Panthera uncia (snow leopard): 125933228 Help Entry 125933228         CDS       T08832                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism puc  Panthera uncia (snow leopard) Pathway puc04020   Calcium signaling pathway puc04024   cAMP signaling pathway puc04260   Cardiac muscle contraction puc04261   Adrenergic signaling in cardiomyocytes puc04371   Apelin signaling pathway puc04713   Circadian entrainment puc04911   Insulin secretion puc04921   Oxytocin signaling pathway puc04972   Pancreatic secretion puc05020   Prion disease puc05022   Pathways of neurodegeneration - multiple diseases puc05410   Hypertrophic cardiomyopathy puc05412   Arrhythmogenic right ventricular cardiomyopathy puc05414   Dilated cardiomyopathy puc05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:puc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125933228    04020 Calcium signaling pathway     125933228    04024 cAMP signaling pathway     125933228  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     125933228    04921 Oxytocin signaling pathway     125933228   09153 Circulatory system    04260 Cardiac muscle contraction     125933228    04261 Adrenergic signaling in cardiomyocytes     125933228   09154 Digestive system    04972 Pancreatic secretion     125933228   09159 Environmental adaptation    04713 Circadian entrainment     125933228  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     125933228    05022 Pathways of neurodegeneration - multiple diseases     125933228   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     125933228    05412 Arrhythmogenic right ventricular cardiomyopathy     125933228    05414 Dilated cardiomyopathy     125933228    05415 Diabetic cardiomyopathy     125933228  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:puc04040]     125933228    04990 Domain-containing proteins not elsewhere classified [BR:puc04990]     125933228 Ion channels [BR:puc04040]  Voltage-gated cation channels   Ryanodine receptor    125933228 Domain-containing proteins not elsewhere classified [BR:puc04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    125933228 SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  125933228 NCBI-ProteinID:  XP_049502051 LinkDB All DBs Position D2:complement(10590103..11344924) Genome browser AA seq 4848 aa AA seqDB search MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHIN TGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFN RFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGREGGEAWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS AQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF DGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT RDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLP KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSGTGERFRI FRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQ GNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH IEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYRLSMPIECAEVFSKTVAGGLPGAGL FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQR FLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWIT SDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEI GCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAAFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQF MSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLY AIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFPDENKKHG LPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHAR DPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEDTEALEKE PSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVA FSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECP CPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKP VESGSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYT INGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPMLVSKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMH LIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAA MVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQH LLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVD TSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKE KEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNRSRRISQTSQVSVDAAHGYSPRAID MSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDRE KAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGS RSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSL FCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRTFLDNAAED LEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQ VSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTK SSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMS RWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPII NKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLY AFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINN MSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNICAPGDQE LIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKT VERVLDIANVLFHLEQKSTSMHRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAP LYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEGTKRVDPLHQL ILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEM EKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNSTVQQKMLD YLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDL FRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVID EQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLS QDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDM FLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLD YEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIM GSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFE MQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTVKSALFALRYNILTLMRML SLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASVSRGFFRIICSLLLGGSLV EGAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSEDLTDLKELTEESDLLSDI FGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEESKSEP EKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNF YNMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGNAKVSSLDSGSPRIMAVHY VLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITE QPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDF SDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDG DTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14547 nt NT seq  +upstreamnt  +downstreamnt atgtatctgtgctgtctgtccacctcccggtcttcaactgataaactggcctttgacgtt ggcttgcaagaggacacaacaggtgaggcttgttggtggaccattcatcctgcctccaag cagaggtcggaaggagaaaaggtgcgcgttggagatgacctcatcttagtcagtgtgtcc tctgagaggtacctgcatttgtcttatggcaatggcagcttacacgtggatgccgctttc cagcagactctctggagcgtggccccaatcagctcaggaagtgaagccgcccaagggtat ctaattggtggtgacgtcctcaggttgctgcacggacacatggatgaatgcctcactgtc ccttcaggagaacacggtgaagagcaacggagaactgttcactatgaaggcggtgctgta tctgtccatgcacgttccctgtggagactagagacactaagagttgcgtggagtggaagc cacataagatggggccagcccttccgactacgccatgtcacaacaggaaagtacttgagt ctcatggaagacaaaaaccttctactcatggacaaagaaaaggctgatgtaaagtcaaca gcatttaccttccgatcttccaaggaaaaattggatgtaggggtgagaaaagaagtcgat ggcatgggaacatcagaaataaaatatggagactcagtatgctatattcaacatataaat actggcctgtggcttacttaccagtctgtggatgtgaaatcagtgagaatgggatccata caacgtaaggctattatgcatcatgaaggtcacatggatgacggcttaaatctctctaga tctcagcatgaagaatcacggaccgcacgagtcatccggagcactgtcttccttttcaac aggtttataaggggccttgatgcgctcagcaaaaaagtgaaggcttccacagtagacctc cctatagaatctgtgagtctgagtctgcaggacctgattggttacttccatccccccgac gagcacttagagcatgaagacaaacagaacagattacgggctctaaagaaccgtcagaat ctcttccaggaagagggcatgatcaacctcgtgctcgagtgcatcgacaggctgcatgtc tatagcagtgcggcgcatttcgcggacgtggcggggagagaaggaggcgaggcttggaag tcgattctgaattctctctatgagttgctagcggctctaattagaggaaatcgtaaaaac tgtgcccaattttctggctccctggactggttgatcagccgattggaaagactggaagct tcttctggtattcttgaagttttgcactgtgtgttagtagaaagtccagaagccctaaat attatcaaagaaggacacattaaatccataatctcccttttagacaagcatggaagaaac cacaaggttctggacgtcttgtgctctctctgcgtctgccacggagtagcggtccgttcc aaccagcatctcatctgcgacaatctgctgccgggaagagatctgcttctgcagacacgt cttgtaaaccacgttagcagcatgagacccaatatttttctgggcgtcagtgaagggtcc gcccagtataagaagtggtactatgagctgatggtggaccacacggagccgttcgtgact gccgaagccactcacctgagggtgggctgggcgtccaccgaagggtactctccctaccct ggaggcggtgaggagtggggtggcaatggagttggagacgatctcttttcctacggattt gatggccttcacctctggtcaggttgtattgcacgtactgtaagctcaccgaatcaacat ctcttgagaactgacgatgtcatcagttgctgtttagatctgagcgccccaagcatctca ttccgaattaacgggcaacctgttcaaggaatgtttgagaatttcaacatcgatggcctc ttctttccagttgttagtttctctgcaggaataaaggtacgctttctgcttggggggaga catggagaatttaaattccttcctccacctgggtatgctccttgttatgaagctgttctg ccaaaagagaagttgaaagtggaacacagcagagaatacaagcaagaaagaacttacacc cgagacctgctgggccccacggtttccctgacgcaggccgccttcacaccaatccctgtg gacaccagccagattgtgttacctcctcacctggagagaataagagaaaaactggcagag aatatccatgaactctgggttatgaataaaattgaacttggctggcagtatggtccggtt agagatgacaataagagacagcatccgtgtctggtggagttctccaagctaccggagcag gaacgcaattacaatttgcagatgtcgcttgagaccctgaagactttgttggcattagga tgtcatgtgggaatagcagatgaacatgctgaagaaaaggtgaaaaaaatgaagctgccc aagaattaccagctgacaagtgggtataagcctgccccgatggacctgagcttcattaaa ctcacgccgtctcaggaagcgatggtggacaagttggcggagaacgcgcacaacgtgtgg gcccgggatcgaatccggcagggctggacttacggcatccagcaggatgtaaagaacaga agaaaccctcgcctggttccctacacccttctagatgaccgcaccaagaagtccaacaag gacagcctccgcgaggccgtgcgcacgctgctgggatatggctatcatctggaggcgcca gatcaagatcatgctgcccgagccgaagtgtgtagcggcaccggggagaggttccgaatc ttccgcgctgagaaaacctatgccgtcaaggcaggaaggtggtattttgaatttgaggct gtcactgctggagacatgagagttggatggagcaggccaggttgtcaacctgaccaagag ctgggctcagacgaacgtgcctttgcttttgatggcttcaaggcccagcggtggcaccag ggcaacgaacactatgggcgctcttggcaagcgggcgatgttgtgggatgcatggtggac atgacagagcacaccatgatgttcacactgaatggcgaaatccttctggatgactcgggc tcggaactggcgttcaaggacttcgatgttggtgacggattcattcctgtctgtagcctt ggagtggctcaggtgggcaggatgaactttggaaaggatgtcagcaccttgaaatatttc accatctgtggcttacaagagggttacgaaccgtttgctgtgaacacgaacagggatatt accatgtggctaagcaagaggcttcctcagtttctccaggtcccttcaaaccatgagcac atcgaggtgaccagaatagatggcaccatcgacagttctccgtgtttaaaagtcacccag aagtcctttggcgctcagaacagcactgccgacatcatgttctatcgcctgagcatgccg atcgagtgtgccgaggttttctccaagacggtggcaggcgggctcccaggcgccggcctc tttgggcccaagaatgatctggaggattacgatgcggattctgactttgaggttctaatg aagaccgctcatggccatctggtgccagaccgtgttgacaaagacaaggaagccacaaaa ccagagtttaataaccacaaagactatgctcaggaaaagccctctcgtctgaaacaaaga tttttgcttagaagaacaaagccagattatagcacgagccattctgcaaggctcaccgaa gatgtccttgcagatgatcgggatgattatgattacttgatgcaaacgtccacgtactat tactcagtgagaatctttcccggccaagaacctgctaacgtctgggtgggctggattaca tcagatttccatcagtatgatacaggctttgacttggacagagttcgtacagtaaccgtt actctaggagatgaaaagggaaaagtacacgaaagcatcaaacgcagcaactgctatatg gtgtgcgcgggcgagagcatgagcccagggcaaggacgcaacaataatggcctggagatc gggtgcgtggtggatgctgccagtgggcttctcacattcaccgccaacggcaaggagctg agcacctactaccaggtggagccaagtacgaaattatttcctgcagcttttgcccaagct acaagtcccaacgttttccagtttgagctgggaagaatcaagaatgtgatgcctctctcc gcgggattattcaagagtgagcacaaaaaccctgtgccacagtgtcccccgcgtctccac gtgcagtttctgtcccacgtcctgtggagcagaatgcccaaccagttcctgaaggtagat gtgtctcgaataagtgagcgccaaggctggctggtgcagtgtttggatcctctgcagttc atgtctctccatatcccggaggagaacagatctgtggacatactggagctgacagagcag gaagagctgctgaaattccactaccacacgctccggctttactccgccgtctgcgccctc gggaaccaccgggtggcgcatgcgttgtgcagccacgtggatgaaccccagctgctctac gccatcgagaacaagtacatgcccggtttgctgcgggccggctactatgacctgctgatt gacatccacctgagctcctacgccactgccaggctcatgatgaacagtgagttcatcgtg cccatgacggaggagaccaaaagcatcaccctcttccctgatgagaacaaaaagcacggc ctccccgggattggcctcagcacctccctcaggccacggatacagttctcctcccccagt tttgtgagcatcaataacgaatgctaccaatacagtccagagttcccgctggacatcctg aaggccaaaaccattcagatgctgacagaagctgttaaagagggcagcctgcatgcccgg gaccccgtggggggcaccactgaatttctctttgtacctctcatcaagcttttctatact ctgctcatcatggggatcttccacaatgaggacttaaaacacatcttgcagctgatagag cccagtgtgttcaaggaagccgccactccggaagaagacactgaggctctggagaaagag ccctccatggaagactccaagccagaaggagctggagaagaagaagccaaagggggtaag aggcccaaggaaggactgctccaaatgaaactgcctgagccagttaaattgcagatgtgt ctgctgctccagtacctctgtgactgccaggtccgacaccggatagaagccatcgtggcc ttttcagatgactttgtagccaagctccaagacaatcagcgcttccgttacaacgaagtt atgcaagctttaaacatgtcggccgcgctcactgccaggaagacaaaggaatttcgatcc ccacctcaggaacagatcaatatgcttctcaattttaaggatgacaaaagtgaatgtcca tgtcctgaagaaatccgagaccagctcttagattttcacgaagatttgatgacacattgt ggaattgagctggatgaagatgggtctcttgatggaaacagtgacttaacaattagagga cgcctgctgtccttggtagaaaaggtgacatacctgaagaagaaacaagccgaaaaacca gttgagagtggctccaagaagtcctctactcttcagcagttgatttctgagaccatggtc cgatgggcgcaagagtctgtcattgaagaccctgaactggtgagggccatgtttgtgttg ctccatcgacagtacgatggcattgggggtctggtccgggctctgccaaagacctacact ataaatggtgtctccgtggaggataccatcaacctgctggcatctctcggtcagattcgt tctctgctgagtgtaagaatgggcaaagaagaagagaagcttatgattcgtggattaggg gatatcatgaataataaagtattttaccagcaccctaatctcatgagggcacttgggatg cacgagacggtgatggaggtcatggtgaatgtccttggaggtggagagtccaaggaaatc acttttcccaagatggtggccaactgttgccgttttctttgttacttctgtcgtataagt cggcagaatcaaaaagctatgtttgaccatctcagctatttattggagaacagcagtgtt ggtcttgcctcaccagcaatgagaggttcaacaccattggatgtggcagccgcatcagtg atggataataatgaactggccttagctctgcgtgagccagatttggaaaaggtagttcga tatttggctggttgtggactgcagagttgcccgatgctggtatctaagggttacccagat attgggtggaatccagttgaaggagagagataccttgactttctccgatttgctgtcttc tgtaatggggagagtgtggaggagaatgctaatgttgtggtgaggttgctcatccggagg cccgagtgtttcggtcctgctttgagaggggaaggtgggaacggtcttcttgcagcaatg gaagaagccataaaaatagccgaggatccctctcgagatggtccctcaccaactagcgga tccagtaaaacacttgagacagaagaggaggaggatgacactatccacatggggaatgcc atcatgacgttttatgcagctttgattgacctcttaggacgctgtgctcctgaaatgcat ttgattcatgctggtaagggggaagccatcagaatccggtcaattctgagatccctaatt ccactgggagatttggtgggagtaatcagcattgcttttcagatgccaacaatagccaaa gatgggaatgtggtggagcctgacatgtctgcggggttttgcccagatcacaaggcagcc atggttttgttccttgacagggtctatggcattgaggttcaagatttcctcctccatctt ctcgaggttggctttctgcctgatctccgggctgctgcttctttagatacggctgctttg agtgccacagacatggccctggccctcaatcggtacctttgcacagccgtgttgcctttg ttaacaagatgtgcccctctttttgcgggcacagaacaccacgcttctctcattgactcg ttactgcacactgtgtacagactttcgaagggctgctcacttaccaaagctcagcgggat tccatagaagtttgtttgctctctatttgtggccaattgagaccttctatgatgcagcac ttgctccgaagattagtgtttgatgtcccattattaaatgaacatgcgaagatgcctctt aagttgctgacaaatcattatgaaagatgctggaaatattactgcctgcctggagggtgg gggaacttcggagctgcctcagaagaagaacttcatttatcaagaaagttgttttggggc atttttgacgccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactgcct tgcctgagtgccgttgcgggagctttgcctccagactacatggagtcaaattatgtcagt atgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaacctgttgat acctcaaacattacaattcctgagaagttggaatacttcattaacaaatatgctgaacat tctcatgacaaatggtcaatggacaagttggcaaatggatggatttatggagaaatatat tcagactcgtctaaagttcagccgttaatgaagccatataaactattatctgaaaaggaa aaagaaatttatcgctggccaatcaaagaatctttaaaaaccatgctggcatggggttgg agggttgagagaacacgggagggagacagcatggccctctacaaccgttctcgtcgtatt tcgcagacaagccaggtttctgttgatgctgcgcatggttatagcccccgagccattgat atgagcaatgtcacactgtccagagacctgcacgctatggcagaaatgatggctgaaaac taccataatatatgggcaaagaaaaagaaaatggagctggagtccaaaggaggtggaaac catcccctgctggtaccctatgatacactgacagccaaagagaaagccaaggatagggaa aaagcacaggacatcctcaagttcttacagatcaatggatatgctgtatccaggggattc aaggacctggaattggacacaccttccattgagaaacgatttgcctatagtttccttcag caactcattcgctatgtggatgaagcccatcagtatatcctggagtttgatggtggcagc agaagcaaggcggaacattttccttacgagcaagaaatcaagttctttgctaaagttgtg cttcctttaattgatcagtatttcaaaaaccatcgtttatacttcttatctgcagcaagc agacccctctgttctggaggacatgcgtcaaacaaggagaaagaaatggtgacgagccta ttctgcaaacttggagttcttgtcaggcataggatttcactatttggaaatgatgccaca tcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggaccgtcatgaag actggcctggagagtgttaaaagtgcgctcagaacgtttctggacaatgcggcggaggat ctggagaagacgatggagaatctcaagcagggccagttcacccacacccgaaaccaaccc aaaggtgttactcagattatcaattataccacggtggctctgttgccaatgctgtcatca ttatttgagcatattggccagcatcagttcggagaagatctaatattggaagatgtacag gtgtcatgttatagaattctgactagcttatatgctttgggaaccagcaaaagtatttat gtggaaaggcaacgctctgcattaggagaatgtcttgctgcttttgctggtgcctttcct gtcgcatttttggaaactcatctcgacaaacataacatctactctatctacaataccaag tcatcgcgagaaagagcagctctgaatttgccaactaacgtggaagatgtgtgcccaaat ataccgtctttggagaaactcatggaagaaattgtggaattagcggagtccggcattcgc tacacgcagatgccacacgtcatggaagtcatactgcccatgctttgcagctacatgtct cgttggtgggagcacggacctgaaaataatccagaaagggctgaaatgtgctgtaccgcc ctgaactccgagcacatgaacacgctcttggggaatatattgaaaatcatatataataac ctgggaattgatgagggagcctggatgaagaggttagcagtattttcacagcccattata aataaagtgaaacctcagctcctgaaaactcatttcttgccattaatggagaaactcaag aaaaaagcagcgatggtggtgtcggaggaggaccatctgaaagctgaggccaggggggat atgtccgaggcagagcttctcattcttgatgagttcaccactctggccagagacctctat gccttctacccgctcttgattagatttgtggactataacagggcaaagtggctaaaagaa cctaacccagaagcagaggaccttttccgcatggtggccgaagtgtttatctactggtca aaatcccacaatttcaaaagagaagagcagaactttgtggtacagaatgaaatcaacaat atgtctttccttatcacggacaccaagtcaaagatgtcaaaggccgctgtctctgatcag gaaaggaagaagatgaagcgcaaaggagatcggtactccacgcagacctctctcattgtg gcagctctgaagcggttgctgcccattgggttgaacatctgtgcccctggggaccaggag ctcatcgctctggccaaaaaccgatttagtatgaaagacactgaggatgaagtacgagat ataatccgcagtaatattcatttacaaggcaagttggaggatcctgctatcagatggcaa atggctctttacaaagacttaccgaacaggactgaagatacatcagatccagagaagacc gtagagagagtattagatatagcaaatgtgctttttcatcttgagcagaaatctacatct atgcaccggagatattacagtctggtggagcacccacagagatcgaagaaagctgtatgg cacaaacttctgtccaagcagaggaagagggcagtggtggcctgcttccgaatggctcct ttatataatctgccaaggcaccgggccgttaacctctttcttcagggatacgaaaagtct tggattgaaacagaagaacactactttgaagataagctgatagaagatttagcaaaacct ggagcagaccctccagaggaagaggaaggcacgaagagagtcgatcccctccatcagctc atccttctgtttagtcgaacagctttaacagagaaatgcaaactggaggaagatttttta tatatggcttatgcagatattatggcaaagagttgtcatgatgaggaagatgatgatggt gaagaagaagtgaagagttttgaagtcacaggatcccaacgcagcaaggaaaaagaaatg gagaagcagaagcttctgtaccagcaagccaggctccatgaccgcggggctgctgagatg gtgctacagaccatcagtgccagcaaaggtgatactggaccaatggtagcggcgactttg aaacttggaattgcaatcttaaatggcgggaactccacagttcagcagaaaatgcttgac tatctcaaggagaagaaggacgtgggtttctttcagagccttgccggcctgatgcagtcg tgcagcgtcctcgacctaaatgcatttgagcggcagaacaaagctgaaggacttggaatg gtcactgaagaaggatcaggagaaaaggttctccaagatgatgagttcacgtgtgacctc ttccgtttcctccagctgctttgtgagggacacaactcagattttcaaaattatctgaga actcagactggcaataacacaactgtcaacatcatcatctctaccgtagactacctactc agagtccaggaatccattagtgatttctattggtattactctgggaaagatgttattgat gaacaaggacaacggaatttctccaaagcaattcaagtagcaaaacaagtctttaacacg ctcacagagtatattcagggtccctgcactgggaatcagcagagcttggcccacagcagg ctatgggacgcggttgtgggcttccttcacgtattcgcccacatgcagatgaagctgtct caggattccagtcaaatcgagctattaaaagaattaatggatcttcagaaggatatggtg gtcatgttgctgtccatgctagaaggtaatgttgtcaatggaaccattggcaaacagatg gtcgatatgcttgtggagtcttccaacaacgtggagatgattctcaagttttttgacatg ttcttaaaactaaaggatttgacctcttctgacacatttaaagaatacgaccctgacggc aagggagtcatttccaagagggacttccataaagcgatggagagccataaacactacacg caatcagaaaccgagtttcttctgtcctgtgcagagacggatgaaaacgaaaccctggac tatgaagagtttgtcaaaaggtttcacgagcccgcaaaggacatcggcttcaacgtggcc gttcttctgaccaacctttcggagcacatgcccaatgatacgcgactgcagactttcctg gagttggcagagagcgtgctgaattacttccagccctttctgggccgcatcgagatcatg ggaagtgccaaacgcatcgagagggtgtattttgaaatcagtgagtccagccgaacccag tgggagaagccccaggtcaaggagtccaaaaggcagttcatatttgacgtggtcaacgaa gggggagaaaaggagaaaatggaactttttgtcaacttctgtgaggacaccatattcgaa atgcagctggcagcgcagatctcagagtcggatttgaatgagaggtcagcaaataaagaa gagagtgagaaggagaagccagaagagcaggggcccagaatgggtttcttttccatcgtg acggtcaagtcggccctgtttgctctcaggtataatatcttgaccctcatgagaatgctc agcctgaagagcctgaagaaacagatgaaaaaggtgaagaagatgacgatgaaggatatg gtcacggccgccttttcgtcctactggagtattttcatgagcctcctgcactttgtggcc agcgtttccagaggcttcttccgcatcatttgcagcctgctgcttggcgggagcctagta gaaggagcaaaaaagatccgagtggcagagctcttagccaacatgccagaccccactcag gatgaggtgagaggggatggagaagagggggacaggaggcccatggaggctgccctgccc tcggaagatctgacagacctgaaggaactgacagaggaaagcgaccttctttcggacata tttggcttggatctgaagagagaaggaggacagtacaaacttattcctcataatccaaac gctggcctcagcgatctaatgagcaacccggtccctatccctgacgtgcaagaaaaattt caggaacagaaggtgaaagaggaagaaaaggaggagaaagaagaaagcaaatctgaacct gaaaaggccgagggagaagatggagaaaaagaagaaaaagccaaagaagataagggtaaa cagaagttgaggcagctccacacacacagatacggagagccagaagttcccgagtcggca ttctggaagaaaatcatcgcatatcaacagaaacttctaaactattttgctcgcaacttt tacaacatgagaatgttagccttattcgtcgcgtttgcaatcaatttcatcttgctcttt tataaggtctccacttcttctgtggttgaaggaaaggagccccccactcgcagttcaagt ggaaatgccaaagttagcagcctggacagtggctcgcctagaatcatggcggttcactac gtcctggaggagagcagcggctacatggagcccacgctgcggatcttagccattcttcac acggtcatttctttcttctgcatcatcggctactactgcttgaaagtcccattggttatt tttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttatattacagaa cagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtca tttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatatggggag ttctatggccgggacagaatcagcgagctccttggtatggacaaagccgccctagatttc agcgatgcccgggaaaagaagaagccaaagaaagacagctccctgtcagccgtactgaac tctattgatgtgaagtatcagatgtggaaactaggagtcgtcttcacggacaactctttc ctctacctggcctggtatatgactatgtccgttctgggacactataacaacttttttttt gctgctcatcttcttgacattgccatgggattcaagacactgagaaccatcttgtcatcg gtaactcacaatggcaagcagcttgtattaactgttggcttgttagctgttgttgtatac ctatatactgttgtggcattcaactttttccgaaaattctacaataaaagtgaagatggt gacacaccggatatgaaatgtgatgatatgttaacgtgctacatgttccacatgtacgtc ggggtacgtgccggagggggtatcggcgatgaaatcgaagacccagcaggcgacgaatat gagatctatcgaatcatctttgacatcaccttcttcttcttcgtgattgtcatcctcttg gccataattcaaggtttaattattgatgcttttggagagctaagagaccaacaggagcaa gtcaaagaagacatggagaccaaatgtttcatctgtgggataggcaacgattacttcgac acagtgccacatggctttgaaacccacactttacaggaacacaacctggccaattacctg ttttttctgatgtatctcataaacaaagatgaaacagagcacacgggacaggaatcttat gtctggaagatgtatcaagaaagatgctgggaattcttcccagcaggggattgtttccgg aaacagtatgaagaccagctaaattaa

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