Puma yagouaroundi (jaguarundi): 121041441 Help Entry 121041441         CDS       T07555                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism pyu  Puma yagouaroundi (jaguarundi) Pathway pyu04020   Calcium signaling pathway pyu04371   Apelin signaling pathway pyu04713   Circadian entrainment pyu04921   Oxytocin signaling pathway pyu04970   Salivary secretion pyu05010   Alzheimer disease pyu05012   Parkinson disease pyu05020   Prion disease pyu05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pyu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121041441 (RYR3)    04020 Calcium signaling pathway     121041441 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     121041441 (RYR3)   09154 Digestive system    04970 Salivary secretion     121041441 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     121041441 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     121041441 (RYR3)    05012 Parkinson disease     121041441 (RYR3)    05020 Prion disease     121041441 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     121041441 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pyu04040]     121041441 (RYR3) Ion channels [BR:pyu04040]  Voltage-gated cation channels   Ryanodine receptor    121041441 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  121041441 NCBI-ProteinID:  XP_040348139 LinkDB All DBs Position Unknown AA seq 4869 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQCEESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDVEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKTRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAGEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYLRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSGETENRAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWAGKLRALVYKIKGPPKPAKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDGEYEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGAEHYTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALVQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYS IQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHVRNNLHLQEKSD DPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKCPKVEEE EEEETDKHPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKE KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNA GVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESI SDFYWYYSGKDIIDDSGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSNQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDF LLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESV LNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDSAERPEEEEEDEDSSYTLEIEGEEEDDKSFESASA FAMACASVKKNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFQLFFT ILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVTEPGTT PELVHFVKGEKGDADIMSDLFGFRSKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVQK KRRAQAAEMKASHEAEGKVEPEKTDMEDGEKEGTAKEEEQADALWAEVTKKKKRRRGQKV EKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEE TEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPALRALAIIHTIISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHIWKLGVVFTDNS FLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgaggactgaggatgaa gtggttctccagtgcatcgcaaacattcacaaggagcagaggaagttctgcctggcagcc gagggcctgggaaaccgcctgtgcttcctggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagctctgcag gaaatgcttgccaatacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctatatggccacgcgattctcctgcggcactccttcagcggaatgtatcta acatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctccgtatcaaatgggaacatacaagtggatgcctcttttatgcaaaca ctctggaatgtacatcccacgtgctcaggaagtagcatcgaagaaggttacctacttggt gggcatgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgactcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgcctccggcatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaggaccgggcaaagtcagacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattctagtcacaagcgggatatagaaggc atgggagttccagaaatcaaatatggagattccgtctgctttgtccagcatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggctaacactgcagagatgc cagtgcgaggagtcccaggctgctcggatcatccggaacacgacagccttattcagccag tttgtaagtgggaacaatcgtacggcggcccccatcaccctgccgatagaagaggtcctg cagaccttacaggacctgatcgcctacttccagcccccggaggaggagatgcaacacgaa gacaaacagaacaagctccgctcacttaagaacagacagaatcttttcaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttaaacatctacaacagcgtggcgcac tttgcaggaattgcaagggaggagagtggcatggcttggaaagagatcctgcgcctgcta tacaaactgctggctgctctcattcgtggaaacagaaacaactgtgctcaattctctaat aaccttgattggctaatcagcaaattggatagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgactgaaagcccagaagccttaaatctgatagcagagggccac atcaagtctatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgccgtgagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaacgacgtgaca agcattcggccaaacatcttcctgggagttgctgagggctcagcacagtacaagaagtgg tacttcgagctgatcatagaccaagtggaccccttcctaacagctgagcccacacaccta cgggtaggctgggcctcttcctcaggctatgctccgtaccctggaggtggagaaggatgg ggaggcaacggtgttggagacgacctgtattcctatggctttgatggccttcacctttgg tcaggccgcatacccagagccgtggcctccatcaaccagcacctcctgagatcagacgac gtggtaagctgttgcctcgacctcggggtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctacgaagccttgctgccaaaagaaaagatgaga ttggagcctgtcaaagaatataaacgcgatgttgaaggagttagagatctgttgggtacc acccagttcctctctcaagcctctttcatcccatgccccatagacaccagtcaggtggtt ttgccacctcacctagagaagatccgagacagactggctgaaaacatccacgaactttgg ggaatgaataaaatagagcttggctggacttttggcaagacacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaacggaaaccttaaaaaccctgctggccctggggtgccacattgctcacgtt aatccagctgctggggaggatctcaagaaagtcaagttgcccaaaaactatatgatgtcc aatggctacaagccagcccctttggatttgtctgatgtgaagctattacctcctcaagaa attttggtggataagcttgcagaaaatgcacataatgtttgggccaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccatacgcattactggatgagcgtacgaagaagtccaatagggacagccttcgtgaagct gttcgcacatttgttggttatggctataacattgaaccgtcagaccaagaactagctgac ccagctgtggagaaagtcagcatagataaaattcgatttttccgggtagagcggtcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgc gttggctgggccaggccgggctgtcggcccgacgttgagctgggagccgatgatcaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acgtggcagccaggagatgtggttggatgtatgattaaccttgatgatgcttcaatgatc ttcacactgaatggggagctgctgattaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggctttgtgcccatctgctctctgggactgtctcagatcggccgc atgaatcttgggatggatgccagtaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagacgtggcgatgtggttcagcaagcgc ctcccgacatttgtcaacgtgccaaaggatcatccgcacatagaggttgtgaggatagat ggcactatggacagccctccatgcctcaaggtgacccacaagacattcggcacacagaat agcaatgccaacatgatctacctacgcctgagcatgcctgtcgaatgccactcctccttc agccacagcccctgcttggacagtgacgcattccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgcaatccgcatcttcgctggacaggacccc tcctgcgtctgggtcggatgggtgactccggactatcacttgtacagcgagaagtttgac ctgagtaaaaactgcacggtgactgttactctaggggatgaaagaggccgggtccacgaa agcgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacttcgcaa agatcaagccggagcaacgtggacctggagatcggctgcctcgtggatctggcgatgggc atgttgtctttctcagccaatgggagagagctgggtacctgctatcaggtggagcctaat accaaagtgtttccagcagtcttcctgcagcccacgagcacttcattgtttcagtttgaa cttgggaagctgaagaatgcgatgcccttgtcggcggccatatttaagagtgaagagaag aacccagttccgcagtgtccacctcggctggacgtccaaaccatccaacccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccctgaggagaac aggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccattaccac acgctgcgactctacagtgcagtgtgcgccctgggaaacagccgcgtggcctacgcccta tgcggccacgtggatctctcccagctgttctacgccattgacaacaagtacctccctggc ctccttcggtctggtttctatgacctgctcatcagcatccatctggccaacgctaaggag aggaagctaatgatgaagaatgagtacatcatccccatcaccagcaccaccagaaaaatc cgcctgtatccagatgagtccaagaggcacgggctgcctggggtgggcctgagaacgtgc ctcaagccagggttcaggttctccaccccttgctttgtcgtgaccagtgaggagcaccag aagcagagccctgagatcccgttggagattctcaagacgaaggcactgagcatgctgacg gaggcagtgcagcacagtggggctcacatccgggaccctgtcggtgggtctgtagagttc cagtttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgac gatgacgtcaggcagatcctcctcctgatcgatccctctgtgtttggggagcacagtggg gagacggagaacagagcagagaaggaggaagtgacccaggtggaggagaaggcagtggag gccggagaaaaggccggcaaggaggctccagtcaaaggcttgttgcagacccgactgcca gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtggaggccattgtggcatttggcgacatttatgtctctaagctccaggcaaat cagaagttccgctacaacgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaaaaccagggagttccgctcacccccccaggagcagatcaacatgcttcttaacttt caactgggagagaattgcccctgcccagaagagatccgagaggagctatatgacttccat gaggaccttctcattcactgtggtgttcccctggaggaggaagaagaggaggaggaagac acatcctgggctgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gcgaaggaacagccaacagaggaggaagagagatgccctacgaccttgaaggagctcatc tcacagaccatgatccgctgggctcaggaggaccagatccaggatgcggagttggtccgg atgatgttcaacctcctccggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagtcaggcctccgtgagcgacaccatcaacctgctggccgcc ctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg atcaatgggctgggagacattatgaacaacaaggtgttctaccagcatcccaacctcatg cgagtccttggcatgcacgagacagtgatggaggtgatggtgaacgtgttggggacagag aagtctcagattgcctttccaaaaatggttgctagctgttgccgcttcctctgctacttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgttggag aacagcagtgttggcctagcctccccttcgatgaggggatctaccccgctggatgtggca gcttcctccgtgatggacaacaacgagttagccctgggcttagaggaaccagaccttgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa gggtaccctgacgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaagctg ctcatcagacgcccagagtgcttcggcccagccttgcgaggtgaaggaggaaacggtcta ttggcagccatgcagggtgccattaagatctctgagaacccagctctcgacctcccctct cagggatataagagagaagtcacggaggacggtgaatatgaagaagagatcgtgcacatg ggcaatgcaattatgtctttctattcagcccttatagatctcctgggccgctgtgctcct gaaatgcatcttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgc tccctggtccccactgaggacctggttgggatcatcagcatccccttgaagctgccttcc ctgaacaaagatgggtcggtcagcgagccagatatggcagccaacttctgccctgaccac aaggcacccatggtgctgttcttggatcgtgtttatggcattaaggatcaaacttttctg ctccacttgctagaggttggatttttacctgacctaagagcctctgcctctctagataca gtttccctaagcaccacagaggccgcgcttgcactaaatagatatctatgttctgctgtg cttccactcctcacaagatgcgcccctctctttgccggagcagaacactacacctctttg atcgattctacactacagacaatatataggctttccaagggacgttccctcaccaaagct cagagggacaccatagaagaatgtttgcttgccatttgcaatcacttgaggccttcaatg ttacagcaactcttgcgacgtcttgtctttgatgtgccacagctcaacgaatactgcaaa atgcctcttaagcttctgacaaatcactatgaacagtgctggaagtattactgtctgcct tcaggatgggggagctacgggctagctgtggaggaggaattgcacctgacggagaagctc ttctgggggattttcgactccctctcccataagaagtatgacccagaccttttccgaatg gcccttccttgtctcagtgctatagctggggcgctaccaccagattacttagataccaga atctcagccacgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaa cccatcaacaccatgaatttttccttgcctgaaaaatgggagtacatcgtcaccaagtac gcggagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga atttccctggatgaaaatgtgaagacccatcccctgataaggcctttcaagacattaaca gaaaaggagaaggaaatttaccgctggcctgctagagagtccctgaaaaccatgctggct gtgggctggtctgtggagaggaccaaagagggagaggccctggtgcaacagcgggaaaat gagaagcttcggagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctg gacctctccaacgttgtgctctccagagagctccagggaatggtggaggtcgtggccgag aactatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggcggc agtcaccctctgttggtaccatatgacaccttgacagccaaggagaagttcagggaccga gaaaaggcacaggacctgtttaaattcctccaggtgaacggcatcgtggtttctagaggt atgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttg aagaagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctggttgaccagtacttcaccaatcaccgcctctacttcctgtcatcc cctctaaaacccctcagcagcagtggctatgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaactcgctgctcttgttcgacacaggatttccctctttggaagtgat tctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtc atgaagtcaggctcagagctggtgaaggctgggttacgagctttctttgaaaatgcggcg gaagacttagagaagacttcggaaaatctgaagctcgggaagtttacgcattccagaaca cagattaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatcctg acgtccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgat gtgcagatttcatgctaccacatactctgcagtctctactcccttgggaccggaaagaac atctacgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgcc ataccagtggcattcttggagcccactcttaaccgctacaatccactctcagtcttcaac accaaaacccccagagagaggtctattctggggatgccagacacagtggaagagatgtgt cccgacatccctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggg gcccggtacacggagatgccccacgtcatcgaggtgatcttgcccatgctgtgcaactac ctgtcctactggtgggagcgggggccagagcacctgccccccagcacggggccctggtgc acgaaggtcacctctgaacacctcagtgtcatcctgggaaacatactgaaaatcatcaac aacaacctgggcatcgatgaggcatcctggatgaagcgcatcgcagtgtatgcccagcca atcatcagcaaagccaggccggacctgctgaaaagccacttcatcccaactctggagaag ctgaagaaaaaggctgtgaagactgtgcaggaggaggagcagctgaaggctgacaccaaa ggagacactcaggaggcggagctcctcatcctggatgagtttgcagtcctctgcagagac ctctatgccttctaccccatgctcatccgctacgtggacaacaacagatcgaactggctc aaaagtcccgatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaagta aagtctggaggacaggaccaggaacggaagaagaccaagcggaggggagacttgtactcc atccagacctctctcatcgtggctgcgctcaagaaaatgctgcccattggtttgaatatg tgcacgccaggcgatcaggagctaatctcccttgcaaagtcacgatacagctatagggac accgatgaagaggtgaaagaacatgtgcggaataacttgcacctgcaggaaaagtcagat gacccagcagtaaagtggcagctgaacctctacaaagatgttttgaagagtgaagaacct tccaatccagaaaagactgtagagcgtgtacagagaatttccgcagctgtcttccatctg gagcaggtcgaacagcctttgaggtccaagaaggcagtctggcacaaactgttatcaaag cagcggaaacgggcagtggtggcctgtttcaggatggcccctctgtacaacttgcccagg caccgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggag tattcctttgaagagaaactagtacaggacttggctaaatgccccaaggtggaagaggag gaggaggaggagacagacaagcacccagacccacttcatcagatcattctccattttagc cgcaatgctctcacggagaggagcaaattggaagacgaccccttgtacacctcctattcc agcatgatggccaagagttgtcagagtggggaggacgaagaagaagaggaagacaaggaa aagacatttgaagagaaggaaatggaaaagcagaaaaccctctaccaacaagctcgactg catgagcgtggggctgcagagatggtcctccagatgataagtgccagcaaaggtgagatg agccccatggtggttgagactctgaagctggggatcgccattctgaatgggggcaacgct ggtgtacaacagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaa agcctttccggccttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcag aataaagctgaaggcctggggatggttactgaggaaggaacactcattgtccgtgagcgt ggtgaaaaagtactccagaatgacgagtttacacgagatctctttagattcctgcagtta ctttgtgaaggacataacagtgacttccagaacttcctgcggactcagatgggcaacacc accactgtaaatgtcatcatcagtaccgtggactatctcctgcgtctgcaggaatcaatc agtgatttctactggtattattcagggaaggacatcattgatgactctggacagcacaac ttttccaaagctctggcagtcacgaagcagattttcaattctcttacagaatacatccag ggcccttgcattgggaaccaacagagcctggctcacagcaggctgtgggatgcagtggtc ggcttcctgcacgtatttgctaacatgcagatgaaactctctcaggattccaatcagatc gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctc ctggaagggaatgtggtaaatggaactattggcaagcagatggttgacacgctggtagag tcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagac ctaaccagctcagacaccttcaaagaatatgacccagatggtaaagggattatctccaaa aaagaattccagaaggccatggaagggcaaaaacagtacacacagtcagagattgacttt ctcctttcatgtgcagaagctgatgagaatgatatgtttaattacattgattttgtagac cggtttcatgagccggccaaggacatagggtttaacgtggcagtgttattgacaaatctc tccgaacacatgccaaatgattctcgccttaagtgcctattggacccagcggaaagtgta ctaaattacttcgaaccctacctaggacgtattgagatcatgggtggggccaagaaaatt gagcgcgtttattttgagatcagtgaatccagtcgaacccagtgggagaagccccaagtg aaggaatctaagcggcagttcatctttgatgtggtcaacgaaggtggagagcaagaaaaa atggaactgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcgtctcag atctctgaatctgactcagccgaaaggccagaagaggaggaggaagatgaagattcttct tacacgttagaaattgagggggaagaggaggatgacaagtcttttgagtctgcctctgca tttgccatggcctgtgcctcagtgaagaaaaacgttgccaacttcctgaagaaggcaacc ctgaagaacttgaggaagcagtacaggaaggtgaagaagatgaccgtgaaggagctggtg aaggtgttcttctctttcttctggatgttatttgtggggctattccagttgttcttcacc atattgggaggaatctttcagatcctctggaacacagtgtttggagggggcctagtggaa ggggcaaagaacatcagagtgaccaagatcctgggtgacatgcctgacccaacccagttt ggtatccatgacgatgccatggaggctgagcgggcagaggtgactgagccaggtactaca ccagaactagtccacttcgtcaagggtgagaaaggagatgcagatatcatgtcagatctc tttggattccgctcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggt gatctctctgagattattggcaaggatgaaccccctacactagagagtaccgtacagaag aaaaggagagcacaggcagcagaaatgaaagcatcacatgaagcagaaggaaaagtggag cctgagaagacagacatggaagatggggagaaggagggtacagccaaggaggaagagcaa gctgacgccctgtgggcagaagtgacaaagaagaagaagcggcgacggggccagaaagtt gagaagcctgaagccttcatggctaatttcttcaaagggctggaaatctatcagaccaag ttactgcattacctggccaggaatttctacaacctgaggttcctcgctctgtttgtagcc ttcgctatcaacttcatcctgctcttttacaaggtcactgaagagcctttagaagaagag acagaggacgttgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcgatg gtgttctttgtcctacaggagagcactgggtatatggcaccagcactgcgggccttggcc attatccacaccatcatctctttggtctgtgtggtgggctattactgcctgaaggtccct ttggtggtgttcaaaagagaaaaagaaattgccaggaagctggagttcgatggcctgtat atcactgaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtaatcaac acaccatcttttcctaataactactgggacaagtttgtaaagagaaaggtgattaacaag tatggtgatctctacggagcagaacgcattgctgaactcctaggtttggacaaaaatgcc cttgatttcagcccagtagaagaaagcaaagcagaggcggcctctctggtgtcatggctg agttccatcgacatgaagtaccatatctggaagctgggagttgtttttaccgataactcc tttctctaccttgcctggtatacaaccatgtcgatcctgggccactacaacaacttcttc tttgctgcccatctgctagacattgcaatgggcttcaagacgctgaggactattctgtca tctgtaactcacaacggcaaacagctggttctgactgtgggtctcttggccgtggtggtt tacctctacaccgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagat gacgatgagcctgatatgaagtgtgacgacatgatgacgtgttacctattccacatgtat gtgggagtaagagcaggaggcggcattggtgacgaaattgaagaccctgctggtgatcct tacgaaatgtaccgcattgtctttgacatcacgttcttcttctttgtcattgtcatcttg ctggccatcattcaaggtcttattattgatgcttttggagagctaagagaccagcaggaa caggtgcgagaagatatggagactaaatgtttcatctgcgggattggcaatgattacttt gacacgacccctcatggttttgaaacacacaccttacaggagcacaacttagccaactat ttgttcttcctgatgtatctgattaacaaagatgaaacagaacacacgggtcaggaatct tatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgcttt cggaaacaatatgaagatcagcttggataa

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