Pteropus vampyrus (large flying fox): 105303335 Help Entry 105303335         CDS       T07815                                  Symbol TSC2 Name (RefSeq) LOW QUALITY PROTEIN: tuberin   KO K07207   tuberous sclerosis 2 Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp04072   Phospholipase D signaling pathway pvp04115   p53 signaling pathway pvp04140   Autophagy - animal pvp04150   mTOR signaling pathway pvp04151   PI3K-Akt signaling pathway pvp04152   AMPK signaling pathway pvp04211   Longevity regulating pathway pvp04218   Cellular senescence pvp04714   Thermogenesis pvp04910   Insulin signaling pathway pvp04919   Thyroid hormone signaling pathway pvp05163   Human cytomegalovirus infection pvp05165   Human papillomavirus infection pvp05168   Herpes simplex virus 1 infection pvp05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     105303335 (TSC2)    04151 PI3K-Akt signaling pathway     105303335 (TSC2)    04152 AMPK signaling pathway     105303335 (TSC2)    04150 mTOR signaling pathway     105303335 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     105303335 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     105303335 (TSC2)    04218 Cellular senescence     105303335 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     105303335 (TSC2)    04919 Thyroid hormone signaling pathway     105303335 (TSC2)   09149 Aging    04211 Longevity regulating pathway     105303335 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     105303335 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     105303335 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     105303335 (TSC2)    05163 Human cytomegalovirus infection     105303335 (TSC2)    05165 Human papillomavirus infection     105303335 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pvp01009]     105303335 (TSC2) Protein phosphatases and associated proteins [BR:pvp01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      105303335 (TSC2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP Cnd1 Motif Other DBs NCBI-GeneID:  105303335 NCBI-ProteinID:  XP_023377171 UniProt:  A0A6P6BPY9 LinkDB All DBs Position Unknown AA seq 1813 aa AA seqDB search MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFVITTEILRELSVECGLNNRIRV IGQICEIAKTKKFEEHAVEALWKAVADLLQPERPPEARHAVLALLKAIVQGQGDRLGILR ALFFKAIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAEFVLQWMDVGLSSEFLMVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDI LLNIIERLLQQLQSLESPELRAIVHDLLTTVEELCDQNEFHGSQEXYFELIESCADQRPE SSLLNLITYRAQSIHPAKDGWINNLQLLMERFFRSESRSAVRIKVLDVLSFVLLINRQFY EEELINMVVISQLSHIPEDRDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVIARSLS PPAELEERDVAAYSASLEDVKTAVLGLLVILQTKLYALPASHAMRVYEMLVSHIQLHYKH SYTLPIASSIRLQAFDFLLLLRADALHRLGLPTKDGVVRFSPYCLCDYMEPERGSEKKAS GPLSPPTGPPGPAPVGPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLNKLPESLRYK VLIFTSPCSVDQLSSALCSMLSGPKTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL DKARQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIMIKALPILVVKLTHISATASMA IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPFITKGLRSNVLRSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS PPVKEFKESSAADAFRCRSISVSEHVVRSRIQTSLTSSSLGSADENSMAQADDNLKNLHL ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLITVTTSVGTGTRSL LGLDSGELQGSPELSSDPSMRVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRIG ALDTPASYFPGGPTLPGPQTAVVSKPEKASAGTQRPAQKEKTNLAAYVPLLTQGWAEILV RRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKERRDTALYKSLSVPAAS SAKPPPPPRSNTVASFSSLYQSSCQGKLHRSISWADSAVVLEEGSPGETNLPVEPPELED FEATLGTDRRCQHAEAYSRSSSTSSQEEKSFHAEELPAGGIPIERAGPCKAARPSVDLSF QPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEAKARSQSGILDGEGAAWSAPGED SRGSAQPEGPLPSNCPRSPSGLRPRGYTISDSAPSRRGKRVERDSFKSRAGASNAEKVPG INPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSN SELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQ AVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPL DYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIY PSKWIARLRHIKRLRHRIREEAHYSNPSLPLMQMHPPGHAKAPVQAPAEPMPTYETGQRK RLISSVDDFTEFV NT seq 5442 nt NT seq  +upstreamnt  +downstreamnt atggccaagccaacaagcaaagattcaggcttgaaggagaagtttaagattcttttggga ctgggaactccaaggccaaatcccaggtctgcggagggcaaacagacggagtttgtcatc acaacggaaatcctgagagaactaagtgttgaatgcggcctcaacaatcgcatccgggtg atagggcagatttgtgaaatcgcaaaaacgaagaaattcgaagagcatgcagtggaagca ctctggaaggccgttgcagacctgctgcagccggagcggccaccagaggcccgacacgca gtcctggctctgctgaaggctattgtgcaggggcagggggaccgcttgggcattctcagg gccctattcttcaaggctattaaggattacccctccaacgaagacctccacgaaagactg gaagttttcaaggccctcacggacaatgggagacacattacctacttggaagaagaactg gctgagtttgtcctgcagtggatggatgttggcttgtcctcagaattccttatggtgctt gtgaacttggtcaaattcaacagctgttacctcgatgaatacatcgcatcaatggtccac atgatatgcctgctgtgtgtccagactgtgtcttctgtggacatagaggtctctctgcag gtgctggatgctgtggtctgttataactgcctgccagcggagagcctccccctgtttatt gtcaccctctgccgcaccatcaatgtcaaggagctctgtgagccttgctggaagctgatg cgtaacctcctgggcactcacctgggccatagtgctatctacaatatgtgccgcataatg gaggacagagcctacatggaagatgccccgctgctgagaggagctgtgttctttgttggc atggctctctggggagcccaccgactctattctctcaagaactccccgacatctgtgttg ccatcgttttatgaggccatgacctgtccgaatgaggtggtgtcctatgagatcgtcctc tccataaccagactcataaagaagtacaggagggagctccaagctgtgacatgggacatt ctgctaaacattattgaacgcttgcttcagcagctccagagcctggagagcccggagctc agggccatcgtccacgacctactgactacggtggaagagctttgtgatcagaatgaattc cacggctcgcaggagtgatactttgagctcattgagagttgtgcggaccagaggcctgag tcctccctcttaaacttaataacctacagagctcagtcaatccatccggcaaaagatggc tggattaacaacctgcagttgctgatggagagattcttcaggagtgaatctcgcagtgct gtgcgcatcaaggtgctggatgttctatcctttgtgctgctcatcaacagacagttctat gaggaggagctgatcaacatggtggtcatctcacagctctcccacatccctgaggacaga gaccatcaggtccggaagctggccacccagttgctggtggacctggctgaaggctgccac acccaccacttcaatagcctgctggacatcattgagaaagtgatcgcccgctccctctct ccacccgccgagctggaggaaagagatgtggcagcatactcagcctccttggaggatgtg aagactgccgtcctggggctcctggtcatccttcagaccaagctgtatgccttgcctgcc agccatgccatgcgtgtgtacgagatgctcgtcagccacatccagctccactacaagcac agctataccctacccattgccagtagcattcggctgcaggcctttgacttcctgctgttg ctgcgggctgatgcactacaccgccttggcctgcccacaaaggatggggttgtgcggttc agtccctactgcctctgtgactacatggagccagagagaggctctgagaagaaggccagt ggccctctgtcacctcccactggaccacctggcccagcacctgtaggccctgctgtgcga cttggctctttgccgtactccctcctctttcgcgtcctgctacaatgtttgaagcaggag accgactggaaggtgctgaagcttgtgctcaacaagctgccagagtcgctgcgctacaag gtcctcatttttacctctccatgcagcgtcgaccaactatcctccgccctctgctccatg ctttcaggtcccaagaccctcgagcggctcagaggcactccagaagggttctctagaacc gacctgcatctggctgtggttcccgtgctgacagctttgatctcttaccacaactacttg gacaaagccagacagcgggaaatggtgtactgcctggagcaaggcctcatctaccgctgt gccagccagtgcgtggtggccctggccatctgcagcgtggagatgcctgacatcatgatc aaggccctgcccatcttggttgtgaagctcacgcacatctcagccacggccagcatggct attccacttcttgagttcctgtcgactctggccaggttgcctcacctctacaggaacttt gcagcagagcagtacgcaagcgtgtttgccatctccctgccgtataccaacccctccaag ttcaatcagtatattgtgtgtctggcccatcacgtcatagctatgtggttcattaggtgc cgcctgcccttccggaaagactttgttccgtttatcactaagggcctgcgctccaacgtc ctccggtcttttgatgacacgccagagaaggacagcttcagagcacggagcaccagtctc aacgagaggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactct ccacccgtcaaagaattcaaggagagctctgcagccgatgccttccggtgccgcagcatc agtgtgtctgaacatgtggtccgcagtaggatccagacgtcccttacaagctccagcttg ggatctgcagatgagaactcgatggctcaggctgatgacaatttgaaaaatcttcaccta gagctcacagaaacatgtctggacatgatggccagatacgtgttctcaaacttcacggca gtccccaagaggtcccctgtaggagagttcctcctggccggtggcagaaccaaaacctgg ctggttgggaacaagcttatcaccgtgacgacaagcgtggggactggaacccggtcgctg ctgggtctggactcaggagagctacagggcagcccagaattgagctctgaccccagcatg cgtgtgagacagacaaaggaggcgccagccaagctagagtcccaggctgggcagcaggtg tgccgtggggcccgggaccgggtccgctccatgtctgggggccatggccttcgcattggt gccctggacactccagcctcctacttcccaggaggccccactttgccaggcccacagact gcagtggtcagcaagcctgagaaggcctcagctggcacccagcgcccagcgcagaaagag aagacgaacctggcggcctacgtacccctgctgacccagggctgggcggagatcttggtc cggaggcccacagggaacaccagctggctgatgagcctggagaacccgcttagccccttc tcctcggacatcaacaacatgccgctgcaggagctgtccaacgctctcatggctgccgag cgcttcaaggagcgccgtgacacagctctgtacaagtcgctgtcagtgccggcggccagc tcagccaagcctccgccacccccacgttctaacacagtggcctctttctcctccctgtac cagtccagttgccaaggaaagttgcacaggagcatttcctgggcagactctgcggtggtt ctggaggagggaagtccaggtgagactaatttgccagtggagcccccggagttggaggac ttcgaggcaacactaggcacagacagacgctgtcagcatgctgaagcttacagcaggtca tcttcaacctccagccaggaggagaagtcgttccacgcagaggagctgcctgctgggggg atccccattgagcgagctggcccctgcaaggcagcccggccctctgtggacctctccttc cagccctcgcagcccctgagcaagtccagctcctcaccagaactgcagaccctgcaggac attcttggggaccctggggacaaggctgatgttggtcggttgagccctgaggccaaggcc cggtcacagtcagggatcctagacggagaaggtgctgcttggtcagccccaggcgaagac agccggggctctgcccagcccgagggtcctttgccttccaactgtccccgctcccccagt ggcctgcggccccgaggctacactatttctgattcagccccgtcacgcaggggcaagagg gtggagagggattccttcaagagcagagctggggcctccaatgctgagaaagtaccaggc atcaaccccagcttcgtgttcctgcagctctatcattctcctttctttggtgacgagtcc aacaagccaatccttttgcccaatgagtccttcgaacggtcagtgcagctccttgaccag atcccgtcatacgacacgcacaagattgccgtcctgtacgtgggagaaggccagagcaac agtgagctcgccatcctatccaatgagcatggctcctacaggtatacggaattcctgaca ggcttgggcaagctcattgagcttaaggactgccagccagataaagtgtacctgggtggc ctggatgtgtgcggcgaggatggccagttcacctactgctggcacgatgacatcatgcaa gctgtctttcacattgctaccctgatgcccaccaaggacgtggacaagcaccgctgtgac aagaagcgccacctgggcaatgactttgtgtccattgtctacaatgattctggcgaggac ttcaaactgggtaccatcaaaggccagttcaactttgtccatgtgattatcacccccctg gactacgagtgcaacctggtgtcgctgcagtgcaggaaagacatggagggcctcgtggat accagtgtagccaagatcgtgtctgaccgcaacctgcccttcgtggcccgccagatggcc ctgcatgcaaatatggcctcgcaggtacaccacagccgctccaaccccactgacatctac ccctccaagtggattgccaggctccgccacatcaagcgactccgtcaccggatccgtgag gaagcccactactcaaatcccagcctgcccctgatgcagatgcaccccccaggccacgcc aaagccccagtgcaggccccagccgagcccatgcccacctatgagacaggccagcggaag cgtctcatctcctccgtggacgacttcacagagtttgtgtga

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