KEGG   Prionailurus viverrinus (fishing cat): 125157334
Entry
125157334         CDS       T09889                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pviv  Prionailurus viverrinus (fishing cat)
Pathway
pviv01521  EGFR tyrosine kinase inhibitor resistance
pviv01522  Endocrine resistance
pviv04010  MAPK signaling pathway
pviv04012  ErbB signaling pathway
pviv04068  FoxO signaling pathway
pviv04270  Vascular smooth muscle contraction
pviv04650  Natural killer cell mediated cytotoxicity
pviv04720  Long-term potentiation
pviv04726  Serotonergic synapse
pviv04730  Long-term depression
pviv04810  Regulation of actin cytoskeleton
pviv04910  Insulin signaling pathway
pviv04914  Progesterone-mediated oocyte maturation
pviv04928  Parathyroid hormone synthesis, secretion and action
pviv05010  Alzheimer disease
pviv05022  Pathways of neurodegeneration - multiple diseases
pviv05034  Alcoholism
pviv05160  Hepatitis C
pviv05161  Hepatitis B
pviv05200  Pathways in cancer
pviv05205  Proteoglycans in cancer
pviv05208  Chemical carcinogenesis - reactive oxygen species
pviv05210  Colorectal cancer
pviv05211  Renal cell carcinoma
pviv05212  Pancreatic cancer
pviv05213  Endometrial cancer
pviv05214  Glioma
pviv05215  Prostate cancer
pviv05218  Melanoma
pviv05219  Bladder cancer
pviv05220  Chronic myeloid leukemia
pviv05221  Acute myeloid leukemia
pviv05223  Non-small cell lung cancer
pviv05224  Breast cancer
pviv05225  Hepatocellular carcinoma
pviv05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pviv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125157334 (ARAF)
   04012 ErbB signaling pathway
    125157334 (ARAF)
   04068 FoxO signaling pathway
    125157334 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125157334 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    125157334 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125157334 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    125157334 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    125157334 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    125157334 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    125157334 (ARAF)
   04720 Long-term potentiation
    125157334 (ARAF)
   04730 Long-term depression
    125157334 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125157334 (ARAF)
   05205 Proteoglycans in cancer
    125157334 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    125157334 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125157334 (ARAF)
   05212 Pancreatic cancer
    125157334 (ARAF)
   05225 Hepatocellular carcinoma
    125157334 (ARAF)
   05226 Gastric cancer
    125157334 (ARAF)
   05214 Glioma
    125157334 (ARAF)
   05221 Acute myeloid leukemia
    125157334 (ARAF)
   05220 Chronic myeloid leukemia
    125157334 (ARAF)
   05218 Melanoma
    125157334 (ARAF)
   05211 Renal cell carcinoma
    125157334 (ARAF)
   05219 Bladder cancer
    125157334 (ARAF)
   05215 Prostate cancer
    125157334 (ARAF)
   05213 Endometrial cancer
    125157334 (ARAF)
   05224 Breast cancer
    125157334 (ARAF)
   05223 Non-small cell lung cancer
    125157334 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    125157334 (ARAF)
   05160 Hepatitis C
    125157334 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125157334 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    125157334 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    125157334 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125157334 (ARAF)
   01522 Endocrine resistance
    125157334 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pviv01001]
    125157334 (ARAF)
Enzymes [BR:pviv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     125157334 (ARAF)
Protein kinases [BR:pviv01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   125157334 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal Kdo TUG-UBL1 UPF0767
Other DBs
NCBI-GeneID: 125157334
NCBI-ProteinID: XP_047699897
LinkDB
Position
X:38384172..38395463
AA seq 609 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQVYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSRTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLLQLTAQSFS
TDAAGSRGGGGDGAPRGSPSPSVPSGRKSPHSKSPSEQREQRERKSLADDKKKVKNLGYR
DSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQV
LRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGM
DYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEV
IRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSN
CPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPAC
LLSAARLVP
NT seq 1830 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtcttaatcaggattgctgtgtg
gtctaccggctgattgaggggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggagaggagctcatcgtagaggtccttgaagatgtgccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcactgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacaggtctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcccgcacccagcaccgagaccctgagcactttcccttccct
gcccctgccaacgccccactccagcgcatccgctccacatccactcccaacgtgcacatg
gtcagcaccacggcccccatggactccagcctcctccagctcactgcccagagtttcagc
accgatgctgctggtagtagaggcggtggcggcgacggagccccccgggggagccccagc
cccagcgtgccctcggggaggaagtccccacattccaaatccccgtcggagcagcgggag
cagcgggagcggaagtccttggctgatgacaagaagaaagtgaagaatctggggtaccgg
gactcgggctattactgggaggtgccgcccagcgaggtgcagctgctgaagaggatcggg
acgggctcgtttggcaccgtgtttcgcgggcggtggcatggcgacgtggccgtgaaggtg
ctcaaggtggctcaacccacagcggagcaggcgcaggccttcaagaacgagatgcaggtg
ctcaggaagacacgccatgtcaacatcttgctattcatgggcttcatgacccggccggga
tttgccatcatcacacagtggtgtgagggctccagcctgtaccaccacctacatgtggcc
gacacacgcttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatg
gactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatcttccta
cacgaggggctcacagtgaagatcggtgactttggcctggccacggtgaagacacggtgg
agcggggcccagcccttggaacagccctcgggctctgtgctatggatggcggctgaggtg
atccgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcctacggggtt
gtgctctatgagctcatgaccggctcgctgccttacagccacattggcagccgtgaccag
attatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaac
tgccccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgagaggaacgt
cccctcttcccccagatcctggccacgattgagctgctgcagcggtcactccccaagatt
gagcggagtgcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgc
ctcctcagcgcggcccgccttgtgccttag

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