Pteropus vampyrus (large flying fox): 105307548 Help Entry 105307548         CDS       T07815                                  Symbol TOP2A Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:pvp00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     105307548 (TOP2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:pvp03032]     105307548 (TOP2A)    03036 Chromosome and associated proteins [BR:pvp03036]     105307548 (TOP2A) Enzymes [BR:pvp01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      105307548 (TOP2A) DNA replication proteins [BR:pvp03032]  Eukaryotic type   DNA Topoisomerases    105307548 (TOP2A) Chromosome and associated proteins [BR:pvp03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     105307548 (TOP2A)   Centrosome formation proteins    Centriole proteins     105307548 (TOP2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim Microp_apicomplexa_20 Motif Other DBs NCBI-GeneID:  105307548 NCBI-ProteinID:  XP_011381397 UniProt:  A0A6P3RJN1 LinkDB All DBs Position Unknown AA seq 1449 aa AA seqDB search MEVSPLQPVNENMQINKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ MWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPWMDNMGRAG EMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL PVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKG GRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMT LQVKNFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLD DANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKILNVREASHKQIM ENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWP SLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSK EAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTHFMEDRRQRKLLGLPE DYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREV KVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSAS PRYIFTMLSPLARLLFPPQDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSC KIPNFDIREVVNNIRLLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIE ISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAER VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTALDILRDFFELRLKYYGLRKEWLLGMLG AESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEE NEESDNEKETEKSDSVTGPTFNYLLDMPLWYLTKEKKDELCKLRKEKEQELETLKKKSPS DLWKEDLAAFIEELETVEAKEKQDEQVGLPGKGGKGKGKKTQMAEVLPSPSGKRVIPRVT IEMKAEAEKKIKRKIKNENSEGTPQENGMEPESLKQRLEKKLKKEPGTKTKKQTTLPFKP VKKGKKRNPWSDSESDASSNESDFDVPPREIEPRRAATKTKFTMDLDSDEDFSDFDQETQ DEDFVPSDASPVKTRTSPKRTNKELKPQKSTTSVTDFDADDAKDDVPLSPSSPAADFPAE TEIVNPVSKKNVTVKKTAAKSQASTSTTDAKKRAAPKRTKKDPGVNSDAPQKPDPPKSKT RRKRKPSTSDDSDSNFEKMISKAVTSKKSKGESDDFHLDLDSAVAPRVKSGRAKKPIKYL EESDEDDLF NT seq 4350 nt NT seq  +upstreamnt  +downstreamnt atggaggtgtcaccactgcagcctgtaaatgaaaatatgcaaatcaacaaaacaaagaaa aatgaagatgctaagaaaagactgtctattgaaagaatctatcaaaagaaaacacagttg gaacatattttgctccgtccagacacctacattggctctgtggaattagtgacccagcaa atgtgggtttacgatgaagatattggcattaactatagggaagtcactttcgttcctggt ttatacaaaatctttgatgagattctagtcaatgctgcagacaacaaacaaagagaccca aaaatgtcttgtattagagtcacaattgacccgtggatggataacatggggagagctggt gagatggaactcaagccctttaatggagaagattatacatgtattaccttccagcctgat ttgtctaagtttaaaatgcagagccttgacaaagatattgttgcactgatggttagaaga gcatatgatattgctggatccactaaagatgtcaaagtctttctcaatggaaataagttg ccagtgaaaggattccgtagctatgtggatatgtatttgaaggataaagtagatgaaact ggcaatccattgaaaatcatccacgaacaagtaaaccacaggtgggaagtgtgtttaaca atgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgctacttccaagggt ggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgttgtgaag aagaagaacaagggcggtgttgcagtaaaagcacatcaggtgaaaaatcacatgtggatt tttgtgaatgccttaatcgaaaacccaacctttgactctcagacaaaagaaaacatgact ttacaagtcaagaactttggatcaacatgccaactaagtgaaaaattcatcaaagctgca attggctgtggtattgtagaaagcatactaaactgggtgaagtttaaggctcaaatccag ttaaacaagaagtgttccgctgtgaaacataacagaatcaagggtattcccaaacttgat gatgccaatgatgcagggggccgaaactccactgagtgtacacttatcctgaccgaggga gactcagctaaaactttggctgtttcaggccttggtgtggttgggagagatagatatggg gttttccctcttagaggaaaaatactcaatgttcgagaagcttctcataaacagataatg gaaaatgccgaaattaacaatatcatcaagattgtgggtcttcaatacaagaaaaactat gaagatgaagattcattgaagactcttcgttatgggaagataatgattatgacagatcag gaccaagacggttcccatatcaaaggcttgctgattaattttatccatcacaactggccc tctcttctgcgacatcgttttctggaggaatttatcactcccattgtaaaggtatctaaa aacaagcaagaaatggcattctatagtctgcctgaatttgaagaatggaagagttctaca ccaaatcataaaaaatggaaagtcaagtattacaaaggtttgggcaccagcacatcaaaa gaagctaaagaatactttgcagatatgaaaagacatcgtatccagttcaaatattctggt cctgaagatgatgctgcaatcagcctggcctttagcaaaaaacagatagacgatcgaaag gaatggttaactcatttcatggaggataggagacaacgaaagttacttggccttcctgag gattacttgtatgggcaaacaaccacatatctgacctacaatgacttcataaacaaggaa ctaatcctgttctcaaattctgataacgagagatctatcccgtctatggtggatggtttg aaaccaggtcagagaaaggttttgtttacgtgtttcaaacggaatgacaagcgagaggtg aaggtagcccagttagctgggtcagtggctgagatgtcctcttatcatcatggtgagatg tcgctaatgatgaccattatcaatttggctcagaattttgtgggtagcaataatctgaac ctcttgcagcccattggtcagtttggtaccaggctgcatggtggcaaggattctgctagt cctcgatacatcttcacaatgctcagccctttggctcggttgttatttccaccacaagat gatcacacattaaagttcttatatgatgacaaccagcgtgtggagcctgagtggtacatt cctattatacccatggtgctgataaatggtgctgaaggaatcggtactgggtggtcctgc aaaattcccaactttgatattcgtgaagttgtgaataatatcaggcttttgatggatgga gaagaacctttgccaatgcttcccagttacaagaacttcaagggtactattgaagagctg gctccaaatcagtatgtgattagtggtgaagtggctattcttaattccacaaccattgaa atctcagagcttcccatcagaacatggacccagacatataaagaacaggttctggaaccc atgttgaacggcacagagaagacacctcctcttataacagattatagggaataccataca gataccactgtgaagtttgttgtgaaaatgactgaagaaaaactggcagaggccgagaga gtgggactacacaaagtcttcaaactccaaactagtctcacatgcaactctatggtgctt tttgaccacgtaggctgtttaaagaaatatgacacagcgttggatattctaagagacttc tttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatgcttggc gctgaatctgctaaactgaacaatcaggctcgcttcatcttagagaaaatagatggcaaa ataatcattgaaaataagcctaagaaagaattgattaaagttttgattcagagaggatat gattcggatcctgtgaaagcttggaaagaagcccagcaaaaggttccagatgaagaagaa aacgaagagagcgataatgaaaaggaaactgaaaagagtgactctgtaactggaccaacc ttcaactaccttcttgatatgcctctttggtatcttaccaaggaaaagaaagatgaacta tgcaaattaagaaaggaaaaagaacaagagctagaaacattaaagaaaaagagtccatca gatttgtggaaagaagacttggctgcttttattgaagagctggagactgttgaagccaag gaaaaacaagatgaacaagtaggacttcctgggaaaggggggaaaggaaaagggaaaaaa acacaaatggctgaagttttgccttcaccaagtggaaaaagagtcattccccgagttacc atagagatgaaagcagaagcagaaaagaaaattaaaaggaaaattaagaatgaaaattct gaaggaactcctcaagagaatggtatggaaccagaaagcctaaaacaaagattagagaag aaactgaaaaaagaaccaggtaccaagacgaagaaacaaactacattgccatttaaaccg gtcaaaaaaggaaagaagagaaacccctggtctgattcagaatcagatgcgagcagtaac gaaagtgattttgatgtccctccacgagaaatagagccacggagagcagcaacaaaaacc aaattcacaatggatttagattcagatgaagatttctcagattttgatcaagaaactcaa gatgaagattttgtgccatctgatgctagtccagttaagaccagaacttccccgaaacgt actaacaaagaactgaagccacagaagagcaccacgtcagtaacggactttgatgctgat gatgccaaggatgatgttccactttctccaagttctcctgctgctgatttcccagccgaa acagaaattgtaaaccctgtttctaaaaagaacgtgacggtgaagaagacggcagcaaaa agtcaggcttccacctcgactacagatgccaaaaaaagggctgcaccaaaaagaaccaaa aaggatccaggcgtgaattctgatgcccctcaaaagcctgatcccccaaaatccaagact cgccgcaaaagaaagccatccacttctgatgattccgactctaattttgagaaaatgatt tctaaagcagtcacaagcaagaaatccaagggggagagtgatgacttccacctggactta gactcagctgtggctcctcgtgtaaaatctgggcgggcaaagaagccgataaagtacctt gaagaatcagatgaagatgatctgttttaa

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