KEGG   Panthera uncia (snow leopard): 125921289
Entry
125921289         CDS       T08832                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
puc  Panthera uncia (snow leopard)
Pathway
puc00562  Inositol phosphate metabolism
puc01100  Metabolic pathways
puc01521  EGFR tyrosine kinase inhibitor resistance
puc01522  Endocrine resistance
puc01524  Platinum drug resistance
puc04012  ErbB signaling pathway
puc04014  Ras signaling pathway
puc04015  Rap1 signaling pathway
puc04024  cAMP signaling pathway
puc04062  Chemokine signaling pathway
puc04066  HIF-1 signaling pathway
puc04068  FoxO signaling pathway
puc04070  Phosphatidylinositol signaling system
puc04071  Sphingolipid signaling pathway
puc04072  Phospholipase D signaling pathway
puc04081  Hormone signaling
puc04140  Autophagy - animal
puc04150  mTOR signaling pathway
puc04151  PI3K-Akt signaling pathway
puc04152  AMPK signaling pathway
puc04210  Apoptosis
puc04211  Longevity regulating pathway
puc04213  Longevity regulating pathway - multiple species
puc04218  Cellular senescence
puc04360  Axon guidance
puc04370  VEGF signaling pathway
puc04380  Osteoclast differentiation
puc04510  Focal adhesion
puc04550  Signaling pathways regulating pluripotency of stem cells
puc04611  Platelet activation
puc04613  Neutrophil extracellular trap formation
puc04620  Toll-like receptor signaling pathway
puc04625  C-type lectin receptor signaling pathway
puc04630  JAK-STAT signaling pathway
puc04650  Natural killer cell mediated cytotoxicity
puc04660  T cell receptor signaling pathway
puc04662  B cell receptor signaling pathway
puc04664  Fc epsilon RI signaling pathway
puc04666  Fc gamma R-mediated phagocytosis
puc04668  TNF signaling pathway
puc04670  Leukocyte transendothelial migration
puc04722  Neurotrophin signaling pathway
puc04725  Cholinergic synapse
puc04750  Inflammatory mediator regulation of TRP channels
puc04810  Regulation of actin cytoskeleton
puc04910  Insulin signaling pathway
puc04914  Progesterone-mediated oocyte maturation
puc04915  Estrogen signaling pathway
puc04917  Prolactin signaling pathway
puc04919  Thyroid hormone signaling pathway
puc04923  Regulation of lipolysis in adipocytes
puc04926  Relaxin signaling pathway
puc04929  GnRH secretion
puc04930  Type II diabetes mellitus
puc04931  Insulin resistance
puc04932  Non-alcoholic fatty liver disease
puc04933  AGE-RAGE signaling pathway in diabetic complications
puc04935  Growth hormone synthesis, secretion and action
puc04960  Aldosterone-regulated sodium reabsorption
puc04973  Carbohydrate digestion and absorption
puc05010  Alzheimer disease
puc05017  Spinocerebellar ataxia
puc05020  Prion disease
puc05100  Bacterial invasion of epithelial cells
puc05132  Salmonella infection
puc05135  Yersinia infection
puc05142  Chagas disease
puc05146  Amoebiasis
puc05160  Hepatitis C
puc05161  Hepatitis B
puc05162  Measles
puc05163  Human cytomegalovirus infection
puc05164  Influenza A
puc05165  Human papillomavirus infection
puc05166  Human T-cell leukemia virus 1 infection
puc05167  Kaposi sarcoma-associated herpesvirus infection
puc05168  Herpes simplex virus 1 infection
puc05169  Epstein-Barr virus infection
puc05170  Human immunodeficiency virus 1 infection
puc05171  Coronavirus disease - COVID-19
puc05200  Pathways in cancer
puc05203  Viral carcinogenesis
puc05205  Proteoglycans in cancer
puc05206  MicroRNAs in cancer
puc05207  Chemical carcinogenesis - receptor activation
puc05208  Chemical carcinogenesis - reactive oxygen species
puc05210  Colorectal cancer
puc05211  Renal cell carcinoma
puc05212  Pancreatic cancer
puc05213  Endometrial cancer
puc05214  Glioma
puc05215  Prostate cancer
puc05218  Melanoma
puc05220  Chronic myeloid leukemia
puc05221  Acute myeloid leukemia
puc05222  Small cell lung cancer
puc05223  Non-small cell lung cancer
puc05224  Breast cancer
puc05225  Hepatocellular carcinoma
puc05226  Gastric cancer
puc05230  Central carbon metabolism in cancer
puc05231  Choline metabolism in cancer
puc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
puc05415  Diabetic cardiomyopathy
puc05417  Lipid and atherosclerosis
puc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:puc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125921289
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    125921289
   04014 Ras signaling pathway
    125921289
   04015 Rap1 signaling pathway
    125921289
   04370 VEGF signaling pathway
    125921289
   04630 JAK-STAT signaling pathway
    125921289
   04668 TNF signaling pathway
    125921289
   04066 HIF-1 signaling pathway
    125921289
   04068 FoxO signaling pathway
    125921289
   04070 Phosphatidylinositol signaling system
    125921289
   04072 Phospholipase D signaling pathway
    125921289
   04071 Sphingolipid signaling pathway
    125921289
   04024 cAMP signaling pathway
    125921289
   04151 PI3K-Akt signaling pathway
    125921289
   04152 AMPK signaling pathway
    125921289
   04150 mTOR signaling pathway
    125921289
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    125921289
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125921289
  09143 Cell growth and death
   04210 Apoptosis
    125921289
   04218 Cellular senescence
    125921289
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125921289
   04550 Signaling pathways regulating pluripotency of stem cells
    125921289
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125921289
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125921289
   04613 Neutrophil extracellular trap formation
    125921289
   04620 Toll-like receptor signaling pathway
    125921289
   04625 C-type lectin receptor signaling pathway
    125921289
   04650 Natural killer cell mediated cytotoxicity
    125921289
   04660 T cell receptor signaling pathway
    125921289
   04662 B cell receptor signaling pathway
    125921289
   04664 Fc epsilon RI signaling pathway
    125921289
   04666 Fc gamma R-mediated phagocytosis
    125921289
   04670 Leukocyte transendothelial migration
    125921289
   04062 Chemokine signaling pathway
    125921289
  09152 Endocrine system
   04910 Insulin signaling pathway
    125921289
   04923 Regulation of lipolysis in adipocytes
    125921289
   04929 GnRH secretion
    125921289
   04915 Estrogen signaling pathway
    125921289
   04914 Progesterone-mediated oocyte maturation
    125921289
   04917 Prolactin signaling pathway
    125921289
   04926 Relaxin signaling pathway
    125921289
   04935 Growth hormone synthesis, secretion and action
    125921289
   04919 Thyroid hormone signaling pathway
    125921289
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    125921289
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    125921289
  09156 Nervous system
   04725 Cholinergic synapse
    125921289
   04722 Neurotrophin signaling pathway
    125921289
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125921289
  09158 Development and regeneration
   04360 Axon guidance
    125921289
   04380 Osteoclast differentiation
    125921289
  09149 Aging
   04211 Longevity regulating pathway
    125921289
   04213 Longevity regulating pathway - multiple species
    125921289
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125921289
   05206 MicroRNAs in cancer
    125921289
   05205 Proteoglycans in cancer
    125921289
   05207 Chemical carcinogenesis - receptor activation
    125921289
   05208 Chemical carcinogenesis - reactive oxygen species
    125921289
   05203 Viral carcinogenesis
    125921289
   05230 Central carbon metabolism in cancer
    125921289
   05231 Choline metabolism in cancer
    125921289
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125921289
  09162 Cancer: specific types
   05210 Colorectal cancer
    125921289
   05212 Pancreatic cancer
    125921289
   05225 Hepatocellular carcinoma
    125921289
   05226 Gastric cancer
    125921289
   05214 Glioma
    125921289
   05221 Acute myeloid leukemia
    125921289
   05220 Chronic myeloid leukemia
    125921289
   05218 Melanoma
    125921289
   05211 Renal cell carcinoma
    125921289
   05215 Prostate cancer
    125921289
   05213 Endometrial cancer
    125921289
   05224 Breast cancer
    125921289
   05222 Small cell lung cancer
    125921289
   05223 Non-small cell lung cancer
    125921289
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125921289
   05170 Human immunodeficiency virus 1 infection
    125921289
   05161 Hepatitis B
    125921289
   05160 Hepatitis C
    125921289
   05171 Coronavirus disease - COVID-19
    125921289
   05164 Influenza A
    125921289
   05162 Measles
    125921289
   05168 Herpes simplex virus 1 infection
    125921289
   05163 Human cytomegalovirus infection
    125921289
   05167 Kaposi sarcoma-associated herpesvirus infection
    125921289
   05169 Epstein-Barr virus infection
    125921289
   05165 Human papillomavirus infection
    125921289
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125921289
   05135 Yersinia infection
    125921289
   05100 Bacterial invasion of epithelial cells
    125921289
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    125921289
   05142 Chagas disease
    125921289
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125921289
   05017 Spinocerebellar ataxia
    125921289
   05020 Prion disease
    125921289
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125921289
   05418 Fluid shear stress and atherosclerosis
    125921289
   05415 Diabetic cardiomyopathy
    125921289
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    125921289
   04932 Non-alcoholic fatty liver disease
    125921289
   04931 Insulin resistance
    125921289
   04933 AGE-RAGE signaling pathway in diabetic complications
    125921289
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125921289
   01524 Platinum drug resistance
    125921289
   01522 Endocrine resistance
    125921289
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:puc04131]
    125921289
Enzymes [BR:puc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     125921289
Membrane trafficking [BR:puc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    125921289
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 125921289
NCBI-ProteinID: XP_049484700
LinkDB
Position
C2:121736054..121907139
AA seq 1070 aa
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINICDLPRMARLCFAIYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaaggctctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaagaaaagatt
cagtcacttgtgggattgtcttggatggattggctaaaacagacgtatccaccagaacat
gaaccatccatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagcccgtatgactatgtgttacaagtcagtgggcgagtagaatatgtgtttggtgat
cacccactaattcagttccagtatatccggaactgtgtaatgaataggaccttgcctcat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaatgattgccata
gaagctgccataaatagaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
accgaactcctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatatttgtgacctgccacgaatggctcgatta
tgttttgctatttatgcagttttggataaagtgaaaacgaaaaaatcgactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtaaatacaatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatacagaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcaactgtgtgagaacgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcgatc
aagtggaataaacttgaagatgttgctcagcttcaagccctacttcagatttggcctaaa
ctgcccccccgggaggccttggagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcaatatctttta
caactggtgcaagttttgaaatacgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttgctaaccgcaggatagggcagtttctattttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagtgtagggcatatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtca
cctctgaatccgtgtgtcatcctctcagaactctatgttgaaaaatgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtttttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgttg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcatcgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgcagcagcggccttcaacaaagacgcc
cttctgaactggcttaaagaatacaactctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaagaaaaccggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgagtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cgtttccgccagtgttgtgaggatgcatatctgattttacgacgtcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcgcttaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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