Puma yagouaroundi (jaguarundi): 121023156 Help Entry 121023156         CDS       T07555                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism pyu  Puma yagouaroundi (jaguarundi) Pathway pyu04020   Calcium signaling pathway pyu04024   cAMP signaling pathway pyu04260   Cardiac muscle contraction pyu04261   Adrenergic signaling in cardiomyocytes pyu04371   Apelin signaling pathway pyu04713   Circadian entrainment pyu04911   Insulin secretion pyu04921   Oxytocin signaling pathway pyu04972   Pancreatic secretion pyu05020   Prion disease pyu05022   Pathways of neurodegeneration - multiple diseases pyu05410   Hypertrophic cardiomyopathy pyu05412   Arrhythmogenic right ventricular cardiomyopathy pyu05414   Dilated cardiomyopathy pyu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pyu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121023156 (RYR2)    04020 Calcium signaling pathway     121023156 (RYR2)    04024 cAMP signaling pathway     121023156 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     121023156 (RYR2)    04921 Oxytocin signaling pathway     121023156 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     121023156 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     121023156 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     121023156 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     121023156 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     121023156 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     121023156 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     121023156 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     121023156 (RYR2)    05414 Dilated cardiomyopathy     121023156 (RYR2)    05415 Diabetic cardiomyopathy     121023156 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pyu04040]     121023156 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pyu04990]     121023156 (RYR2) Ion channels [BR:pyu04040]  Voltage-gated cation channels   Ryanodine receptor    121023156 (RYR2) Domain-containing proteins not elsewhere classified [BR:pyu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121023156 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  121023156 NCBI-ProteinID:  XP_040320824 LinkDB All DBs Position Unknown AA seq 5005 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDAGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREGGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPRCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAAFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNDCYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEED TEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESGSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNRSRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLETVKSALRTF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTSMHRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKHDIIKDLRNKFASLGENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGP MVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSASHFESHRLQTGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQT GNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTE YIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVML LSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGV ISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLL TNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEK PQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESE KEKPEEQGPRMGFFSIVTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTA AFSSYWSIFLSLLHFVASVSRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEV RGDGEEGDRRPMEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGL SDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKL RQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKV STSSVVEGKEPPTRSSSGNAKVSSLDSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVI SFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPN NYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSID VKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTH NGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVR AGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKE DMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWK MYQERCWEFFPAGDCFRKQYEDQLN NT seq 15018 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gtcctacagtgcaccgcgaccatccacaaagaacaacagaaactgtgcttggcagcagaa gggtttggcaacagactttgcttcctggagtctacttcgaattccaagaatgttccccca gacctctccatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggag atgctggctaacacagtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtacctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacgacaggtgaggcttgttggtgg actattcatcctgcgtccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgctgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgctgcacggacac atggatgaatgcctcactgtcccttcgggagaacacggtgaagagcagcggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccggtcttccaaggaaaaattggatgca ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacatataaatacaggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gatggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agcactgtcttccttttcaatagatttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccacagtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagcgcggcgcatttcgcggacgtggcggggaga gaaggaggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccagttttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaaatccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgtgtctgc catggggtagcggtccgttccaaccagcatctcatctgcgacaatctgctgccgggaaga gatctacttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtattatgagctgatggtggac cacacggagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagttggagat gacctcttttcctacggatttgatggccttcacctctggtcaggttgtattgcacgtact gtaagctcaccgaatcaacatctcttgagaaccgatgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctacttggggggagacatggagaatttaaattccttcctccacctgggtatgct ccttgttatgaagctgttctcccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccctgtggacaccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttgcagatgtcgcttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccgtctcaggaagcgatggtggacaagttggcg gagaacgctcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacagaagaaaccctcgcctagttccctacacccttctagatgac cgcaccaagaagtccaacaaggacagcctccgtgaggccgtgcgcacgctgctgggatat ggctaccatctggaggcgccagatcaagatcatgctgcccgagccgaagtgtgtagcggc accggggagaggttccgaatcttccgcgcggagaaaacctatgccgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgctggagacatgagagtcggatggagcaggcca cgttgtcaacctgaccaagagctgggctcagacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgat gttgtgggatgcatggtggacatgacggagcacaccatgatgttcacactgaatggcgaa atccttctggatgactcgggctcagaactggcgttcaaggacttcgacgttggtgacgga ttcattcctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgct gtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccttcaaaccatgagcatatcgaggtgaccagaatagacggcaccatcgacagttct ccgtgtttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatg ttctatcgcctgagcatgccaatcgagtgtgccgaggttttctccaagacggtggcaggc gggctcccaggcgccggcctctttgggcccaagaatgatctggaggattacgatgcagat tctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagc cattctgcaaggctcacggaagatgtccttgcagatgatcgggatgattatgactacttg atgcaaacgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgatacaggctttgacttggac agagttcgtacagtaaccgtgactctaggagatgaaaagggaaaagtacatgaaagcatc aaacgcagcaactgctatatggtgtgcgcgggtgagagcatgagcccagggcaaggacgc aacaataatggcctggagattgggtgtgtggtggatgctgccagtgggcttctcacgttc accgccaacggcaaggagctgagcacctactaccaggtggagccaagtacaaagttattt cctgcagcttttgcccaagctacaagtcccaatgttttccagtttgagctgggaagaatc aagaatgtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgccc cagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctctccatatcccggaggagaacagatctgttgac atactggagctgacagagcaggaagagctgctgaaattccactaccacacgctccggctt tactccgccgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtg gacgaaccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggcc ggctactatgacctgctgattgacatccacctgagctcctacgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccct gatgagaacaaaaagcatggcctcccagggattggcctcagcacctccctcaggccacgg atacagttttcctcccccagttttgtgagcatcaataacgactgctaccaatacagtcca gagttcccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaa gagggcagcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacct ctcatcaagctcttctatactctgctcatcatggggatcttccacaatgaggacttaaaa cacatcttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagac actgaggctctggagaaagagccctccatggaagactccaagccagaaggagctggagaa gaagaagccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgag ccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcag cgcttccgttacaatgaagttatgcaggctttaaacatgtcggccgcgctcactgccagg aagacaaaggaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaag gatgataaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcat gaagatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaac agtgacttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaaacaggccgaaaaaccagttgagagtggctccaagaagtcctccactcttcagcag ttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat ctcatgagggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctt tgttacttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagcaatgagaggttcaacaccactg gatgtggcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagttgcccaatgctg gtatctaagggttacccagatattgggtggaatccagttgaaggagagagataccttgac tttctccgatttgctgtcttctgtaatggggagagcgtggaagagaatgctaatgttgtg gtgaggttgctcatccggaggcctgagtgtttcggtcctgctttgagaggggaaggtggg aacggtcttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcgccaactagcggatccagtaaaacacttgagacagaagaggaggaggatgac actatccacatggggaatgccatcatgacgttttatgcagctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattctgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggtt caagatttcctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgct tctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctt tgcacagccgtgttgcctttattaacaagatgtgcccctcttttcgcgggcacagaacac cacgcttctctcattgactcgctactgcacactgtgtacagactttcgaagggctgctca cttaccaaagctcagcgggattccatagaagtttgtttgctctctatttgtggccaattg agaccttctatgatgcagcacttgctccgaagattagtgtttgatgtcccattattaaat gaacatgcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa accatgctggcgtggggttggagggttgagagaacacgggagggagacagcatggccctc tacaaccgttctcgtcgtatttctcagacaagccaggtttctgttgatgctgcgcatggt tatagcccccgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaagatggagctg gagtccaaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcttacagatcaatgga tatgctgtatccaggggattcaaggacctggaattggacacaccttccattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatc aagttctttgctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagcagacccctctgttctggaggacatgcgtcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggactgtcatgaagactggcctggagactgttaaaagtgctctcagaacgttt ctggacaatgcggcggaggatctggagaagacaatggagaatctcaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtcttgct gcttttgctggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacatc tactctatctacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactaac gtggaggatgtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaa ttagctgagtccggcattcgctacacacagatgccacacgtcatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcacggacctgaaaataatccagaaagg gctgaaatgtgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatata ttgaaaatcatatataataacctgggaattgatgagggagcctggatgaagaggttagca gtattttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggtggtgtcggaggaggaccatctg aaagctgaggccaggggggatatgtctgaggcagagcttctcattctcgatgagttcacc actctggccagagatctctatgccttctacccgctcttgattagatttgtggactataac agggcaaagtggctaaaagaacctaacccagaagcagaggaccttttccgcatggtggcc gaagtgtttatctactggtcaaaatcccacaatttcaaaagagaagagcagaactttgtg gtacagaatgaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtca aaggccgctgtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactcc acgcagacctctctcattgtggcagctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagac actgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagatttaccgaacaggactgaagat acatcagatccagagaagaccgtagagagagtattagatatagcaaatgtgctttttcat cttgagcagaaatctacatctatgcaccggagatattacagtctggtggagcacccacag agatcgaagaaagctgtatggcacaaacttctgtccaagcagaggaagagggcagtggtg gcctgcttccgaatggctcctttatataatctgccaaggcaccgggccgttaacctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataagctg atagaagatttagcaaaacctggagcagaccctccagaggaagaggaaggcacaaagaga gtcgatcccctccatcagctcatccttctgtttagtcgaacagctttaacggagaaatgc aaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaagcacgatattatcaaagatttaagaaacaaatttgccagcctcggcgagaac tctctggaaaaagaaatggagaagcagaagcttctgtaccagcaagccaggctccatgac cgcggggctgctgagatggtgctacagaccatcagtgccagcaaaggtgatactggacca atggtagcggcgactttgaaacttggaattgcaatcttaaatggcgggaactccacagtt cagcagaaaatgctggactatctcaaggagaagaaggacgtgggtttctttcagagcctt gccggcctgatgcagtcgtgcagcgtcctcgacctaaatgcatttgagcggcagaacaaa gctgaaggacttggaatggtcaccgaagaaggatcagcctctcactttgaaagtcacaga ctgcagactggagaaaaggttctccaagatgacgagttcacgtgtgacctcttccgtttc ctccagctgctttgtgagggacacaactcagattttcaaaattatctgagaactcagact ggcaataacacaactgtcaacatcatcatctctaccgtagactacctactcagagtccag gaatccattagtgatttctattggtattactctgggaaagatgttattgatgaacaagga caacggaatttctccaaagcaattcaagtagcaaaacaagtctttaacacgctcacagag tatattcagggtccttgcactgggaatcagcagagcttggcccacagcaggctatgggac gcagttgtgggcttccttcacgtattcgcccacatgcagatgaagctgtctcaggattcc agtcaaatcgagctattaaaagaattaatggatcttcagaaggatatggtggtcatgttg ctgtccatgctagaaggtaatgttgtcaatggaaccattggcaaacagatggtcgatatg cttgtggagtcttccaacaacgtggagatgattctcaagttttttgacatgttcttaaaa ctaaaggatttgacctcttctgacacatttaaagaatacgaccctgacggcaagggagtc atttccaagagggacttccataaagcgatggagagccataaacactacacgcaatcagaa accgagtttcttctgtcctgtgcggagacagatgagaacgaaaccctggactatgaagag tttgtcaaaaggtttcacgagcccgcaaaggacatcggcttcaatgtggccgttcttctg accaacctttcggagcacatgcccaatgatacgcgactgcagactttcctggagttggca gagagcgtgctgaattacttccagccttttctgggccgcatcgagatcatgggaagtgcc aagcgcatcgagagggtgtattttgaaatcagtgagtccagccgaacccagtgggagaag ccccaggtcaaggagtccaagaggcagttcatatttgatgtggtcaacgaagggggagaa aaggagaaaatggaactttttgtcaacttctgtgaggacaccatattcgaaatgcagctg gcagcgcagatctcagagtcggatttgaatgagaggtcagcgaataaagaagagagtgag aaggagaagccggaagagcaggggcccagaatgggtttcttttccatcgtgacggtcaag tcggccctgtttgctctcaggtataatatcttgaccctcatgagaatgctcagcctgaag agcctgaagaaacagatgaaaaaagtgaagaagatgacgatgaaggatatggtcacggcc gccttttcgtcctactggagtattttcctgagcctcctgcactttgtggccagcgtttcc agaggcttcttccgcatcatttgcagcctgctgcttggcgggagcctagtagaaggagca aaaaagatccgagtggcagagctcttagccaacatgccagaccccactcaggatgaggtg agaggggatggagaagagggggacaggaggcccatggaggccgccctgccctcggaagat ctgacagacctgaaggaactgacagaggaaagcgaccttctttcggacatatttggcttg gatctgaagagagaaggaggacagtacaaacttattcctcataatccaaacgccggcctc agcgatctaatgagcaacccggtccctatccctgacgtgcaagaaaaatttcaggaacag aaggtgaaagaggaagaaaaggaggagaaagaagaaagcaaatctgaacctgaaaaggcc gagggagaagatggagaaaaagaagaaaaagccaaagaagataagggtaaacagaagttg aggcagctccatacacacagatacggagagccagaagttcccgagtcggcattctggaag aaaatcatcgcatatcaacagaaacttctaaactattttgctcgcaacttttacaacatg agaatgttagccttattcgtcgcgtttgcaatcaatttcatcttgctcttttataaggtc tccacttcttctgtggttgaaggaaaggagccccccactcgcagttcaagtggaaatgcc aaagttagcagcctggacagtggctcgcctagaatcatcgcggttcactacgtcctggag gagagcagcggctacatggagcccacgctgcggatcttagccattcttcacacggtcatt tctttcttctgcatcatcggctactactgcttgaaagtcccattggttatttttaagcga gaaaaggaagtagctcgaaaattggaatttgatgggctttatattacagaacagccttca gaagatgatattaaaggccagtgggatcgactcgtaatcaacacacagtcatttcccaac aactactgggacaaatttgttaaaagaaaggttatggataaatatggggagttctatggc cgggacagaatcagtgagctccttggtatggacaaagccgccctagatttcagcgatgcc cgggaaaagaagaagccaaagaaagacagctccctgtcagccgtactgaactctattgat gtgaagtatcagatgtggaaactaggagtcgtcttcacggacaactctttcctctacctg gcctggtatatgactatgtccgttctgggacactataacaactttttttttgctgctcat cttcttgacattgctatgggattcaagacactgagaaccatcttgtcatcagtaactcac aatggcaagcagcttgtattaactgttggcttgttagctgttgttgtatacctatatact gttgtggcattcaactttttccgaaaattctacaataaaagtgaagatggtgacacaccg gatatgaaatgtgatgatatgctaacgtgctacatgttccacatgtacgtcggggtacgt gctggagggggtatcggcgatgaaatcgaagacccagcaggcgatgaatatgagatctat cgaatcatctttgacatcaccttcttcttcttcgtgattgtcattctcttggccataatt caaggtttaattattgatgcttttggagagctaagagaccaacaggagcaagtcaaagaa gacatggagaccaaatgtttcatctgtgggataggcaacgattacttcgacacagtgcca catggctttgaaacccacactttacaggaacacaacctggccaattacctgttttttctg atgtatctcataaacaaagatgaaacagagcacacgggacaggaatcttatgtctggaag atgtatcaagaaaggtgctgggaattcttcccagcaggggattgtttccggaaacagtat gaagaccagctaaattaa

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