KEGG   Prionailurus viverrinus (fishing cat): 125152491
Entry
125152491         CDS       T09889                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pviv  Prionailurus viverrinus (fishing cat)
Pathway
pviv01521  EGFR tyrosine kinase inhibitor resistance
pviv01522  Endocrine resistance
pviv04010  MAPK signaling pathway
pviv04012  ErbB signaling pathway
pviv04014  Ras signaling pathway
pviv04015  Rap1 signaling pathway
pviv04022  cGMP-PKG signaling pathway
pviv04024  cAMP signaling pathway
pviv04062  Chemokine signaling pathway
pviv04068  FoxO signaling pathway
pviv04071  Sphingolipid signaling pathway
pviv04072  Phospholipase D signaling pathway
pviv04140  Autophagy - animal
pviv04150  mTOR signaling pathway
pviv04151  PI3K-Akt signaling pathway
pviv04210  Apoptosis
pviv04218  Cellular senescence
pviv04270  Vascular smooth muscle contraction
pviv04360  Axon guidance
pviv04370  VEGF signaling pathway
pviv04371  Apelin signaling pathway
pviv04510  Focal adhesion
pviv04540  Gap junction
pviv04550  Signaling pathways regulating pluripotency of stem cells
pviv04613  Neutrophil extracellular trap formation
pviv04625  C-type lectin receptor signaling pathway
pviv04630  JAK-STAT signaling pathway
pviv04650  Natural killer cell mediated cytotoxicity
pviv04660  T cell receptor signaling pathway
pviv04662  B cell receptor signaling pathway
pviv04664  Fc epsilon RI signaling pathway
pviv04666  Fc gamma R-mediated phagocytosis
pviv04720  Long-term potentiation
pviv04722  Neurotrophin signaling pathway
pviv04726  Serotonergic synapse
pviv04730  Long-term depression
pviv04810  Regulation of actin cytoskeleton
pviv04910  Insulin signaling pathway
pviv04912  GnRH signaling pathway
pviv04914  Progesterone-mediated oocyte maturation
pviv04915  Estrogen signaling pathway
pviv04916  Melanogenesis
pviv04917  Prolactin signaling pathway
pviv04919  Thyroid hormone signaling pathway
pviv04921  Oxytocin signaling pathway
pviv04926  Relaxin signaling pathway
pviv04928  Parathyroid hormone synthesis, secretion and action
pviv04929  GnRH secretion
pviv04935  Growth hormone synthesis, secretion and action
pviv05010  Alzheimer disease
pviv05022  Pathways of neurodegeneration - multiple diseases
pviv05034  Alcoholism
pviv05132  Salmonella infection
pviv05152  Tuberculosis
pviv05160  Hepatitis C
pviv05161  Hepatitis B
pviv05163  Human cytomegalovirus infection
pviv05164  Influenza A
pviv05165  Human papillomavirus infection
pviv05167  Kaposi sarcoma-associated herpesvirus infection
pviv05170  Human immunodeficiency virus 1 infection
pviv05200  Pathways in cancer
pviv05205  Proteoglycans in cancer
pviv05206  MicroRNAs in cancer
pviv05207  Chemical carcinogenesis - receptor activation
pviv05208  Chemical carcinogenesis - reactive oxygen species
pviv05210  Colorectal cancer
pviv05211  Renal cell carcinoma
pviv05212  Pancreatic cancer
pviv05213  Endometrial cancer
pviv05214  Glioma
pviv05215  Prostate cancer
pviv05218  Melanoma
pviv05219  Bladder cancer
pviv05220  Chronic myeloid leukemia
pviv05221  Acute myeloid leukemia
pviv05223  Non-small cell lung cancer
pviv05224  Breast cancer
pviv05225  Hepatocellular carcinoma
pviv05226  Gastric cancer
pviv05230  Central carbon metabolism in cancer
pviv05231  Choline metabolism in cancer
pviv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pviv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125152491 (RAF1)
   04012 ErbB signaling pathway
    125152491 (RAF1)
   04014 Ras signaling pathway
    125152491 (RAF1)
   04015 Rap1 signaling pathway
    125152491 (RAF1)
   04370 VEGF signaling pathway
    125152491 (RAF1)
   04371 Apelin signaling pathway
    125152491 (RAF1)
   04630 JAK-STAT signaling pathway
    125152491 (RAF1)
   04068 FoxO signaling pathway
    125152491 (RAF1)
   04072 Phospholipase D signaling pathway
    125152491 (RAF1)
   04071 Sphingolipid signaling pathway
    125152491 (RAF1)
   04024 cAMP signaling pathway
    125152491 (RAF1)
   04022 cGMP-PKG signaling pathway
    125152491 (RAF1)
   04151 PI3K-Akt signaling pathway
    125152491 (RAF1)
   04150 mTOR signaling pathway
    125152491 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125152491 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    125152491 (RAF1)
   04218 Cellular senescence
    125152491 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125152491 (RAF1)
   04540 Gap junction
    125152491 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    125152491 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125152491 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    125152491 (RAF1)
   04625 C-type lectin receptor signaling pathway
    125152491 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    125152491 (RAF1)
   04660 T cell receptor signaling pathway
    125152491 (RAF1)
   04662 B cell receptor signaling pathway
    125152491 (RAF1)
   04664 Fc epsilon RI signaling pathway
    125152491 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    125152491 (RAF1)
   04062 Chemokine signaling pathway
    125152491 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125152491 (RAF1)
   04929 GnRH secretion
    125152491 (RAF1)
   04912 GnRH signaling pathway
    125152491 (RAF1)
   04915 Estrogen signaling pathway
    125152491 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    125152491 (RAF1)
   04917 Prolactin signaling pathway
    125152491 (RAF1)
   04921 Oxytocin signaling pathway
    125152491 (RAF1)
   04926 Relaxin signaling pathway
    125152491 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    125152491 (RAF1)
   04919 Thyroid hormone signaling pathway
    125152491 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    125152491 (RAF1)
   04916 Melanogenesis
    125152491 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    125152491 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    125152491 (RAF1)
   04720 Long-term potentiation
    125152491 (RAF1)
   04730 Long-term depression
    125152491 (RAF1)
   04722 Neurotrophin signaling pathway
    125152491 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    125152491 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125152491 (RAF1)
   05206 MicroRNAs in cancer
    125152491 (RAF1)
   05205 Proteoglycans in cancer
    125152491 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    125152491 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    125152491 (RAF1)
   05230 Central carbon metabolism in cancer
    125152491 (RAF1)
   05231 Choline metabolism in cancer
    125152491 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125152491 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125152491 (RAF1)
   05212 Pancreatic cancer
    125152491 (RAF1)
   05225 Hepatocellular carcinoma
    125152491 (RAF1)
   05226 Gastric cancer
    125152491 (RAF1)
   05214 Glioma
    125152491 (RAF1)
   05221 Acute myeloid leukemia
    125152491 (RAF1)
   05220 Chronic myeloid leukemia
    125152491 (RAF1)
   05218 Melanoma
    125152491 (RAF1)
   05211 Renal cell carcinoma
    125152491 (RAF1)
   05219 Bladder cancer
    125152491 (RAF1)
   05215 Prostate cancer
    125152491 (RAF1)
   05213 Endometrial cancer
    125152491 (RAF1)
   05224 Breast cancer
    125152491 (RAF1)
   05223 Non-small cell lung cancer
    125152491 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    125152491 (RAF1)
   05161 Hepatitis B
    125152491 (RAF1)
   05160 Hepatitis C
    125152491 (RAF1)
   05164 Influenza A
    125152491 (RAF1)
   05163 Human cytomegalovirus infection
    125152491 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125152491 (RAF1)
   05165 Human papillomavirus infection
    125152491 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125152491 (RAF1)
   05152 Tuberculosis
    125152491 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125152491 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    125152491 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    125152491 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125152491 (RAF1)
   01522 Endocrine resistance
    125152491 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pviv01001]
    125152491 (RAF1)
Enzymes [BR:pviv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     125152491 (RAF1)
Protein kinases [BR:pviv01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   125152491 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 125152491
NCBI-ProteinID: XP_047690455
LinkDB
Position
A2:complement(53294723..53378645)
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDATS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSPIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacaaggggcctggaagacgatcagcaatggctttggattcaaagatgca
gtgtttgatggccccagctgcatctcccctacaatagttcagccatttggctttcagcgt
cgggcatcagatgatggcaaacttacggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgagaaatggaatgagcttgcatgat
tgccttatgaaagcactcaaggtgaggggcctgcagccggagtgctgtgcagtgttcaga
cttctccatgaacataaaggtaaaaaagcgcgtttagattggaatactgatgccacctcg
ttgattggagaagaacttcaagtagatttcctggatcacgttcccctcacaacacacaac
tttgctcggaagaccttcctgaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgttcccaaattctcct
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aactcttccagcccttcctctgaaggttccctctcccagaggcagaggtcaacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccagcacagagagagagggcacca
ggatccgggacccaggagaaaaacaaaatcaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctttccactcggattggatcaggctcattt
ggaacagtgtataagggcaagtggcatggagatgttgcagtgaaaattctaaaagttgtc
gaccccacgccagagcagttccaggccttcaggaatgaggtggctgtcctacgcaaaaca
cggcacgtgaacatcctgctcttcatgggctatatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagactaagttc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcgcgctggagtggttctcag
caggtcgaacaacccactggctctgtcctgtggatggcccccgaggtgatccgaatgcag
gataataacccattcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggggagcttccttactcccacatcaataaccgcgaccagatcatcttcatg
gtgggccgaggatatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagctgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagcttctccaacactctctgccgaaaatcaaccggagtgct
tctgagccatccctgcaccgggcggcccacactgaagatatcaacgcctgcacgttgacc
acatcccctagactgcctgtcttctag

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