Prionailurus viverrinus (fishing cat): 125147556 Help Entry 125147556         CDS       T09889                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism pviv  Prionailurus viverrinus (fishing cat) Pathway pviv04020   Calcium signaling pathway pviv04024   cAMP signaling pathway pviv04260   Cardiac muscle contraction pviv04261   Adrenergic signaling in cardiomyocytes pviv04371   Apelin signaling pathway pviv04713   Circadian entrainment pviv04911   Insulin secretion pviv04921   Oxytocin signaling pathway pviv04972   Pancreatic secretion pviv05020   Prion disease pviv05022   Pathways of neurodegeneration - multiple diseases pviv05410   Hypertrophic cardiomyopathy pviv05412   Arrhythmogenic right ventricular cardiomyopathy pviv05414   Dilated cardiomyopathy pviv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pviv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125147556 (RYR2)    04020 Calcium signaling pathway     125147556 (RYR2)    04024 cAMP signaling pathway     125147556 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     125147556 (RYR2)    04921 Oxytocin signaling pathway     125147556 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     125147556 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     125147556 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     125147556 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     125147556 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     125147556 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     125147556 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     125147556 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     125147556 (RYR2)    05414 Dilated cardiomyopathy     125147556 (RYR2)    05415 Diabetic cardiomyopathy     125147556 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pviv04040]     125147556 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pviv04990]     125147556 (RYR2) Ion channels [BR:pviv04040]  Voltage-gated cation channels   Ryanodine receptor    125147556 (RYR2) Domain-containing proteins not elsewhere classified [BR:pviv04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    125147556 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  125147556 NCBI-ProteinID:  XP_047680609 LinkDB All DBs Position D2:complement(11011230..11768032) Genome browser AA seq 4967 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREGGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAAFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNDCYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEED TEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESGSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNRSRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRTF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTSLHRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME KQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNSTVQQKMLDY LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTVKSALFALRYNILTLMRMLS LKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASVSRGFFRIICSLLLGGSLVE GAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSEDLTDLKELTEESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEESKSEPE KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY NMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGNAKVSSLDSGSPRIIAVHYV LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14904 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgcgaactgacgatgaagtg gtcctacagtgcaccgcgaccatccacaaagaacaacagaaactgtgcttggcagcggaa gggtttggcaacagactttgcttcctggagtctacttcgaattccaagaatgttccccca gacctctccatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggag atgctggctaacacagtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtacctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacaacaggtgaggcttgttggtgg actattcatcctgcctccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcctagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgttgcacggacac atggatgaatgcctcactgtcccttcgggagaacacggtgaagagcagcggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacctgagtctcatggaagacaaaagccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccggtcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacatataaatacaggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gacggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agcactgtcttccttttcaatagatttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccacagtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagtgcggcgcattttgcggacgtggcggggaga gaaggaggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaaatccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgc catggagtagcggtccgttccaaccagcatctcatctgcgacaatctgctgccgggaaga gacctacttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcgcagtacaagaagtggtactatgagctgatggtggat catacggagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagttggagat gatctcttttcctacggatttgatggccttcacctgtggtcaggttgtattgcacgtact gtaagctcaccgaatcaacatctcttgagaaccgatgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacacggagaatttaaattccttcctccacctgggtatgct ccttgttatgaagctgttctcccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccctgtggataccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccagttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttacagatgtcgcttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccgtctcaggaagcgatggtggacaagctggcg gagaacgctcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacagaagaaaccctcgcctggttccctacacccttctagatgac cgcaccaagaagtccaacaaggacagcctccgtgaggccgtgcgcacgctgctgggatat ggctaccatctggaggcgccagatcaagatcacgctgcccgagccgaagtgtgtagcggc accggggagaggttccgaatcttccgcgcggagaaaacctatgccgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgctggagacatgagagtcggatggagcaggcca ggttgtcaacctgaccaagagctgggctcagacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaacgaacactatgggcggtcttggcaagcgggcgat gttgtgggatgcatggtggacatgacggagcacaccatgatgttcacactgaatggcgaa atccttctggatgactcaggctcagaactggcgttcaaggactttgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgct gtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccttcaaaccatgagcatatcgaggtgaccagaatagacggcaccatcgacagttct ccgtgtttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatg ttctatcgcctgagcatgccaatcgagtgtgccgaggttttctccaagacggtggcaggc gggctcccaggcgcaggcctctttgggcccaagaatgatctggaggattacgatgcagat tctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagc cattctgcaaggctcacggaagatgtccttgcagatgatcgggatgattatgactacttg atgcaaacgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgatacaggctttgacttggac agagttcgtacagtaaccgttactctaggagatgaaaagggaaaagtacatgaaagcatc aaacgcagcaactgctatatggtgtgcgcgggcgagagcatgagcccagggcaaggacgc aacaataatggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacgttc accgccaacggcaaggagctgagcacctactaccaggtggagccaagtacaaagttattt cctgcagcttttgcccaagctacaagtcccaatgttttccagtttgagctgggaagaatc aagaatgtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgcca cagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctctccatatcccagaggagaacagatctgttgac atactggagctgacagagcaggaagagctgctgaagttccactaccacacgctccggctt tactccgctgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtg gacgaaccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggcc ggctactatgacctgctgattgacatccacttgagctcctacgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccct gatgagaacaaaaagcatggcctcccggggattggcctcagcacctccctcaggccacgg atacagttttcttcccccagttttgtgagcatcaataacgactgctaccaatacagtcca gagttcccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaag gagggcagcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgaggacttaaaa cacatcttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagac actgaggctctggagaaagagccctccatggaagactccaagccagaaggagctggagaa gaagaagccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgag ccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcaa cgcttccgttacaatgaagttatgcaagctttaaacatgtcggccgcgctcactgccagg aagacaaaggaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcac gaagatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaac agtgacttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaaacaagccgaaaaaccagttgagagtggctccaagaagtcctccactcttcagcag ttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat ctcatgagggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctt tgttacttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagcaatgagaggttcaacacccctg gatgtggcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagttgcccgatgctg gtatctaagggttacccagatattgggtggaatccagttgaaggagagagataccttgac tttctccgatttgctgtcttctgtaatggggagagcgtggaagagaatgctaatgttgtg gtgaggttgctcatccggaggcctgagtgtttcggtcctgctttgagaggggaaggtggg aacggtcttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcaccaactagcggatccagtaaaacacttgagacagaagaggaggaggatgac actatccacatggggaatgccatcatgacgttttatgcggctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattctgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacgatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggtt caagatttcctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgct tctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctc tgcacagccgtgttgcctttattaacaagatgtgcccctcttttcgcgggcacagaacac catgcttctctcattgactcgttactgcacactgtgtacagactttcgaagggctgctca cttaccaaagctcagcgggattccatagaagtttgtttgctctctatttgtggccaattg agaccttctatgatgcagcacttgctccgaagattagtgtttgatgtcccattattaaat gaacatgcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa accatgctggcgtggggttggagggttgagagaacacgggagggagacagcatggccctc 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gaagagtttgtcaaaaggtttcacgagcccgcaaaggacatcggcttcaatgtggccgtt cttctgaccaacctttcggagcacatgcccaatgatacgcgactgcagactttcctggag ttggcagagagcgtgctgaattacttccagccttttctgggccgcatcgagatcatggga agtgccaaacgcatcgagagggtgtattttgaaatcagtgagtccagccgaacccagtgg gagaagccccaggtcaaggagtccaaaaggcagttcatatttgacgtggtcaacgaaggg ggagaaaaggagaaaatggaactttttgtcaacttctgtgaggacaccatattcgaaatg cagctggcagcgcagatctcagagtcggatttgaatgagaggtcagcgaataaagaagag agtgagaaggagaagccggaagagcaggggcccagaatgggtttcttttccatcgtgacg gtcaagtcggccctgtttgctctcaggtataatatcttgaccctcatgagaatgctcagc ctgaagagcctgaagaaacagatgaaaaaagtgaagaagatgacgatgaaggatatggtc acggccgccttttcgtcctactggagtattttcatgagcctcctgcactttgtggccagc gtttccagaggcttcttccgcatcatttgcagcctgctgcttggggggagcctagtagaa ggagcaaaaaagatccgagtggccgagctcttagccaacatgccagaccccactcaggat gaggtgagaggggatggagaagagggggacaggaggcccatggaggccgccctgccctcg gaagatctgacagacctgaaggaactgacagaggaaagcgaccttctttcggacatattt ggcttggatctgaagagagaaggaggacagtacaaacttattcctcataatccaaacgct 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tacctggcctggtatatgactatgtccgttctgggacactataacaactttttttttgct gctcatcttcttgacattgctatgggattcaagacactgagaaccatcttgtcatcggta actcacaatggcaagcagcttgtattaactgttggcttgttagctgttgttgtataccta tatactgttgtggcattcaactttttccgaaaattctacaataaaagtgaagatggtgac acaccggatatgaaatgtgatgatatgctaacgtgctacatgttccacatgtacgtcggg gtacgtgccggagggggtatcggcgatgaaatcgaagacccagcaggcgacgaatatgag atctatcgaatcatctttgacatcaccttcttcttcttcgtgattgttattctcttggcc ataattcaaggtttaattattgatgcttttggagagctaagagaccaacaggagcaagtc aaagaagacatggagaccaaatgtttcatctgcgggataggcaacgattacttcgacaca gtgccacatggctttgaaacccacactttacaggaacacaacctggccaattacctgttt tttctgatgtatctcataaacaaagatgaaacagagcacacgggacaggaatcttatgtc tggaagatgtatcaagaaaggtgctgggaattcttcccagcaggggattgtttccggaaa cagtatgaagaccagctaaattaa

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