KEGG   Prionailurus viverrinus (fishing cat): 125150241
Entry
125150241         CDS       T09889                                 
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
pviv  Prionailurus viverrinus (fishing cat)
Pathway
pviv01521  EGFR tyrosine kinase inhibitor resistance
pviv04062  Chemokine signaling pathway
pviv04081  Hormone signaling
pviv04148  Efferocytosis
pviv04151  PI3K-Akt signaling pathway
pviv04217  Necroptosis
pviv04550  Signaling pathways regulating pluripotency of stem cells
pviv04630  JAK-STAT signaling pathway
pviv04658  Th1 and Th2 cell differentiation
pviv04659  Th17 cell differentiation
pviv04725  Cholinergic synapse
pviv04917  Prolactin signaling pathway
pviv04920  Adipocytokine signaling pathway
pviv04933  AGE-RAGE signaling pathway in diabetic complications
pviv04935  Growth hormone synthesis, secretion and action
pviv05140  Leishmaniasis
pviv05145  Toxoplasmosis
pviv05152  Tuberculosis
pviv05161  Hepatitis B
pviv05164  Influenza A
pviv05167  Kaposi sarcoma-associated herpesvirus infection
pviv05168  Herpes simplex virus 1 infection
pviv05200  Pathways in cancer
pviv05207  Chemical carcinogenesis - receptor activation
pviv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pviv05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pviv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    125150241 (JAK2)
   04151 PI3K-Akt signaling pathway
    125150241 (JAK2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    125150241 (JAK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    125150241 (JAK2)
  09143 Cell growth and death
   04217 Necroptosis
    125150241 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    125150241 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    125150241 (JAK2)
   04659 Th17 cell differentiation
    125150241 (JAK2)
   04062 Chemokine signaling pathway
    125150241 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    125150241 (JAK2)
   04917 Prolactin signaling pathway
    125150241 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    125150241 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    125150241 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125150241 (JAK2)
   05207 Chemical carcinogenesis - receptor activation
    125150241 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125150241 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    125150241 (JAK2)
   05164 Influenza A
    125150241 (JAK2)
   05168 Herpes simplex virus 1 infection
    125150241 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125150241 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    125150241 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    125150241 (JAK2)
   05140 Leishmaniasis
    125150241 (JAK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125150241 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    125150241 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125150241 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pviv01001]
    125150241 (JAK2)
Enzymes [BR:pviv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     125150241 (JAK2)
Protein kinases [BR:pviv01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   125150241 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 125150241
NCBI-ProteinID: XP_047685794
LinkDB
Position
D4:81465497..81582838
AA seq 1131 aa
MGMACLTVTEMEGVSVSPVHPNGDIPGNADSVKQIDPLLQVYLYHSLEKADGEYLKFPTG
EHVAEEICVAASKACGITPVYHSMFALMSETERTWYPPNHVFHVDESTRHNVLYRIRFYF
PYWYCNGSNRTYRHGVSRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIVITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQGNQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERDNVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSISILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNRIGTLGFSGAFEDRDP
TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI
LKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQIC
KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY
APESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL
LKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3396 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttaccgtgacggaaatggaaggagtatctgtatctcctgtacat
ccgaacggtgatattcctggaaatgctgattctgtgaagcaaatagatccactcctgcag
gtgtatctttatcattctctggagaaggctgatggggaatatctgaagtttccaactggg
gagcatgttgcagaagaaatttgtgttgctgcttctaaagcctgtggaatcacgcccgtg
tatcatagtatgtttgctttaatgagtgaaactgaaaggacctggtatccgcccaaccat
gtcttccatgtagatgaatcaaccaggcacaacgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggagtgtctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaataccggtgactcatgaaacgcaggaagaatgtcttgga
atggcagtgttagatatgatgagactagccaaagagaaggatcaaaccccattggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaagagaataaggtatagatttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaaca
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattgtaataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatatcattgatgtgactattaaacaaggaaaccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaatctggaaattgaactaagctcattaaga
gaagctttatcctttgtgtcattaattgatggctattacagattaaccgcggatgcacat
cattacctctgtaaagaagtagctcctccgatggtgcttgaaaatatacaaagcaactgt
catggcccgattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct
gtcgagcgagataatgtcatcgaatataagcattgtttgattacaaaaaatgagaatgga
gaatacaacctcagtgggaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgcccc
ccaaagttgaaagataaatcaaatcttctagtctttagaaccaatggcgtttctgatgta
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttgggcaaggcacttttacaaaaattttt
aaaggtgtaagaagagaagtaggagactatggtcaactgcatgaaacagaagttctttta
aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcacctggttttaaattatggagtatgtgtctgtggagag
gaaaatattctggttcaggagtttgtaaaatttggatcattagatacatacctgaaaaag
aataaaaattctataagtatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcccttattcatgggaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacagaaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaacttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagacaagcctctgagtgctttggattctcaa
agaaagctccagttttatgaagataggcaccagcttcctgcacccaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattacgagctattaacagaaaatgac
atgttgccaaataggataggcacccttgggttttctggagcttttgaagaccgagacccg
acacagtttgaagagagacacttgaaatttctacagcagcttggcaagggcaattttggc
agtgtggagatgtgccggtatgaccctctacaagacaacactggggaggtggtggccgtg
aagaagctccagcacagtactgaggagcacctgagagactttgaaagagaaattgaaatc
cttaaatccctgcagcatgacaacattgtcaagtacaagggagtgtgctacagtgctggc
cggcgtaatttaagattaattatggaatatttaccatatggaagtttacgagattatctc
caaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgc
aagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaggaat
atattggtggagaatgaaaacagggttaaaattggagattttggtttaaccaaagtcttg
ccacaagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtat
gctccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttcgga
gtggttctgtatgaacttttcacatacatcgagaagagtaaaagtccaccagcggaattt
atgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactc
ctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttgatt
atgactgaatgctggaacaataatgtaaatcagcgcccctcttttagagacctagctctt
cgagttgatcaaataagggacaacatggctggatga

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