KEGG   Pleurodeles waltl (Iberian ribbed newt): 138295690
Entry
138295690         CDS       T10800                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pwl  Pleurodeles waltl (Iberian ribbed newt)
Pathway
pwl00562  Inositol phosphate metabolism
pwl01100  Metabolic pathways
pwl04020  Calcium signaling pathway
pwl04070  Phosphatidylinositol signaling system
pwl04081  Hormone signaling
pwl04082  Neuroactive ligand signaling
pwl04261  Adrenergic signaling in cardiomyocytes
pwl04270  Vascular smooth muscle contraction
pwl04310  Wnt signaling pathway
pwl04371  Apelin signaling pathway
pwl04540  Gap junction
pwl04621  NOD-like receptor signaling pathway
pwl04912  GnRH signaling pathway
pwl04916  Melanogenesis
Module
pwl_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pwl00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    138295690 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    138295690 (PLCB4)
   04371 Apelin signaling pathway
    138295690 (PLCB4)
   04020 Calcium signaling pathway
    138295690 (PLCB4)
   04070 Phosphatidylinositol signaling system
    138295690 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    138295690 (PLCB4)
   04081 Hormone signaling
    138295690 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    138295690 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    138295690 (PLCB4)
  09152 Endocrine system
   04912 GnRH signaling pathway
    138295690 (PLCB4)
   04916 Melanogenesis
    138295690 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    138295690 (PLCB4)
   04270 Vascular smooth muscle contraction
    138295690 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pwl04131]
    138295690 (PLCB4)
Enzymes [BR:pwl01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     138295690 (PLCB4)
Membrane trafficking [BR:pwl04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    138295690 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    138295690 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like PLC-beta_C C2 EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 138295690
NCBI-ProteinID: XP_069090241
LinkDB
Position
5:complement(384467872..385453839)
AA seq 1205 aa
MAKPYEFNWQKVVPAFMQDGAVFDRYEEESFAFEPNCLFRVDEFGFFLTWKSEGKEGQVL
ECSLINSIRFPAVPKDPKILSALEAAGKAEQELEGRIVCVCSGTDLVNISFNYMVAESAE
VAKQWGEGLMSVIHNFRANNVSPMTCLKKHWMKLAFLTNINGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPPAFTFEKFYELTQKICPRTDIEELFRKVNGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAIQIIENYEPDDNLKQKGLMSSDGFCRYLMSDE
NAPVFLDRLELYQEMEHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAVCTDILFKDVIQAIKETAFVTSQYPVILSFENHCSKYQQYKM
SKYCEDIFGDLLLKQPLEGYPLEPGRPLPSPNDLKKKILIKNKRLKPEVEKKQLDALKCM
MEAGETVAPVNILEDDIEEEIENADQEEEAHPEFKFGAELSTDDLSQKEAAANSVKKIAE
DSEQENKKGLETVEDEQAWMASYQYVGATTNIHPYLSTLINYAQPVKFQGFSVAEERNIH
YNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSL
NFQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVIS
GQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAV
VRIAVYDDNSKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFG
DIVDALSDPKKFLSVMEKRADQMRAMGIETSEIADVPSDNTKNDKKSKSNNAKQNVTPQT
SSEARPSAPTGLGTSMDTKKAVEPIPHVNIEDLKQMKAYLKQLKKHQKELNSLKKKHAKE
HSIMQKLHCTQVDKIVAQFNKEKLSQEKTLEKSIKRKGVNNSSEMKKETEQKVQTLTSNH
KSKVKDIVAQQTKEWSEMVNTHTAEEQELRDSHLSQQCELLKKMLIGVHEQQTQQLKISQ
EREGKEMRANQAKISMENSKAISQDKSIKNKAERERRVRELNSTNTKKFLDERKRLAAKQ
AKEMEQLKKAQLEHLEILEKQNEQLLKSSHAVSHSQGKGDAADGEAGSRDGSQACNSGVK
LQHAN
NT seq 3618 nt   +upstreamnt  +downstreamnt
atggcaaaaccatatgaattcaattggcagaaggttgttccagcctttatgcaagatggg
gctgtatttgatagatatgaagaggagtcctttgcctttgaacctaactgcctttttagg
gtggacgagtttgggttcttcctgacatggaaaagtgaaggaaaggaagggcaggtctta
gaatgctccctgatcaacagcatacggtttccagctgtaccgaaggatccaaaaattctc
tctgccctggaggctgctgggaaagctgagcaggagttggagggccgcatagtgtgcgtc
tgcagtggcacagacctggtgaacatcagcttcaactacatggtagcagagtctgcggag
gtcgccaagcaatggggagaaggtctgatgtctgtcattcataactttcgggcaaataat
gtcagccccatgacatgcctcaagaaacactggatgaagttggcatttttaacaaacata
aatggaaaaatcccagttcgaagcataacaagaacctttgcatcaggcaaaacggaaaaa
gttatctttcaagcacttaaagaattaggtcttccgagcggaaagaatgatgaaatagaa
cctccagcatttacttttgaaaaattttatgagctcacgcaaaagatttgtccacgaact
gacatcgaagagctctttcggaaggtcaatggagacaaaactgattatttaacggtagac
cagttagtcagctttctgaatgaacatcaacgagatcctcgtctgaatgaaatattattt
cctttctacgatacgaaaagggcgatacaaataattgagaattatgaacctgatgataac
ctgaagcaaaaaggtcttatgtcgagtgatgggttttgtagatatttgatgtcagatgaa
aatgcccctgtcttccttgaccgattggaactttatcaggaaatggagcaccctttggca
cactacttcatcagctcctcccacaacacgtatcttacaggcaggcagtttggcggaaaa
tcttctgtggagatgtatcgtcaggttcttctagcaggatgcaggtgtgttgagctcgat
tgttgggatggaaaaggtgaagaccaagaacctataataactcacggaaaagcggtgtgc
acagatattttatttaaagatgttattcaagccattaaagaaacagcatttgttacctct
cagtatccagtcattttatcattcgagaaccactgcagcaaatatcaacagtataagatg
tcaaagtattgtgaagacatatttggagatcttctgctgaagcagcctctggaaggatac
ccacttgagccaggccggccattaccctcccccaatgatctcaagaagaaaatactcatc
aaaaataaacggttgaagcctgaagtagaaaagaagcagcttgatgccctgaagtgtatg
atggaggccggagaaactgttgcaccagtaaatatcttggaggatgacatagaagaggaa
atagaaaatgctgaccaagaggaagaggcacacccagaatttaagtttggagcagaactt
tcaacagatgatctaagtcaaaaggaagctgctgcaaacagtgttaaaaagattgctgaa
gacagcgaacaagaaaataaaaagggtttggaaactgtagaagatgagcaagcatggatg
gcttcgtaccaatatgtcggagctacaacaaacatccatccctatttatcaacattgatc
aactacgctcaacccgtcaagtttcaaggtttcagtgtggctgaagagcgcaacattcat
tacaacatgtcctcattcaatgagtccgtgggattgggctatctgaagacgcacgcgatt
gagtttgtgaactataacaaacgccaaatgagccggatataccccaagggaggcagagtg
gattccagtaattacatgcctcagattttctggaacgctggctgccagatggtctcactg
aactttcagaccccagatttagcaatgcagttaaatcaaggaaagtttgagtataatggc
tcatgtgggtacctccttaaaccagactttatgcgacgaccggacagaacatttgaccct
ttctctgaaacacccgttgatggtgtcattgcagctacttgttctgtacaggtgatatct
ggacagtttttgtcagacaaaaaaattggcacatatgttgaagtagacatgtacggctta
ccaacggacacaatacggaaagaattccggacacgtatggtgatgaacaatggtctgaac
cctgtttacaatgaggaatcatttgttttccgaaaggtgatcctgcctgacctcgctgtt
gtaaggatcgcagtgtacgatgacaacagcaagttaatcggtcagagaattctgcctcta
gacggtcttcaggctggatacaggcacatctccctcagaaacgaaggcaacaagcccctg
tctcttccaacagttttttgcaatatcgttctgaaaacatatgtgcctgatggatttgga
gatattgtggatgcattgtctgacccaaagaaattcctctctgttatggagaaaagggca
gatcaaatgagggctatgggtattgaaactagtgaaattgctgacgttcccagtgacaat
acaaaaaatgacaagaagagtaaatcaaacaatgccaaacaaaatgtaactccacagact
agctctgaagcccgaccaagcgcacctacaggtttggggacaagcatggacactaaaaaa
gccgtggaacccattcctcatgtcaatatagaagacttaaagcagatgaaggcttacttg
aagcaattgaagaagcatcaaaaagagctgaattctttgaagaagaagcatgcgaaggaa
cacagtataatgcagaagttgcactgtacgcaagttgataaaattgttgctcagttcaat
aaggaaaagctgtcccaagagaaaactttagagaagtcaatcaagaggaaaggcgtaaat
aacagttctgaaatgaaaaaggagacagaacaaaaggttcaaacactgacatccaatcat
aaatcgaaggtaaaagatattgtggcacagcagacaaaagaatggtcagaaatggttaac
acgcacaccgcggaagagcaagagcttcgagatagtcatctaagtcagcagtgtgagcta
ctgaaaaagatgcttataggcgtccatgaacaacaaactcagcaactgaagatatcccaa
gaaagggaaggcaaggagatgcgcgccaaccaagcaaagatttcaatggaaaacagcaaa
gccatcagccaggataagtccatcaaaaacaaagcagaaagagagaggcgagtacgggag
ctgaacagcacaaacacaaagaagtttctggatgagaggaagaggctggcagcaaagcag
gcaaaagaaatggagcagttgaaaaaagcacagcttgagcatttggagatcttggagaag
cagaatgaacagcttttgaaatccagtcatgcagtgtcccactcacaaggcaaaggagat
gcagcagatggtgaagctggaagccgagatggatcgcaggcctgcaacagtggtgtgaaa
ctccagcatgcaaactga

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