Pteropus vampyrus (large flying fox): 105300457
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Entry
105300457 CDS
T07815
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pvp
Pteropus vampyrus (large flying fox)
Pathway
pvp00310
Lysine degradation
pvp01100
Metabolic pathways
pvp05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pvp00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
105300457 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
105300457 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pvp03036
]
105300457 (DOT1L)
Enzymes [BR:
pvp01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
105300457 (DOT1L)
Chromosome and associated proteins [BR:
pvp03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
105300457 (DOT1L)
HMT complexes
Dot1-containing complex
105300457 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
105300457
NCBI-ProteinID:
XP_023393875
UniProt:
A0A6P6D3R8
LinkDB
All DBs
Position
Unknown
AA seq
1672 aa
AA seq
DB search
MDYFGSFRFWKDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCD
KYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVY
GETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAE
TMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKER
FANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHT
IDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVPESKVAVTADTPVDSGA
EEEKTGTATIKKPSPSKARKKKLNKKGRKLAGRKRGRPKKMSTANPERKPRKSPTALDLL
HAQTVSQAAASPQDAYKSPHSPFHQLPPSVQRHPPDQLLLAPTPPALQKLLESFRIQYLQ
FLAYTKTPQYKAGLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEEIKRLFQQKLDELGVK
ALTYDDLIQAQKEISAHNQQLREQTEQLETDNRALRGQSLQLLKARCEELRLDWPTLSLE
KLLKEKQALKSQISEKQRRCLELQISIVELEKSQRQQELLQLKSCVPPDEAVAMHLRGKG
GLGRELEVEPSRLHLELDCSKFSLPPFSSLSPELSVNGHAAGYELCGTLSRPPSKQNTPQ
DLASVLDQEVVPCTPSHGSRPRLDKLSGLASPDYTRLSPAKLVLRRHLSQDHAAGSKAAT
SELHPRAEHVKENGLPYHSPGLANGIKLSPQEPRPSSPVALQMTGEKGSEKGLKERGHAS
SGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVTVSFPTGFSYAGSVAITGAL
TGSPAPLAPGAEPPAFDESSSSGSLFAPMGSRSSTPQHPPLLAQPRNSGPASPAHQLCAS
PRLGATQGPLPDASKGDLPSEAGFSDPESEAKRRAVFTVSASAGSAKQSPSSKHSPLPAG
TQNHGQDSRKRGRRKRASAGTPGLSTGVSPKRRALPSVAGLFTQSSGSPLNLNSMVNNIN
QPLEITAISSPESSLKSSPIPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEP
GSARIERKIATISLESKSPPKTLENGGGLAARKPMPASEPVNSSKWKATFSPISDLGLAK
AADSPLQAGPALSQNSLFAFRPAPEEPGPADAKLAAHPRKSFPGAVPGAGGLSPSSNPSN
GFAFSGGLAADLSLHSFSDGASLPHKAPEAAGLGAPLSFPAPRGKEGGTEPSPFVNKRQL
DGLGGLKGEGGKGREAELGPPTCAPSDKASAHGKAGKGRDREPDFKNGHNLFISAAAVPP
GGLLSGPGLATAASSAGSTAPSAQTHRPFLGTFAPGPQFSLGPMSLQANLGPSVLQSLFS
SVPAAAGLVHVSSAATRLTNSHAMGSFSSGVAGGAVGGVSNHAVPSASAHPFGASFGSGA
ACHSSTLSLTPLQAVASTPASSFQAPPSMEPRPPPPPPPPPPGQPPAGPPTLHAPPPPNA
ALPPAPALHPANSEPVLLQNLAPLSANQAFLPVSSAASLPPANSALSIKLASLPHKVSRP
SFTVHHQPLPGLALAQAAPVLPQASSTGPSAVWVSLGMPPPYAARLAGVKPR
NT seq
5019 nt
NT seq
+upstream
nt +downstream
nt
atggactacttcggaagcttcagattttggaaggacaaacaccacgatgctgctcacgaa
atcatcgagaccatcagatgggtctgcgaggaaattccggacctcaagctcgccatggag
aactacgtcctcattgactacgacaccaaaagctttgaaagcatgcagaggctttgtgac
aagtacaaccgggccatcgacagcattcaccagctgtggaagggcaccacgcagcccatg
aagctgaacacgcggccgtccaacggactcctgcggcacatcctgcagcaggtgtacaac
cactcggtgacggaccccgagaagctcaacaactacgagcccttctccccggaggtgtac
ggggagacctcctttgacctggtcgcgcagatgatcgacgagatcaagatgaccgaggat
gacctgttcgtggacctgggcagtggagtgggccaggtcgtgctgcaggttgccgcggcc
accaactgcaaacatcactacggcgtcgagaaagctgatatcccagccaagtatgcggag
accatggaccgcgagttcaggaagtggatgaaatggtacggaaaaaagcatgcagaatac
acactggaaagaggcgacttcctctcggaggagtggagagagcggatcgccaacacgagt
gttatatttgtgaataactttgcctttggtcctgaggtggatcaccagctgaaggagcga
tttgcaaacatgaaggaaggtggcagaatcgtgtcctcgaagccctttgcacctctgaac
ttcagaataaacagtagaaacttgagtgacatcggcaccatcatgcgcgttgtggagctc
tctcctctgaagggctcggtgtcatggacggggaagccggtgtcctactacctgcatacc
atcgaccgcactatacttgaaaactatttttctagtctgaaaaatccaaaactcagggag
gaacaagaggcagctcggcgccggcagcaacgagaaaacaagagcaacacgaccacgccc
acgaaagtgcctgagagcaaggtggccgtgaccgcggacacccccgtggattctggtgct
gaggaagaaaaaacagggacggctaccatcaagaagccgtctccctccaaggcacggaaa
aagaagctgaacaagaaggggcggaagctggctggccggaagcgcgggcgccccaagaag
atgagcactgcgaaccccgagcgtaagcccaggaagagcccaactgcactggacctgctg
cacgcccagaccgtgtcccaggccgcggcctcgccgcaggatgcgtacaagtcacctcac
agcccatttcatcagctacctcccagcgtgcagcggcaccctcccgaccagctgctgttg
gcacccaccccccctgcactgcagaagctgctagagtccttcaggattcagtatctgcag
ttcctggcatacacgaagaccccccagtacaaggccggcctgcagcagctgctggaccag
gagaaggagaagaatgcccgcttgctgggtgccgcccagcagctgttcggccactgccag
gcccagaaggaagagatcaagaggctgttccagcagaagctggacgagctgggagtgaag
gctctgacctacgacgacctgatccaggctcagaaggagatctccgcccacaatcagcag
ctgcgggagcagacggagcagctggagacggacaaccgggcgctgaggggccagagcctg
cagctgctgaaggctcgctgtgaggagctgaggctggactggcccacactgtccctggag
aagctgctgaaggagaagcaggccctgaagagccagatctcggagaagcagaggcgctgc
ctggagctgcagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctg
cagctcaagtcctgcgtgccgcctgacgaggccgtggccatgcacctgcgtgggaagggt
ggcctgggccgagagctggaggtggagcccagtcggctgcacctggagctggactgctcc
aagttttcactacccccgttcagcagcctgagccccgagctctccgtgaacggccatgca
gccggctacgagctgtgcggcacactgagccggccaccatccaagcagaacacgccccag
gacctggcctccgtgctggaccaggaagtcgtgccctgcacccccagccacggcagccgg
ccccggctcgacaagctgtcgggcctggcctcacctgactacactcggctctcaccagcc
aagctcgtgctgaggcggcacctgagccaggaccacgccgccggcagcaaggcggccacc
agtgagctgcacccacgagctgagcacgtcaaggagaacggccttccataccacagtcca
ggcctggctaacggcatcaagctgagccctcaggagccacggccctcgtcccccgtggcc
ttgcagatgaccggagagaagggcagcgagaagggtctgaaggaacgcggccacgccagc
agcggggaggccatcaccagcctacccgtcagcatcccgctcagcactgtgcagcccagc
aagctgcccgtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaaggtg
actgtgtccttcccaacaggcttttcctacgccggctcagtggctatcactggggccctg
acaggcagcccggctccgctcgctcctggggccgagccccctgcctttgacgagtcctcc
agctcggggagcctcttcgcacccatgggctcccgcagctcgacgccgcaacacccccca
ctgctggcccagccccggaactccggcccagcctcgcctgcccaccagctctgtgccagc
ccccggctcggcgccacccagggcccgctccccgacgccagcaaaggggacctgccctcc
gaggccggcttctcggatccagagagcgaggctaaaaggagggctgtcttcaccgtgtcg
gccagcgccggcagcgccaagcagtcaccttccagcaagcacagccctttgcccgcaggc
acccagaaccacgggcaggacagccgcaagcggggcaggaggaagcgggcgtcagcgggc
acgcccggcctgagtacgggcgtgtcccccaagcgccgggccctgccgtccgttgccggc
ctcttcacgcagtcttcagggtcccccctcaacctcaactccatggtcaacaacattaac
cagcccttggaaatcacggccatctcgtcccccgagagctccctgaagagctcccccatc
ccttaccaggacaatgaccagccgcccgtgctcaagaaggagaagcccctgagccagacc
aacggggcccactactcccctctgacttcagacgaagagccaggctctgaggatgagccg
ggcagcgccagaattgagagaaaaattgcaactatctccttagaaagcaaatctcctcca
aaaaccttggaaaatggcggtggcctggcggcaaggaagcccatgcctgccagcgagccg
gtcaacagcagcaagtggaaggccaccttctcgcccatctccgaccttggcctggccaag
gccgccgacagcccgctgcaggctggccccgccctgagccagaactccctgttcgctttc
cggcccgccccagaggagcccggcccggccgacgccaagctggccgcccaccccaggaag
agcttccccggggccgtgccgggggccggtgggctgagccccagcagcaacccctccaac
ggcttcgccttcagcggaggcctggccgctgacctcagtttacacagtttcagtgatggt
gcttctctcccccacaaggcccccgaggcggccggcctgggcgcccccttgagcttccct
gccccacgaggcaaggagggtggcacggaacccagcccctttgtgaacaagaggcagctg
gacggactgggcggcctgaagggcgagggcggcaagggcagggaggcagagctgggcccc
cccacgtgtgcgccctcggacaaggcctcggcacacggcaaggcgggcaagggccgggac
cgcgagcccgacttcaagaacggccacaacctcttcatttccgccgccgccgtgcccccc
gggggcctcctcagcggcccgggcctcgccacggcggcgtcctcggcgggcagcacggcg
ccctccgcccagacgcaccggcccttcctgggcaccttcgcgcccggcccgcagttttcc
ctgggccccatgtccctgcaagccaacctgggcccatccgtgctgcagtccttgttcagc
tccgtgcccgccgccgccggcctggtgcacgtctcgtccgccgcgaccagactgaccaac
tcgcacgccatgggcagcttttcctccggggtggcaggcggcgcagttggaggtgtctct
aaccacgcggtgccctccgcctccgctcatccgtttggagccagtttcggcagcggggct
gcgtgtcacagcagcacgctgagcttaaccccgctgcaggcggtggccagcacccccgcc
tcttcctttcaggccccgccctccatggagccgaggccgcccccgcccccgcctcctcca
cccccgggccagccccctgcggggccacccaccctccacgcacccccacctcctaacgcc
gccttgcctcctgctcccgcgctacaccccgctaactctgagcctgtgctcctgcagaac
ctcgcgcctctctcggctaaccaagctttcttacctgtctcctctgccgcctctctgccg
cctgctaacagcgctctgtccatcaagctcgcctccctcccgcacaaggtctcccgcccc
tccttcacggtgcaccaccagcccctgcccgggctggccctggcccaggccgcgcccgtg
ctcccgcaggccagctccacggggccgtccgccgtgtgggtttcccttggcatgccgcct
ccttatgccgcgcgccttgcgggggttaagccgcgataa
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