| Entry |
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| Symbol |
TOP2B
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| Name |
(RefSeq) DNA topoisomerase 2-beta isoform X1
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| KO |
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| Organism |
pyu Puma yagouaroundi (jaguarundi)
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| Pathway |
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| Brite |
KEGG Orthology (KO) [BR:pyu00001]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
121033580 (TOP2B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:pyu03032]
121033580 (TOP2B)
03036 Chromosome and associated proteins [BR:pyu03036]
121033580 (TOP2B)
Enzymes [BR:pyu01000]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
121033580 (TOP2B)
DNA replication proteins [BR:pyu03032]
Eukaryotic type
DNA Topoisomerases
121033580 (TOP2B)
Chromosome and associated proteins [BR:pyu03036]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
121033580 (TOP2B)
Centrosome formation proteins
Centriole proteins
121033580 (TOP2B)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
1621 aa
MAKAGGGGGAGAGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLE
HILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKN
MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGG
RNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQP
DLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDE
TGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVV
KKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKA
ASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTE
GDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKS
YDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKAS
KNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYA
GPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINK
ELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGE
QALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLSRLLFPAV
DDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLD
GLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLE
PMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMV
LFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQG
KITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEETQNQHDDSSSDSGTPSGPD
FNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQ
EREDILAGMAGKAIKGKVGKPKVKKLQLEETMPSPYGRRIVPEITAMKADASKKLLKRKK
GDLDTTAVKVEFDEEFSGTPVEGTGEEALIPSAPVNKGPKPKREKKEPGTRVRKTPTSSG
KSTAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDA
DDDEDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSSHDKKGQD
FGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDT
TAKPKRTPKQKKVETINSDSDSEFGIPKKSTPPKGKGRGAKKRKASGSENEGDYNPGRKT
SKTPSKKMKKTSFDQDSDVDIFPSDFTSEAPSLPRSGRARKEVKYFAESDDEEDVDFAMF
N |
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| NT seq |
4866 nt +upstreamnt +downstreamnt
atggccaaggcgggcggcggcggcggcgcgggagccggcggcaacggggcactgacctgg
gtgactctttttgatcagaacaatgctgcaaaaaaagaagagtcagaaactgcaaacaaa
aatgattcttcaaagaagttgtctgttgagagagtgtatcagaaaaagacacaacttgaa
catattctccttcgtcctgatacgtatattgggtcagtggagccgttgacacagctaatg
tgggtatatgatgaagatgtaggaatgaattgcagagaggttacctttgtgccaggttta
tacaagatctttgatgaaattttggttaatgcagctgacaataaacagagggataagaat
atgacctgtattaaagtttctattgatcctgaatctaacattataagcatttggaataat
gggaaaggcattccagtagtagaacacaaagtagagaaagtttatgttcctgcattaatt
tttggacagcttttaacatccagtaactatgatgatgatgagaaaaaagtaacaggtggt
cgcaatggttatggtgcaaaactttgtaatattttcagtacaaagtttacagtagagact
gcttgcaaagaatacaagcatagttttaagcagacatggatgaataacatgatgaaaact
tctgaagccaaaattaaacattttgatggtgaagattatacatgcataacattccaacca
gatctgtctaaatttaagatggaaaaacttgacaaggatattgtggccctcatgaccaga
agagcttatgatttggctggttcatgcaaaggggtcaaggtcatgtttaatggaaagaaa
ttgcctgtaaatgggtttcgcagttatgtagatctttatgtgaaagacaaattggacgaa
actggagtggccctgaaagttattcatgaacttgcaaatgaaagatgggatgtttgtctc
acactgagtgaaaagggattccagcaaatcagctttgtaaatagtattgcgacaacaaaa
ggtggacgtcatgtggattacgtagtagatcaagttgttggtaaactgattgaagtagtt
aagaaaaagaacaaagctggggtatcagtaaaaccatttcaagtaaaaaaccatatatgg
gtttttattaattgccttatcgaaaatccaacttttgattctcagacgaaagaaaacatg
actctgcagcccaaaagttttgggtccaaatgccaactgtcagaaaaattttttaaagca
gcctctaactgtggcattgtagaaagtattctgaactgggtgaaatttaaggctcagact
cagctgaacaagaagtgttcatcagtaaagtatagtaaaatcaaaggtattcccaagctg
gatgatgctaatgatgctggtggcaaacattccctggagtgtacattgatactaacagag
ggagactctgctaagtcgctggctgtgtctggattaggtgtgatcgggcgagacagatac
ggagtctttccacttaggggaaaaattcttaacgtccgagaagcttcccataaacagatc
atggaaaatgcagaaataaacaatattatcaaaatagttggtctacaatacaagaaaagt
tacgatgatgcagaatctctgaaaactttacgctatgggaagattatgattatgactgat
caggatcaagatggttctcacataaaaggcctgcttattaatttcatccatcacaattgg
ccatcacttttgaagcatggttttcttgaagagttcattactcctattgtaaaggctagc
aaaaataagcaggaactttccttctatagtattcctgaatttgacgagtggaaaaaacat
atagaaaaccagaaagcctggaaaataaagtactacaaaggtttgggtaccagtacagct
aaagaagcaaaggaatattttgctgatatggaaaggcaccgcatcttgtttagatatgct
ggccctgaagatgatgctgccattactttggcattcagtaagaagaagattgatgacaga
aaagaatggttaacaaattttatggaagatcggagacagcgtaggttacatggcttacca
gagcaatttttgtatggtacagcaacaaagcatttgacttacaatgatttcatcaacaaa
gaattgattctcttctcaaactcagacaatgaaagatctataccatctcttgttgatggc
tttaaaccaggccaacgtaaagttttatttacctgtttcaagaggaatgataaacgtgaa
gtaaaagttgcccagttggctggatctgttgctgagatgtctgcttatcatcatggagag
caagcattgatgatgactattgtgaatttggctcagaactttgtgggaagtaacaacatt
aacttgcttcagccaattggtcagtttggaactcggcttcatggtggcaaagatgctgca
agccctcgttatattttcacaatgttaagctctttatcaagactgctttttcctgctgtg
gatgacaacctgcttaaattcctttatgatgataatcaacgtgtagagcctgagtggtat
attcctataattcccatggttttaataaatggtgctgagggcattggcactggatgggct
tgtaaactacccaactatgatgctagggaaattgtgaacaacgtcagacgaatgctagat
ggcttggatcctcatcctatgcttccaaactacaaaaactttaaaggaacgatccaagag
cttggtcaaaaccaatatgcagtcagtggtgaaatatttgtggtggatagaaacacagta
gagattacagagcttccagttagaacttggacacaggtatacaaagaacaggttttggaa
cctatgctaaatggaacagataaaacaccagcattaatttctgattataaagaatatcat
actgatacaactgtgaaatttgtggtgaaaatgactgaagagaagctagcacaagcagaa
gctgctggattacataaagtttttaaacttcaaactactcttacttgtaattccatggta
ctctttgatcatatgggatgtctcaagaaatatgaaactgtgcaagacattttgaaagaa
ttctttgatttacgattaagttattacggtttacgtaaggagtggcttgtaggaatgttg
ggagcagaatctacaaagcttaacaatcaagcccgtttcattttagagaagatacaggga
aaaattaccatagagaataggtcaaagaaagatttgattcaaatgttagtccagagaggt
tatgaatctgacccagtgaaagcctggaaagaagcacaagaaaaggcagcagaagaggaa
gaaacacaaaaccagcatgatgatagttcctctgactcaggaactccttcaggccccgat
tttaattatattttaaatatgtctctgtggtctcttactaaagaaaaagttgaagaactg
attaaacagagagatgcaaaagggcgagaggtcaatgatcttaaaagaaaatctccttca
gatctttggaaagaagatttagcagcatttgttgaggaactggataaagtggaggcgcaa
gaacgagaagatattctggctggaatggctgggaaagcaataaaaggtaaagttggcaaa
cctaaggtgaagaaacttcagttggaagagacaatgccttccccttatgggagaagaata
gttcctgaaattactgctatgaaggcagatgccagcaaaaagttgttgaagaggaaaaag
ggtgatctcgataccacagcagtaaaagtagaatttgatgaagaattcagtggaacacca
gtagagggtacaggagaagaggcattgatcccgtcagctcctgtaaataaaggtcccaaa
cccaaaagggagaaaaaggagcctggtaccagggtgagaaaaacacctacatcatctggt
aaatccactgcaaagaaagtgaagaaacggaatccttggtcagatgatgaatccaagtca
gaaagtgacttggaagaaacagagcctgtggttattcccagagattctttgcttaggaga
gcagctgctgaaaggcctaagtacacgtttgacttctcagaagaggaggatgatgatgct
gatgatgatgaggacaataatgatttagaggaattgaaagtgaaagcatctcccataaca
aatgatggggaagatgaatttgttccttcagatggcctagataaagatgaatatacattt
tcacctggcaaatcaaaagctactccagaaaaatcttcacatgacaaaaaaggtcaagat
tttgggaatctcttctcatttccttcatactctcagaagtcagaagatgattcagctaaa
tttgacagtaatgaagaagattctgcctctgttttttcaccatcgtttggtctgaaacaa
acagataaagttccaagtaaaacagtagctgctaaaaagggaaaaccatcttcagataca
actgctaagcccaagagaacccctaaacagaagaaagtagagactataaactctgactca
gattcagaattcggcattccaaagaagagtacacccccaaaaggtaaaggccgaggagca
aagaaaaggaaagcatctggctctgaaaatgaaggtgattataaccctggcaggaaaaca
tccaaaacaccaagcaagaaaatgaagaaaacctcttttgatcaggattcagatgtggac
atcttcccatcagatttcacttctgaagcaccttctctgccacggagcggtcgggctagg
aaagaagtaaaatattttgcagagtccgatgatgaagaagatgttgattttgcaatgttt
aattaa |
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