KEGG   Herpailurus yagouaroundi (jaguarundi): 121026094
Entry
121026094         CDS       T07555                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pyu  Herpailurus yagouaroundi (jaguarundi)
Pathway
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04068  FoxO signaling pathway
pyu04270  Vascular smooth muscle contraction
pyu04650  Natural killer cell mediated cytotoxicity
pyu04720  Long-term potentiation
pyu04726  Serotonergic synapse
pyu04730  Long-term depression
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04928  Parathyroid hormone synthesis, secretion and action
pyu05010  Alzheimer disease
pyu05022  Pathways of neurodegeneration - multiple diseases
pyu05034  Alcoholism
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05200  Pathways in cancer
pyu05205  Proteoglycans in cancer
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05212  Pancreatic cancer
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05218  Melanoma
pyu05219  Bladder cancer
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121026094 (ARAF)
   04012 ErbB signaling pathway
    121026094 (ARAF)
   04068 FoxO signaling pathway
    121026094 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121026094 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    121026094 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121026094 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    121026094 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    121026094 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    121026094 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    121026094 (ARAF)
   04720 Long-term potentiation
    121026094 (ARAF)
   04730 Long-term depression
    121026094 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121026094 (ARAF)
   05205 Proteoglycans in cancer
    121026094 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    121026094 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121026094 (ARAF)
   05212 Pancreatic cancer
    121026094 (ARAF)
   05225 Hepatocellular carcinoma
    121026094 (ARAF)
   05226 Gastric cancer
    121026094 (ARAF)
   05214 Glioma
    121026094 (ARAF)
   05221 Acute myeloid leukemia
    121026094 (ARAF)
   05220 Chronic myeloid leukemia
    121026094 (ARAF)
   05218 Melanoma
    121026094 (ARAF)
   05211 Renal cell carcinoma
    121026094 (ARAF)
   05219 Bladder cancer
    121026094 (ARAF)
   05215 Prostate cancer
    121026094 (ARAF)
   05213 Endometrial cancer
    121026094 (ARAF)
   05224 Breast cancer
    121026094 (ARAF)
   05223 Non-small cell lung cancer
    121026094 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    121026094 (ARAF)
   05160 Hepatitis C
    121026094 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121026094 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    121026094 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    121026094 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121026094 (ARAF)
   01522 Endocrine resistance
    121026094 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pyu01001]
    121026094 (ARAF)
Enzymes [BR:pyu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     121026094 (ARAF)
Protein kinases [BR:pyu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   121026094 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal Kdo TUG-UBL1 UPF0767
Other DBs
NCBI-GeneID: 121026094
NCBI-ProteinID: XP_040324851
LinkDB
Position
Unknown
AA seq 608 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQVYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSRTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLLQLTAQSFS
TDAAGSRGGGDGAPRGSPSPSVPSGRKSPHSKSPSEQREQRERKSLADDKKKVKNLGYRD
SGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVL
RKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMD
YLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVI
RMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQVIFMVGRGYLSPDLSKISSNC
PKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACL
LSAARLVP
NT seq 1827 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtcttaatcaggattgctgtgtg
gtctaccggctgattgaggggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggagaggagctcatcgtagaggtccttgaagatgtgccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcactgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacaggtctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcccgcacccagcaccgagaccctgagcactttcccttcccc
gcccctgccaacgccccactccagcgcatccgctccacatccactcccaacgtgcacatg
gtcagcaccacggcccccatggactccagcctcctccagctcactgcccagagtttcagc
accgatgctgctggtagtagaggcggtggcgacggagccccccgggggagccccagcccc
agcgtgccctcggggaggaagtccccacattccaaatccccgtcggagcagcgtgagcag
cgggagcggaagtccttggctgatgacaagaagaaagtgaagaatctggggtaccgggac
tcgggctattactgggaggtgccgcccagcgaggtgcagctgctgaagaggatcgggacg
ggctcgtttggcaccgtgtttcgcgggcggtggcatggcgacgtggccgtgaaggtgctc
aaggtggctcaacccacagcggagcaggcgcaggccttcaagaacgagatgcaggtgctc
aggaagacacgtcatgtcaacatcttgctattcatgggcttcatgacccggccgggattt
gccatcatcacacagtggtgtgagggctccagcctgtaccaccacctacatgtggccgac
acgcgcttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggac
tacctccatgccaagaacattatccaccgagatctcaagtctaacaacatcttcctacac
gaggggctcacagtgaagattggtgactttggcctggccacggtgaagacacggtggagc
ggagcccagcccttggaacagccctcgggctctgtgctatggatggcggctgaggtgatc
cgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcctacggggttgtg
ctctatgagctcatgaccggctctctgccttacagccacattggcagccgtgaccaggtt
atcttcatggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgc
cccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgagaggaacgtccc
ctcttcccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgag
cggagtgcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctc
ctcagcgcggcccgccttgtgccttag

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