELVKVF FSFFWMLFVGLFQLFFTILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIH DDAMEAERAEVTEPGITPELVHFVKGEKGDADIMSDLFGFRSKKEGGLKHGPEVGLGDLS EIIGKDEPPTLESTVQKKRRAQAAEMKASHEAEGKVEPEKTDMEDGEKEGTAKEEEQADA LWAEVTKKKKRRRGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAI NFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPALRALAIIH TIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPS FPSNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSI DMKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGV RAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVR EDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVW KMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14661 nt NT seq  +upstreamnt  +downstreamnt atggtagaatcagaattggatgccctttgcatggttctcgggttacagtgctcagactac atgaggatggagacacagagcaaactcatcagcgtccataatgaggatgaagtggttctc cagtgcatcgcaaacattcacaaggagcagaggaagttctgcctggcagccgagggcctg ggaaaccgcctgtgcttcctggaacccacttcagaagccaagtatgttcctccagatctc tgcgtctgcaattttgtgctggaacagtccctctctgtgagagctctgcaggaaatgctt gccaatacaggtgaaaatggcggcgaaggggcagcacaagggggtggccacaggaccctg ctatatggccacgcgattctcctgcggcactccttcagcggaatgtatctaacatgtttg accacatcaagatcccagacagataaacttgcctttgatgtaggtctacgggaacatgcc acaggagaagcctgttggtggaccatacatcctgcttccaaacagagatccgagggagag aaagttcgaattggtgatgacctcatcctcgtcagcgtgtcctctgaaagataccttcat ctctccgtatcaaatgggaacatacaagtggatgcctcttttatgcaaacactctggaat gtacatcccacgtgctcaggaagtagcatcgaagaaggttacctacttggtgggcatgta gtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagaccagaatgac tcccagcacaggaggatattctatgaagctgggggagctgggacacgagccagatctctg tggagagtggaaccccttcggataagttggagtggcagtaacatcagatggggccaggct ttccgcctccggcatctcaccacaggccactacctggccttgacagaggaccaaggcctt atactgcaggaccgggcaaagtcagacaccaagtccacagccttctctttccgggcttcc aaggaaatcaaggagaaattggattctagtcacaagcgggatatagaaggcatgggagtt ccagaaatcaaatacggagattccgtctgctttgtccagcacatagccagtggtctgtgg gtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaaagaaaggtc atactccatcaggaaggccacatggatgacgggctaacactgcagagatgccagtgcgag gagtcccaggctgctcggatcatccggaacacgacagccttattcagccagtttgtaagt ggaaacaatcgtacggcggcccccatcaccctgccgatagaagaggtcctgcagacctta caggacctgatcgcctacttccagcccccggaggaggagatgcaacacgaagacaaacag aacaagctccgctcacttaagaacagacagaatcttttcaaggaagaaggaatgttggcc cttgtgttaaactgcatcgatcgcttaaacatctacaacagtgtggcgcactttgcagga attgcaagggaggagagtggcatggcttggaaagagatcctgcgcctgctatacaaactg ctggctgctctcattcgtggaaacagaaacaactgtgctcaattctctaataaccttgat tggctaatcagcaaattggatagactagaatcttcctcaggtatcttggaagttttgcac tgcatcttgactgaaagcccagaagccttaaatctgatagcagagggtcacatcaagtct atcatctccctgttggataagcatgggcggaatcacaaggttctggatgtgctgtgctcc ctctgtctctgcaatggggtcgccgtgagagccaaccagaatctgatttgtgacaacttg ctgccccggagaaacctgctcctgcagacgcggctgattaacgacgtgacaagcattcgg ccaaacatcttcctgggagttgctgagggctcagcacagtacaagaagtggtactttgag ctgatcatagaccaagtggaccccttcctaacagctgagcccacacacctacgggtgggc tgggcctcttcctcaggctatgctccgtaccctggaggtggagaaggatggggaggcaac ggtgttggagacgacctgtattcctatggctttgatggccttcacctttggtcaggccgc atacccagagccgtggcctccatcaaccagcacctcctgagatcagacgacgtggtaagc tgttgcctcgacctcggggtgcccagcatctctttccgcatcaacgggcagcctgtgcag gggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagcttctcagca ggtgtcaaagtgcgtttcctgatgggtggacgtcatggagaatttaagttcctgcctccc tctggctatgccccttgctatgaagccttactgccaaaagaaaagatgagattggagccc atcaaagaatataaacgcgatgctgaaggagttagagatctgttgggtaccacccagttc ctctctcaagcctctttcatcccatgccccatagacaccagtcaggtggttttgccacct cacctagagaaggtccgagacaggctggctgaaaacatccacgaactttggggaatgaat aaaatagagcttggctggacttttggcaagacacgggatgacaataaaagacaacacccc tgtcttgtggagttttcaaagctgcctgaaactgagaagaattataacctacaaatgtca acggaaaccttaaaaacccttctggccctggggtgccacattgctcacgttaatccagct gctggggaggatctcaagaaagtcaagttgcccaaaaactatatgatgtccaatggctac aagccagcccctttggatttgtctgatgtgaagctattacctcctcaagaaattttggtg gataagcttgcagaaaatgcacataatgtttgggccaaagacagaataaaacaaggatgg acctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtgccgtacgca ttactggatgagcgtacgaagaagtccaatagggacagccttcgtgaagctgttcgcaca tttgttggttatggctataacattgagccgtcagaccaagaactagctgacccagctgtg gagaaagtcagcatagataaaattcgatttttccgggtagagcggtcttatgcagtgaga tctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgcgttggctgg gccaggccgggctgtcggcccgatgttgagctgggagccgatgatcaagcctttgtgttt gaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgtacgtggcag ccaggagatgtggttggatgtatgattaaccttgatgatgcttcaatgatcttcacactg aatggggagctgctgattaccaacaaaggctctgaacttgccttcgctgattatgagatt gagaatggcttcgtgcccatctgctctctgggactgtctcagatcggccgcatgaatctt gggatggatgccagtaccttcaagttttataccatgtgcggcctccaagagggctttgag ccttttgctgtcaacatgaaccgagacgtggcgatgtggttcagcaagcgcctcccgaca tttgtcaacgtgccaaaggatcatccgcacatagaggttgtgaggatagatggcactatg gacagccctccatgcctcaaggtgacccacaagacattcggcacacagaatagcaatgcc aacatgatctacctacgcctgagcatgcccgtcgaatgccactcctccttcagccacagc ccctgcttggacagtgacgcattccagaaaaggaaacagatgcaagaaatactctctcat acaacaacacagtgctactatgcaatccgcatcttcgctggacaggacccctcctgcgtc tgggtcggatgggtgacaccggactatcacttgtacagcgaaaagtttgacctgagtaaa aactgcacagtgactgttactctaggggatgaaagaggccgggtccatgaaagcgtgaaa cgcagcaactgctacatggtctggggtggggatattgtggccacttcgcaaagatcaagc cggagcaacgtggacctggagatcggctgcctcgtggatctggcgatgggcatgttgtct ttctcagccaatgggagagagctcggtacctgctatcaggtggagcccaataccaaagtg tttccagcagtcttcctgcagcccacgagcacttcattgtttcagtttgaacttgggaag ctgaagaatgcgatgcccttgtcggcggccatatttaagagtgaagagaagaacccagtt ccgcagtgtccacctcggctggacgtccaaaccatccagcccgtgctctggagccgcatg cccagcagcttcctgaaggtggagacggaacgggtgagcgagcgccatggctgggtggtg cagtgcctggagcccctgcagatgatggcactccacatccctgaggagaacaggtgtgtg gatgtcctggagctctgtgagcaggaggacctgatgcagttccattaccacacgctgcga ctctacagtgcagtgtgcgccctgggaaacagccgcgtggcctacgccctatgcggccac gtggatctctcccagctgttctacgccattgacaacaagtacctccctggcctccttcgt tctggtttctatgacctgctcatcagcatccatctggccaatgctaaggagaggaagcta atgatgaggaatgagtacatcatccccatcaccagcaccaccagaaaaatccgcctgtat ccagatgagtccaagaggcacgggctgcctggggtgggcctgagaacgtgcctcaagcca gggttcaggttctccaccccttgctttgtcgtgaccagtgaggagcaccagaagcagagc cctgagatccccttggagattctcaagacgaaggcactgagcatgctgacggaggcagtg cagcacagcggggctcacatccgggaccctgtcggtgggtctgtagagttccagtttgtg cctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgacgatgacgtc aggcagatcctcctcctgatcgatccctctgtgtttggggagcacagtggggagactgag aacagagcagagaaggaggaagtgacccaggtggaagagaaggcagtggaggccggagaa aaggccggcaaggaggctccagtcaaaggcttactgcagacccgactgccagagtccgtg aagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcagcatcgagtg gaggccattgtggcatttggcgacatttatgtctctaagctccaggcaaatcagaagttc cgctacaacgagctcatgcaggccttgaacatgtctgcagccctgactgcccggaaaacc agggagttccgctcacccccccaggagcagatcaacatgcttcttaactttcaactggga gagaattgcccctgcccagaagagatccgagaggagctatatgacttccatgaggacctt ctcattcactgtggtgttcccctggaggaggaagaagaggaggaggaagacacatcctgg gctgggaaactccgtaccttggtgtataaaatcaaaggccctcccaagcctgcgaaggaa cagccaacagaggaggaagagagatgccctacgaccttgaaggagctcatctcacagacc atgatccgctgggctcaggaggaccagatccaggatgcggagttggtccggatgatgttc aacctcctccggaggcagtacgacagcatcggggagctgctgcaggcgctgcggaagacc tacaccatcagtcaggcctccgtgagcgacaccatcagcctgctggctgccctgggccag atccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatgatcaatggg ctgggagacattatgaacaacaaggtgttctaccagcatcccaacctcatgcgagtcctt ggcatgcacgagacagtgatggaggtgatggtgaacgtgttggggacagagaagtctcag attgcctttccaaaaatggttgctagctgttgccgcttcctctgctacttctgtcgaatt agccggcaaaatcagaaggccatgtttgagcatctgagttacctgttggagaacagcagt gttggcctagcttccccttcgatgaggggatctaccccgctggatgtggcagcttcctcc gtgatggacaacaacgagttagccctgggcttagaggaaccagaccttgagaaggtggtg acctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaagggtaccct gacgtcggctggaaccccatcgaaggggagcgctacctgtccttcctgaggtttgccgtc tttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaagctgctcatcaga cgcccagagtgcttcggcccagccttgcgaggtgaaggaggaaacggtctattggcagcc atgcagggtgccattaagatctctgagaacccagctctcgacctcccctctcagggatat aagagagaagtcacggaggacggtgaatatgaagaagagatcgtgcacatgggcaatgca attatgtctttctattcagcccttatagatctcctgggccgctgtgctcctgaaatgcat cttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgctccctggtc cccactgaggacctggttgggatcatcagcatccccttgaagctgccttccctgaacaaa gatgggtcggtcagcgagccagatatggcagccaacttctgccctgaccacaaggcaccc atggtgctgttcttggatcgtgtttatggcattaaggatcaaacttttctgctccacttg ctagaggttggatttttacctgacttaagagcctctgcctctctagatacagtttcccta agcaccacagaggccgcactcgcactaaataggtatctatgttctgctgtgcttccgctc ctcacaagatgtgcccctctctttgccggagcagaacactacacctctttgatcgattct acactccagacaatatataggctttccaagggacgttccctcaccaaagcccagagggac accatagaagaatgtttgcttgccatttgcaatcacttgaggccttcgatgttacagcaa ctcttgcgacgtcttgtctttgatgtgccgcagctcaacgaatactgcaaaatgcctctt aagcttctgacaaatcactatgaacagtgctggaagtattactgtctgccttcaggatgg gggagctacgggctagctgtggaggaggaattgcacctgacggagaagctcttctggggg attttcgactccctctcccataagaagtatgacccagaccttttccgaatggcccttcct tgtctcagtgctatagctggggcgctaccaccagattacttagataccagaatctcagcc acgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaacccatcaac accatgaatttttccttgcctgaaaaatgggagtacatcgtcaccaagtacgcggagcat tcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatggaatttccctg gatgaaaatgtgaagacccatccactgataaggcctttcaagacattaacagaaaaggag aaggaaatttaccgctggcctgctagagagtccctgaaaaccatgctggctgtgggctgg tctgtggagaggaccaaagagggagaggccctggtgcaacagcgggaaaatgagaagctt cggagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctggacctctcc aacgttgtgctctccagggagctccagggaatggtggaggtcgtggccgagaactatcac aacatctgggccaagaagaagaagctggagctggagagcaaaggtggcggcagtcaccct ctgttggtaccatatgacaccttgacagccaaggagaagttcagggaccgagaaaaggca caggacctgtttaaattcctccaggtgaacggcatcgtggtttctagaggtatgaaggat atggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaagaagatc ctgaaatatgttgattccgcccaagagtttattgcccatttggaagccattgtcagcagt gggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaagttctcctc ccgctggttgaccagtacttcaccaatcaccgcctctacttcctgtcatcccctctaaaa cccctcagcagcagtggctatgcctcccataaggagaaagaaatggtggccagcctgttc tgcaaactcgctgctcttgttcgacacaggatttccctctttggaagtgattctactaca atggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatgaagtca ggctcagagctggtgaaggctgggttacgagctttctttgaaaatgcggcggaagactta gagaagacttcggaaaatctgaagctcgggaagtttacgcattccagaacacagattaaa ggcgtgtctcagaatattaactataccacggtggctctgctccccatcctgacgtccatc tttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgatgtgcagatt tcatgctaccacatactctgcagcctctactcccttgggactggaaagaacatctacgtt gaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccataccggtg gcattcttggagcccactcttaaccgctacaatccactctcagtcttcaacaccaaaacc cccagagagaggtctattctggggatgccagacacagtggaagagatgtgtcctgacatc cctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggggcccggtac acggagatgccccacgtcatcgaggtgatcttgcccatgctgtgcaactacctgtcctac tggtgggagcgggggccagagcacctgccccccagcacggggccctggtgcaccaaggtc acctctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaacaacaacctg ggcatcgacgaggcatcctggatgaagcgcatcgcagtgtatgcccagccaatcatcagc aaagccaggccggacctgctgaaaagccacttcatcccaactctggagaagctgaagaaa aaggctgtgaagactgtgcaggaggaggagcagctgaaggccgacaccaaaggagacact caggaggcggagctcctcatcctggatgagtttgcagtcctctgcagagacctctatgcc ttctaccccatgctcatccgctacgtggacaacaacagatcgaactggctcaaaagtccc gatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctgtggtgcaaa tctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaataatttg gcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaagtaaagtctgga ggacaggaccaggaacggaagaagaccaagcggaggggagacttatactccatccagacc tctctcatcgtggctgcgctcaagaaaatgctgcccattggtttgaatatgtgcacgcca ggcgatcaggagctaatctcccttgcaaagtcacgatacagctatagggataccgatgaa gaggtgaaagaacatgtgcggaataacttgcacctgcaggaaaagtcggatgacccagca gtaaagtggcagctgaacctctacaaagatgttttgaagagtgaagaaccttccaatcca gaaaagaccgtagagcgtgtacagagaatttccgcagctgtcttccatctggagcaggtc gaacagcctttgaggtccaagaaggcagtctggcacaaactgttatcaaagcagcggaaa cgggcagtggtggcctgtttcaggatggcccctctgtacaacttgcccaggcaccgctcc attaacctcttcctccatggctatcagagattttggatagaaacagaggagtattccttt gaagagaaactagtacaggacttggctaaatgccccaaggtggaagaggaggaggaggag gagacagacaagcacccagacccacttcatcagatcattctccattttagccgcaatgct ctcacggagaggagcaaattggaagacgaccccttgtacacctcctattccagcatgatg gccaagagttgtcagagtggggaggacgaagaagaagaggaagacaaggaaaagacattt gaagagaaggaaatggaaaagcagaaaaccctctaccaacaagctcgactgcatgagcgt ggggctgcagagatggtcctccagatgataagtgccagcaaaggtgagatgagccccatg gtggttgagactctgaagctggggatcgccattctgaatgggggcaacgctggtgtacaa cagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaaagcctttcc ggccttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagct gaaggcctggggatggttactgaggaaggaacactcattgtccgtgagcgtggtgaaaaa gtactccagaatgacgagtttacacgagatctctttagattcctgcagttactttgtgaa ggacataacagtgacttccagaacttcctgcggactcagatgggcaacaccaccactgtc aatgtcatcatcagtaccgtggactacctcctgcgtctgcaggaatcaatcagtgatttc tactggtattattcagggaaggacatcattgatgaatctggacagcacaacttttccaaa gctctggcagtcacgaagcagattttcaattctcttacagaatacatccagggcccttgc attgggaaccaacagagcctggctcacagcaggctgtgggatgcagtggtcggcttcctg cacgtatttgctaatatgcagatgaaactctctcaggattccaatcagatcgagctgctg aaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaaggg aatgtggtaaatggaactattggcaagcagatggttgacacgctggtagagtcatctacc aatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacctaaccagc tcagacaccttcaaagaatatgacccagatggtaaagggattatctccaaaaaagaattc cagaaggccatggaagggcaaaaacagtacacacagtcagagatcgactttctcctttca tgtgcagaagctgatgagaatgatatgtttaattacattgattttgtagaccggtttcat gagccggccaaggacatagggtttaatgtggcagtgttattgacaaatctctccgaacac atgccaaatgattctcgccttaagtgcctattggacccagcagaaagtgtactaaattac ttcgaaccctacctaggacgtattgagatcatgggtggggccaagaaaattgagcgcgtt tattttgagatcagtgaatccagtcgaacccagtgggagaagccccaggtgaaggaatct aagcggcagttcatctttgatgtggtcaatgaaggtggagagcaagaaaagatggaactg tttgtgaacttctgtgaggataccatctttgaaatgcagttagcgtctcagatctctgaa tctgactcagccgaaaggccagaagaggaggaggaagatgaagattcttcttacacgtta gaaattgagggggaagaggaggatgacaagtcttttgagtctgcctctgcatttgccatg gcctgtgcctcagtgaagaaaaacgttgccaacttcctgaagaaggcaaccctgaagaac ttcaggaagcagtacaggaaggtgaagaagatgaccgtgaaggagctggtgaaggtgttc ttctctttcttctggatgttatttgtggggctattccagttgttcttcaccatattggga ggaatctttcagatcctctggagcacagtgtttggagggggcctagtggaaggggcaaag aacatcagagtgaccaagatcctgggtgacatgcctgacccaacccagtttggtatccat gacgatgccatggaggctgagcgggcagaggtgactgagccaggtattacaccggaacta gtccacttcgtcaagggtgagaaaggagatgcagatatcatgtcagatctctttggattc cgctcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgatctctct gagattattggcaaggatgaaccccctacactagagagtactgtacagaagaaaaggaga gcacaggcagcagaaatgaaagcatcacatgaagcagaaggaaaagtggagcctgagaag acagacatggaagatggggagaaggagggtacggccaaggaggaagagcaagctgacgcc ctgtgggcagaagtgacaaagaagaagaagcggcgacggggccagaaagttgagaagcct gaagccttcatggctaatttcttcaaagggctggaaatctatcagaccaagttactgcat tacctggccaggaatttctacaacctgaggttcctcgctctgtttgtagccttcgctatc aacttcatcctgctcttttacaaggtcactgaagagcctttggaagaagagacagaggac gttgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcgatggtgttcttc gtcctacaggagagcactgggtatatggcgccagcactgcgggccttggccattatccac accatcatctctttggtctgtgtggtgggctattactgcctgaaggtccctttggtggtg ttcaaaagagaaaaagaaattgccaggaagctggagttcgatggcctgtatatcactgaa cagccatctgaagatgacatcaaggggcagtgggaccgcttggtaatcaacacaccatct tttcctagtaactactgggacaagtttgtaaagagaaaggtgattaacaagtatggtgat ctctacggagcagaacgcattgctgaactcctaggtttggacaaaaatgcccttgatttc agcccagtagaagaaagcaaagcagaggcggcctctttggtgtcatggctgagttccatc gacatgaagtaccatatctggaagctgggagttgtttttactgataactcttttctctac cttgcctggtatacaaccatgtcgatcctgggccactacaacaacttcttctttgctgcc catctgctagacattgcaatgggcttcaagacgctgaggactattctgtcatctgtaact cacaacggcaaacagctggttctgactgtgggtctcctggctgtggtggtttacctctac accgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagatgacgatgag cctgatatgaagtgtgacgacatgatgacgtgttacctattccacatgtatgtgggagta agagcaggaggcggcattggcgacgaaattgaagaccctgctggtgatccttacgaaatg taccgcattgtctttgacatcacgttcttcttctttgtcattgtcatcttgctggccatc attcaaggtcttattattgatgcttttggagagttaagagaccagcaggaacaggtgcga gaagatatggagactaaatgtttcatctgcgggattggcaatgactactttgacacgacc cctcatggttttgaaacacacaccttacaggagcacaacttagccaactatttgttcttc ctgatgtatctgattaacaaagatgaaacagaacacacgggtcaggaatcttatgtctgg aagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgctttcggaaacaa tatgaagatcagcttggataa

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