Puma yagouaroundi (jaguarundi): 121022952
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Entry
121022952 CDS
T07555
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
pyu
Puma yagouaroundi (jaguarundi)
Pathway
pyu00220
Arginine biosynthesis
pyu00330
Arginine and proline metabolism
pyu01100
Metabolic pathways
pyu04020
Calcium signaling pathway
pyu04022
cGMP-PKG signaling pathway
pyu04066
HIF-1 signaling pathway
pyu04071
Sphingolipid signaling pathway
pyu04151
PI3K-Akt signaling pathway
pyu04370
VEGF signaling pathway
pyu04371
Apelin signaling pathway
pyu04611
Platelet activation
pyu04915
Estrogen signaling pathway
pyu04921
Oxytocin signaling pathway
pyu04926
Relaxin signaling pathway
pyu04931
Insulin resistance
pyu04933
AGE-RAGE signaling pathway in diabetic complications
pyu05415
Diabetic cardiomyopathy
pyu05417
Lipid and atherosclerosis
pyu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pyu00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
121022952 (NOS3)
00330 Arginine and proline metabolism
121022952 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
121022952 (NOS3)
04371 Apelin signaling pathway
121022952 (NOS3)
04066 HIF-1 signaling pathway
121022952 (NOS3)
04020 Calcium signaling pathway
121022952 (NOS3)
04071 Sphingolipid signaling pathway
121022952 (NOS3)
04022 cGMP-PKG signaling pathway
121022952 (NOS3)
04151 PI3K-Akt signaling pathway
121022952 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
121022952 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
121022952 (NOS3)
04921 Oxytocin signaling pathway
121022952 (NOS3)
04926 Relaxin signaling pathway
121022952 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
121022952 (NOS3)
05418 Fluid shear stress and atherosclerosis
121022952 (NOS3)
05415 Diabetic cardiomyopathy
121022952 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
121022952 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
121022952 (NOS3)
Enzymes [BR:
pyu01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
121022952 (NOS3)
BRITE hierarchy
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Paralog
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
121022952
NCBI-ProteinID:
XP_040320480
LinkDB
All DBs
Position
Unknown
AA seq
1203 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPTAEPGRAPAPAPPPPPAPDRSSPPLT
KPPEGPKFPRVKNWEVGSITYDTLSAQAQQEGPCTPRRCLGSLVFPRKLQSRPSQDPPPT
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEIAAAGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCNSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFALPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFHYQPDPW
KGSGSKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHRSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAA
RDIFSAKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATILSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGP
PPSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESGEQQELESLSQDPRRY
EEWKWFRCPTLLEALEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSRE
PDCPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDT
PSL
NT seq
3612 nt
NT seq
+upstream
nt +downstream
nt
atgggtaatttgaagagtgtgggccaggagccggggcctccctgcggcctggggctgggg
ctgggcctgggcctgtgcggcaagcagggcccagcctccccgacagcagagcccggcagg
gcaccggcacccgcacccccacccccacccgcgccagaccgcagcagtcccccgctcacc
aagcccccggaggggcccaagttccctcgtgtgaagaactgggaggtggggagcatcact
tacgacaccctgagtgcccaggcacagcaggaggggccctgcacccctagacgctgcctg
ggctccctggtttttccacggaagctgcagagccggccctcccaggacccaccacccact
gagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatcaagagg
agtggctcccaggcccatgagcagaggcttcaggaggtggaagccgagatagcagccgca
ggcacataccagcttcgggagagcgagctggtgttcggggctaagcaggcttggagaaat
gcaccccgctgcgtgggccggatccagtgggggaaactgcaggtgtttgatgcccgggat
tgcaactctgcccaggagatgttcacctacatctgcaaccacatcaagtacgccaccaac
cggggcaacctccgctcggccatcacagtgttcccccagcgcgccccaggccgcggagac
ttccgaatctggaacagccaactggtgcgctacgctgggtacaggcagcaggatggctcc
gtgcggggggacccagccaacgtggagatcactgagctctgcatccagcacggctggacc
ccgggaaacggccgctttgacgtactgcccctactgctccaggccccagatgagcccccc
gaactctttgccctgccccccgagctggtcctcgaggtgcccctggagcaccccacgctg
gagtggtttgcggccctgggcctgcgctggtacgccctcccggcggtgagcaacatgctg
ctggaaattggggggctggagttccccgcggcccctttcagcggctggtacatgagcact
gagatcggcacgcggaacctgtgtgacccgcaccgatacaacatcctggaggatgtggcc
gtctgcatggacttggatacccgaaccacctcatccctgtggaaagacaaggcagccgtg
gaaatcaacttggccgtgctgcacagttaccagctggccaaagtgaccattgtggaccac
catgccgccacggcctccttcatgaaacacctggagaatgaacagaaggctagggggggc
tgccctgccgactgggcctggatcgtgccccccatctccggcagcctcacccctgtgttc
catcaggagatggtcaactacgtcctgtcccctgccttccactatcagccagacccgtgg
aagggaagtgggtccaagggtgccggcatcaccaggaagaagaccttcaaggaagtggcc
aatgcggtgaagatctctgcctcactcatgggcaccgtgatggcaaagcgagtaaaggca
acaatcctgtatggctccgagaccggccgggcccagagctatgcacagcagctggggaga
ctcttccggaaggctttcgatccccgggtcctgtgcatggatgagtatgatgtcgtgtcc
ctcgagcatgagacgctagtgctggtcgtgaccagcacattcgggaatggtgatccccca
gagaatggagagagttttgcggcggccctgatggaaatgtctggtccctacaacagctcc
cctcggccagaacaacacaggagttacaaaatccgcttcaacagtgtctcctgctcagac
ccgctggtgtcctcctggaggcggaagagaaaggagtccagtaacacagacagtgcaggg
gcactgggtaccctcaggttctgtgtgttcgggctgggctcccgggcgtacccccacttc
tgtgcctttgcccgcgcggtggacacacggctggaggagctgggtggcgagcggctgctg
cagctgggccagggagatgagctgtgtggccaggaggaggccttccgtggctgggcccag
gccgccttccaggcctcctgtgagactttctgcgtgggagaggacgccaaggctgccgcc
agggacatattcagcgccaaacggagctggaagcgccaaaggtaccggctcagcacccag
gcggagggcctccagctgctgccaggcctgatccatgtgcacaggaggaagatgttccag
gctaccatcctctcagtcgaaaacctgcaaagcagcaagtccacccgggccacgatcctg
gtgcgcctggacactggaggccaggaggggctgcagtaccagccgggggaccacataggc
atctgcccgcccaaccgaccgggcctcgtggaggcgctgctgagccgtgtggaggacccg
cctccgccaggagaacccgtggccgtggagcagctggagaagggcagccctggtggccca
ccccccagctgggttcgggacccccggctgcccccctgcacgctgcgccaggctctcacc
ttcttcctggacatcacctccccgcccagccctcaactccttcgactgctcagcaccctg
gccgaagagtccggtgaacagcaggagctggagagcctcagccaggacccccggcgctac
gaggagtggaagtggttccggtgccccacgctgctggaggcgctggaacagttcccgtcc
gtggcgctgcctgcccccctgctcctcacccagctgcctctgctccagccccggtactac
tccgtcagctcggcgcccagcgcccacccgggagagattcacctcacggtggccgtgctg
gcgtacaggacccaggatggactgggccccctgcactatggagtctgctccacatggctg
agccagctgaaggctggagatcccgtaccttgcttcatcaggggggctccctccttccgg
ctgccgcctgatcccagcttgccctgcatcctagtgggccctggcacaggtattgccccc
ttccggggattttggcaggagcggctgcacgacattgacagcaaagggctgcagccggcc
cccatgaccttggtgttcggctgccgatgctcccagctcgaccacctctaccgcgacgag
gtgcaggatgcccagcagcgcggggtttttggacgcgtcctcaccgccttctctcgggag
cccgactgccctaagacctacgtgcaggacatcctgcggacggagctggcggctgaggtg
caccgcgtgctgtgcctcgagcggggccacatgtttgtgtgcggcgacgtcaccatggca
accagcgtcctgcagacggtgcagcgaatcctagcgacggagggcgacatggagctggac
gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttc
gggctcacactgcgcacccaggaggtgactagccgcattcgcacccagagcttttctctg
caggagcggcatctgcgcggcgcagtgccctgggcgttcgaccctcccggcccagacacc
cccagtctctga
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