KEGG   Rousettus aegyptiacus (Egyptian rousette): 107517828
Entry
107517828         CDS       T06036                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ray  Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray00562  Inositol phosphate metabolism
ray01100  Metabolic pathways
ray01521  EGFR tyrosine kinase inhibitor resistance
ray01522  Endocrine resistance
ray01524  Platinum drug resistance
ray04012  ErbB signaling pathway
ray04014  Ras signaling pathway
ray04015  Rap1 signaling pathway
ray04024  cAMP signaling pathway
ray04062  Chemokine signaling pathway
ray04066  HIF-1 signaling pathway
ray04068  FoxO signaling pathway
ray04070  Phosphatidylinositol signaling system
ray04071  Sphingolipid signaling pathway
ray04072  Phospholipase D signaling pathway
ray04081  Hormone signaling
ray04140  Autophagy - animal
ray04150  mTOR signaling pathway
ray04151  PI3K-Akt signaling pathway
ray04152  AMPK signaling pathway
ray04210  Apoptosis
ray04211  Longevity regulating pathway
ray04213  Longevity regulating pathway - multiple species
ray04218  Cellular senescence
ray04360  Axon guidance
ray04370  VEGF signaling pathway
ray04380  Osteoclast differentiation
ray04510  Focal adhesion
ray04517  IgSF CAM signaling
ray04518  Integrin signaling
ray04550  Signaling pathways regulating pluripotency of stem cells
ray04611  Platelet activation
ray04613  Neutrophil extracellular trap formation
ray04620  Toll-like receptor signaling pathway
ray04625  C-type lectin receptor signaling pathway
ray04630  JAK-STAT signaling pathway
ray04650  Natural killer cell mediated cytotoxicity
ray04660  T cell receptor signaling pathway
ray04662  B cell receptor signaling pathway
ray04664  Fc epsilon RI signaling pathway
ray04666  Fc gamma R-mediated phagocytosis
ray04668  TNF signaling pathway
ray04670  Leukocyte transendothelial migration
ray04722  Neurotrophin signaling pathway
ray04725  Cholinergic synapse
ray04750  Inflammatory mediator regulation of TRP channels
ray04810  Regulation of actin cytoskeleton
ray04910  Insulin signaling pathway
ray04914  Progesterone-mediated oocyte maturation
ray04915  Estrogen signaling pathway
ray04917  Prolactin signaling pathway
ray04919  Thyroid hormone signaling pathway
ray04923  Regulation of lipolysis in adipocytes
ray04926  Relaxin signaling pathway
ray04929  GnRH secretion
ray04930  Type II diabetes mellitus
ray04931  Insulin resistance
ray04932  Non-alcoholic fatty liver disease
ray04933  AGE-RAGE signaling pathway in diabetic complications
ray04935  Growth hormone synthesis, secretion and action
ray04960  Aldosterone-regulated sodium reabsorption
ray04973  Carbohydrate digestion and absorption
ray05010  Alzheimer disease
ray05017  Spinocerebellar ataxia
ray05020  Prion disease
ray05100  Bacterial invasion of epithelial cells
ray05132  Salmonella infection
ray05135  Yersinia infection
ray05142  Chagas disease
ray05146  Amoebiasis
ray05160  Hepatitis C
ray05161  Hepatitis B
ray05162  Measles
ray05163  Human cytomegalovirus infection
ray05164  Influenza A
ray05165  Human papillomavirus infection
ray05166  Human T-cell leukemia virus 1 infection
ray05167  Kaposi sarcoma-associated herpesvirus infection
ray05168  Herpes simplex virus 1 infection
ray05169  Epstein-Barr virus infection
ray05170  Human immunodeficiency virus 1 infection
ray05171  Coronavirus disease - COVID-19
ray05200  Pathways in cancer
ray05203  Viral carcinogenesis
ray05205  Proteoglycans in cancer
ray05206  MicroRNAs in cancer
ray05207  Chemical carcinogenesis - receptor activation
ray05208  Chemical carcinogenesis - reactive oxygen species
ray05210  Colorectal cancer
ray05211  Renal cell carcinoma
ray05212  Pancreatic cancer
ray05213  Endometrial cancer
ray05214  Glioma
ray05215  Prostate cancer
ray05218  Melanoma
ray05220  Chronic myeloid leukemia
ray05221  Acute myeloid leukemia
ray05222  Small cell lung cancer
ray05223  Non-small cell lung cancer
ray05224  Breast cancer
ray05225  Hepatocellular carcinoma
ray05226  Gastric cancer
ray05230  Central carbon metabolism in cancer
ray05231  Choline metabolism in cancer
ray05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ray05415  Diabetic cardiomyopathy
ray05417  Lipid and atherosclerosis
ray05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ray00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    107517828 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    107517828 (PIK3CA)
   04014 Ras signaling pathway
    107517828 (PIK3CA)
   04015 Rap1 signaling pathway
    107517828 (PIK3CA)
   04370 VEGF signaling pathway
    107517828 (PIK3CA)
   04630 JAK-STAT signaling pathway
    107517828 (PIK3CA)
   04668 TNF signaling pathway
    107517828 (PIK3CA)
   04066 HIF-1 signaling pathway
    107517828 (PIK3CA)
   04068 FoxO signaling pathway
    107517828 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    107517828 (PIK3CA)
   04072 Phospholipase D signaling pathway
    107517828 (PIK3CA)
   04071 Sphingolipid signaling pathway
    107517828 (PIK3CA)
   04024 cAMP signaling pathway
    107517828 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    107517828 (PIK3CA)
   04152 AMPK signaling pathway
    107517828 (PIK3CA)
   04150 mTOR signaling pathway
    107517828 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    107517828 (PIK3CA)
   04517 IgSF CAM signaling
    107517828 (PIK3CA)
   04518 Integrin signaling
    107517828 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    107517828 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    107517828 (PIK3CA)
   04218 Cellular senescence
    107517828 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107517828 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    107517828 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107517828 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    107517828 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    107517828 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    107517828 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    107517828 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    107517828 (PIK3CA)
   04660 T cell receptor signaling pathway
    107517828 (PIK3CA)
   04662 B cell receptor signaling pathway
    107517828 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    107517828 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    107517828 (PIK3CA)
   04670 Leukocyte transendothelial migration
    107517828 (PIK3CA)
   04062 Chemokine signaling pathway
    107517828 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107517828 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    107517828 (PIK3CA)
   04929 GnRH secretion
    107517828 (PIK3CA)
   04915 Estrogen signaling pathway
    107517828 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    107517828 (PIK3CA)
   04917 Prolactin signaling pathway
    107517828 (PIK3CA)
   04926 Relaxin signaling pathway
    107517828 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    107517828 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    107517828 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    107517828 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    107517828 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    107517828 (PIK3CA)
   04722 Neurotrophin signaling pathway
    107517828 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    107517828 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    107517828 (PIK3CA)
   04380 Osteoclast differentiation
    107517828 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    107517828 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    107517828 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107517828 (PIK3CA)
   05206 MicroRNAs in cancer
    107517828 (PIK3CA)
   05205 Proteoglycans in cancer
    107517828 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    107517828 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    107517828 (PIK3CA)
   05203 Viral carcinogenesis
    107517828 (PIK3CA)
   05230 Central carbon metabolism in cancer
    107517828 (PIK3CA)
   05231 Choline metabolism in cancer
    107517828 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107517828 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107517828 (PIK3CA)
   05212 Pancreatic cancer
    107517828 (PIK3CA)
   05225 Hepatocellular carcinoma
    107517828 (PIK3CA)
   05226 Gastric cancer
    107517828 (PIK3CA)
   05214 Glioma
    107517828 (PIK3CA)
   05221 Acute myeloid leukemia
    107517828 (PIK3CA)
   05220 Chronic myeloid leukemia
    107517828 (PIK3CA)
   05218 Melanoma
    107517828 (PIK3CA)
   05211 Renal cell carcinoma
    107517828 (PIK3CA)
   05215 Prostate cancer
    107517828 (PIK3CA)
   05213 Endometrial cancer
    107517828 (PIK3CA)
   05224 Breast cancer
    107517828 (PIK3CA)
   05222 Small cell lung cancer
    107517828 (PIK3CA)
   05223 Non-small cell lung cancer
    107517828 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    107517828 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    107517828 (PIK3CA)
   05161 Hepatitis B
    107517828 (PIK3CA)
   05160 Hepatitis C
    107517828 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    107517828 (PIK3CA)
   05164 Influenza A
    107517828 (PIK3CA)
   05162 Measles
    107517828 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    107517828 (PIK3CA)
   05163 Human cytomegalovirus infection
    107517828 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    107517828 (PIK3CA)
   05169 Epstein-Barr virus infection
    107517828 (PIK3CA)
   05165 Human papillomavirus infection
    107517828 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    107517828 (PIK3CA)
   05135 Yersinia infection
    107517828 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    107517828 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    107517828 (PIK3CA)
   05142 Chagas disease
    107517828 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107517828 (PIK3CA)
   05017 Spinocerebellar ataxia
    107517828 (PIK3CA)
   05020 Prion disease
    107517828 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    107517828 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    107517828 (PIK3CA)
   05415 Diabetic cardiomyopathy
    107517828 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    107517828 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    107517828 (PIK3CA)
   04931 Insulin resistance
    107517828 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    107517828 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107517828 (PIK3CA)
   01524 Platinum drug resistance
    107517828 (PIK3CA)
   01522 Endocrine resistance
    107517828 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ray04131]
    107517828 (PIK3CA)
Enzymes [BR:ray01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     107517828 (PIK3CA)
Membrane trafficking [BR:ray04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    107517828 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 107517828
NCBI-ProteinID: XP_016014557
UniProt: A0A7J8HUD3
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYAHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactttttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagttcaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agcagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaatcatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgttatcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaaatatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtacataagaagctgcataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccgtcttattctagacgtatctccacagctacaccgtatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttagaacaggtatc
taccacggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgagtggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgtaaaaggccgaaagggtgctaaagaggaacactgc
ccattggcctggggaaatataaacctgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttactgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagttatgcccacgcaggactgagtaacagactagccagagac
aacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacaggcactattgtgtaact
atccctgaaattctacctaaattgcttctctccgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctagactgcaactacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacttgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctacttctggagtcctattgtcgtgcatgtggaatgtatttgaag
cacctgaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctgcagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcagattatccgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccatatggttgtctctca
attggtgactgtgtgggacttattgaagtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcctgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatacgatgcagccattgatctgtttacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggctataaacgagagcgtgtgccatttgttttgactcaagatttc
ttgatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgaaaggttt
caggagatgtgttacaaagcttatctagctattcggcagcatgccaatctctttataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaagctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccat
acaattaagcagcatgctttgaactga

DBGET integrated database retrieval system