KEGG   Panthera uncia (snow leopard): 125915806
Entry
125915806         CDS       T08832                                 
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
puc  Panthera uncia (snow leopard)
Pathway
puc01521  EGFR tyrosine kinase inhibitor resistance
puc01522  Endocrine resistance
puc01524  Platinum drug resistance
puc04010  MAPK signaling pathway
puc04012  ErbB signaling pathway
puc04014  Ras signaling pathway
puc04015  Rap1 signaling pathway
puc04022  cGMP-PKG signaling pathway
puc04024  cAMP signaling pathway
puc04062  Chemokine signaling pathway
puc04066  HIF-1 signaling pathway
puc04068  FoxO signaling pathway
puc04071  Sphingolipid signaling pathway
puc04072  Phospholipase D signaling pathway
puc04140  Autophagy - animal
puc04150  mTOR signaling pathway
puc04151  PI3K-Akt signaling pathway
puc04152  AMPK signaling pathway
puc04210  Apoptosis
puc04211  Longevity regulating pathway
puc04213  Longevity regulating pathway - multiple species
puc04218  Cellular senescence
puc04261  Adrenergic signaling in cardiomyocytes
puc04370  VEGF signaling pathway
puc04371  Apelin signaling pathway
puc04380  Osteoclast differentiation
puc04510  Focal adhesion
puc04550  Signaling pathways regulating pluripotency of stem cells
puc04611  Platelet activation
puc04613  Neutrophil extracellular trap formation
puc04620  Toll-like receptor signaling pathway
puc04625  C-type lectin receptor signaling pathway
puc04630  JAK-STAT signaling pathway
puc04660  T cell receptor signaling pathway
puc04662  B cell receptor signaling pathway
puc04664  Fc epsilon RI signaling pathway
puc04666  Fc gamma R-mediated phagocytosis
puc04668  TNF signaling pathway
puc04722  Neurotrophin signaling pathway
puc04725  Cholinergic synapse
puc04728  Dopaminergic synapse
puc04810  Regulation of actin cytoskeleton
puc04910  Insulin signaling pathway
puc04914  Progesterone-mediated oocyte maturation
puc04915  Estrogen signaling pathway
puc04917  Prolactin signaling pathway
puc04919  Thyroid hormone signaling pathway
puc04920  Adipocytokine signaling pathway
puc04922  Glucagon signaling pathway
puc04923  Regulation of lipolysis in adipocytes
puc04926  Relaxin signaling pathway
puc04929  GnRH secretion
puc04931  Insulin resistance
puc04932  Non-alcoholic fatty liver disease
puc04933  AGE-RAGE signaling pathway in diabetic complications
puc04935  Growth hormone synthesis, secretion and action
puc04936  Alcoholic liver disease
puc04973  Carbohydrate digestion and absorption
puc05010  Alzheimer disease
puc05017  Spinocerebellar ataxia
puc05132  Salmonella infection
puc05135  Yersinia infection
puc05142  Chagas disease
puc05145  Toxoplasmosis
puc05152  Tuberculosis
puc05160  Hepatitis C
puc05161  Hepatitis B
puc05162  Measles
puc05163  Human cytomegalovirus infection
puc05164  Influenza A
puc05165  Human papillomavirus infection
puc05166  Human T-cell leukemia virus 1 infection
puc05167  Kaposi sarcoma-associated herpesvirus infection
puc05168  Herpes simplex virus 1 infection
puc05169  Epstein-Barr virus infection
puc05170  Human immunodeficiency virus 1 infection
puc05200  Pathways in cancer
puc05205  Proteoglycans in cancer
puc05207  Chemical carcinogenesis - receptor activation
puc05208  Chemical carcinogenesis - reactive oxygen species
puc05210  Colorectal cancer
puc05211  Renal cell carcinoma
puc05212  Pancreatic cancer
puc05213  Endometrial cancer
puc05214  Glioma
puc05215  Prostate cancer
puc05218  Melanoma
puc05220  Chronic myeloid leukemia
puc05221  Acute myeloid leukemia
puc05222  Small cell lung cancer
puc05223  Non-small cell lung cancer
puc05224  Breast cancer
puc05225  Hepatocellular carcinoma
puc05226  Gastric cancer
puc05230  Central carbon metabolism in cancer
puc05231  Choline metabolism in cancer
puc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
puc05415  Diabetic cardiomyopathy
puc05417  Lipid and atherosclerosis
puc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:puc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125915806
   04012 ErbB signaling pathway
    125915806
   04014 Ras signaling pathway
    125915806
   04015 Rap1 signaling pathway
    125915806
   04370 VEGF signaling pathway
    125915806
   04371 Apelin signaling pathway
    125915806
   04630 JAK-STAT signaling pathway
    125915806
   04668 TNF signaling pathway
    125915806
   04066 HIF-1 signaling pathway
    125915806
   04068 FoxO signaling pathway
    125915806
   04072 Phospholipase D signaling pathway
    125915806
   04071 Sphingolipid signaling pathway
    125915806
   04024 cAMP signaling pathway
    125915806
   04022 cGMP-PKG signaling pathway
    125915806
   04151 PI3K-Akt signaling pathway
    125915806
   04152 AMPK signaling pathway
    125915806
   04150 mTOR signaling pathway
    125915806
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125915806
  09143 Cell growth and death
   04210 Apoptosis
    125915806
   04218 Cellular senescence
    125915806
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125915806
   04550 Signaling pathways regulating pluripotency of stem cells
    125915806
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125915806
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125915806
   04613 Neutrophil extracellular trap formation
    125915806
   04620 Toll-like receptor signaling pathway
    125915806
   04625 C-type lectin receptor signaling pathway
    125915806
   04660 T cell receptor signaling pathway
    125915806
   04662 B cell receptor signaling pathway
    125915806
   04664 Fc epsilon RI signaling pathway
    125915806
   04666 Fc gamma R-mediated phagocytosis
    125915806
   04062 Chemokine signaling pathway
    125915806
  09152 Endocrine system
   04910 Insulin signaling pathway
    125915806
   04922 Glucagon signaling pathway
    125915806
   04923 Regulation of lipolysis in adipocytes
    125915806
   04920 Adipocytokine signaling pathway
    125915806
   04929 GnRH secretion
    125915806
   04915 Estrogen signaling pathway
    125915806
   04914 Progesterone-mediated oocyte maturation
    125915806
   04917 Prolactin signaling pathway
    125915806
   04926 Relaxin signaling pathway
    125915806
   04935 Growth hormone synthesis, secretion and action
    125915806
   04919 Thyroid hormone signaling pathway
    125915806
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    125915806
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    125915806
  09156 Nervous system
   04725 Cholinergic synapse
    125915806
   04728 Dopaminergic synapse
    125915806
   04722 Neurotrophin signaling pathway
    125915806
  09158 Development and regeneration
   04380 Osteoclast differentiation
    125915806
  09149 Aging
   04211 Longevity regulating pathway
    125915806
   04213 Longevity regulating pathway - multiple species
    125915806
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125915806
   05205 Proteoglycans in cancer
    125915806
   05207 Chemical carcinogenesis - receptor activation
    125915806
   05208 Chemical carcinogenesis - reactive oxygen species
    125915806
   05230 Central carbon metabolism in cancer
    125915806
   05231 Choline metabolism in cancer
    125915806
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125915806
  09162 Cancer: specific types
   05210 Colorectal cancer
    125915806
   05212 Pancreatic cancer
    125915806
   05225 Hepatocellular carcinoma
    125915806
   05226 Gastric cancer
    125915806
   05214 Glioma
    125915806
   05221 Acute myeloid leukemia
    125915806
   05220 Chronic myeloid leukemia
    125915806
   05218 Melanoma
    125915806
   05211 Renal cell carcinoma
    125915806
   05215 Prostate cancer
    125915806
   05213 Endometrial cancer
    125915806
   05224 Breast cancer
    125915806
   05222 Small cell lung cancer
    125915806
   05223 Non-small cell lung cancer
    125915806
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125915806
   05170 Human immunodeficiency virus 1 infection
    125915806
   05161 Hepatitis B
    125915806
   05160 Hepatitis C
    125915806
   05164 Influenza A
    125915806
   05162 Measles
    125915806
   05168 Herpes simplex virus 1 infection
    125915806
   05163 Human cytomegalovirus infection
    125915806
   05167 Kaposi sarcoma-associated herpesvirus infection
    125915806
   05169 Epstein-Barr virus infection
    125915806
   05165 Human papillomavirus infection
    125915806
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125915806
   05135 Yersinia infection
    125915806
   05152 Tuberculosis
    125915806
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125915806
   05142 Chagas disease
    125915806
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125915806
   05017 Spinocerebellar ataxia
    125915806
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125915806
   05418 Fluid shear stress and atherosclerosis
    125915806
   05415 Diabetic cardiomyopathy
    125915806
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    125915806
   04932 Non-alcoholic fatty liver disease
    125915806
   04931 Insulin resistance
    125915806
   04933 AGE-RAGE signaling pathway in diabetic complications
    125915806
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125915806
   01524 Platinum drug resistance
    125915806
   01522 Endocrine resistance
    125915806
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:puc01001]
    125915806
Enzymes [BR:puc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     125915806
Protein kinases [BR:puc01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   125915806
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 125915806
NCBI-ProteinID: XP_049477777
LinkDB
Position
E2
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPDAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDERREWMRAIQMVANSLKQRGPGEDPM
DYKCGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAREVMEHRFFLSVNWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccccggtacttcctgctgaagagtgacggctccttcatcggatacaaggag
cggcctgatgccccagaccagaccctgccccccctaaacaacttctctgtcgcagagtgc
cagctgatgaagactgagagaccacggcccaacaccttcgtcatacgctgcctacagtgg
accactgtcatcgagaggaccttccacgtagactctccagatgagaggcgagagtggatg
cgggccattcagatggtcgccaacagccttaagcagcggggcccaggtgaggaccccatg
gactataagtgtggctcccccagtgacccttctgcggccgaggagatggaagtggcagtt
agcaaggctcgggccaaggtgaccatgaatgacttcgactatctcaaacttctgggcaag
ggcacctttggcaaagtgattctggtgcgggagaaagccagcggccgctactacgccatg
aagatcctgcggaaggaagttatcattgccaaggatgaagttgcccacacggtcaccgag
agccgggtcctccagaacaccaggcacccattcctcactgcactgaagtatgccttccag
acccacgaccgcctgtgcttcgtgatggaatacgccaacggtggtgagctgtttttccac
ctgtcccgggaacgtgtcttcacggaggagcgagcccgcttctatggtgcagagatcgtc
tctgcccttgagtatttgcattcgcgggacgtggtgtaccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgacttcggactgtgcaaagagggc
atcagtgacggggctaccatgaaaaccttctgtgggacgcccgagtacctggcacccgag
gtgctggaggacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaggagatccgtttcccacgcacactgagccctgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggctcggcggggggcccagcgatgcc
agggaggtcatggagcacaggttcttcctcagcgtcaactggcaggacgtggtgcagaag
aagctcctgccacccttcaaacctcaggtcacctctgaggttgacacaaggtactttgac
gacgagttcaccgcccagtccattacaatcacacccccggaccgctatgacagcctgggc
tccctcgaactggaccagcggacccacttcccccagttctcctactcagccagcatccgc
gagtga

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