KEGG   Herpailurus yagouaroundi (jaguarundi): 121034018
Entry
121034018         CDS       T07555                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pyu  Herpailurus yagouaroundi (jaguarundi)
Pathway
pyu00562  Inositol phosphate metabolism
pyu01100  Metabolic pathways
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu01524  Platinum drug resistance
pyu04012  ErbB signaling pathway
pyu04014  Ras signaling pathway
pyu04015  Rap1 signaling pathway
pyu04024  cAMP signaling pathway
pyu04062  Chemokine signaling pathway
pyu04066  HIF-1 signaling pathway
pyu04068  FoxO signaling pathway
pyu04070  Phosphatidylinositol signaling system
pyu04071  Sphingolipid signaling pathway
pyu04072  Phospholipase D signaling pathway
pyu04081  Hormone signaling
pyu04140  Autophagy - animal
pyu04145  Phagocytosis
pyu04150  mTOR signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04152  AMPK signaling pathway
pyu04210  Apoptosis
pyu04211  Longevity regulating pathway
pyu04213  Longevity regulating pathway - multiple species
pyu04218  Cellular senescence
pyu04360  Axon guidance
pyu04370  VEGF signaling pathway
pyu04380  Osteoclast differentiation
pyu04510  Focal adhesion
pyu04517  IgSF CAM signaling
pyu04518  Integrin signaling
pyu04550  Signaling pathways regulating pluripotency of stem cells
pyu04611  Platelet activation
pyu04613  Neutrophil extracellular trap formation
pyu04620  Toll-like receptor signaling pathway
pyu04625  C-type lectin receptor signaling pathway
pyu04630  JAK-STAT signaling pathway
pyu04650  Natural killer cell mediated cytotoxicity
pyu04660  T cell receptor signaling pathway
pyu04662  B cell receptor signaling pathway
pyu04664  Fc epsilon RI signaling pathway
pyu04666  Fc gamma R-mediated phagosome formation
pyu04668  TNF signaling pathway
pyu04670  Leukocyte transendothelial migration
pyu04722  Neurotrophin signaling pathway
pyu04725  Cholinergic synapse
pyu04750  Inflammatory mediator regulation of TRP channels
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04915  Estrogen signaling pathway
pyu04917  Prolactin signaling pathway
pyu04919  Thyroid hormone signaling pathway
pyu04923  Regulation of lipolysis in adipocytes
pyu04926  Relaxin signaling pathway
pyu04929  GnRH secretion
pyu04930  Type II diabetes mellitus
pyu04931  Insulin resistance
pyu04932  Non-alcoholic fatty liver disease
pyu04933  AGE-RAGE signaling pathway in diabetic complications
pyu04935  Growth hormone synthesis, secretion and action
pyu04960  Aldosterone-regulated sodium reabsorption
pyu04973  Carbohydrate digestion and absorption
pyu05010  Alzheimer disease
pyu05017  Spinocerebellar ataxia
pyu05020  Prion disease
pyu05100  Bacterial invasion of epithelial cells
pyu05132  Salmonella infection
pyu05135  Yersinia infection
pyu05142  Chagas disease
pyu05146  Amoebiasis
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05162  Measles
pyu05163  Human cytomegalovirus infection
pyu05164  Influenza A
pyu05165  Human papillomavirus infection
pyu05166  Human T-cell leukemia virus 1 infection
pyu05167  Kaposi sarcoma-associated herpesvirus infection
pyu05168  Herpes simplex virus 1 infection
pyu05169  Epstein-Barr virus infection
pyu05170  Human immunodeficiency virus 1 infection
pyu05171  Coronavirus disease
pyu05200  Pathways in cancer
pyu05203  Viral carcinogenesis
pyu05205  Proteoglycans in cancer
pyu05206  MicroRNAs in cancer
pyu05207  Chemical carcinogenesis - receptor activation
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05212  Pancreatic cancer
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05218  Melanoma
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05222  Small cell lung cancer
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
pyu05230  Central carbon metabolism in cancer
pyu05231  Choline metabolism in cancer
pyu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pyu05415  Diabetic cardiomyopathy
pyu05417  Lipid and atherosclerosis
pyu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121034018 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    121034018 (PIK3CA)
   04014 Ras signaling pathway
    121034018 (PIK3CA)
   04015 Rap1 signaling pathway
    121034018 (PIK3CA)
   04370 VEGF signaling pathway
    121034018 (PIK3CA)
   04630 JAK-STAT signaling pathway
    121034018 (PIK3CA)
   04668 TNF signaling pathway
    121034018 (PIK3CA)
   04066 HIF-1 signaling pathway
    121034018 (PIK3CA)
   04068 FoxO signaling pathway
    121034018 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    121034018 (PIK3CA)
   04072 Phospholipase D signaling pathway
    121034018 (PIK3CA)
   04071 Sphingolipid signaling pathway
    121034018 (PIK3CA)
   04024 cAMP signaling pathway
    121034018 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    121034018 (PIK3CA)
   04152 AMPK signaling pathway
    121034018 (PIK3CA)
   04150 mTOR signaling pathway
    121034018 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    121034018 (PIK3CA)
   04517 IgSF CAM signaling
    121034018 (PIK3CA)
   04518 Integrin signaling
    121034018 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    121034018 (PIK3CA)
   04140 Autophagy - animal
    121034018 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    121034018 (PIK3CA)
   04218 Cellular senescence
    121034018 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121034018 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    121034018 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121034018 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121034018 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    121034018 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    121034018 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    121034018 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    121034018 (PIK3CA)
   04660 T cell receptor signaling pathway
    121034018 (PIK3CA)
   04662 B cell receptor signaling pathway
    121034018 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    121034018 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    121034018 (PIK3CA)
   04670 Leukocyte transendothelial migration
    121034018 (PIK3CA)
   04062 Chemokine signaling pathway
    121034018 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121034018 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    121034018 (PIK3CA)
   04929 GnRH secretion
    121034018 (PIK3CA)
   04915 Estrogen signaling pathway
    121034018 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    121034018 (PIK3CA)
   04917 Prolactin signaling pathway
    121034018 (PIK3CA)
   04926 Relaxin signaling pathway
    121034018 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    121034018 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    121034018 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121034018 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    121034018 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    121034018 (PIK3CA)
   04722 Neurotrophin signaling pathway
    121034018 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121034018 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    121034018 (PIK3CA)
   04380 Osteoclast differentiation
    121034018 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    121034018 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    121034018 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121034018 (PIK3CA)
   05206 MicroRNAs in cancer
    121034018 (PIK3CA)
   05205 Proteoglycans in cancer
    121034018 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    121034018 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    121034018 (PIK3CA)
   05203 Viral carcinogenesis
    121034018 (PIK3CA)
   05230 Central carbon metabolism in cancer
    121034018 (PIK3CA)
   05231 Choline metabolism in cancer
    121034018 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121034018 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121034018 (PIK3CA)
   05212 Pancreatic cancer
    121034018 (PIK3CA)
   05225 Hepatocellular carcinoma
    121034018 (PIK3CA)
   05226 Gastric cancer
    121034018 (PIK3CA)
   05214 Glioma
    121034018 (PIK3CA)
   05221 Acute myeloid leukemia
    121034018 (PIK3CA)
   05220 Chronic myeloid leukemia
    121034018 (PIK3CA)
   05218 Melanoma
    121034018 (PIK3CA)
   05211 Renal cell carcinoma
    121034018 (PIK3CA)
   05215 Prostate cancer
    121034018 (PIK3CA)
   05213 Endometrial cancer
    121034018 (PIK3CA)
   05224 Breast cancer
    121034018 (PIK3CA)
   05222 Small cell lung cancer
    121034018 (PIK3CA)
   05223 Non-small cell lung cancer
    121034018 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121034018 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    121034018 (PIK3CA)
   05161 Hepatitis B
    121034018 (PIK3CA)
   05160 Hepatitis C
    121034018 (PIK3CA)
   05171 Coronavirus disease
    121034018 (PIK3CA)
   05164 Influenza A
    121034018 (PIK3CA)
   05162 Measles
    121034018 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    121034018 (PIK3CA)
   05163 Human cytomegalovirus infection
    121034018 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121034018 (PIK3CA)
   05169 Epstein-Barr virus infection
    121034018 (PIK3CA)
   05165 Human papillomavirus infection
    121034018 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121034018 (PIK3CA)
   05135 Yersinia infection
    121034018 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    121034018 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121034018 (PIK3CA)
   05142 Chagas disease
    121034018 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121034018 (PIK3CA)
   05017 Spinocerebellar ataxia
    121034018 (PIK3CA)
   05020 Prion disease
    121034018 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121034018 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    121034018 (PIK3CA)
   05415 Diabetic cardiomyopathy
    121034018 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121034018 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    121034018 (PIK3CA)
   04931 Insulin resistance
    121034018 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121034018 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121034018 (PIK3CA)
   01524 Platinum drug resistance
    121034018 (PIK3CA)
   01522 Endocrine resistance
    121034018 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pyu04131]
    121034018 (PIK3CA)
Enzymes [BR:pyu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     121034018 (PIK3CA)
Membrane trafficking [BR:pyu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    121034018 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 121034018
NCBI-ProteinID: XP_040336743
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
tttcttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
caatgcaaaggtggtctgaaaggcgcactgcagttcaacagccacactctacaccagtgg
ctcaaagataagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccat
acaattaagcagcatgctttgaactga

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