Pteropus vampyrus (large flying fox): 105309535 Help Entry 105309535         CDS       T07815                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp01521   EGFR tyrosine kinase inhibitor resistance pvp01522   Endocrine resistance pvp04010   MAPK signaling pathway pvp04012   ErbB signaling pathway pvp04014   Ras signaling pathway pvp04062   Chemokine signaling pathway pvp04068   FoxO signaling pathway pvp04072   Phospholipase D signaling pathway pvp04150   mTOR signaling pathway pvp04151   PI3K-Akt signaling pathway pvp04510   Focal adhesion pvp04540   Gap junction pvp04630   JAK-STAT signaling pathway pvp04650   Natural killer cell mediated cytotoxicity pvp04660   T cell receptor signaling pathway pvp04662   B cell receptor signaling pathway pvp04664   Fc epsilon RI signaling pathway pvp04714   Thermogenesis pvp04722   Neurotrophin signaling pathway pvp04810   Regulation of actin cytoskeleton pvp04910   Insulin signaling pathway pvp04912   GnRH signaling pathway pvp04915   Estrogen signaling pathway pvp04917   Prolactin signaling pathway pvp04926   Relaxin signaling pathway pvp04935   Growth hormone synthesis, secretion and action pvp05034   Alcoholism pvp05160   Hepatitis C pvp05161   Hepatitis B pvp05163   Human cytomegalovirus infection pvp05165   Human papillomavirus infection pvp05200   Pathways in cancer pvp05205   Proteoglycans in cancer pvp05206   MicroRNAs in cancer pvp05207   Chemical carcinogenesis - receptor activation pvp05208   Chemical carcinogenesis - reactive oxygen species pvp05210   Colorectal cancer pvp05211   Renal cell carcinoma pvp05213   Endometrial cancer pvp05214   Glioma pvp05215   Prostate cancer pvp05220   Chronic myeloid leukemia pvp05221   Acute myeloid leukemia pvp05223   Non-small cell lung cancer pvp05224   Breast cancer pvp05225   Hepatocellular carcinoma pvp05226   Gastric cancer pvp05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     105309535 (SOS2)    04012 ErbB signaling pathway     105309535 (SOS2)    04014 Ras signaling pathway     105309535 (SOS2)    04630 JAK-STAT signaling pathway     105309535 (SOS2)    04068 FoxO signaling pathway     105309535 (SOS2)    04072 Phospholipase D signaling pathway     105309535 (SOS2)    04151 PI3K-Akt signaling pathway     105309535 (SOS2)    04150 mTOR signaling pathway     105309535 (SOS2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     105309535 (SOS2)    04540 Gap junction     105309535 (SOS2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     105309535 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     105309535 (SOS2)    04660 T cell receptor signaling pathway     105309535 (SOS2)    04662 B cell receptor signaling pathway     105309535 (SOS2)    04664 Fc epsilon RI signaling pathway     105309535 (SOS2)    04062 Chemokine signaling pathway     105309535 (SOS2)   09152 Endocrine system    04910 Insulin signaling pathway     105309535 (SOS2)    04912 GnRH signaling pathway     105309535 (SOS2)    04915 Estrogen signaling pathway     105309535 (SOS2)    04917 Prolactin signaling pathway     105309535 (SOS2)    04926 Relaxin signaling pathway     105309535 (SOS2)    04935 Growth hormone synthesis, secretion and action     105309535 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     105309535 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     105309535 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105309535 (SOS2)    05206 MicroRNAs in cancer     105309535 (SOS2)    05205 Proteoglycans in cancer     105309535 (SOS2)    05207 Chemical carcinogenesis - receptor activation     105309535 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     105309535 (SOS2)    05231 Choline metabolism in cancer     105309535 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     105309535 (SOS2)    05225 Hepatocellular carcinoma     105309535 (SOS2)    05226 Gastric cancer     105309535 (SOS2)    05214 Glioma     105309535 (SOS2)    05221 Acute myeloid leukemia     105309535 (SOS2)    05220 Chronic myeloid leukemia     105309535 (SOS2)    05211 Renal cell carcinoma     105309535 (SOS2)    05215 Prostate cancer     105309535 (SOS2)    05213 Endometrial cancer     105309535 (SOS2)    05224 Breast cancer     105309535 (SOS2)    05223 Non-small cell lung cancer     105309535 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     105309535 (SOS2)    05160 Hepatitis C     105309535 (SOS2)    05163 Human cytomegalovirus infection     105309535 (SOS2)    05165 Human papillomavirus infection     105309535 (SOS2)   09165 Substance dependence    05034 Alcoholism     105309535 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105309535 (SOS2)    01522 Endocrine resistance     105309535 (SOS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH IQ_SEC7_PH PH_19 RHG20_PH PH_10 PH_13 Motif Other DBs NCBI-GeneID:  105309535 NCBI-ProteinID:  XP_011384025 UniProt:  A0A6P3RN08 LinkDB All DBs Position Unknown AA seq 1332 aa AA seqDB search MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPSLSANEESLYYIEELIFQLLNKLC MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD IGLVSLCEDEPTSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFKPSDI EKIFSNISDIHELTIKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI LSPKFSEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKM NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG YSSAEYRLKEKFVMRKIQICDKEDTCEYKHAFELVSKDENSIIFAAKSAEEKNNWMAALI SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA VEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILD EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPAPTGAFDGPL HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHKDPDWFRDVSTCPNSPN TPPSTPSPRVPRRCYVLNSSQNNLAHPQAPPVPPRQTSSPHLPKLPPKTYKRELSHPPLY RLPLLENAETPQ NT seq 3999 nt NT seq  +upstreamnt  +downstreamnt atgcagcaggcgccgcagccgtacgagttcttcagcgaagagaacagtccgaaatggcgg ggactgttagtctcggccctgcggaaggttcaggagcaagtacatcccagtctctcagct aatgaagaatctctgtattatattgaagagctaatttttcagctgcttaataaattatgc atggcccaaccaaggactgttcaagatgtggaggaacgagttcaaaaaacctttcctcat ccaattgataaatgggctattgctgatgcacagtctgccatagagaaacgaaaacgaaga aatcctctcttgctgcctgtggacaaaatccatccttcactgaaggaagttttagggtac aaagtggactaccatgtgtctttatatattgtggctgtactagagtatatctcagctgat attttgaaattggctggtaattatgtttttaatattcgacattatgaaatatctcagcag gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac ataggtttggtttctctttgtgaagatgaacctacttcttcaggtgaattaaactactat gatcttgtcagaactgaaattgcagaagaaagacagtatttacgggaactaaatatgatc ataaaagtttttcgagaagcctttctttctgacaaaaagctgtttaaaccttctgacatt gaaaagattttcagtaatatttcagatatacatgagttgactataaaacttttaggtttg attgaagacacagttgaaatgactgatgaaagcagtcctcatcctttagctggcagctgt tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggacatt ctttcacctaaattcagtgaacatttcagtaagttgatggccagacctgcagtggctctt cactttcagtccattgctgatggttttaaagaagcagttcgttatgtccttccacgcctt atgctggtgccagtgtatcactgttggcactattttgaattattgaagcaattgaaagca tgtagtgaagaacaagaagacagagaatgtttgaaccaagctattactgctctcatgaat ctccaaggtagtatggaccgaatttataagcagtattcaccccgacgccgacctggggat cctgtttgccctttttataatcgccaattaagaagcaagcatctggctattaaaaaaatg aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat gaatttattatggaaggtccattgacaagaattggtgctaaacatgaacggcatattttt ctctttgatggcttaatgattagctgcaaacccaatcatagccagtcacgccttccaggt tacagtagtgcagaatacagattaaaagaaaaatttgtcatgagaaaaatacaaatatgt gataaagaagatacttgtgagtacaaacatgcttttgagttagtatccaaagatgaaaac agtataatatttgcagctaagtccgctgaagagaaaaacaattggatggcagcacttatt tctcttcattatcgtagtactctagatcgaatgctagattcagtattattgaaagaagaa aatgaacaaccattgagattaccaagtcctgaagtatatcgttttgtggtaaaagactct gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaatccccattattaaa ggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat tttgttcgtacttttcttactacatatcgttcattttgtaaaccacaggaattgctaagc ttactaattgaacgatttgaaattccagagccagaacctactgaagccgataaattggca gtagagaaaggcgagcagccaattagtgcagaccttaaaaggtttcgcaaggaatacgtc caaccagtacaacttagaatcttaaatgtttttcggcactgggttgaacaccatttttat gactttgaaagagatttggagttgcttgaaagactagaatccttcatttcaagtgtaaga gggaaagccatgaagaaatgggtagaatcaattgctaagatcatcaagaggaagaaacaa gctcaggcaaatggaataagccacaatattacctttgaaagtccacctccaccaattgaa tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacacttcatccaata gaaattgcacgtcaactgacacttttggaatctgatctttacaggaaagtacaaccttct gaacttgtaggaagtgtatggaccaaagaagataaagaaataaattctccaaatttatta aaaatgattcgccacactacaaatcttacgctctggtttgaaaagtgcattgtggaagca gaaaattttgaggaacgagtggcagtactgagtagaattatagaaattctgcaagttttt caagatttgaataatttcaatggtgtattggagatagtcagtgcagtaaattcagtgtca gtatacagactagaccatacctttgaggcattgcaggaaagaaaaaggagaattttggat gaagctgtggaattgagtcaagaccactttaaaaaatacctagtaaaacttaagtcaatc aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaa gggaataatgattttttaaaaaagaaagggaaagacttaatcaatttcagtaagaggagg aaagtggctgaaattactggagaaattcagcagtatcagaatcaaccttattgtttacgg atagaaccagaaatgaggcgattctttgaaaatcttaaccccatgggaagtgcttctgaa aaagagtttacagattatttgttcaacaagtcactagaaattgaaccccgaaactgcaaa cagccacctcgatttcctaggaaatcaactttctctttgaaatctcctggaataaggcct aatacaggccgacatggctctacctcaggcactttacgaggtcatccaacaccattggaa agagaaccatgtaaaataagctttagtcggattgctgaaactgagcttgagtcaacagtg tcagcaccaacctctccaaacacaccatctactccgccagtatctgcttcttcagacctc agtgtgtttttagatgtggatctcaatagttcctgtggcagcaatagcatctttgctcca gttctcttgccacattcaaagtctttcttcagttcgtgtggtagtttacataaacttagt gaagagccactgattcctcctcctcttcctcctcgaaaaaagtttgatcatgatgcttca aattccaagggaaatatgaaatctgatgatgacccccctgctattccaccgagacaacct cctcctccaaaggtaaaacccagagttcctgctcctactggtgcatttgatgggcctctg catagtccacctccaccgccaccgagagatcctcttcctgatacccctccaccggttccc cttcggcctccagaacactttataaactgtccatttaatcttcagccacctccgctggga catcttcacaaagatccagactggttcagagatgttagtacgtgtcctaattcgccaaac actcctcctagcacaccctctccaagggtgccacgtcgatgctatgtgctcaattctagt cagaataatcttgctcatcctcaagctccccctgttccaccacggcagacttcaagccct cacctcccaaaactgccaccaaagacttacaaacgggagctttcacatcccccattgtac agactgcctttgctagaaaatgcagaaactcctcaatga

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