Pteropus vampyrus (large flying fox): 105292652 Help Entry 105292652         CDS       T07815                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4   KO K10160   toll-like receptor 4 Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp04064   NF-kappa B signaling pathway pvp04066   HIF-1 signaling pathway pvp04145   Phagosome pvp04151   PI3K-Akt signaling pathway pvp04217   Necroptosis pvp04613   Neutrophil extracellular trap formation pvp04620   Toll-like receptor signaling pathway pvp04621   NOD-like receptor signaling pathway pvp04936   Alcoholic liver disease pvp05132   Salmonella infection pvp05133   Pertussis pvp05134   Legionellosis pvp05135   Yersinia infection pvp05140   Leishmaniasis pvp05142   Chagas disease pvp05144   Malaria pvp05145   Toxoplasmosis pvp05146   Amoebiasis pvp05152   Tuberculosis pvp05161   Hepatitis B pvp05162   Measles pvp05164   Influenza A pvp05170   Human immunodeficiency virus 1 infection pvp05171   Coronavirus disease - COVID-19 pvp05205   Proteoglycans in cancer pvp05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pvp05321   Inflammatory bowel disease pvp05323   Rheumatoid arthritis pvp05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     105292652 (TLR4)    04066 HIF-1 signaling pathway     105292652 (TLR4)    04151 PI3K-Akt signaling pathway     105292652 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     105292652 (TLR4)   09143 Cell growth and death    04217 Necroptosis     105292652 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     105292652 (TLR4)    04620 Toll-like receptor signaling pathway     105292652 (TLR4)    04621 NOD-like receptor signaling pathway     105292652 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     105292652 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     105292652 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     105292652 (TLR4)    05161 Hepatitis B     105292652 (TLR4)    05171 Coronavirus disease - COVID-19     105292652 (TLR4)    05164 Influenza A     105292652 (TLR4)    05162 Measles     105292652 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     105292652 (TLR4)    05135 Yersinia infection     105292652 (TLR4)    05133 Pertussis     105292652 (TLR4)    05134 Legionellosis     105292652 (TLR4)    05152 Tuberculosis     105292652 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     105292652 (TLR4)    05144 Malaria     105292652 (TLR4)    05145 Toxoplasmosis     105292652 (TLR4)    05140 Leishmaniasis     105292652 (TLR4)    05142 Chagas disease     105292652 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     105292652 (TLR4)    05321 Inflammatory bowel disease     105292652 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     105292652 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     105292652 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pvp04131]     105292652 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:pvp04054]     105292652 (TLR4)    04090 CD molecules [BR:pvp04090]     105292652 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:pvp00536]     105292652 (TLR4) Membrane trafficking [BR:pvp04131]  Endocytosis   Phagocytosis    Toll-like receptors     105292652 (TLR4) Pattern recognition receptors [BR:pvp04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    105292652 (TLR4) CD molecules [BR:pvp04090]  Proteins   105292652 (TLR4) Glycosaminoglycan binding proteins [BR:pvp00536]  Hyaluronan   Cell surface receptors    105292652 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_9 LRR_5 LRR_NXF1-5 LRR_LRWD1 LRR_Zer-1 LRR_EndoS ThsB_TIR LRR_R13L1-DRL21 Curto_V2 Motif Other DBs NCBI-GeneID:  105292652 NCBI-ProteinID:  XP_011359267 UniProt:  A0A6P3Q4Z1 LinkDB All DBs Position Unknown AA seq 841 aa AA seqDB search MMPPIRLAGILIPAMAFLSCLRPESWDPCVQVVPHITYQCMELNLYKIPNNIPTSVKKLD LSFNPLRRLSSHIFSNFSELQVLDLSRCEIEMIEDDAYEGLNHLSTLILTGNPIQSLAMG AFSGLSSLQTLVAVEINLVSLEDFPIGHLKTLKELNVAHNLIDSFKLPEYFSNLSNLEHL DLSNNKIQTICHKDLQVLHQMPPFKLSLDLSLNPLDFIQRGAFKEIKLHELTLRSNFNST DVMKTCIQGLAGLKINRLVLGEFKNERAINHFDKSAMEGLCNLTIDEFRMTYFDDFSEDV INFFNCLANVSTISLVSLYLNRLEVLSKDFKWQHLKLTNSKFDHFPRLALDSLKKLVFTA NRGMSTFTEVKLPKLEFLDLSRNGLSFKSCCSHTFWGTTRLKHLDLSFNDVITMSSNFLG LEQLKYLDFQHSNLKQASDFSVFLSLKNLLYLDISYTRIRIIFHGIFDGLFSLEVLKMAG NSFQDNSVPNIFKALTNLTFLDLSNCQLERVSQAAFGSLVKLKSLNMSHNHLLSLDLFPY KLPHSLQDLDCSFNRIVASNRQELQHFPSNLTSLNLTGNDFACICEHQSFLQWVKDHRHL LVGVTQMVCVQPLDMQGVPVLSFRNATCQMSKTVISVSVLTVLVVSVVAVLVYKFYFHLM LLAGCKKYGRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKLWSPEGAADAESSQHEATIT I NT seq 2526 nt NT seq  +upstreamnt  +downstreamnt atgatgcctcccatccgcctggctgggattctgatcccagccatggccttcctttcctgc ctgagacctgagagctgggacccttgcgtgcaggtggttcctcacattacctaccagtgc atggagctgaatctctacaaaatccccaacaacatccccacatcagtcaagaaactggat ctgagctttaaccccctgagacgtctaagcagccatatcttctccaacttctcagaattg caggtgctggatttatctaggtgtgaaattgagatgattgaagatgatgcatatgagggt ctaaaccatctctccaccttgatattgacaggaaaccctatccagagtttagccatggga gccttttctggactatcaagtttacagacactggtggctgtggagataaacctagtgtct ctagaggacttccccattggacacctgaaaaccttgaaggagcttaatgtggctcacaat cttattgattccttcaagttacctgaatatttttctaacctgtccaacctggagcactta gacctttccaataacaagatccaaactatttgtcataaagacctacaggttctacatcaa atgcccccattcaaactctctttagacttgtccctgaaccctttagacttcatccaacga ggtgcctttaaagaaattaagctccatgaactaactttgagaagtaattttaacagtaca gatgtaatgaaaacttgtattcaaggcctggctggcttaaaaatcaatcgtttggttcta ggagaatttaaaaatgaaagagccataaaccattttgacaaatctgccatggagggactg tgcaacttgaccattgacgaattccggatgacatacttcgatgacttctcagaggatgtt attaacttttttaattgtttggcaaatgtttctacaatttctctggtgagtctgtattta aacaggctagaagtcctttctaaagatttcaaatggcaacacttaaaactgactaactct aaatttgatcattttcccaggttggcgcttgactctctcaaaaagttggttttcactgcc aacaggggtatgagcacttttactgaagttaaactaccaaaacttgagtttctagatctc agtagaaatggtttgagtttcaagagttgctgttctcacactttttgggggacaactaga ctgaaacacttagatctgagctttaatgatgttattaccatgagctcaaacttcttgggc ttagagcaactaaaatatctggatttccagcattccaatttgaaacaggccagtgatttt tcggtattcctatcactcaaaaacctactttaccttgatatttcttatactcgcatccga atcatcttccatggcatctttgatggcttgttcagcctcgaagtcttgaaaatggctggc aattcttttcaggacaactccgttccaaatatcttcaaagcgctgactaacttaaccttc ctggacctctctaattgccagctagaacgagtgtcccaggcggcatttggctcactcgtt aaacttaagtcactaaatatgagtcacaaccaccttttgtccttggatctatttccttat aaacttccccactctctccaggatctggactgcagttttaatcgcatagtggcctccaat aggcaagaactacagcattttccaagtaatctaacttccttaaatctcactgggaatgac tttgcttgcatttgtgaacaccagagttttctgcagtgggtcaaggaccacaggcacctc ttggtgggagttacacaaatggtgtgtgtgcaacctttagatatgcagggtgtgcctgta ctcagttttagaaatgccacctgtcagatgagcaagactgtcattagtgtgtcggttctc actgtactcgtggtatctgtggtagcagttctggtttataagttctatttccacctgatg cttcttgctggctgcaaaaagtatggcagaggtgaaagcacctatgatgcctttgttatt tactcaagccaggatgaggactgggtgaggaatgagttggtaaagaacttggaggagggg gtgcccccctttcagctctgccttcactacagagactttattcctggtgtggccattgct gccaacatcatccaagaaggtttccacaagagccgaaaggttatcgtcgtggtgtcccag cacttcatccagagccgatggtgtatttttgagtatgagattgcccagacctggcagttt ctgagcagtcgtgcgggcatcattttcattgtcctacagaaggtggagaagtccctgctc cggcagcaggtggagctgtatcgccttctcagcaggaacacttacctggagtgggaggac agtgtcctcgggcggcacatcttctggagacgactcagaaaagccttgctagatggcaaa ctgtggagtccagaaggagcagcagatgcagaaagcagccagcatgaagcaacaatcact atctga

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