Puma yagouaroundi (jaguarundi): 121017018 Help Entry 121017018         CDS       T07555                                  Symbol EGFR Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism pyu  Puma yagouaroundi (jaguarundi) Pathway pyu01521   EGFR tyrosine kinase inhibitor resistance pyu01522   Endocrine resistance pyu03272   Virion - Hepatitis viruses pyu04010   MAPK signaling pathway pyu04012   ErbB signaling pathway pyu04014   Ras signaling pathway pyu04015   Rap1 signaling pathway pyu04020   Calcium signaling pathway pyu04066   HIF-1 signaling pathway pyu04068   FoxO signaling pathway pyu04072   Phospholipase D signaling pathway pyu04144   Endocytosis pyu04151   PI3K-Akt signaling pathway pyu04510   Focal adhesion pyu04520   Adherens junction pyu04540   Gap junction pyu04630   JAK-STAT signaling pathway pyu04810   Regulation of actin cytoskeleton pyu04912   GnRH signaling pathway pyu04915   Estrogen signaling pathway pyu04921   Oxytocin signaling pathway pyu04926   Relaxin signaling pathway pyu04928   Parathyroid hormone synthesis, secretion and action pyu04934   Cushing syndrome pyu05160   Hepatitis C pyu05163   Human cytomegalovirus infection pyu05165   Human papillomavirus infection pyu05171   Coronavirus disease - COVID-19 pyu05200   Pathways in cancer pyu05205   Proteoglycans in cancer pyu05206   MicroRNAs in cancer pyu05207   Chemical carcinogenesis - receptor activation pyu05208   Chemical carcinogenesis - reactive oxygen species pyu05210   Colorectal cancer pyu05212   Pancreatic cancer pyu05213   Endometrial cancer pyu05214   Glioma pyu05215   Prostate cancer pyu05218   Melanoma pyu05219   Bladder cancer pyu05223   Non-small cell lung cancer pyu05224   Breast cancer pyu05225   Hepatocellular carcinoma pyu05226   Gastric cancer pyu05230   Central carbon metabolism in cancer pyu05231   Choline metabolism in cancer pyu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:pyu00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     121017018 (EGFR)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     121017018 (EGFR)    04015 Rap1 signaling pathway     121017018 (EGFR)    04630 JAK-STAT signaling pathway     121017018 (EGFR)    04066 HIF-1 signaling pathway     121017018 (EGFR)    04068 FoxO signaling pathway     121017018 (EGFR)    04072 Phospholipase D signaling pathway     121017018 (EGFR)    04151 PI3K-Akt signaling pathway     121017018 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     121017018 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04915 Estrogen signaling pathway     121017018 (EGFR)    04921 Oxytocin signaling pathway     121017018 (EGFR)    04926 Relaxin signaling pathway     121017018 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     121017018 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     121017018 (EGFR)    05206 MicroRNAs in cancer     121017018 (EGFR)    05205 Proteoglycans in cancer     121017018 (EGFR)    05207 Chemical carcinogenesis - receptor activation     121017018 (EGFR)    05208 Chemical carcinogenesis - reactive oxygen species     121017018 (EGFR)    05230 Central carbon metabolism in cancer     121017018 (EGFR)    05231 Choline metabolism in cancer     121017018 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     121017018 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     121017018 (EGFR)    05212 Pancreatic cancer     121017018 (EGFR)    05225 Hepatocellular carcinoma     121017018 (EGFR)    05226 Gastric cancer     121017018 (EGFR)    05214 Glioma     121017018 (EGFR)    05218 Melanoma     121017018 (EGFR)    05219 Bladder cancer     121017018 (EGFR)    05215 Prostate cancer     121017018 (EGFR)    05213 Endometrial cancer     121017018 (EGFR)    05224 Breast cancer     121017018 (EGFR)    05223 Non-small cell lung cancer     121017018 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     121017018 (EGFR)    05171 Coronavirus disease - COVID-19     121017018 (EGFR)    05163 Human cytomegalovirus infection     121017018 (EGFR)    05165 Human papillomavirus infection     121017018 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     121017018 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     121017018 (EGFR)    01522 Endocrine resistance     121017018 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pyu01001]     121017018 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pyu04147]     121017018 (EGFR) Enzymes [BR:pyu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      121017018 (EGFR) Protein kinases [BR:pyu01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    121017018 (EGFR) Exosome [BR:pyu04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    121017018 (EGFR)   Exosomal proteins of pancreatic cancer cells    121017018 (EGFR)   Exosomal proteins of bladder cancer cells    121017018 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 Borrelia_P83 Motif Other DBs NCBI-GeneID:  121017018 NCBI-ProteinID:  XP_040311015 LinkDB All DBs Position Unknown AA seq 1207 aa AA seqDB search MRPSGTAGAALLLLLAAHFQASPALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALS VLSNYGTNKTGLRELPMRNLHEILQGAVRFSNNPVLCNVETIQWRDIVDNDFISNMSMDF QNHVGNCQKCDPGCPNGSCWGPGKENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK NCTSISGDLHILPVAFRGDSFTHTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIVSGNQKLCYANTINWKKL FGTSSQKTKIINNKDEKGCKAIGHVCHPLCSSEGCWGPEPKDCVSCQNVTRGKECVEKCN VLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDSCVQCAHYIDGPHCVKTCPAGIM GENNTLVWKFADANRMCHLCHSNCTYGCSGPGLEGCATDGPKIPSIATGIVGGLLLVVVV ALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ QGFFHSPSTSRTPLLSSLSATSNNSTVTCIDRNGSCPLKEDSFLQRYSSDPTGTLTEDNM DDTFLPAPEYINQAVPKRPAGSVQNPVYHNQPLNPAPVRDPHYQNPHSNAVDNPEYLNTH PTCVNSVLDGPTLWAQKGNHQISLDNPDYQQDFFPKEAKSNGIFKGPAAENADYLRVAPP SSEFIGA NT seq 3624 nt NT seq  +upstreamnt  +downstreamnt atgcgaccctccgggaccgcgggagccgcgctcctgctgctgctggctgcgcacttccag gcgagtccggcgctggaggagaagaaagtttgccaaggcacaagtaaccggctcacccag ttgggcacttttgaggaccactttctcagcctgcagaggatgtttaataactgtgaggtg gtccttgggaatttggaaatcacctacatgcaaaggaattatgacctttccttcttaaaa accatccaagaggttgccggctatgtactcattgccctcaacacagtggagaagattcct ttggaaaacctgcagatcatccgaggaaatgtgctctatgaaaacacccatgccttatcc gtcttatccaactatggcacaaataaaaccggactgcgggagctgcccatgagaaactta catgaaatcctgcaaggcgctgtgcggttcagcaacaaccctgtcctctgcaacgtggaa accatccagtggcgggatatcgttgacaacgatttcataagcaacatgtcgatggacttc cagaaccacgtgggcaactgccaaaagtgtgatccaggatgtcccaatggaagctgctgg ggtccgggaaaggagaattgccagaaattgaccaaaatcatctgcgcccagcagtgttcc gggcgctgccgcggcaggtcccccagcgactgctgccataaccagtgtgctgccggctgc acggggccccgagagagcgactgcctggtctgccgcaagttccgggatgaagccacgtgc aaggacacctgcccgccactcatgctctacaaccccaccacctaccagatggatgtcaac ccagagggaaaatacagctttggtgccacctgtgtgaagaaatgcccccgtaactatgtg gtgacagaccacggttcgtgtgtccgtgcctgcagttctgatagctatgaagtggaggaa gatggcgtccgcaagtgtaaaaagtgtgaagggccttgccgtaaagtttgtaatggaata ggaattggtgaatttaaagacacactttccatcaatgctacaaatattaaacacttcaaa aattgcacctcgatcagtggagatcttcatatcctgccagtagcatttagaggtgactcc ttcacgcatactccacctctagatccaaaggaactggatattctaaaaactgtaaaggaa attacagggtttttgctgattcaggcctggcctgaaaacaggactgacctccatgctttc gagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttctcttgcggtt gtcggcctggacataacgtccttgggattacgctccctcaaggagataagtgatggagat gtgatcgtttcaggaaaccaaaaattgtgctatgcaaatacaataaactggaaaaaactg tttgggacttcaagtcagaaaaccaaaattataaacaacaaagatgaaaaaggctgcaag gccataggccatgtctgtcatccgttatgctcatcagagggatgctggggcccggagcca aaagactgcgtgtcctgccaaaacgtcacccgtggcaaggaatgtgtggagaagtgcaat gttctggagggggagccaagggagtttgtggagaattccgagtgcatacagtgccatcca gaatgcctgccccaggccatgaatatcacctgcacaggacgaggaccagacagctgcgtg cagtgtgcacactacattgacggccctcactgcgtcaagacctgcccggctggcatcatg ggagaaaacaacaccctggtctggaagtttgcagacgccaatcgcatgtgtcacctgtgc cattcaaactgtacctacggctgttctgggccaggtcttgaaggctgtgcaacagatggg cccaagatcccatccatcgccactgggattgttgggggcctcctcttggtggtggtggtg gcccttggggtgggcctctttctgcgccgacgccacatcgtccgcaagcgcacacttcgc agactgctgcaggaaagagagcttgttgagcctcttactcccagcggagaagctcccaac caagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtgctgggctct ggagcatttggcacagtgtacaagggactctggatcccagaaggtgagaaggttaaaatt cccgtggccatcaaggagttacgagaagccacatctccaaaagccaacaaggaaatcctt gatgaagcttacgtgatggccagtgtggacaatccccacgtgtgccgcctcctgggcatc tgcctgacgtccacggtccagctcatcacacagctcatgccgttcggctgcctcctggac tatgtccgcgagcacaaggacaacattggctcccaatacctgctcaactggtgtgtgcag attgcgaagggcatgaactacctggaagaccggcgcttggtgcaccgtgacctggcagcc aggaatgtcctggtgaagacgccacagcatgtcaagatcacagattttgggctggccaaa ctgcttggcgccgaggagaaagaataccatgcggaaggaggcaaagtgcctatcaagtgg atggctttggaatcaattttacaccgaatttacacccaccaaagtgacgtctggagctat ggagtcaccgtttgggagttgatgacctttgggtctaaaccttacgacggaatccccgca agtgagatctcgaccatcctggagaaaggagagcgcctcccgcagccacccatatgcacc atcgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccgaaa ttccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc atccagggagatgagagaatgcatctgccaagccctacagactccaatttttaccgcgcc ctgatggacgaagaagacatggaagacgtcgtagatgccgatgagtacctcatcccccag caaggcttcttccacagcccctccacatcccggacccccctcctgagttctctgagtgcc accagcaacaattccaccgtgacttgcatcgatagaaatgggagctgccccctcaaggaa gacagcttcttgcagcggtacagctcagaccccactggcaccttgactgaggacaacatg gatgacactttcctcccggcacctgaatacataaaccaggctgttcccaaaaggcctgcg ggttccgtccagaaccccgtctatcacaatcagcctctaaatccagctcctgtcagagac cctcactaccaaaatccccacagcaatgcagtggacaaccctgagtatctcaacacccac cccacttgcgtcaacagtgtgctcgatggccccaccctctgggcccagaaaggcaaccac cagattagcctggacaaccctgactaccagcaggacttctttcccaaggaagccaagtca aatggcatctttaagggtcctgcagctgaaaatgcagactacctaagggtagcaccgccc agcagtgaatttattggagcatga

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