KEGG   Rousettus aegyptiacus (Egyptian rousette): 107519930
Entry
107519930         CDS       T06036                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ray  Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray00562  Inositol phosphate metabolism
ray01100  Metabolic pathways
ray04015  Rap1 signaling pathway
ray04020  Calcium signaling pathway
ray04022  cGMP-PKG signaling pathway
ray04062  Chemokine signaling pathway
ray04070  Phosphatidylinositol signaling system
ray04071  Sphingolipid signaling pathway
ray04072  Phospholipase D signaling pathway
ray04081  Hormone signaling
ray04082  Neuroactive ligand signaling
ray04261  Adrenergic signaling in cardiomyocytes
ray04270  Vascular smooth muscle contraction
ray04310  Wnt signaling pathway
ray04371  Apelin signaling pathway
ray04540  Gap junction
ray04611  Platelet activation
ray04613  Neutrophil extracellular trap formation
ray04621  NOD-like receptor signaling pathway
ray04713  Circadian entrainment
ray04720  Long-term potentiation
ray04723  Retrograde endocannabinoid signaling
ray04724  Glutamatergic synapse
ray04725  Cholinergic synapse
ray04726  Serotonergic synapse
ray04728  Dopaminergic synapse
ray04730  Long-term depression
ray04742  Taste transduction
ray04750  Inflammatory mediator regulation of TRP channels
ray04911  Insulin secretion
ray04912  GnRH signaling pathway
ray04915  Estrogen signaling pathway
ray04916  Melanogenesis
ray04918  Thyroid hormone synthesis
ray04919  Thyroid hormone signaling pathway
ray04921  Oxytocin signaling pathway
ray04922  Glucagon signaling pathway
ray04924  Renin secretion
ray04925  Aldosterone synthesis and secretion
ray04926  Relaxin signaling pathway
ray04927  Cortisol synthesis and secretion
ray04928  Parathyroid hormone synthesis, secretion and action
ray04929  GnRH secretion
ray04933  AGE-RAGE signaling pathway in diabetic complications
ray04934  Cushing syndrome
ray04935  Growth hormone synthesis, secretion and action
ray04961  Endocrine and other factor-regulated calcium reabsorption
ray04970  Salivary secretion
ray04971  Gastric acid secretion
ray04972  Pancreatic secretion
ray04973  Carbohydrate digestion and absorption
ray05010  Alzheimer disease
ray05016  Huntington disease
ray05017  Spinocerebellar ataxia
ray05022  Pathways of neurodegeneration - multiple diseases
ray05142  Chagas disease
ray05143  African trypanosomiasis
ray05146  Amoebiasis
ray05163  Human cytomegalovirus infection
ray05200  Pathways in cancer
ray05415  Diabetic cardiomyopathy
ray05417  Lipid and atherosclerosis
Module
ray_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ray00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    107519930 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    107519930 (PLCB4)
   04310 Wnt signaling pathway
    107519930 (PLCB4)
   04371 Apelin signaling pathway
    107519930 (PLCB4)
   04020 Calcium signaling pathway
    107519930 (PLCB4)
   04070 Phosphatidylinositol signaling system
    107519930 (PLCB4)
   04072 Phospholipase D signaling pathway
    107519930 (PLCB4)
   04071 Sphingolipid signaling pathway
    107519930 (PLCB4)
   04022 cGMP-PKG signaling pathway
    107519930 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    107519930 (PLCB4)
   04081 Hormone signaling
    107519930 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    107519930 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    107519930 (PLCB4)
   04613 Neutrophil extracellular trap formation
    107519930 (PLCB4)
   04621 NOD-like receptor signaling pathway
    107519930 (PLCB4)
   04062 Chemokine signaling pathway
    107519930 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    107519930 (PLCB4)
   04922 Glucagon signaling pathway
    107519930 (PLCB4)
   04929 GnRH secretion
    107519930 (PLCB4)
   04912 GnRH signaling pathway
    107519930 (PLCB4)
   04915 Estrogen signaling pathway
    107519930 (PLCB4)
   04921 Oxytocin signaling pathway
    107519930 (PLCB4)
   04926 Relaxin signaling pathway
    107519930 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    107519930 (PLCB4)
   04918 Thyroid hormone synthesis
    107519930 (PLCB4)
   04919 Thyroid hormone signaling pathway
    107519930 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    107519930 (PLCB4)
   04916 Melanogenesis
    107519930 (PLCB4)
   04924 Renin secretion
    107519930 (PLCB4)
   04925 Aldosterone synthesis and secretion
    107519930 (PLCB4)
   04927 Cortisol synthesis and secretion
    107519930 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    107519930 (PLCB4)
   04270 Vascular smooth muscle contraction
    107519930 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    107519930 (PLCB4)
   04971 Gastric acid secretion
    107519930 (PLCB4)
   04972 Pancreatic secretion
    107519930 (PLCB4)
   04973 Carbohydrate digestion and absorption
    107519930 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    107519930 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    107519930 (PLCB4)
   04725 Cholinergic synapse
    107519930 (PLCB4)
   04728 Dopaminergic synapse
    107519930 (PLCB4)
   04726 Serotonergic synapse
    107519930 (PLCB4)
   04720 Long-term potentiation
    107519930 (PLCB4)
   04730 Long-term depression
    107519930 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    107519930 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    107519930 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    107519930 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    107519930 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107519930 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    107519930 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    107519930 (PLCB4)
   05142 Chagas disease
    107519930 (PLCB4)
   05143 African trypanosomiasis
    107519930 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107519930 (PLCB4)
   05016 Huntington disease
    107519930 (PLCB4)
   05017 Spinocerebellar ataxia
    107519930 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    107519930 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    107519930 (PLCB4)
   05415 Diabetic cardiomyopathy
    107519930 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    107519930 (PLCB4)
   04934 Cushing syndrome
    107519930 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ray04131]
    107519930 (PLCB4)
Enzymes [BR:ray01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     107519930 (PLCB4)
Membrane trafficking [BR:ray04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    107519930 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    107519930 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 107519930
NCBI-ProteinID: XP_015973825
UniProt: A0A7J8DKD4
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGADLVNIGFTYMVAENPE
VTKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGVISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEQKQLEALKSM
MEAGESAAPVNILEDDNEEEVENAEQEEEAHPEYKFGNELSVDDLGHKEAVANSVKKASD
DLEHENNKKGLITVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKTLEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNTN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcaaaaggaagttccttcctttttgcaagaagga
gcaatttttgacagatacgaagaggaatcctttgtgtttgaacccaattgcctcttcaaa
gtggatgaatttggcttctttctgacctggaaaagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtgttcggttgggagccacaccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaaatccgaaaatgatctggaagggcggatagtttgtgtc
tgcagtggcgcagatctggtgaacatcggtttcacttatatggtggctgagaatccagaa
gtaactaagcaatgggtagatggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgaaaagttctatgaactgacacaaaaaatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgcctgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
ttaaagaaaaaaggcgtcatatcaagtgatggattttgcagatatctgatgtcagatgaa
aatgcccccgtctttctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagctcttcccacaatacctatctcactggccgacaatttggtgggaag
tcttcggtggaaatgtacagacaggttctcctggccgggtgcagatgtgtcgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccgataataactcatggaaaagcaatgtgt
acagatatcctttttaaagatgttattcaagccatcaaggaaacagcatttgtcacatct
gaatatccagtaattctctcctttgaaaatcactgcagcaaataccaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttgccatcccccaatgacctcaaaagaaaaatacttata
aaaaataaacggctgaaacctgaagttgaacaaaaacaacttgaagctttgaaaagcatg
atggaagctggagaatccgctgccccggttaacattttagaggatgataatgaagaagaa
gtagaaaatgctgagcaagaggaggaagctcaccctgaatacaaatttggaaatgaactt
tctgtggatgacttgggtcacaaggaagctgttgcaaatagtgtcaagaaggcttctgat
gacctcgaacatgaaaacaacaaaaagggcctgattactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccgtatttgtccacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagtcggtctaggctacttgaagacacacgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtaccttctcaaaccggatttcatgaggcggcctgatcgaacatttgat
cccttctctgaaactcctgttgacggtgttattgcagccacttgctcagtgcaggtcata
tcaggtcagttcttatcagataagaaaattggcacatatgtagaagtggatatgtatggg
ttgcccaccgacactatacgtaaggaatttcgaactcgcatggtgatgaacaatgggctc
aatccagtttacaatgaagaatcatttgtatttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgatgacaacaacaagctgattggccagaggattcttcca
ctggatggccttcaggcaggctatcgacacatttcccttcgaaacgagggaaataagcca
ttatcgttgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaagtttctttcaattacagaaaagagg
gcagaccaaatgagagctatgggcattgaaaccagtgacatagccgatgtgcccagtgac
acttctaagaatgacaagaaaggaaaggccaacactgccaaagcaaatgtgaccccacag
agcagctcagagctcagaccaaccaccacagccgccctggggtctggcatggaagccaaa
aaaggtattgaacttatccctcaagtgaggatagaagatttaaagcaaatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaagcatgcaaag
gagcacagtaccatgcagaagttacattgcacacaagttgacaaaattgtggcacaatat
gacaaggagaagtcgactcatgagaaaactctagagaaggcaatgaagaaaaagggggga
agtaattgtcttgagatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatcgtggcacaacacaccaaggagtggtcagaaatgatc
aacactcacagtgctgaggagcaagaaatccgggacctgcacctcagccagcagtgcgag
ctgctgaaaaagctcctgatcagtgcccacgagcagcaaacccagcagctgaaattgtcc
cacgacagggaaagcaaggaaatgagagcacaccaagctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgagaaaggcgagttagg
gagttaaacagcagcaacactaagaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcaattgaaaaaagtccagcttgaacacctagaattcctagag
aaacagaatgaacagcttttgaaatcctgtcatgcagtgtcccaaactcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaacacaaactga

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