Pteropus vampyrus (large flying fox): 105303769
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Entry
105303769 CDS
T07815
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
pvp
Pteropus vampyrus (large flying fox)
Pathway
pvp00220
Arginine biosynthesis
pvp00330
Arginine and proline metabolism
pvp01100
Metabolic pathways
pvp04020
Calcium signaling pathway
pvp04022
cGMP-PKG signaling pathway
pvp04066
HIF-1 signaling pathway
pvp04071
Sphingolipid signaling pathway
pvp04151
PI3K-Akt signaling pathway
pvp04370
VEGF signaling pathway
pvp04371
Apelin signaling pathway
pvp04611
Platelet activation
pvp04915
Estrogen signaling pathway
pvp04921
Oxytocin signaling pathway
pvp04926
Relaxin signaling pathway
pvp04931
Insulin resistance
pvp04933
AGE-RAGE signaling pathway in diabetic complications
pvp05415
Diabetic cardiomyopathy
pvp05417
Lipid and atherosclerosis
pvp05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pvp00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
105303769 (NOS3)
00330 Arginine and proline metabolism
105303769 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
105303769 (NOS3)
04371 Apelin signaling pathway
105303769 (NOS3)
04066 HIF-1 signaling pathway
105303769 (NOS3)
04020 Calcium signaling pathway
105303769 (NOS3)
04071 Sphingolipid signaling pathway
105303769 (NOS3)
04022 cGMP-PKG signaling pathway
105303769 (NOS3)
04151 PI3K-Akt signaling pathway
105303769 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
105303769 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
105303769 (NOS3)
04921 Oxytocin signaling pathway
105303769 (NOS3)
04926 Relaxin signaling pathway
105303769 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
105303769 (NOS3)
05418 Fluid shear stress and atherosclerosis
105303769 (NOS3)
05415 Diabetic cardiomyopathy
105303769 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
105303769 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
105303769 (NOS3)
Enzymes [BR:
pvp01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
105303769 (NOS3)
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Ortholog
Paralog
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Motif
Pfam:
NO_synthase
FAD_binding_1
NAD_binding_1
Flavodoxin_1
Motif
Other DBs
NCBI-GeneID:
105303769
NCBI-ProteinID:
XP_011375875
UniProt:
A0A6P3REC9
LinkDB
All DBs
Position
Unknown
AA seq
1053 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPVSEPNWTPAPAPLPEPDHSPPPTRSP
EGPKFPRVKNWEVGSITYDTLSARAQQDGPCTPRRCLGSLVFPRKLQGRPSQGPPPPEQL
LSQARDFIDQYYSAIKRSGSQAHEQRLEEVEAEVAATGTYQLRESELVFGAKQAWRNAPR
CVGRIQWGKLQVFDARDCSSAQEMFTYICSHIKYATNRGNLRSAITVFPQRTPGRGDFRI
WNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDESPELF
TLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIG
SRNLCDPHRYNILEDVAVCMDLDTRTSSSLWKDKAAVEINLAVLHSYQLAKVTIVDHHAA
TSSFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGS
TAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFR
KAFDPRVLCMDEYDASCETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGL
TYVHRRKMFQATVLSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGICPPNRPGLV
EALLSRVEDLPPPGEAMAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPS
PRLLQLLSTLAEEPGEQQELETLSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAALLLT
QLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKAGAPVP
CFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPAPMTLVFGCRC
SQLDHLYRDEVQDAQQRGVFGRVLTAFSREPASPKTYVQDILRTELAAEVHRVLCLERGH
MFVCGDVTMATSVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVT
SRIRTQSFSLQERHLRGAVPWSFDPPGPDTPGP
NT seq
3162 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtgggccaggagccggggccaccctgcggcctggggctgggg
ctgggcctcgggctgtgcggcaagcagggcccagcctccccggtgtctgagcccaactgg
acgccagcacctgcacccctgcctgagccagaccacagccccccgcccacccggtccccg
gaggggcccaagttccctcgcgtgaagaactgggaagtggggagcatcacctacgacacc
ctgagtgcccgggcacagcaggacggaccctgcaccccacgacgctgcctgggctccctg
gtatttccacggaaactgcagggacggccatcccagggccccccaccccccgagcagctg
ctgagccaggccagggacttcatcgaccagtactacagcgccatcaagcggagcggctcc
caggcccacgagcagcggcttgaggaggtggaagccgaggtggcagccacaggcacctac
cagcttcgggaaagcgagctagtgttcggggccaagcaggcctggcgcaacgctccccgc
tgcgtgggccggatccagtgggggaagctgcaggtgtttgacgcccgtgattgcagctct
gctcaggagatgttcacctacatctgtagccacatcaagtatgccaccaacaggggcaac
ctccgctccgcaatcacagtgttcccccaacgcaccccgggccgcggggacttccgcatc
tggaacagccagctggtgcgctacgcgggctaccgacagcaggacggctcggtgcgcggg
gacccagccaacgtggaaatcaccgagctctgcatccagcacggctggaccccgggaaac
ggccgcttcgacgtgctgcccctgctgctccaggccccagacgagtccccagaactcttc
actctaccccccgagctagtcctcgaggtgcccctggagcaccccacgctggagtggttc
gcggccctgggcctgcgctggtacgccctccccgccgtgtccaacatgctgctggagatc
gggggcctggagttccctgcggcgcccttcagcggctggtacatgagcacggagatcggc
tcgcggaacctgtgtgacccgcaccgctacaacatcctggaggatgtggccgtctgcatg
gacctggacacccggacgtcctcgtccctgtggaaagacaaggcggccgtggaaatcaac
ttggcggtgctgcacagttaccagctggccaaagtgaccattgtggaccaccatgccgcc
acctcctccttcatgaagcacctggagaatgagcagaaggcgagggggggctgccctgcc
gattgggcctggatcgtgccccccatctcgggcagcctcacccctgtgttccatcaggag
atggtcaactatttcctgtcccctgccttccgctaccagccagatccgtggaaggggagc
acagccaagggtgccggcatcaccaggaaaaagacctttaaggaagtggccaatgctgtg
aagatctctgcctcactcatgggcaccgtgatggccaagcgtgtgaaggccacaatcctg
tatggctctgagaccggccgggcccagagctacgcacagcagctggggaggctcttccgg
aaggctttcgacccccgggtcctgtgcatggatgagtatgacgcctcctgtgagaccttc
tgcgtgggagaggatgccaaggccgccgcccgggacatattcagccccaaacggagctgg
aagcgccagaggtaccggctgagtgcccaggctgagggcctccagctgctgccaggcctg
acctacgtgcacagacgaaagatgttccaggccacagtcctctcagtggaaaacctgcag
agcagcaagtccactcgggccacgatcctcgtgcgcctggacaccggaggccaggagggg
ctccagtaccagccaggggaccacataggcatctgcccgcccaaccggcccggcctcgtg
gaggcgctgctgagccgtgtggaggacctgccgccgccgggcgaggccatggccgtggag
cagctggagaagggcagccccggtggccctcccccgggctgggtgcgggacccccggctg
cccccgtgcaccctgcgccaggctctcaccttcttcctggacatcacttccccgcccagc
ccccgactccttcaactgctcagcaccctggctgaagagcccggcgaacagcaggagctg
gagaccctcagccaggacccccggcgctacgaggagtggaagtggttccgctgccccacg
ctgctggaggtgctggagcagtttccgtccgtggctctgcccgccgcgctgctcctcacc
cagctgcccctgctccagccccggtactactccgtcagctcggcgcccagcgcccacccc
ggagagatccacctcacggtggccgtgctggcatacaggacccaggatgggctgggcccc
ctgcactacggcgtctgctccacgtggctgagccagctcaaggccggagcccctgtcccc
tgcttcatcaggggggctccctccttccggctgccaccggaccccagcttgccctgcatc
ctggtgggcccaggcactggcatcgcccccttccggggcttctggcaggagcggctacat
gacattgagagcaaagggctgcagcccgcccctatgaccttggtgttcggctgccgatgc
tcccagctcgaccacctctaccgcgacgaggtgcaggatgcccagcagcgcggagtgttc
ggccgtgtcctcactgccttctcccgggaacccgccagccctaagacctacgtacaggac
atcctgcggacagagctggctgctgaggtgcaccgcgtgctgtgcctcgaacgaggccac
atgtttgtctgcggcgatgtcaccatggcaaccagcgtcctgcagacagtgcagcgcata
ctggcgacagagggcgacatggagctggatgaggccggagacgtcatcggcgtgctgcgg
gatcagcaacgctatcacgaggacattttcgggctcacgctacgcacccaggaggtgaca
agccgcattcgcacccagagcttttccttgcaggagcggcatctgcgcggcgcagtgccc
tggtccttcgacccgcccggcccagacacccccggcccctga
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