KEGG   Herpailurus yagouaroundi (jaguarundi): 121011444
Entry
121011444         CDS       T07555                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pyu  Herpailurus yagouaroundi (jaguarundi)
Pathway
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu01524  Platinum drug resistance
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04014  Ras signaling pathway
pyu04015  Rap1 signaling pathway
pyu04022  cGMP-PKG signaling pathway
pyu04024  cAMP signaling pathway
pyu04062  Chemokine signaling pathway
pyu04066  HIF-1 signaling pathway
pyu04068  FoxO signaling pathway
pyu04071  Sphingolipid signaling pathway
pyu04072  Phospholipase D signaling pathway
pyu04140  Autophagy - animal
pyu04150  mTOR signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04152  AMPK signaling pathway
pyu04210  Apoptosis
pyu04211  Longevity regulating pathway
pyu04213  Longevity regulating pathway - multiple species
pyu04218  Cellular senescence
pyu04261  Adrenergic signaling in cardiomyocytes
pyu04370  VEGF signaling pathway
pyu04371  Apelin signaling pathway
pyu04380  Osteoclast differentiation
pyu04510  Focal adhesion
pyu04550  Signaling pathways regulating pluripotency of stem cells
pyu04611  Platelet activation
pyu04613  Neutrophil extracellular trap formation
pyu04620  Toll-like receptor signaling pathway
pyu04625  C-type lectin receptor signaling pathway
pyu04630  JAK-STAT signaling pathway
pyu04660  T cell receptor signaling pathway
pyu04662  B cell receptor signaling pathway
pyu04664  Fc epsilon RI signaling pathway
pyu04666  Fc gamma R-mediated phagocytosis
pyu04668  TNF signaling pathway
pyu04722  Neurotrophin signaling pathway
pyu04725  Cholinergic synapse
pyu04728  Dopaminergic synapse
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04915  Estrogen signaling pathway
pyu04917  Prolactin signaling pathway
pyu04919  Thyroid hormone signaling pathway
pyu04920  Adipocytokine signaling pathway
pyu04922  Glucagon signaling pathway
pyu04923  Regulation of lipolysis in adipocytes
pyu04926  Relaxin signaling pathway
pyu04929  GnRH secretion
pyu04931  Insulin resistance
pyu04932  Non-alcoholic fatty liver disease
pyu04933  AGE-RAGE signaling pathway in diabetic complications
pyu04935  Growth hormone synthesis, secretion and action
pyu04936  Alcoholic liver disease
pyu04973  Carbohydrate digestion and absorption
pyu05010  Alzheimer disease
pyu05017  Spinocerebellar ataxia
pyu05132  Salmonella infection
pyu05135  Yersinia infection
pyu05142  Chagas disease
pyu05145  Toxoplasmosis
pyu05152  Tuberculosis
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05162  Measles
pyu05163  Human cytomegalovirus infection
pyu05164  Influenza A
pyu05165  Human papillomavirus infection
pyu05166  Human T-cell leukemia virus 1 infection
pyu05167  Kaposi sarcoma-associated herpesvirus infection
pyu05168  Herpes simplex virus 1 infection
pyu05169  Epstein-Barr virus infection
pyu05170  Human immunodeficiency virus 1 infection
pyu05200  Pathways in cancer
pyu05205  Proteoglycans in cancer
pyu05207  Chemical carcinogenesis - receptor activation
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05212  Pancreatic cancer
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05218  Melanoma
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05222  Small cell lung cancer
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
pyu05230  Central carbon metabolism in cancer
pyu05231  Choline metabolism in cancer
pyu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pyu05415  Diabetic cardiomyopathy
pyu05417  Lipid and atherosclerosis
pyu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121011444 (AKT2)
   04012 ErbB signaling pathway
    121011444 (AKT2)
   04014 Ras signaling pathway
    121011444 (AKT2)
   04015 Rap1 signaling pathway
    121011444 (AKT2)
   04370 VEGF signaling pathway
    121011444 (AKT2)
   04371 Apelin signaling pathway
    121011444 (AKT2)
   04630 JAK-STAT signaling pathway
    121011444 (AKT2)
   04668 TNF signaling pathway
    121011444 (AKT2)
   04066 HIF-1 signaling pathway
    121011444 (AKT2)
   04068 FoxO signaling pathway
    121011444 (AKT2)
   04072 Phospholipase D signaling pathway
    121011444 (AKT2)
   04071 Sphingolipid signaling pathway
    121011444 (AKT2)
   04024 cAMP signaling pathway
    121011444 (AKT2)
   04022 cGMP-PKG signaling pathway
    121011444 (AKT2)
   04151 PI3K-Akt signaling pathway
    121011444 (AKT2)
   04152 AMPK signaling pathway
    121011444 (AKT2)
   04150 mTOR signaling pathway
    121011444 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121011444 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    121011444 (AKT2)
   04218 Cellular senescence
    121011444 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121011444 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    121011444 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121011444 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121011444 (AKT2)
   04613 Neutrophil extracellular trap formation
    121011444 (AKT2)
   04620 Toll-like receptor signaling pathway
    121011444 (AKT2)
   04625 C-type lectin receptor signaling pathway
    121011444 (AKT2)
   04660 T cell receptor signaling pathway
    121011444 (AKT2)
   04662 B cell receptor signaling pathway
    121011444 (AKT2)
   04664 Fc epsilon RI signaling pathway
    121011444 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    121011444 (AKT2)
   04062 Chemokine signaling pathway
    121011444 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121011444 (AKT2)
   04922 Glucagon signaling pathway
    121011444 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    121011444 (AKT2)
   04920 Adipocytokine signaling pathway
    121011444 (AKT2)
   04929 GnRH secretion
    121011444 (AKT2)
   04915 Estrogen signaling pathway
    121011444 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    121011444 (AKT2)
   04917 Prolactin signaling pathway
    121011444 (AKT2)
   04926 Relaxin signaling pathway
    121011444 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    121011444 (AKT2)
   04919 Thyroid hormone signaling pathway
    121011444 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    121011444 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121011444 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    121011444 (AKT2)
   04728 Dopaminergic synapse
    121011444 (AKT2)
   04722 Neurotrophin signaling pathway
    121011444 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    121011444 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    121011444 (AKT2)
   04213 Longevity regulating pathway - multiple species
    121011444 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121011444 (AKT2)
   05205 Proteoglycans in cancer
    121011444 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    121011444 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    121011444 (AKT2)
   05230 Central carbon metabolism in cancer
    121011444 (AKT2)
   05231 Choline metabolism in cancer
    121011444 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121011444 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121011444 (AKT2)
   05212 Pancreatic cancer
    121011444 (AKT2)
   05225 Hepatocellular carcinoma
    121011444 (AKT2)
   05226 Gastric cancer
    121011444 (AKT2)
   05214 Glioma
    121011444 (AKT2)
   05221 Acute myeloid leukemia
    121011444 (AKT2)
   05220 Chronic myeloid leukemia
    121011444 (AKT2)
   05218 Melanoma
    121011444 (AKT2)
   05211 Renal cell carcinoma
    121011444 (AKT2)
   05215 Prostate cancer
    121011444 (AKT2)
   05213 Endometrial cancer
    121011444 (AKT2)
   05224 Breast cancer
    121011444 (AKT2)
   05222 Small cell lung cancer
    121011444 (AKT2)
   05223 Non-small cell lung cancer
    121011444 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121011444 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    121011444 (AKT2)
   05161 Hepatitis B
    121011444 (AKT2)
   05160 Hepatitis C
    121011444 (AKT2)
   05164 Influenza A
    121011444 (AKT2)
   05162 Measles
    121011444 (AKT2)
   05168 Herpes simplex virus 1 infection
    121011444 (AKT2)
   05163 Human cytomegalovirus infection
    121011444 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121011444 (AKT2)
   05169 Epstein-Barr virus infection
    121011444 (AKT2)
   05165 Human papillomavirus infection
    121011444 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121011444 (AKT2)
   05135 Yersinia infection
    121011444 (AKT2)
   05152 Tuberculosis
    121011444 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    121011444 (AKT2)
   05142 Chagas disease
    121011444 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121011444 (AKT2)
   05017 Spinocerebellar ataxia
    121011444 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121011444 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    121011444 (AKT2)
   05415 Diabetic cardiomyopathy
    121011444 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    121011444 (AKT2)
   04932 Non-alcoholic fatty liver disease
    121011444 (AKT2)
   04931 Insulin resistance
    121011444 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121011444 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121011444 (AKT2)
   01524 Platinum drug resistance
    121011444 (AKT2)
   01522 Endocrine resistance
    121011444 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pyu01001]
    121011444 (AKT2)
Enzymes [BR:pyu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     121011444 (AKT2)
Protein kinases [BR:pyu01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   121011444 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 121011444
NCBI-ProteinID: XP_040301783
LinkDB
Position
Unknown
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPDAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPM
DYKCGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAREVMEHRFFLSVNWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccccggtacttcctgctgaagagtgacggctccttcattggatacaaggag
cggcctgatgccccagaccagaccctgcccccgctaaacaacttctctgtcgcagagtgc
cagctgatgaagactgagagaccacggcccaacaccttcgtcatacgctgcctacagtgg
accactgtcatcgagaggaccttccatgtagactctccagatgagagggaggagtggatg
cgggccattcagatggtcgccaacagccttaagcagcggggcccaggtgaggaccccatg
gactataagtgtggctcccccagtgacccttctgcggccgaggagatggaagtggcagtt
agcaaggctcgggccaaggtgaccatgaatgacttcgactatctcaaacttctgggcaag
ggcacctttggcaaagtgattctggtgcgggagaaagccagcggccgctactacgccatg
aagatcctgcggaaggaagttatcattgccaaggatgaagttgcccacacggtcaccgag
agccgggtcctccagaacaccaggcacccattcctcactgcactgaagtatgccttccag
acccacgaccgcctgtgcttcgtgatggaatacgccaacggtggtgagctgtttttccac
ctgtcccgggaacgagtcttcacggaggagcgagcccgcttctatggtgcggagatcgtc
tctgcccttgagtatttgcattcgcgggacgtggtgtaccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgacttcggactgtgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggacacccgagtacctggcacccgag
gtgctggaggacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaggagatccgtttcccacgcacactgagccctgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggctcggcggggggcccagcgatgcc
agggaggtcatggagcacaggttcttcctcagcgtcaactggcaggacgtggtgcagaag
aagctcctgccacccttcaaacctcaggtcacctctgaggttgacacaaggtactttgac
gatgagttcaccgcccagtccattacaatcacacccccggaccgctatgacagcctgggc
tccctcgaactggaccagcggacccacttcccccagttctcctactcagccagcatccgc
gagtga

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