KEGG   Herpailurus yagouaroundi (jaguarundi): 121036923
Entry
121036923         CDS       T07555                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
pyu  Herpailurus yagouaroundi (jaguarundi)
Pathway
pyu01522  Endocrine resistance
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04014  Ras signaling pathway
pyu04024  cAMP signaling pathway
pyu04068  FoxO signaling pathway
pyu04071  Sphingolipid signaling pathway
pyu04137  Mitophagy - animal
pyu04140  Autophagy - animal
pyu04141  Protein processing in endoplasmic reticulum
pyu04210  Apoptosis
pyu04215  Apoptosis - multiple species
pyu04217  Necroptosis
pyu04310  Wnt signaling pathway
pyu04380  Osteoclast differentiation
pyu04510  Focal adhesion
pyu04530  Tight junction
pyu04620  Toll-like receptor signaling pathway
pyu04621  NOD-like receptor signaling pathway
pyu04622  RIG-I-like receptor signaling pathway
pyu04625  C-type lectin receptor signaling pathway
pyu04657  IL-17 signaling pathway
pyu04658  Th1 and Th2 cell differentiation
pyu04659  Th17 cell differentiation
pyu04660  T cell receptor signaling pathway
pyu04664  Fc epsilon RI signaling pathway
pyu04668  TNF signaling pathway
pyu04722  Neurotrophin signaling pathway
pyu04723  Retrograde endocannabinoid signaling
pyu04728  Dopaminergic synapse
pyu04750  Inflammatory mediator regulation of TRP channels
pyu04910  Insulin signaling pathway
pyu04912  GnRH signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04917  Prolactin signaling pathway
pyu04920  Adipocytokine signaling pathway
pyu04926  Relaxin signaling pathway
pyu04930  Type II diabetes mellitus
pyu04931  Insulin resistance
pyu04932  Non-alcoholic fatty liver disease
pyu04933  AGE-RAGE signaling pathway in diabetic complications
pyu04935  Growth hormone synthesis, secretion and action
pyu04936  Alcoholic liver disease
pyu05010  Alzheimer disease
pyu05012  Parkinson disease
pyu05016  Huntington disease
pyu05017  Spinocerebellar ataxia
pyu05020  Prion disease
pyu05022  Pathways of neurodegeneration - multiple diseases
pyu05132  Salmonella infection
pyu05133  Pertussis
pyu05135  Yersinia infection
pyu05142  Chagas disease
pyu05145  Toxoplasmosis
pyu05152  Tuberculosis
pyu05161  Hepatitis B
pyu05162  Measles
pyu05166  Human T-cell leukemia virus 1 infection
pyu05167  Kaposi sarcoma-associated herpesvirus infection
pyu05169  Epstein-Barr virus infection
pyu05170  Human immunodeficiency virus 1 infection
pyu05171  Coronavirus disease - COVID-19
pyu05200  Pathways in cancer
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05212  Pancreatic cancer
pyu05231  Choline metabolism in cancer
pyu05415  Diabetic cardiomyopathy
pyu05417  Lipid and atherosclerosis
pyu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    121036923 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121036923 (MAPK8)
   04012 ErbB signaling pathway
    121036923 (MAPK8)
   04014 Ras signaling pathway
    121036923 (MAPK8)
   04310 Wnt signaling pathway
    121036923 (MAPK8)
   04668 TNF signaling pathway
    121036923 (MAPK8)
   04068 FoxO signaling pathway
    121036923 (MAPK8)
   04071 Sphingolipid signaling pathway
    121036923 (MAPK8)
   04024 cAMP signaling pathway
    121036923 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121036923 (MAPK8)
   04137 Mitophagy - animal
    121036923 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    121036923 (MAPK8)
   04215 Apoptosis - multiple species
    121036923 (MAPK8)
   04217 Necroptosis
    121036923 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121036923 (MAPK8)
   04530 Tight junction
    121036923 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    121036923 (MAPK8)
   04621 NOD-like receptor signaling pathway
    121036923 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    121036923 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    121036923 (MAPK8)
   04660 T cell receptor signaling pathway
    121036923 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    121036923 (MAPK8)
   04659 Th17 cell differentiation
    121036923 (MAPK8)
   04657 IL-17 signaling pathway
    121036923 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    121036923 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121036923 (MAPK8)
   04920 Adipocytokine signaling pathway
    121036923 (MAPK8)
   04912 GnRH signaling pathway
    121036923 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    121036923 (MAPK8)
   04917 Prolactin signaling pathway
    121036923 (MAPK8)
   04926 Relaxin signaling pathway
    121036923 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    121036923 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    121036923 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    121036923 (MAPK8)
   04722 Neurotrophin signaling pathway
    121036923 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121036923 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    121036923 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121036923 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    121036923 (MAPK8)
   05231 Choline metabolism in cancer
    121036923 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121036923 (MAPK8)
   05212 Pancreatic cancer
    121036923 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121036923 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    121036923 (MAPK8)
   05161 Hepatitis B
    121036923 (MAPK8)
   05171 Coronavirus disease - COVID-19
    121036923 (MAPK8)
   05162 Measles
    121036923 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121036923 (MAPK8)
   05169 Epstein-Barr virus infection
    121036923 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121036923 (MAPK8)
   05135 Yersinia infection
    121036923 (MAPK8)
   05133 Pertussis
    121036923 (MAPK8)
   05152 Tuberculosis
    121036923 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    121036923 (MAPK8)
   05142 Chagas disease
    121036923 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121036923 (MAPK8)
   05012 Parkinson disease
    121036923 (MAPK8)
   05016 Huntington disease
    121036923 (MAPK8)
   05017 Spinocerebellar ataxia
    121036923 (MAPK8)
   05020 Prion disease
    121036923 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    121036923 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121036923 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    121036923 (MAPK8)
   05415 Diabetic cardiomyopathy
    121036923 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121036923 (MAPK8)
   04936 Alcoholic liver disease
    121036923 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    121036923 (MAPK8)
   04931 Insulin resistance
    121036923 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121036923 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    121036923 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pyu01001]
    121036923 (MAPK8)
Enzymes [BR:pyu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     121036923 (MAPK8)
Protein kinases [BR:pyu01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   121036923 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 121036923
NCBI-ProteinID: XP_040341617
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattt
acagttttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctgagccggccg
tttcagaatcagactcatgctaaacgggcttacagagagctagttctaatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttc
atgatgacgccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacaaccaacagtaaggacttacgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggacttgttatccaaa
atgctggtaattgatgcatctaaaaggatctctgtagatgaagccctccagcatccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccacccaagatacctgacaag
caattagatgaaagggaacatacaatagaagagtggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagatagcagtctggaagcatcagct
ggacctctgggctgttgtagatga

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