| Entry |
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| Symbol |
HUWE1
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|---|
| Name |
(RefSeq) E3 ubiquitin-protein ligase HUWE1 isoform X1
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| KO |
|
|---|
| Organism |
pyu Puma yagouaroundi (jaguarundi)
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| Pathway |
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| Brite |
KEGG Orthology (KO) [BR:pyu00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
121024799 (HUWE1)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
121024799 (HUWE1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:pyu04121]
121024799 (HUWE1)
Enzymes [BR:pyu01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
121024799 (HUWE1)
Ubiquitin system [BR:pyu04121]
Ubiquitin ligases (E3)
HECT type E3
121024799 (HUWE1)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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|---|
| AA seq |
4426 aa
MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVFISPFAVYSNAL
QESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTA
SYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALL
KVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPF
VIKPKIQRPSTTQEGEEMETDMDVADVTMESSPGLSISMEHRLDVDLRASSSSSSTSISS
GSGPGPRPGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAE
YYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVF
SALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMR
HQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSE
DEEEEEVQAMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDD
HCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQL
DSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVH
TCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQ
ADMQKLVPKDEKAGTTQGGKRSDGEQDGTAASMDASTQGLLEGIGLDGDTLAPMETDEPT
ASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAA
STTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKY
PYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVAEGLEHSDLPDGTGEFLDAWLMLVEK
MVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYGGR
MAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDM
GFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIAMSLGQDIP
MDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFTDTMLPGCF
HLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAALPLTTSDTK
TVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKLLEVVQPCL
QAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNNNNWRWFDDRSGRWC
SYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLRVPRL
NKNSKNSNGQELEKTLEESKEMDIKRKENKPSDTPLALESTNTEKETSLEETKIGEILIQ
GLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLT
QSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREIN
YILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPNAVQLVKTT
PLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEAEKSDPKPGGMTQEVGQLLQDMGDDVY
QQYRSLTRQGSDFDAQSGFSINSQVFAADGTSTETSTSGTSQGEASTPEESRDGKKDKEG
DRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSV
LAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAE
STEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARV
PHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKSKSEQDAQGAAQDSNS
NQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENEL
EDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILD
PEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELD
EDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSL
TLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAAD
ILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTAL
TRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLAEEETKITDKG
KEDKENRDQSAQCTASKTSDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLVTLQPS
QQQTLPPPPALGDIPQELQSPAGEGASSTQLLMPVEPEELGPTRPSGEAETTQMELSPAP
TITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEHPTVGSST
PGDAPPVVTEVQGRGDGSGEPAPPPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLP
STSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSANNSAPAVV
GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDL
RRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPA
FTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLLLDHEALSCL
LVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLSSSE
EKGKKSSKSCGSSSHEHRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGGR
KHTEKHASSGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDRERGS
KQACSPCSSQSTSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEA
SPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSSASSTTVATS
TTSTTTTTAASSTPTPPAATTPVTSAPALVIATAISTIAVAASTTVTTPTTATTTVSTST
TTKASKSPAKVGDGGSSSADFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLLQL
SRGDPATRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPE
EQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQ
VIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQ
QQAATSESSQSEASVRREESPMDVDQPSPGAQDTPSIGSDGTSQGEKEKEERPPELPLLS
EQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQL
AHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQ
ILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFE
DSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDR
VTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMES
EDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH
LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY
HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRD
DRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA |
|---|
| NT seq |
13281 nt +upstreamnt +downstreamnt
atgaaagtagacaggactaaactgaaaaagacacctactgaggctcctgcagactgcaga
gccttaatagacaaactcaaagtttgtaatgatgagcaactactcttggaactgcagcaa
atcaaaacatggaacattggaaagtgtgagttatatcactgggtggatctgttggaccgc
tttgatggaattctggcagatgctggacaaacagtggagaatatgtcatggatgctcgtg
tgtgataggccggagagagaacaactaaaaatgcttctcttggctgtgttgaacttcact
gccttgctcattgagtacagcttttcccggcatctgtacagttccatagagcatttgaca
actttattggcttcctccgatatgcaagtggtgctggcagtccttaatcttctgtatgta
tttagcaagaggtcaaactatatcacacgccttggatctgacaagagaaccccactgcta
acccggctgcaacacttggcagagagctggggtggaaaggagaatggctttggacttgca
gaatgttgcagagacttgcatatgatgaaatacccacccagtgcaactacactacacttt
gaattctatgcagaccctggggccgaggtcaaaatcgagaaaaggacgactagtaacaca
ctacattatattcacatagaacaacttgacaagatttcagaaagcccttctgaaatcatg
gaatctcttaccaaaatgtacagcattcctaaggataaacagatgctgttatttacacac
atacggctggcccatggtttttctaatcacaggaagcgattacaagctgttcaagccagg
ttgcatgctatatctatattagtgtttatttctccttttgcagtgtattccaatgccttg
caggagtctgcaaacagtatcttgtataatgggttgatagaggagttggtagatgtcctt
cagataacagataagcagcttatggagattaaagccgcgtctttacgaacattaacatca
attgtccatttggagagaactcccaaactcagcagtattattgactgtactggaactgcc
tcttaccatggatttttgcctgtacttgtgcggaactgcatccaggccatgattgatcct
tccatggatccataccctcaccagtttgccactgctctcttctcttttttataccatctg
gccagctatgatgcaggtggtgaagccttggtctcctgtggaatgatggaagccttattg
aaggtcataaagtttcttggcgatgaacaggatcagataacgtttgtcaccagagctgtc
agagtggttgacctcatcaccaacctggacatggcagcttttcaatcccatagtggactt
tctatcttcatttatagacttgagcatgaagtagatttgtgccgaaaagaatgtccattt
gtgatcaagccaaagatccagagacctagtactacacaagaaggagaagaaatggaaaca
gatatggatgttgcagatgtgactatggaaagtagtccgggcttatccatctctatggag
caccggctagatgttgacttaagggcatcaagttccagcagcagcactagcatctcctct
ggctctggacctggcccccgtcctggagttcagtgtattccacaaagagcagcacttctc
aaatccatgttaaatttcctcaagaaggccattcaagaccctgctttctcagacggcata
cgacatgtgatggatggttctctccctacctccctgaagcacatcatcagcaatgcagaa
tactatggcccatcactcttcctcctagctactgaagtggtgactgtgtttgtatttcaa
gaaccatcactgctctcctcactccaggacaatggattaacagatgtcatgcttcatgca
ctacttatcaaagatgttcctgctacccgtgaagtccttggctccctcccaaatgtattt
agtgcactctgcttgaatgcccgaggtcttcagtcatttgtacagtgtcagccttttgaa
cgtcttttcaaagttcttctgtctccagattacctcccagccatgcgaaggaggaggagc
tctgatcctcttggggataccgcatctaacctggggagtgctgttgatgagctcatgaga
catcagcccaccctcaaaacagatgcaacaactgcaatcattaagttacttgaagaaatt
tgtaaccttggaagagaccctaaatacatctgtcagaagccatcaatccagaaggcagat
ggcactgccactgctcctcctccaaggtctaatcatgctgcagaagaggcctctagtgag
gatgaggaggaggaagaagtacaggccatgcagagctttaattctgcccaacagaatgaa
actgagcctaatcagcaggttgttggtacagaagaacgtattcctattcccctcatggat
tacatccttaatgtgatgaaatttgtggaatctattctgagcaacaatacaacagatgac
cactgccaggaatttgtgaatcagaaaggactcttgcctttggtcaccattttgggtctt
cccaatctgcccattgattttcctacatctgcggcctgtcaggctgttgcaggtgtctgc
aaatccatattgacactgtcacatgaacccaaagttcttcaggagggtctccttcagttg
gactccatcctttcatccttggagccgttacaccgcccaattgaatcccctgggggctca
gtgttattgcgagaactggcttgtgctggcaatgttgctgatgctaccctctcagctcag
gccacacctctactgcatgcacttactgctgcccacgcctacatcatgatgtttgtacat
acttgcagagttggacagagtgaaattcgttccatctccgtaaaccagtggggttctcag
ttgggtctgagtgttctgagcaagctgagccagttatactgttccctggtgtgggaaagc
actgttcttctctccctgtgtaccccaaacagcctaccatctgggtgtgaatttggccag
gcggacatgcagaaactggttccaaaggatgagaaggcaggtacgacccagggcggaaaa
agatcagatggggaacaggatggaacagctgcaagtatggatgcttctacccagggctta
ttagaaggcattgggcttgatggtgacacattggctcccatggagacagatgaacctact
gcttcagattctaagggcaaatctaaaatcacacctgctatggctgccagaatcaagcaa
atcaagcctttattgtcagcttcctccagattaggccgagcacttgctgaactatttgga
ctccttgttaaactttgcgtggggtctcctgtccgccagagaaggagccatcatgctgcc
agcaccaccacagcaccgacacctgctgctcgatccacagcttcagccctcactaagctc
ctcacaaagggcttatcttggcaacctccaccatatacacctactccccgcttcaggctg
acattcttcatctgttccgttggttttacatctccaatgctgtttgatgagaggaaatat
ccttaccacctcatgctgcagaaatttctctgctctggaggccacaatgctctttttgaa
actttcaactgggctctgtccatgggaggcaaagttcctgttgctgagggattagaacat
tcagatttacctgatggcacaggagaattcctagatgcctggctaatgctagtggagaag
atggtgaatcccaccacggtgcttgaatctccacattcactgcctgccaaattgcctgga
ggtgtccagaactttccacaattcagtgccctccgcttccttgtggtaactcagaaagca
gcctttacttgcatcaagaacctttggaaccggaaacccctgaaggtatatggtgggcga
atggctgagtccatgctggccatcctatgccacattctccgaggagaacctgtgattcga
gagagactaagcaaagagaaggaggggtctcgaggagaagaggacacagggcaagaagaa
ggtggctctcgccgggaacctcaagtcaaccagcagcaactgcaacagctcatggacatg
ggcttcacaagggaacatgccatggaggccctcttgaacaccagcaccatggagcaggcc
acagagtaccttctaacccaccctcccccaatcatgggaggagttgttcgagatctgagt
atgtcggaagaggaccagatgatgagagcaattgccatgtctctaggacaggatatccca
atggatcaaagagcggaatcacctgaggaagttgcttgtcggaaggaggaggaggaacgg
aaagctcgggaaaagcaggaggaggaagaagctaaatgtctagagaagttccaggatgct
gatccattggaacaagatgagctccacactttcacagataccatgttgccaggctgcttt
caccttcttgatgagctgccggacacagtataccgggtgtgtgatctgatcatgaccgca
atcaaacgtaatggagctgactatcgagacatgattctgaagcaagtagtcaatcaggtg
tgggaagctgctgatgtgttgatcaaagctgctcttcccctgacaacaagtgacacaaaa
actgtgtcagagtggatcagtcagatggccaccctgccccaagcctccaatttagctact
agaatcttgcttttaacactgctttttgaggagttgaagctaccttgtgcctgggtcgtt
gaatctagtggcatccttaatgtcctaatcaaactcttggaagtggttcaaccctgccta
caggccgccaaggagcaaaaagaggtccagaccccgaagtggatcacccctgtgttgctc
ctgatagatttctatgagaagacagccatctcttcaaaaaggagagcccaaatgactaag
tatctacagtccaacaacaacaactggcgctggtttgatgaccgctctgggcgttggtgt
agttacagtgcaagcaacaacagcactattgattctgcctggaaatctggagagacgagt
gtgcgtttcactgcaggccgaagaagatacactgtccagttcactacaatggtgcaggtt
aatgaggaaacggggaatcggcgccctgtgatgctgactctcctgagggtaccacggctg
aataaaaactcaaaaaatagcaatggacaggaactagagaagacgctggaagaaagcaaa
gaaatggatatcaaacgtaaagaaaataaacccagtgatactcctttggccctagagagt
acaaatactgaaaaggagacgagcctggaagaaacaaaaattggggagatcctgatccag
ggcctgacagaggatatggtgactgttttaatccgggcctgtgtgagcatgctaggagtc
cctgtagacccagacactttgcatgccacccttcgtctctgcctgaggctcacccgagac
cacaaatacgccatgatgtttgcagagctaaagagtacccgcatgatcttgaatttgacc
cagagttcaggcttcaatgggtttacccccctggtcacccttcttttaagacatatcatt
gaggatccctgcaccctccgtcataccatggaaaaggtggttcgctcagcagctacaagt
ggagctggtagcactacctctggtgttgtatctggcagccttggttctcgggagatcaat
tatatccttcgtgtcctggggccagctgcatgccgcaatccagacattttcactgaagta
gccaactgctgtatccgcattgcccttccagcccctcgaggctcaggaactgcttcagat
gatgaatttgagaatcttagaattaaaggtcctaatgctgtacagctagtgaagacgacc
cctttgaagccctcacctctgcctgtcattcctgataccatcaaggaagtgatctatgat
atgctgaatgccctggctgcataccatgctccagaggaagcagagaaatctgatcctaaa
cctgggggtatgacccaagaggttggccagctcctgcaagacatgggtgatgatgtatac
cagcagtaccggtcacttactcgtcagggcagtgactttgatgcacagtcaggtttttcc
attaatagtcaggtctttgctgcagatggtacctccactgagacttccacatctgggaca
tcccaaggagaagcatcaactccagaagagtctcgtgatgggaagaaagataaagaaggg
gaccgagcctctgaggaaggcaagcagaagggcaagggcagcaaacctttaatgcccacc
tccactattcttcgtcttctggcagagttggtgaggtcctatgttggtatcgctactctg
attgccaactacagctacactgtgggccagtctgagctgattaaagaggactgcagtgtg
ctagcctttgttctggaccacctcctcccacatacccagaatgcagaagacaaggacaca
cctgccctggcccgcctattccttgcaagcctagctgctgcagggagtggcacagatgcc
caggtagcccttgtgaatgaagtaaaagcagctctgggacgggcactggctatggctgag
agtacagagaaacatgccaggcttcaagcagtgatgtgtatcatcagtactatcatggag
tcctgcccctcaacgtccagcttctacagcagtgccacagccaagacccagcacaatggc
atgaacaacattattcgactcttcctgaagaaaggactggttaatgacctggcaagagtg
cctcatagcctggacctgtccagtccaaacatggccaacacagtcaatgctgctttgaag
cctttggaaacactttcccggattgtgaaccagcctagtagcctttttggcagcaagagt
gcttctagcaagagcaagtctgagcaggatgcccaaggagctgctcaggactccaatagc
aaccagcaggacccaggcgagcctggggaagcagaagtgcaggaggaggatcatgatgtc
actcagacagaggtggcagatggggatatcatggatggggaggctgaaaccgactcagtg
gtgattgctgggcagcctgaggtgctcagttcacaagagatgcaggttgagaatgagctg
gaggacctgatagatgagttgcttgagagggatggcggatctgggaacagtacaattata
gtgagcagaagtggagaggatgaatcacaagaggacgtgctgatggatgaagctccttcc
aacctcagccaagcttccaccttgcaggccaaccgagaagattccatgaatatcctggac
cctgaggatgaggaggagcacactcaggaagaggacagcagtggcagtaacgaggatgag
gatgatagtcaggatgaagaggaggaggaggaggaagatgaggaagatgatcaggaggat
gatgaaggtgaagagggagatgaagacgatgacgacgatggctctgaaatggaattggat
gaggattaccctgatatgaacgcttctcccttggtccgatttgagcgctttgaccgggag
gatgatctcatcattgagtttgacaacatgttctccagtgctacagacatccccccatcc
ccaggaaatatccctaccactcacccactgatggtacgccatgcagaccacagttctctg
acgctgggcagtggctcctccacaacacgtctcacccagggcatcgggcgcagtcagaga
accctaaggcagctgacagccaatacaggccacaccattcatgttcattaccctgggaat
cgccagcccaaccctcctcttatactccagaggttgcttggtccttctgctgctgctgac
atccttcagctgagcagcagccttcccctacaaagccgaggccgagcccgcctcctcgtg
ggcaacgatgatgtccacattattgccagatctgatgatgagctgctggatgactttttc
catgaccagagcacagctaccagtcaagcagggactctgtccagcatccccacagcccta
acccgctggacagaggaatgcaaagttcttgatgctgagagcatgcatgactgtgtttca
gttgttaaagtgcccattgtcaatcacctggaattcctgagggatgaggagctggaagaa
aggcgggagaaacggaggaaacagttggctgaggaagaaacaaagataactgacaaaggc
aaagaagataaggagaacagagatcagagtgcacagtgtactgcatctaagaccagtgac
tccaccgaacagaacctctcagatgggactcctatgcctgacagctacccaacaacccca
tcttcaaccgatgcagcaacatctgagtccaaggagacccttgtcactctgcagccctca
caacaacaaacactcccacccccaccagccttgggagacattcctcaagagctgcagtcc
ccagctggtgaaggggcaagctctacacagctattgatgcccgtagagccagaggaacta
ggtcccacaaggccaagtggagaagcagaaacgactcagatggagttgtccccagctccc
actataacctctctttccccagagagagctgaagattctgatgcactgacagctgtcagc
agtcaactggaaggctctcccatggacaccagtagcctggcttcctgtaccctagaggaa
gctgtgggtgacacctcagcagctggcagttctgagcatcccacagtaggcagctccact
cctggggatgccccaccagttgtcacagaagtgcaaggcaggggtgatgggtcaggggaa
cctgccccaccccctgaggacagctctccccctgcatcctctgagagttcttccaccaga
gattctgctgtggccatttctggagcagattcccggggaatcctagaagagccactgcct
tcaacaagcagtgaagaagaagatccccttgcaggtatcagtctacccgaaggtgtggac
ccctctttcctggctgctctgcctgatgacattcgccgggaagtcctgcagaaccagctg
ggcattcgtccaccaactcggactgccccttcagcaaataactcagctcctgcagtggtg
gggaatcctggtgtgactgaagtgagccctgagttcttggccgccctgcctccagctatc
caagaggaagtgctggcgcagcaaagagctgagcaacagcgacgggaactggcacagaat
gctagctcagacacccccatggaccctgtgaccttcatccagaccctaccctcagacctg
cgccgtagtgtcctagaggacatggaggatagcgtgttggctgtgatgccacctgacatt
gcagctgaggctcaagccctgaggcgagaacaagaagcccggcagcgacaactcatgcat
gagcggctctttggccacagtagcacctctgcactctctgccattctccgaagcccggct
ttcaccagtcgcctcagtggcaaccgtggagttcagtacactcgccttgctgtgcagagg
ggcggcacctttcaaatggggggtagcagcagccataacaggccttctggcagtaatgta
gacactctcctccgcctccgaggacgactcctcctggaccacgaagccctatcctgtctc
ctggtcctacttttcgtggatgagccaaagcttaatacaagccgtctacaccgagtactg
agaaatctctgctaccatgcccagactcgccactgggtcatccgcagcctgctgtccatt
ttgcagcgtagcagtgagagtgagctgtgcattgaaacacccaagctctcctcaagtgag
gagaagggcaaaaagtcaagcaagagctgtgggtcaagcagccatgaacaccggcccctg
gacctcctacacaagatggagtctaagagctccaaccagctttcctggctctcagtatct
atggacgcagccctaggctgcaggactaatatattccagattcaacgttcagggggtcgt
aaacataccgagaaacatgcaagcagtggctccactgtccacatccacccccaggctgct
cctgttgtctgcagacatgttctggacacgctcattcagttggccaaggtatttcccagc
cactttacacagcagcggaccaaagaaacaaactgtgagagcgatcgggagaggggcagt
aagcaggcctgcagcccatgctcttcacagtccaccagcagtggcatttgcacagacttc
tgggacttattggtaaaactggacaacatgaatgtcagccggaaaggcaagaactccgtg
aagtcagtgccagtgagcgctggtggtgagggggaaacctccccatacagcctcgaggcc
tctcccctggggcagctcatgaacatgttgtcacacccagtcatccgccggagctctctc
ttaactgagaaactcctcagactcctttctctcatctcaattgctctcccagaaaacaaa
gtatcggaagcacaggctaattctggcagcagtgcttcctccaccactgttgccacctca
accacatctaccaccactaccactgccgcctccagcacgcccactccccctgctgcaacc
acccctgtcacttctgctccagctctggttattgccaccgctatatccaccattgccgta
gctgcttcgaccacggtgactacccccacgactgctaccactactgtttcaacttctaca
actactaaggccagcaaatctccagcaaaggtgggtgatgggggcagcagcagtgcagac
tttaagatggtatcctctggcctcacggaaaaccagctacagctctctgtggaggtgttg
acatcacactcttgttctgaagaaggtctggaagatgcagcaaatgtgttactacagctc
tctcggggggaccctgcaacccgggacactgttctcaagctgctactgaatggagctcgc
catctgggctatactctttgtaaacagataggtacccttctggctgagttacgggaatat
aacctagaacagcaacggcgagcccagtgtgagaccctctctcctgatggcctacctgag
gagcagccacagaccaccaagctgaaaggcaaaatgcaaagcaggtttgacatggctgag
aatgtggtaattgtggcatctcagaagcgacctctgggtggccgggagctccagctgcct
tctatgtccatgttgacatccaagacatctacccagaagttcttcttgagggtactgcag
gtcatcatccagctccgggacgacacacgccgagctaacaagaaagccaagcagacaggc
aggctaggttcctccggtttaggctcagctagcagcatccaggcagctgttcggcagctg
gaggctgaggctgatgccattatacaaatggtacgtgagggtcaaagggcgcggagacag
caacaagcagcaacgtcggagtcaagccagtcagaggcctctgtccggagggaggagtca
cccatggatgtggaccagccatctcccggtgctcaggatactccgtccatcggctcagat
ggaacctcacaaggggagaaggagaaggaggagaggccacctgagttacccctgctcagt
gagcagctgagcttggacgagctatgggacatgctgggagagtgtctaaaggaactggag
gaatcccatgaccagcatgcggtgctagtgctacagccagccgtcgaggccttcttcctg
gtccatgccacagagcgagagagcaagcctcctgtccgagacacccgtgagagccagctg
gcacacatcaaggacgagcctcctccactctcccctgcccccttaaccccagccactcct
tcctcccttgacccattcttctccagggagccctcgtctatgcacatctcctcaagcctg
ccccctgacacgcagaagttccttcgctttgcagagactcaccgcactgtgttaaaccag
atcctacggcagtccaccacccacctcgctgatggaccttttgctgtcctggtagactac
attcgtgtcctcgactttgatgtcaagcgcaaatatttccgccaagagctagaacgtttg
gatgaggggcttcggaaagaagacatggctgtgcacgtccgccgtgatcatgtgtttgaa
gattcctatcgtgaactgcaccggaaatcccctgaagaaatgaagaatcgattgtatata
gtgtttgaaggagaagaagggcaggatgctggagggctcctacgggagtggtatatgatc
atctctcgggagatgtttaatcctatgtatgccttgttccgtacctcacccggtgaccgg
gtcacctacaccatcaacccatcttcccactgcaaccccaaccacctcagctacttcaag
tttgttggacgcattgtggccaaagctgtatatgacaaccgcctcctggagtgctatttt
actcggtccttctacaaacacatcttgggcaagtctgtcagatatactgatatggagagt
gaagattaccacttctaccagggcctggtttatctgctggaaaatgatgtctccacacta
ggttatgacctcaccttcagcactgaggtccaagagtttggagtctgtgaagttcgtgac
ctcaaacctaatggggccaacatcttggtaacagaagagaataagaaggagtatgtacac
ctggtgtgccagatgagaatgacaggagccatccgtaaacagctggcagctttcttagaa
ggcttctatgagatcattccaaagcgcctcatttctatcttcactgagcaggagttagag
ctactcatatcaggactgcccacaattgacattgatgatttgaaatccaacactgaatac
cacaagtaccagtccaactctattcagatccagtggttctggagagcattgcgttctttc
gaccaagctgaccgtgccaagttcctccagtttgtcacgggtacttccaaagtgcccttg
caaggctttgctgcccttgaaggtatgaatggcattcagaagtttcagatccatcgagat
gacaggtccacagatcgcctgccttcagctcacacatgttttaatcagctggacctgcct
gcctatgagagctttgagaagctccgccacatgctactattggccatccaggagtgctct
gaaggctttgggctggcctaa |
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