Pteropus vampyrus (large flying fox): 105288773 Help Entry 105288773         CDS       T07815                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp04020   Calcium signaling pathway pvp04371   Apelin signaling pathway pvp04713   Circadian entrainment pvp04921   Oxytocin signaling pathway pvp04970   Salivary secretion pvp05010   Alzheimer disease pvp05012   Parkinson disease pvp05020   Prion disease pvp05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105288773 (RYR3)    04020 Calcium signaling pathway     105288773 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105288773 (RYR3)   09154 Digestive system    04970 Salivary secretion     105288773 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     105288773 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105288773 (RYR3)    05012 Parkinson disease     105288773 (RYR3)    05020 Prion disease     105288773 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     105288773 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pvp04040]     105288773 (RYR3) Ion channels [BR:pvp04040]  Voltage-gated cation channels   Ryanodine receptor    105288773 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  105288773 NCBI-ProteinID:  XP_023383470 UniProt:  A0A6P6C8Q1 LinkDB All DBs Position Unknown AA seq 4789 aa AA seqDB search MEELEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCVCNFVLEQS LSVRALQEMLANTGENGSEGAAQGGGHRTLLYGHAILLRHSFSRMYLTCLTTSRSQTDKL AFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNATIQV DASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTILSTDQNDSQHRRIFYEA GGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRGKSDT KSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKT PRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTALFSQFISGNSRTAAPIT LPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLN IYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLE SSSGILEVLHCILIESPEALNLIAEGHIRSIISLLDKHGRNHKVLDVLCSLCLCNGVAVR ANQNLICDNLLPRRNLLLQTRLINNVTSIRPNILLGVAEGSAQYKKWYFELIIDQVDPFL TAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQ HLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFLMGG RHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDTEGVRDLLGTTQFLSQASFIPCP IDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKLPE TEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLSKNYMMSNGYKPAPLDLSDV KLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSN RDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEV VTGGDMRVGWARPGCRPDVALGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMIN LDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRMNLGMDASTFKFY TMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTH KTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEILSQTTTQCYYAIR IFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCMVTVTLGDERGRVHESVKRSNCYMVWGG DIVATSQRSSRSNVDLEIGCLLDLAMGMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTS TSLFQFELGKLKTAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPSSFLKVETE RVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYHTLRLYSAVCALGN SRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKERKLMMKNEYIIPI NSTTRKIRLYPDEFKRHGLPGVGLRTCLKPGFRFSTPCVVMTSEEHQKQSPEIPLEILKT KALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPS VFGEHSGETEEAAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLPESVKLQINMLLNF QLGENCPCPDEIREELYDFHEDLLTHCGVPLEGEEEEEEDSSWTGKLRAFLYKIRGPPKP EKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVRMMFTLLRRQYDSVGELLRAL RKTYSISQASVSDTIGLLAALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLM RVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLE NSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCAMLLAR GYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGL LAAMQGAIKISENPALDLPSQGCKREVSTEDNEDEEIVHMGNAIMSFYSALIDLLGRCAP EMHLIRTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDH KAPMVLFLDRVYGIKDQAFLLHLLEVGFLPDLRASASLDTVSLSTTEAVLALNRYVCSAV LPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSM LQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKL FWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRISATLEKQISVDTDGNFDPK PINTMNFPVPEKLEYIVTKYAEHSHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLT EKEKEIYRWPARESLKTMLAVGWTVERTKEGDALAQQRENEKLRNVSQASQGNSYSPAPL DLSNVVLSKELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFKDR EKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAI VSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVA SLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAA EDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGADLLLGD VQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFN TKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNY LSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQP IISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADSKGDTQEAELLILDEFAVLCRD LYAFYPMLIRYVDNSRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEI NNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNM CTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEP SNPERTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPR HRSINLFLHGYQRFWIETEEYFFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILHFS RNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARL HERGAAEMVLQMISASKGEMSPMVIETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQ SLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQL LCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHN FSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQI ELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKD LTSSDTFKEYDPDGKGILSKKEFQKAMEGQKQYTQSEIEFLLSCAEADENDMFNYIDFVD RFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKI ERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQ ISESDSADRPEEEEEDEDSSYTSEIEGEEEDKKSFESASAFAMACASVKRNVANFLKRAT LKNLRKQYRKVKKMTVKELVRVFFSFFWMMFVGLFQLFFTILGGIFQILWNTVFGGGLVE GAKNIRVTKILGDMPDPTQFGIHDDAVEAERAEVTEPGITTELVHFIKGEKGNADIMSDL FGFHSKKEGGIKHGPEVGLGDLSEIIGKDEPPTLESTVRKKRKAQAAEMKAADESEGKVE PEKADMEDGEKEDTAREGEQAKALWAEVTKKKKRRRGQKVEKPEALMANFFKGLEIYQTK LLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEEAEDIANLWHSFNDEEEEEAM VFFVLQESTGYMAPTLRALAVIHTVISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLY ITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNA LDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFF FAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSED DDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVIL LAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANY LFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14370 nt NT seq  +upstreamnt  +downstreamnt atggaggagctggaagatgaagtggttctccagtgcatcgcgaacattcacaaggagcaa aggaagttctgcctagcagccgagggacttgggaatcgcctgtgcttcttggaacccact tcagaagccaagtatgttcctccagatctctgcgtctgcaattttgtgctggaacagtcc ctctctgtcagagccctacaggaaatgctcgccaacacaggtgaaaatggcagtgaaggg gcagcacaagggggtggccacaggaccctgctgtatggccacgcgattctcctgcggcac tctttcagcagaatgtatctaacatgtttgactacatcgagatcccagacagataaactt gcctttgatgtaggtctacgggaacatgccacaggggaagcctgttggtggaccatacat cctgcttccaaacagaggtccgagggagaaaaagttcgaattggagatgacctcatcctt gtcagcgtgtcttctgaaagataccttcatctctccatatcaaacgctaccatacaagtg gatgcctcttttatgcaaacactctggaatgtacatcctacatgctcaggaagtagcatc gaagaaggatacctacttggtgggcatgtggtacgtcttttccatggtcatgatgagtgt ctgacgatactatctacagaccagaatgattcccagcacaggaggatattctatgaagcg ggaggagctgggacacgagccagatctctctggagagtggaaccccttcggataagctgg agtggcagtaacatcagatggggccaggctttccgactgcggcacctcaccacaggccac tacctggccctgacagaggaccaaggccttatactgcaagaccggggaaagtcagacacc aagtccacagccttctctttcagggcatcaaaggaaatcaaggagaaattggattccagt cacaagcgagatatagaaggcatgggagttccagaaataaagtatggagattctgtctgc tttgtccagcatgtagccagtggtctgtgggtgacctacaaagcacaggatgccaagaca ccccgccttggacctctgaaaagaaaggtcatactccatcaggaaggccacatggatgat gggttaacactgcagagatgccagcatgaggagtcccaggctgctcggatcatccggaac acaacagccttattcagccagtttataagtgggaacagtcgcacagctgcccccatcacc ttgccaatagaagaagtcctgcagactttacaggacttgatcgcctacttccagccccca gaggaggagatgcagcatgaagacaagcagaacaagctccgctcgctcaaaaacagacag aatcttttcaaggaagaaggaatgttggcccttgtgttaaattgcattgatcgcttaaat atctacaatagcgtagcacactttgctggaattgcaagagaagagagtggcatggcctgg aaagaaattctgaaccttctatacaaattgttggccgccctcattcgtggaaacagaaac aattgtgctcaattctccaataaccttgattggctaatcagcaaattggacagactggaa tcttcctcaggtatcttggaagttttgcactgcatcctgattgaaagcccagaagcctta aatctgatagcagagggccacatcaggtccatcatctccctgttggataagcatggacgg aatcacaaggttctggatgtgctgtgctccctctgtctctgcaatggggttgcagtgaga gccaaccaaaatctgatctgtgacaacttgcttcccaggagaaacctgctcctgcagaca cggctgattaacaatgtgacaagtattcgaccaaatatcttgctgggggtcgctgagggc tcagcacagtacaagaagtggtacttcgagctcattatcgaccaggtggaccccttccta acagcagagcccacacacttgcgggtgggctgggcctcttcctcaggctatgctccgtac cccggaggcggagaaggatggggaggcaacggcgttggcgatgacctgtactcctatggc tttgatggacttcacctttggtcaggccgcattcccagagccgtggcctccatcaaccag cacctcttgaaatcagatgacgtggtgagctgttgcctggacctcggagtgcccagcatc tctttccgcatcaatgggcagcctgtgcaggggatgtttgagaatttcaacacagatggg ctcttcttccctgtggtgagcttttcagcaggtgtcaaagtacgtttcctgatgggtgga cgtcatggagaatttaagtttctgcctccttctggctatgccccttgctatgaagcctta cttcccaaagaaaagatgagattggagcctgtcaaagaatataaacgtgatactgaaggc gttagagacctactgggtaccacccagtttctctcccaagcctctttcatcccatgcccc atagacaccagtcaggttgttttgccacctcacctagagaagattcgagacagactggct gaaaacatccacgagctctggggaatgaataaaatagagcttggctggactttcggcaag atacgggatgacaataaaagacaacacccctgccttgtggagttttcaaagctacctgaa actgagaagaattataacctacagatgtcaaccgaaaccttaaaaaccctcctggccttg gggtgccacattgctcacgttaatccagctgctgaagaggatctcaagaaggtcaaactg tccaaaaactacatgatgtccaatggctataagccagcccctttggatttgtctgatgtg aagctgttacctcctcaggaaattttagtggataagcttgcagaaaatgcacataatgtt tgggcaaaggacagaataaaacaaggatggacctatggcattcaacaggatttgaagaac aaaagaaatccccgtctggtgccatatgcgttactggatgagcgtactaagaagtcaaac agggacagccttcgtgaagctgttcggacgtttgttggttacggctataacatcgagcca tcagaccaagaactagctgacccagctgtggagaaagtcagcattgacaagattcgattc ttccgggtagagcgatcctatgcagtgagatctggaaagtggtatttcgagtttgaggtg gtgactggaggagacatgcgtgtcggctgggccaggccaggctgtcggcctgacgttgca ctgggagccgatgaccaagcctttgtgttcgaaggcagccggggccagcgctggcatcaa gggagtgggtattttggccgtacctggcagccaggagatgtggttggatgtatgattaac ctggatgatgcttcaatgatcttcacactgaatggggagctgctgatcaccaacaaaggc tctgaacttgcctttgctgattacgagatcgagaatggctttgtgcccatctgctctctg ggcctgtctcagatcggccgcatgaatctcgggatggatgccagtaccttcaagttttat accatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaaccgagatgtt gcaatgtggttcagcaagcgcctcccaacgtttgtcaatgtgccaaaggatcatccacat atagaggtcgtgaggatcgatggcaccatggacagccctccatgcctcaaagtgacccac aagacgtttggcacacagaatagcaatgccagcatgatctactgccgcctgagcatgccc gtcgaatgccactcctccttcagtcacagcccctgtctggacagtgaagctttccagaaa aggaaacagatgcaagaaatactctctcaaacaaccacacaatgctactacgcaatccgc atctttgctggacaggacccctcctgtgtctgggtcggatgggtgactcccgactatcac ttatacagtgaaaagtttgacctgaataaaaactgtatggtgactgttactctgggggat gaaagaggccgggtccatgaaagtgtaaagcgcagcaactgctacatggtctggggtggg gacattgtggccacttcccaacgatcgagtcgcagcaacgtggacctggagatcggctgc ctcttggatctggcaatgggcatgttgtccttctcagccaatgggagagaactcggcacc tgctaccaggtggaacccaataccaaagtatttccagcagtcttcctgcagcctacaagc acttctttgtttcagtttgaacttgggaaactgaagactgcaatgcccctgtcggcggcc atatttaagagtgaagaaaagaacccagtcccacagtgtccacctcgcctagacgtccaa accatccagcctgtgctctggagccgcatgcccagcagtttcctgaaggtggagacggag cgggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatgatggcg ctccacatccccgaggagaacaggtgtgtggatatcctggagctctgcgagcaggaggac ctgatgcagttccactatcacacgctacgactctacagtgccgtgtgtgccctgggaaac agtcgagtagcctatgccctgtgcagccacgtggacctctcccagctcttctacgccatt gataacaagtacctccccggtctccttcggtctggtttctatgacctgctcatcagcatc catttggccaatgctaaggagagaaagctgatgatgaagaatgagtacatcatccccatt aacagcaccactaggaaaatccgcctttacccagatgagttcaagaggcatgggctgcct ggggtgggcctgagaacgtgcctcaagccaggattcagattctccaccccttgcgttgtc atgaccagtgaggagcatcagaagcagagccccgagattcccttggagattctcaagacg aaggcattgagcatgctaacagaggccgtgcaatgcagtggggctcacatccgggaccct gttggggggtctgtggagttccaatttgtgcctgtgctgaaactcattggaacgctgctg gtcatgggagtgtttgatgatgatgacgttcggcagatcctcctcctgatcgatccttct gtgtttggggagcacagtggagagacagaagaggcagcagagaaggaagaagtgactcag gtagaggagaaggcagtggaggctggggaaaaggccagcaaggaggctccagtcaaaggc ttgttacagacccgattaccagagtccgtcaagctgcagattaacatgcttcttaacttt caactgggagagaactgcccctgcccagacgagatccgggaggagctgtatgacttccac gaggaccttctcactcactgcggagttcccctggagggggaggaagaagaggaagaagac agctcctggactggaaaactccgtgccttcttatacaaaatcagaggccctcccaagcca gagaaagagcagccgacagaggaggaagagagatgccctaccacgctgaaggagctcatc tcccagacgatgattcgctgggcccaagaggaccagatccaggacgcagagctggtccgg atgatgttcacgctcctccggaggcagtacgacagcgtcggggagctgctgcgggcgctg cgcaagacctacagcatcagccaggcctctgtgagcgacaccatcggcctgctggctgcc ctcggccagattcgctgcctcctcagtgtcaggatgggcaaggaagaggagctgcttatg atcaatgggctgggagacataatgaacaacaaggtgttctaccagcaccccaacctcatg cgagtcctcggcatgcacgagacagtgatggaggtgatggtgaacgtgttgggtgcggag aaatcccagattgcttttccaaagatggttgctagctgttgccgcttcctttgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctggag aacagcagtgttggtctagcctccccgtcgatgaggggttccactccactggatgtggca gcttcctccgtgatggacaacaacgagttagcgctgggcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggtctccagagctgcgccatgcttctggccaga gggtaccctgatgtcggctggaaccccatcgaaggggagcgctacctgtccttcctgagg tttgctgtcttcgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaagctg ctcatcagacgtccagagtgcttcggcccagcgctgcggggtgaaggaggaaacggtctg ttggcagccatgcaaggcgccatcaagatctctgagaacccagccctggacctcccctct cagggatgcaagagagaagtcagcacagaggacaatgaagatgaagagatcgtgcacatg ggcaatgcaattatgtcattttattcagctcttatagatcttctgggccgctgtgctcct gaaatgcaccttatccggacaggaaaaggggaagccatcaggatcaggtcaattctacgc tcccttgtccccacggaggacttggttggaatcatcagcatccccttgaaactgccctcc ctgaacaaagatgggtcggtgagtgagccagatatggcggccaacttctgccctgaccac aaggcaccgatggtgctgttcttggaccgcgtttatggcattaaggatcaagcttttctg ctccacttgctggaggttggatttttgccggacttaagagcctctgcctctctagataca gtctcgctgagcaccacagaggccgtgctggcgctaaacaggtatgtgtgttccgccgtg ctcccgctcctcacgagatgcgcccctctctttgctggaacagaacactacacctctttg atcgattctacactgcagacaatatacaggctttccaagggacgttccctcaccaaagct cagagggacaccatagaagaatgtttgcttgccatctgcaatcacttgaggccttccatg ttacagcagctcctgcgacgtcttgtttttgatgtgccccaactcaacgaatactgcaaa atgcctcttaagcttctgacgaatcactatgaacagtgctggaagtattactgtctgcct tcaggatgggggagctatggtctcgctgtggaagaagaactacacctgacagaaaagctc ttctgggggatttttgactccctctctcataagaagtatgacccagaccttttccgaatg gccctgccttgtctcagtgctatagctggggccttgccaccagattatttagataccaga atctcggccacactggagaagcagatctcagtggatacagatggcaactttgaccccaaa cctatcaacaccatgaatttccccgtgcctgaaaaattggaatacatcgtcaccaagtat gctgagcattcacatgataaatgggcctgcgacaagagtcagaatggatggaaatatgga atttccctggacgaaaacgtgaagacccatccattgatcagaccttttaagacattaaca gagaaggagaaagaaatttatcgctggccggccagagagtccctgaaaaccatgctggct gtgggttggacagtggagaggaccaaagagggagacgccctagctcaacagcgggaaaat gagaaacttcgaaacgtgtcccaggccagccagggcaacagctacagccctgctcccctg gacctgtccaacgtggtgctctccaaagagctccagggaatggtggaggtggtggctgag aattatcacaacatctgggccaagaagaagaagctggagctagagagcaaaggtggtggc agtcaccctctcttggtaccatatgacaccttgactgccaaggaaaagtttaaggaccga gagaaggcacaggacctgtttaaattcctccaagtgaacggcattgtggtttctagaggt atgaaggatatggagctggatgcctcctccatggagaagaggtttgcctataaatttttg aagaagatcctgaaatatgttgattccgctcaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctagtggaccagtacttcaccaatcaccgcctctatttcctgtcatcc cctctgaagccgctgagcagcagcgggtacgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaacttgctgctcttgttcgacacaggatttccctctttgggagtgac tctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtc atgaagtcaggctccgagctggtgaaagccggcttacgagccttcttcgaaaatgctgca gaagacttagagaagacttcggaaaacttgaagcttgggaagtttacccattccagaaca cagattaaaggtgtttctcagaacatcaactacaccacggtggcgctgctccccatcctg acgtccatctttgagcatgttgctcaacatcagtttggggcggatttactcttgggtgat gtgcagatttcatgctaccacatcctgtgcagcctctactcccttgggacgggaaagaac atctatgttgaaagacaacgtcctgcccttggagaatgtctggcttcactggcagctgcc atcccggtggcattcctggagcccactcttaaccgctacaatccactctcagtcttcaac accaagacccccagagagagatctattctggggatgcccgacacagtagaagagatgtgt cctgacatcccccagctagaaggcctgatgaaggaaatcaacgacctggctgagtcaggg gcccggtataccgagatgccccacgtcatcgaggtgatcttgcctatgctctgcaactac ctgtcctactggtgggagcgagggcctgagcacctgccccccagcacagggccctggtgc accaaggtcacctctgaacacctcagcgtcatcctgggcaacattctgaaaatcatcaac aacaacctgggcatcgacgaggcctcctggatgaagcgcattgcagtgtatgctcagcca atcatcagcaaagccaggcctgacctgctgagaagccacttcatcccaactctggagaag ctaaagaaaaaggccgtcaagactgtgcaggaagaggagcagctgaaagccgacagcaaa ggggacactcaggaggcagagctcctcatcctggacgagttcgcagtcctctgcagagac ctctacgccttctaccccatgctgatccgctacgtggacaacagcagatctaactggctc aaaagccctgatgctgattctgaccagctcttccgtatggtggcagaagtcttcatcctg tggtgtaaatctcacaacttcaagagggaagagcaaaatttcgtgattcagaatgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaagta aagtctggaggacaggatcaggaacggaagaagacaaagcgaaggggagacttgtattcc atccagacctccctcatcgtggccgcactcaagaaaatgctgcccattggtttgaatatg tgcaccccaggcgatcaggagctgatctccctcgcgaaatcacgatacagctatagggac acagacgaagaggtgaaggaacatctgcggaataacttgcacttgcaggaaaagtctgat gacccagctgtaaagtggcaactgaatctctacaaggatgtgttgaagagtgaagaacct tccaatccagaaaggacagtggagcgcgtgcagagaatttcagcagctgtcttccacctg gagcaggtggagcagcctttgaggtccaagaaggcagtttggcacaaactgttgtcaaag cagcggaaacgggcagtggtggcctgtttcaggatggctcctctctacaacctgcccagg caccgctctattaacctcttcctccatggctatcagagattttggatagaaacagaggag tatttctttgaagagaaactagtacaggatttggctaaatctcccaaggtggaagaggag gaggaagaggagacggaaaagcaaccagacccacttcatcagatcattctccattttagc cgcaatgctctcacggagaggagtaaattggaagacgaccctttgtatacctcctattcc agcatgatggccaagagttgtcagagtggggaggatgaagaagaagaggaagacaaggaa aaaacattcgaagagaaagaaatggaaaagcagaaaacgctgtatcagcaggctcggctg catgaacgcggagccgcagagatggtccttcagatgataagcgccagtaaaggtgagatg agccccatggtgattgagactctgaagctgggaatcgctatcctgaatggaggcaacgct ggtgtgcaacagaaaatgttagattacctcaaggagaaaaaggatgctggattctttcaa agcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcag aataaagctgaaggcctggggatggttacggaggaaggaacactcattgttcgtgaacgt ggtgaaaaagtactccagaatgatgagtttacacgagacctctttagattcctacagtta ctttgtgaaggacataacagcgactttcagaacttcctacggactcaaatgggcaacacc accactgtgaatgtcatcatcagcaccgtggactaccttctgcgtcttcaggaatcgatc agtgatttctactggtattattcagggaaggacatcattgacgaatctggacagcacaat ttttccaaagctctggcggtcaccaagcaaattttcaattctcttacagaatacatccag ggcccttgcattgggaaccaacagagcctggctcacagcaggctgtgggacgcggtggtc ggcttcctccatgtatttgctaacatgcagatgaaactctctcaggattccagtcagatc gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctc ctggaaggaaatgtggtaaatggaactattggcaagcagatggttgacacactggtagag tcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagac ttaaccagctcagacaccttcaaagaatatgacccagatggcaaagggattctctccaaa aaagaattccagaaggccatggaagggcaaaaacagtacacacagtcagagattgagttt ctcctttcgtgtgcagaagctgatgagaatgacatgtttaattacattgattttgtggac cggttccacgagccggccaaggacatagggtttaacgtggcagtgttattgacaaatctc tccgagcatatgccaaatgattctcggcttaaatgtctgttggacccagcagaaagtgtg ctaaattacttcgaaccatacttaggacgcattgagattatgggcggggccaagaaaatt gagcgtgtttattttgagatcagtgaatccagtcgaactcagtgggaaaagccccaagtg aaggaatctaagcgacagtttatctttgatgttgtcaacgaaggtggggagcaagaaaaa atggaactgtttgtgaacttctgtgaagacaccatctttgaaatgcagttagcatcacag atctctgaatctgactcagccgacaggccagaagaagaggaggaagatgaagattcttct tacacctcggaaattgagggtgaagaggaagataaaaagtcctttgagtctgcctctgcg ttcgccatggcctgtgcctcggtgaagagaaacgttgccaactttctaaagagggcaacc ctgaagaacctcaggaagcagtacaggaaggtgaaaaagatgactgtgaaggagctggtg cgggtgttcttttctttcttctggatgatgttcgtggggctattccaactgttcttcacc atactgggaggaatatttcagatcctctggaacacggtgtttggagggggcctggttgag ggggcaaagaacatcagggtgaccaagatcctaggggacatgcctgacccgacccaattt ggtatccacgatgatgctgtggaggccgagagggcagaagtgactgagccaggtatcacc actgaactagtacatttcataaagggtgagaagggaaatgcagatattatgtcagatctt tttggattccactcaaaaaaagaaggtggcataaagcatgggcccgaagtgggtttgggt gacctctctgagattattggcaaggatgaaccccctacgctagagagtactgtacggaag aaaaggaaagcacaggcagcagagatgaaagcagcagatgaatcagaaggaaaagtagaa cctgagaaggcagacatggaagatggggagaaggaggacacagccagagaaggagagcaa gccaaggccctgtgggcagaagtgaccaaaaagaagaagcgacggcgtggccagaaagtc gagaagcctgaagccctcatggccaatttctttaaggggctggaaatctatcagaccaag ttattgcactacttggccagaaatttctacaacctgaggttccttgctctgtttgtagcc ttcgctatcaacttcatcctgctcttttacaaggtcactgaagaacctttagaagaagag gcagaggacatcgcgaacctgtggcattcctttaatgacgaggaagaggaagaagcgatg gtgttctttgtcctgcaggagagcactgggtatatggcaccaacattgcgggctctggcc gttatccacaccgtcatctctttagtctgcgtggtgggctattactgcctgaaggtccct ttggttgtattcaaaagggaaaaagaaattgccaggaagctggagtttgatggcctatat atcactgaacaaccatctgaagatgacatcaaggggcaatgggaccgcttggtaatcaac acaccatcttttcctaataactattgggacaagtttgtaaagagaaaggtgatcaacaag tatggagatctttatggagcagaacgcattgctgaactcctgggtttggacaaaaatgcc cttgactttagcccagtagaagagacgaaagcagaggcggcgtctctagtgtcatggcta agttccatcgacatgaagtaccatatctggaaactaggagttgtttttactgacaactcc tttctctaccttgcctggtacacaaccatgtccatccttggccactacaataacttcttc ttcgctgctcatctgctggacatcgccatgggcttcaagacactgaggactattctgtca tctgtaactcacaatggcaaacagctggttttgactgtcggtctcctggctgtggtggtt tatctctacaccgtggtggctttcaacttctttcgcaagttctacaataagagtgaggat gacgatgagcccgatatgaagtgtgatgacatgatgacgtgttacctattccacatgtac gtcggggtgagagctggaggcggcatcggcgatgaaatcgaagaccctgctggtgaccct tatgaaatgtaccgcatcgtctttgacattacatttttcttcttcgtcattgtcatcttg ctggccatcattcaaggtcttattattgatgcttttggagagctaagagaccagcaggaa caagtgagagaagatatggagactaaatgtttcatctgtgggattggcaatgattacttt gacacgacgcctcatggttttgaaacacatacattacaagagcacaacttagccaactac ttgttcttcctgatgtatctgattaacaaagatgaaacagagcacacgggtcaggaatct tatgtctggaagatgtaccaagaaagatgttgggatttcttcccagctggtgactgcttt cgaaaacaatatgaagatcagcttggataa

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