KEGG   Pteropus vampyrus (large flying fox): 105291659
Entry
105291659         CDS       T07815                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pvp  Pteropus vampyrus (large flying fox)
Pathway
pvp01521  EGFR tyrosine kinase inhibitor resistance
pvp01522  Endocrine resistance
pvp04010  MAPK signaling pathway
pvp04012  ErbB signaling pathway
pvp04015  Rap1 signaling pathway
pvp04024  cAMP signaling pathway
pvp04062  Chemokine signaling pathway
pvp04068  FoxO signaling pathway
pvp04150  mTOR signaling pathway
pvp04270  Vascular smooth muscle contraction
pvp04510  Focal adhesion
pvp04650  Natural killer cell mediated cytotoxicity
pvp04720  Long-term potentiation
pvp04722  Neurotrophin signaling pathway
pvp04726  Serotonergic synapse
pvp04730  Long-term depression
pvp04810  Regulation of actin cytoskeleton
pvp04910  Insulin signaling pathway
pvp04914  Progesterone-mediated oocyte maturation
pvp04928  Parathyroid hormone synthesis, secretion and action
pvp04934  Cushing syndrome
pvp05010  Alzheimer disease
pvp05022  Pathways of neurodegeneration - multiple diseases
pvp05034  Alcoholism
pvp05160  Hepatitis C
pvp05161  Hepatitis B
pvp05200  Pathways in cancer
pvp05205  Proteoglycans in cancer
pvp05208  Chemical carcinogenesis - reactive oxygen species
pvp05210  Colorectal cancer
pvp05211  Renal cell carcinoma
pvp05212  Pancreatic cancer
pvp05213  Endometrial cancer
pvp05214  Glioma
pvp05215  Prostate cancer
pvp05216  Thyroid cancer
pvp05218  Melanoma
pvp05219  Bladder cancer
pvp05220  Chronic myeloid leukemia
pvp05221  Acute myeloid leukemia
pvp05223  Non-small cell lung cancer
pvp05224  Breast cancer
pvp05225  Hepatocellular carcinoma
pvp05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pvp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105291659 (BRAF)
   04012 ErbB signaling pathway
    105291659 (BRAF)
   04015 Rap1 signaling pathway
    105291659 (BRAF)
   04068 FoxO signaling pathway
    105291659 (BRAF)
   04024 cAMP signaling pathway
    105291659 (BRAF)
   04150 mTOR signaling pathway
    105291659 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105291659 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105291659 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    105291659 (BRAF)
   04062 Chemokine signaling pathway
    105291659 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105291659 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    105291659 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    105291659 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105291659 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    105291659 (BRAF)
   04720 Long-term potentiation
    105291659 (BRAF)
   04730 Long-term depression
    105291659 (BRAF)
   04722 Neurotrophin signaling pathway
    105291659 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105291659 (BRAF)
   05205 Proteoglycans in cancer
    105291659 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    105291659 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105291659 (BRAF)
   05212 Pancreatic cancer
    105291659 (BRAF)
   05225 Hepatocellular carcinoma
    105291659 (BRAF)
   05226 Gastric cancer
    105291659 (BRAF)
   05214 Glioma
    105291659 (BRAF)
   05216 Thyroid cancer
    105291659 (BRAF)
   05221 Acute myeloid leukemia
    105291659 (BRAF)
   05220 Chronic myeloid leukemia
    105291659 (BRAF)
   05218 Melanoma
    105291659 (BRAF)
   05211 Renal cell carcinoma
    105291659 (BRAF)
   05219 Bladder cancer
    105291659 (BRAF)
   05215 Prostate cancer
    105291659 (BRAF)
   05213 Endometrial cancer
    105291659 (BRAF)
   05224 Breast cancer
    105291659 (BRAF)
   05223 Non-small cell lung cancer
    105291659 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    105291659 (BRAF)
   05160 Hepatitis C
    105291659 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105291659 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    105291659 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    105291659 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105291659 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105291659 (BRAF)
   01522 Endocrine resistance
    105291659 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pvp01001]
    105291659 (BRAF)
Enzymes [BR:pvp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     105291659 (BRAF)
Protein kinases [BR:pvp01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   105291659 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase C1_1 RBD Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 105291659
NCBI-ProteinID: XP_023386037
UniProt: A0A6P6CF47
LinkDB
Position
Unknown
AA seq 581 aa
MMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTL
AFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEA
SLAETTLTSGSSPSAPPSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSS
APNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE
RKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKML
NVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE
TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS
GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI
IFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIH
RSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq 1746 nt   +upstreamnt  +downstreamnt
atgatgagaggtctaatcccagagtgctgtgccgtttacagaattcaagatggagagaag
aagccaattggctgggacaccgatatttcctggcttactggagaggagttacatgtagaa
gtgctggaaaatgttccacttacaacacacaactttgtacggaaaacttttttcacctta
gcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaaacatgtggt
tataaatttcaccagcgttgtagtacagaggttcctctgatgtgtgttaattatgaccaa
cttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggaggaggcc
tccctagcagagaccacccttacgtctggatcatccccttccgcacccccttccgattct
attgggccccaaattctcaccagtccgtctccttcaaaatccattccaattccacagcct
ttccgaccagcagatgaagatcatcgaaatcagtttggacaacgagaccggtcttcatca
gctccaaatgtgcatataaacacaatagagcctgtcaatattgatgacttgattagagac
caagggtttcgtagtgatggaggatcaaccacaggtttgtctgccaccccccctgcctca
ttacctggctcactcactaatgtgaaagcattgcagaaatctccaggacctcagcgggaa
cggaaatcatcttcttcctcagaagacaggaatcgaatgaaaacacttggtagacgggat
tcaagtgatgattgggagattcctgatgggcagatcacagtgggacaaagaattggatct
gggtcatttgggacagtctacaaaggaaagtggcatggtgatgtggcagtgaagatgttg
aatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtaggagtactc
aggaaaacgcgacatgtgaatatcctactcttcatgggctattcaacaaagccacagctg
gctattgttacccagtggtgtgagggctccagcttatatcaccacctccacatcattgag
accaaatttgagatgatcaaacttatagatattgcacggcagactgcacagggcatggat
tacttacacgccaagtcaatcatccacagagacctcaagagtaataatatatttcttcat
gaagacctcacagtaaaaataggtgactttggtctagccacagtgaaatctcgatggagt
gggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagtaatc
agaatgcaagataaaaacccatatagttttcagtcagatgtatatgcatttgggattgtt
ctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagggaccagata
atttttatggtgggacgaggatatctgtctccagatctcagtaaggtacgaagtaactgt
ccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaagagatgaaagacca
ctctttccccaaattctcgcctctattgagctgctggcccgctcattgccaaaaattcac
cgcagtgcatcagaaccctccttgaatcgggccggcttccaaacagaggattttagtcta
tatgcttgtgcttctccaaaaacacccatccaggcagggggatatggtgcgtttcctgtc
cactga

DBGET integrated database retrieval system