Puma yagouaroundi (jaguarundi): 121021471
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Entry
121021471 CDS
T07555
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pyu
Puma yagouaroundi (jaguarundi)
Pathway
pyu00310
Lysine degradation
pyu01100
Metabolic pathways
pyu05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pyu00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
121021471 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
121021471 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pyu03036
]
121021471 (DOT1L)
Enzymes [BR:
pyu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
121021471 (DOT1L)
Chromosome and associated proteins [BR:
pyu03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
121021471 (DOT1L)
HMT complexes
Dot1-containing complex
121021471 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
121021471
NCBI-ProteinID:
XP_040317779
LinkDB
All DBs
Position
Unknown
AA seq
1596 aa
AA seq
DB search
MGAVGEESAEVGVRGGERRVGASTSPRVPPPCPPGRECHRSSSGQGRELAGRPCLVPTPC
TTGGCKTCPFVFQDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRL
CDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPE
VYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKY
AETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLK
ERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYL
HTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVPESKAAVAADTPVDS
GAEEEKAGTTAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAANPERKPRKSQTALD
LLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRPLLAATPPALQKLLESFKIQ
YLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEEIKRLFQQKLDEL
GVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQSLQLLKARCEELKLDWSTL
SLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSAHLR
GKGALGREPEADPGRLHLDLDCSRFSLPRFSSASPELSMNGHAASYELCGALSRPPSKQN
TPQYLASPPDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLSPAKLVLRRHLSQDHAAGGK
TAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQMTGERGSEKGLKERA
YASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRSTPSPVPQTRESLSTL
EKQMGATAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADPGTFDEVPSAGGLFASVGSC
GSTPQHPPLLPQPRGSGAASPAHPLCASPRLGGAAQGPLPDANKGDLPPEAGFSDPEGEA
KRRIVFTVSAGGGGTKQSPPSKPSPLPTGGRGDGSQGHGQDSRKRGRRKRAAAGTPGLSS
GVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESLKSSPVPYQDSDQ
PPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERKIATISLESRSPPKTLENGG
GLAGRKPTPASEPTNSSKWKSTFSPISDLGLAKCADSPLQAGSALSQNSLFAFRPPLEEP
GSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLSLHSFSDGASLSHKV
PEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDGAGGPKGREAGEPGPPACGPPDKASL
AHGKPGKGRDREPDLKNGHNLFIAAANVPPGGLLSGPGLATAASSVVSAAPSAQAHRPFL
GTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATRLTNSHAMGSFPSGV
AGGAVGGSLAGPPKGREAVPVCPLGSTLHPSPRSFS
NT seq
4791 nt
NT seq
+upstream
nt +downstream
nt
atgggggctgtgggtgaagagtcagcagaggtgggggtgcgaggtggggagagaagggtc
ggggcatcgacgtcaccccgggtccctcctccctgcccgcctgggagggagtgccacagg
tccagctcgggccaggggcgggaactggctggtaggccctgcctggtccccacaccctgt
accaccggagggtgtaaaacctgtccctttgtctttcaggacaaacaccacgatgctgct
cacgaaatcatcgagaccatccggtgggtctgcgaagagatcccggacctcaagctcgct
atggagaactacgttttaatcgactacgacaccaaaagcttcgagagcatgcagaggctc
tgtgataagtacaaccgcgccatcgacagcatccaccagctgtggaaggggaccactcag
cccatgaaactgaacacccggccgtccaacgggctcctgcggcacatcctgcagcaggtg
tataaccactcggtgacggaccccgagaagctcaacaactacgagcccttctccccggag
gtgtacggggagacctccttcgacctggtcgcgcagatgatcgacgagatcaagatgacc
gaggacgacctgtttgtggacctgggcagcggagtgggccaggtcgtgctccaggtggcc
gcggccaccaactgcaaacatcactacggcgtggagaaagctgacatcccagccaagtac
gcggagaccatggaccgagagttcaggaagtggatgaaatggtatggaaaaaagcatgca
gaatacacactggaaagaggcgacttcctctcggaggagtggagagagcggatcgccaac
acaagtgttatatttgtgaataactttgcctttggtcctgaggtggatcaccagctgaag
gagcggtttgcgaacatgaaggaaggcggcagaattgtgtcctcgaagccctttgcgcct
ctgaacttcagaataaacagcagaaacttgagcgacatcggcaccatcatgcgcgtcgtg
gagctctcgcccctgaagggctctgtgtcctggacggggaagccggtctcctactacctg
cacaccatcgaccgcaccatacttgaaaactatttttctagtctgaaaaacccaaaactc
agggaggagcaagaggcggctcggcgccggcaacagcgagagaacaagagcaacacgacc
actcccaccaaggtgcccgagagcaaggctgccgtggccgcggacacccccgtggattcc
ggtgccgaggaagagaaggctgggacgaccgccatcaaaaagccgtccccctccaaagcc
cggaagaagaagctgaacaagaaggggcggaaaatggccggcaggaagcgcgggcgcccc
aagaagatgagcgctgccaaccccgagcgcaagccccggaagagccaaactgcactggac
ctcctgcacgccccggcctcgtcgcagacggcggcgccctcgccacaggatgcgtacagg
tcacctcatagccccttctatcagctacctccctgcgtgcagcggcacgcccccgaccgg
ccgctgctggcagccaccccgcccgcactgcagaagctgctagaatccttcaagattcag
tacctgcagttcttggcctacaccaagaccgcccagtacaaggccagccttcagcagctg
ctggaccaggagaaggagaagaacgcccggctgctgggggccgcacagcagctgttcggc
cactgccaggcccagaaagaggagatcaagaggctcttccagcagaaactggatgagctg
ggggtgaaggcgctgacctacaacgacctgattcaggcgcagaaggagatctcggcccat
aaccagcagctgagggagcagacggagcagctgcaggaggacaacagggagctgaggagc
cagagcctgcagctgctcaaggctcggtgtgaggagttgaaactggactggtccacgctg
tcgctggagaacctgctgaaggagaagcaggccctgaggagccagatctccgagaagcag
aggcactgcctggagctgcagatcagcatcgtggagctggagaagagccagcggcagcaa
gagcttctgcagctcaagtcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgc
gggaaaggcgccctgggccgggagccggaggcggaccccggccggttgcacctcgacctg
gactgctctaggttctccctgccgcgcttcagcagcgccagcccggaactctccatgaac
ggccacgcggccagctacgagctctgcggtgcgctgagccggcccccctccaagcagaac
accccccagtacctggcctccccgccggaccaggaggtggtgccctgcacccccagccac
ggcagccggccaaggctcgagaaggtgtctggcctggccttgccggactacaccaggctg
tccccggccaagctggtgctgaggcggcacctcagccaggaccacgcggccggcggcaag
acggcagccggggagctgcaccctcgagccgagcacgccaaggagaacggccttccgtac
cagagcccgggcatcgccaacggcatcaagctgagccctcaggacccccggccctcctcc
cccgtggccttacagatgacaggggagaggggcagcgagaagggtttgaaggagcgtgcc
tacgccagcagcggggaggccatcaccagcctgcccgtcagcatcccgctcagcaccgtg
cagcccagcaagctgcccgtcagcatccctctggccagcgtggtgctgcccagccgtgcc
gagaaagtgagaagcacccccagccccgtgccgcagacccgagagtccttgtccacactt
gaaaagcagatgggcgctactgcacacagcgccggaagcaaaagtctcgccccggcccct
gcaggcttctacgcgggctcggtggccgtcagcccagcccccctcgcttccggagcagat
cccggcacctttgacgaggtccccagcgcaggcggtctgtttgccagcgtggggtcctgt
ggctccaccccgcagcacccgcccctgctgccgcagccccggggctctggcgcagcctcg
cccgcccacccgctctgcgccagcccccgcctgggcggcgccgcccagggtccgctccct
gacgccaacaaaggggaccttcctcccgaggccggcttctcggaccccgagggcgaagcc
aagcggaggatcgtcttcaccgtctcggccggcgggggcggcaccaagcagtcgcctccc
agcaagcccagccctctgcccacgggcggccgtggggacggcagccagggccacgggcag
gacagccgcaagcggggcagaaggaagcgggcggcggcagggacccccggcctgagctca
ggcgtgtcgcccaagcgccgggccctgccgtccgtggccggcctcttcacgcagtcttca
gggtcccccctgaacctcaactccatggttagcaacattaaccagcctttggaaatcacg
gccatttcgtcccctgagagcctgaagagctcccctgtcccctaccaggacagcgaccag
ccgcccgtcctcaagaaggagaagcccctgagccagaccaacggggcccactactcccca
ctgacctcggacgaggagcagggctccgaggatgagccgggcagcaccagaattgagaga
aaaattgcgacaatctccttagaaagcagatctcccccgaaaaccttggaaaacggtgga
ggcctggctgggaggaagccgacccctgccagtgagcccaccaacagcagcaagtggaag
tctaccttttcgcccatctccgacctcggcctggccaagtgcgccgacagcccgctgcag
gccggctccgccctgagccagaactctctgttcgctttccggccccccctggaggagccc
ggctcggccgacgccaagctggccgcccaccccaggaagagctttcccggtgccctgtcg
ggggcaggcgggctgagcccaagcagcaaccctcccaacggcttcgccttcagcgggggc
ctggccgccgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggtc
cccgaggcggcaggcctgggcgcccccctgagctttcccgccccccggggcaaggacagc
gctgcagagcctgggccctttgtgaacaagaggcagctggacggcgcgggcggccccaag
ggcagggaggcaggcgagccgggccccccggcgtgtgggcccccggacaaggcctcgctg
gcgcacggcaagccgggcaagggccgggaccgtgagcccgacctgaagaacggccacaac
ctcttcattgcagccgccaacgtgccccccgggggcctcctcagtggcccgggcctcgcc
acggcggcgtcctcagtggtcagcgcggccccctccgcccaggcgcaccgccccttcctg
ggcacgtttgcccccggcccgcagttcgccctgggccccatgtcgctgcaggccaacctg
ggctcgtccgtgctgcagtccctgtttggctccgtgccggccgccggcctggtgcacgtc
tcgtccgccgcaaccagactgaccaactcgcacgccatgggcagctttccctccggggtg
gcaggcggcgcagttggaggttcccttgcagggccccctaaagggcgagaggctgtgccc
gtgtgtcccctcgggtccactttgcacccgtcacctcgttccttttcgtga
DBGET
integrated database retrieval system
