KEGG   Puma yagouaroundi (jaguarundi): 121028241
Entry
121028241         CDS       T07555                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pyu  Puma yagouaroundi (jaguarundi)
Pathway
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04015  Rap1 signaling pathway
pyu04024  cAMP signaling pathway
pyu04062  Chemokine signaling pathway
pyu04068  FoxO signaling pathway
pyu04150  mTOR signaling pathway
pyu04270  Vascular smooth muscle contraction
pyu04510  Focal adhesion
pyu04650  Natural killer cell mediated cytotoxicity
pyu04720  Long-term potentiation
pyu04722  Neurotrophin signaling pathway
pyu04726  Serotonergic synapse
pyu04730  Long-term depression
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04928  Parathyroid hormone synthesis, secretion and action
pyu04934  Cushing syndrome
pyu05010  Alzheimer disease
pyu05022  Pathways of neurodegeneration - multiple diseases
pyu05034  Alcoholism
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05200  Pathways in cancer
pyu05205  Proteoglycans in cancer
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05212  Pancreatic cancer
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05216  Thyroid cancer
pyu05218  Melanoma
pyu05219  Bladder cancer
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    121028241 (BRAF)
   04068 FoxO signaling pathway
    121028241 (BRAF)
   04024 cAMP signaling pathway
    121028241 (BRAF)
   04150 mTOR signaling pathway
    121028241 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    121028241 (BRAF)
   04062 Chemokine signaling pathway
    121028241 (BRAF)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    121028241 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    121028241 (BRAF)
   04720 Long-term potentiation
    121028241 (BRAF)
   04730 Long-term depression
    121028241 (BRAF)
   04722 Neurotrophin signaling pathway
    121028241 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121028241 (BRAF)
   05205 Proteoglycans in cancer
    121028241 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    121028241 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121028241 (BRAF)
   05212 Pancreatic cancer
    121028241 (BRAF)
   05225 Hepatocellular carcinoma
    121028241 (BRAF)
   05226 Gastric cancer
    121028241 (BRAF)
   05214 Glioma
    121028241 (BRAF)
   05216 Thyroid cancer
    121028241 (BRAF)
   05221 Acute myeloid leukemia
    121028241 (BRAF)
   05220 Chronic myeloid leukemia
    121028241 (BRAF)
   05218 Melanoma
    121028241 (BRAF)
   05211 Renal cell carcinoma
    121028241 (BRAF)
   05219 Bladder cancer
    121028241 (BRAF)
   05215 Prostate cancer
    121028241 (BRAF)
   05213 Endometrial cancer
    121028241 (BRAF)
   05224 Breast cancer
    121028241 (BRAF)
   05223 Non-small cell lung cancer
    121028241 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    121028241 (BRAF)
   05160 Hepatitis C
    121028241 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121028241 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    121028241 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    121028241 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    121028241 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121028241 (BRAF)
   01522 Endocrine resistance
    121028241 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pyu01001]
    121028241 (BRAF)
Enzymes [BR:pyu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     121028241 (BRAF)
Protein kinases [BR:pyu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   121028241 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 121028241
NCBI-ProteinID: XP_040327713
LinkDB
Position
Unknown
AA seq 781 aa
MAALSGGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEA
LLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSS
SSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKK
ALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFF
TLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQE
EASIAETALTSGSSPSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRS
SSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQ
RERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHI
IETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR
WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQERSRRKYRLFNSGY
PWKILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAF
K
NT seq 2346 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggcggcggcggcggcggtggcgcggagcagggccaggctctgttc
aacggggacatggagcccgaagccggcgccgcggcctcttcggctgcggaccctgccatt
cccgaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcc
ctattggacaaatttggtggggagcataatccaccatcaatatatctagaggcctatgaa
gaatacaccagcaagctagatgccctccaacagagagaacaacagttattggaatccctg
gggaatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcc
tcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaaccccacagat
gtgtcacggagcaatcccaagtcaccacagaaacctatcgttagagtcttcctgcctaat
aaacagaggacagtggtacctgcaagatgtggagttacagtccgggacagtctaaagaaa
gctctgatgatgagaggtctaatccctgagtgctgtgctgtttacagaattcaggatgga
gagaagaaaccaattggctgggacactgatatctcctggctcaccggagaggaattgcat
gtagaagtgttggaaaatgttccacttacaactcacaactttgtacggaaaacgtttttc
accttagcattttgtgacttttgtcgaaagctgcttttccaaggttttcgctgtcaaacg
tgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattat
gaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggag
gaggcctccatagcagagactgccctaacgtctggatcgtccccttctgcgcccccctcc
gattctactgggccccaaattctcaccagtccgtctccttcaaaatccattccaattcca
cagcctttccgaccagcagatgaagatcatcgaaatcaatttggacagcgagaccggtcc
tcatcagctccaaatgtgcatataaatacaatagaacctgtcaatattgatgacttgatt
agagaccaggggtttcgtagtgatggaggatcaaccacaggcttgtctgccaccccccct
gcctcattgccgggctctctcactaatgtaaaagcattacagaaatctccagggcctcag
cgggaaaggaaatcttcttcatcctcagaagataggaatcgaatgaaaacacttggtaga
agggattcaagtgatgattgggagattcctgatgggcagatcacagtgggacagagaatt
ggatccgggtcatttgggacagtctacaagggaaagtggcatggtgatgtggcagtgaaa
atgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtagga
gtactcaggaaaactcggcatgtgaacatcctgctcttcatgggctattcaacaaagccc
cagctggctattgtcacccagtggtgtgagggctccagcttataccaccatctccacatc
atcgagaccaaattcgagatgatcaagctgatagatattgctcggcagactgcgcagggc
atggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatattttt
cttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcga
tggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaa
gtaattcgaatgcaagataaaaacccatatagctttcagtcagatgtatatgcatttggg
attgttctatatgaattgatgactggacagttaccttattcaaacatcaacaacagggac
cagataatttttatggtgggacgaggatatctttctccagatctcagtaaggtacgaagt
aactgtccgaaagccatgaagagattgatggcagagtgcctaaaaaagaaaagagatgag
aggccactgtttccccaagaaaggtccagaagaaagtatagactctttaacagtggttac
ccctggaagattcttgcctctattgagctgctggcccgctcattgccaaaaattcaccgc
agtgcatcagaaccctccttgaatcgggctggcttccagacagaggattttagtctctat
gcttgtgcttctccaaaaacacccatccaggcagggggatatggagaatttgcagccttc
aagtag

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