KEGG   Herpailurus yagouaroundi (jaguarundi): 121031737
Entry
121031737         CDS       T07555                                 
Symbol
SOS2
Name
(RefSeq) son of sevenless homolog 2 isoform X1
  KO
K03099  son of sevenless
Organism
pyu  Herpailurus yagouaroundi (jaguarundi)
Pathway
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04014  Ras signaling pathway
pyu04062  Chemokine signaling pathway
pyu04068  FoxO signaling pathway
pyu04072  Phospholipase D signaling pathway
pyu04150  mTOR signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04510  Focal adhesion
pyu04540  Gap junction
pyu04630  JAK-STAT signaling pathway
pyu04650  Natural killer cell mediated cytotoxicity
pyu04660  T cell receptor signaling pathway
pyu04662  B cell receptor signaling pathway
pyu04664  Fc epsilon RI signaling pathway
pyu04714  Thermogenesis
pyu04722  Neurotrophin signaling pathway
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04912  GnRH signaling pathway
pyu04915  Estrogen signaling pathway
pyu04917  Prolactin signaling pathway
pyu04926  Relaxin signaling pathway
pyu04935  Growth hormone synthesis, secretion and action
pyu05034  Alcoholism
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05163  Human cytomegalovirus infection
pyu05165  Human papillomavirus infection
pyu05200  Pathways in cancer
pyu05205  Proteoglycans in cancer
pyu05206  MicroRNAs in cancer
pyu05207  Chemical carcinogenesis - receptor activation
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
pyu05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121031737 (SOS2)
   04012 ErbB signaling pathway
    121031737 (SOS2)
   04014 Ras signaling pathway
    121031737 (SOS2)
   04630 JAK-STAT signaling pathway
    121031737 (SOS2)
   04068 FoxO signaling pathway
    121031737 (SOS2)
   04072 Phospholipase D signaling pathway
    121031737 (SOS2)
   04151 PI3K-Akt signaling pathway
    121031737 (SOS2)
   04150 mTOR signaling pathway
    121031737 (SOS2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121031737 (SOS2)
   04540 Gap junction
    121031737 (SOS2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121031737 (SOS2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    121031737 (SOS2)
   04660 T cell receptor signaling pathway
    121031737 (SOS2)
   04662 B cell receptor signaling pathway
    121031737 (SOS2)
   04664 Fc epsilon RI signaling pathway
    121031737 (SOS2)
   04062 Chemokine signaling pathway
    121031737 (SOS2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121031737 (SOS2)
   04912 GnRH signaling pathway
    121031737 (SOS2)
   04915 Estrogen signaling pathway
    121031737 (SOS2)
   04917 Prolactin signaling pathway
    121031737 (SOS2)
   04926 Relaxin signaling pathway
    121031737 (SOS2)
   04935 Growth hormone synthesis, secretion and action
    121031737 (SOS2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    121031737 (SOS2)
  09159 Environmental adaptation
   04714 Thermogenesis
    121031737 (SOS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121031737 (SOS2)
   05206 MicroRNAs in cancer
    121031737 (SOS2)
   05205 Proteoglycans in cancer
    121031737 (SOS2)
   05207 Chemical carcinogenesis - receptor activation
    121031737 (SOS2)
   05208 Chemical carcinogenesis - reactive oxygen species
    121031737 (SOS2)
   05231 Choline metabolism in cancer
    121031737 (SOS2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121031737 (SOS2)
   05225 Hepatocellular carcinoma
    121031737 (SOS2)
   05226 Gastric cancer
    121031737 (SOS2)
   05214 Glioma
    121031737 (SOS2)
   05221 Acute myeloid leukemia
    121031737 (SOS2)
   05220 Chronic myeloid leukemia
    121031737 (SOS2)
   05211 Renal cell carcinoma
    121031737 (SOS2)
   05215 Prostate cancer
    121031737 (SOS2)
   05213 Endometrial cancer
    121031737 (SOS2)
   05224 Breast cancer
    121031737 (SOS2)
   05223 Non-small cell lung cancer
    121031737 (SOS2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    121031737 (SOS2)
   05160 Hepatitis C
    121031737 (SOS2)
   05163 Human cytomegalovirus infection
    121031737 (SOS2)
   05165 Human papillomavirus infection
    121031737 (SOS2)
  09165 Substance dependence
   05034 Alcoholism
    121031737 (SOS2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121031737 (SOS2)
   01522 Endocrine resistance
    121031737 (SOS2)
SSDB
Motif
Pfam: RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH PH_19 PH_10 IQ_SEC7_PH PH_13
Other DBs
NCBI-GeneID: 121031737
NCBI-ProteinID: XP_040333012
LinkDB
Position
Unknown
AA seq 1332 aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
ERIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPICPFYNRHLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCECKHAFEIVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA
VEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPYKISFSRIAETDLESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLN
EEPLIPPPLPPRKKFDHDASNSKGNTKSDDDPPAIPPRQPPPPKVKPRVPAPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDPEWLRDISTCPNSPN
TPPSTPSPRVPRRCYALSSSHNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPSY
RLPLLENAETPQ
NT seq 3999 nt   +upstreamnt  +downstreamnt
atgcagcaggcgccgcagccgtacgagttcttcagcgaagagaacagtccgaaatggcgg
ggactgctggtctcggccctgcggaaggttcaggagcaagtacatcccaatctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaattatgc
atggctcagccaaggactgttcaagatgtggaggaacgtgttcagaagacctttcctcat
ccaattgacaagtgggctattgctgatgcacaatctgccatagaaaaacgaaaacgaaga
aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaggttttagggtac
aaagtggactatcatgtatccctgtatattgtggctgtactagagtatatctcagctgat
attttgaagttggctggtaattatgtttttaatatccgacattatgaaatatctcagcag
gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac
ataggtttggtttctctctgtgaagatgaaccgagttcttcaggtgaattaaactactat
gaccttgtcagaactgaaattgcagaagaaaggcagtatctacgggaattaaatatgatt
ataaaagtgtttcgagaagctttcctttctgacaggaagctatttaaaccttctgatatt
gaaaggattttcagtaacatttcagatatacatgaattgaccgtgaaacttctaggtctt
attgaagacacagttgaaatgactgatgaaagcagccctcatccattagctggcagctgt
tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggatatt
ctgtctccaaaatttaatgaacatttcagtaagttgatggccagacctgcagtggctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt
atgctggtgcctgtatatcattgttggcactattttgaattattaaagcaattgaaagca
tgtagtgaagagcaggaagacagagaatgtttgaaccaagctattactgctcttatgaat
ctccaaggtagtatggaccgaatttacaagcagtattcacctagacgccgacctggggat
cctatttgccctttttataatcgtcacttaagaagcaagcatctggctattaaaaaaatg
aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat
gaattcattatggaaggtccattgacacgaattggtgctaaacatgaacggcatattttt
ctctttgatggcttaatgattagctgtaagcccaatcatagccagtcacgccttccaggt
tacagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatatgt
gataaagaagatacctgtgagtgtaaacatgcttttgaaatagtatccaaagatgaaaac
agcataatatttgctgctaagtctgctgaagagaaaaataattggatggccgcacttatt
tctcttcactatcgtagtacactagatcgaatgctagattcagtgttattgaaagaagaa
aatgagcagccattgagattaccaagtcctgaagtgtatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaattcccatcattaaa
ggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgtccgtacttttcttactacataccgttcattttgtaaaccacaggaattactaagc
ttactgattgaacgatttgaaattccagagccggaacctactgaagcagataaattggca
gtagagaaaggcgaacagccaatcagtgcagaccttaaaaggtttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaacatcatttttat
gactttgaaagagatttggagttgcttgagagactagaatccttcatttcaagtgtaaga
gggaaagctatgaagaagtgggtagagtcaattgctaagatcatcaagaggaagaaacaa
gctcaggcaaatggaataagccataatattacctttgagagtccacctccaccaattgaa
tggcatattagcagaccaggacagtttgaaacatttgatcttatgacacttcatccaata
gaaattgcacgtcagctgacacttttggaatctgatctctacaggaaagtccagccttct
gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacaaatctcaccctctggtttgaaaagtgcattgtggaagca
gaaaattttgaggaacgggtggcagtgctaagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatagtcagtgcagtaaattcagtgtca
gtgtacagactagaccatacttttgaggcattgcaggaaagaaaaaggagaattttggat
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaaaactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcaaccttactgtttacgg
atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggaagtgcttctgaa
aaggagtttacagattatttgttcaataagtcactagaaattgaaccccgaaactgcaaa
cagccacctcgatttcctaggaaatcaactttctctttaaaatctcctggaataaggcct
aatacaggccgacatggctctacctcaggcactttacgaggtcatccaacaccattagaa
agagaaccatataagataagctttagtcggattgctgaaactgatcttgaatcaactgtg
tcagcaccaacctctccaaatacgccatctactccaccggtatctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggcagcaatagcatctttgctcca
gtcctcttgccacattcaaagtctttcttcagttcatgtggtagtttacataaactaaat
gaagagccactgattcctcctccacttcctcctcgaaaaaagtttgatcatgatgcttca
aattccaagggaaatacgaaatctgatgatgacccccctgctattccaccaagacaacct
cctcctccaaaggtaaaacccagagttcctgctcctactggtgcatttgacgggcctctg
catagtccacctccaccaccgccgagagatcctcttcctgatacccctccaccagttccc
cttcggcctccagaacactttataaactgtccatttaatcttcagccacctccactagga
catcttcacagagatccagagtggctcagagacattagtacctgtccaaattcaccaaat
actcctcctagcacaccctctccaagagtaccacgtcgatgctatgcgctcagttccagt
cacaataaccttgctcatcctcaagctccccctgttccaccaaggcagaattcaagccct
cacctaccaaaactgccaccaaagacttataaacgggagctttcacaccccccatcgtac
agactgcctttgctagaaaatgcagaaactcctcaatga

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