Pleurodeles waltl (Iberian ribbed newt): 138296559
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Entry
138296559 CDS
T10800
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
pwl Pleurodeles waltl (Iberian ribbed newt)
Pathway
pwl00270
Cysteine and methionine metabolism
pwl00480
Glutathione metabolism
pwl01100
Metabolic pathways
pwl01240
Biosynthesis of cofactors
pwl04216
Ferroptosis
Module
pwl_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
pwl00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
138296559 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
138296559 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
138296559 (GCLC)
Enzymes [BR:
pwl01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
138296559 (GCLC)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
138296559
NCBI-ProteinID:
XP_069091896
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Position
5:1505112946..1505271399
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AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETKKHADYVRRHGIRQFLNIYHRVKERQRDVLKWGDEVEYMLVAFDH
ENKKVRLVLKGEELLEILQDKGEKANPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRLEASALLEKNVAICTITAFPRLGCPGFTFPEFEPTPVESGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVAINVPIFKDKNTPSPFIEKFQHDDGDGAGAAKPDHIYMD
AMGFGMGNCCLQVTFQACSIAEARYLYDQLATICPIVMALSAASPFYRGYISDIDCRWGV
ISASVDDRTREERGLEPLKTNKYRIHKSRYDSIDSYLSKCGENYNDIELTTDSEIYKQLV
NDGIDHLLAQHIAHLFIRDPLTLFEEKICLDDDKESDHFENIQSTNWQTMRFKPPPPNSD
IGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKEAQKRDAV
RQGKFYFKKEICKAGNAVVDGCTTAYNGTDTDNEECVLMSIDAIINGKEGVFPGLIPILN
SYLENMEVDVDTRCTILNYLKLIKKRASGELMTVARWMREFVANHPDYKQDSFITDKINY
DLIVKCNQIANEQVECPELHGIAVSKIKLSANQTVSF
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctctcgcagggatctccgctgagctgggaggaaaccaaaaagcacgcagac
tatgtgaggcggcacggcattcgccaatttctaaacatctaccaccgtgtgaaggagcgc
cagcgggacgtgctcaagtggggtgatgaggtggagtacatgctggttgcttttgaccac
gaaaataagaaggttcgtctggtcctaaaaggggaggaacttcttgagatactacaggat
aaaggggagaaggctaatccaaaccatcctactctgtggagaccagaatacggcagctac
atgattgaaggaacacctggtcaaccgtatggcggcaccatgtccgaatttaacactgtg
gaagctaacatgaggaaaagacggctggaggcatctgcgttgttagaaaaaaatgttgcc
atctgcacaattacagcttttccaagattgggatgccctgggtttacttttcctgaattt
gaacccacaccagtagagagtggtgcttctaagtcattgttttttccagacgaagcaata
aacaaacatcctaggtttagtacattaaccagaaatattcgacacaggagaggggaaaag
gttgcaataaatgtaccgatattcaaagataagaatacaccgtctcctttcatagaaaaa
tttcagcacgatgatggagatggggctggtgcagctaagccagatcatatttacatggac
gccatgggatttggaatgggaaactgctgccttcaggtgacattccaagcttgcagtata
gcagaagctagatacctttatgatcaactagccacaatttgtcccattgtgatggcctta
agtgctgcatctccattctacagaggatacatatctgatatagactgtcgatggggagta
atctctgcttctgtggatgaccgaacacgagaggaacgagggcttgagccactgaagacc
aacaagtacagaatccataaatcccgatatgattcaatagatagctacttgtctaagtgt
ggtgaaaactacaatgacatcgagttaactacagattcagaaatttacaagcaactggta
aacgatggcatcgatcatcttcttgcacaacatattgcacatctttttattcgagaccct
cttactttatttgaagagaaaatatgtcttgatgatgataaggagtcagatcattttgag
aatatccagtctacaaactggcagactatgcgttttaaaccacctcctccaaattcagat
atcggatggagagtagaattccggcctatggaggtccagttgactgattttgagaactct
gcgtatgtcgtgtttgtggtattgctaaccagagtgattctttcatacaaactggatttc
ctcatacctttatcaaaggtggatgaaaacatgaaagaagctcagaaacgagatgcagtc
cgtcaaggaaaattttatttcaagaaagagatttgcaaagcgggaaatgctgttgttgat
ggttgcactacagcttataatgggactgatacagataatgaggagtgcgtcttaatgagt
attgatgcgattatcaatggaaaggaaggggtttttcctggtttaatcccaattctgaac
tcctatcttgaaaatatggaagttgatgtggacacaagatgtaccatcttaaactacctt
aaactaatcaaaaaaagagcatcaggagaattgatgactgttgcacgctggatgagggag
tttgttgcaaatcatccggactacaagcaagatagttttattacagataaaataaattat
gaccttattgtgaagtgcaaccagatagcaaatgagcaggttgaatgtccagaattgcat
ggaatagcagttagcaaaataaaattaagtgcaaatcaaactgtttctttttag
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