KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108527553
Entry
108527553         CDS       T04641                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb00562  Inositol phosphate metabolism
rbb01100  Metabolic pathways
rbb04015  Rap1 signaling pathway
rbb04020  Calcium signaling pathway
rbb04022  cGMP-PKG signaling pathway
rbb04062  Chemokine signaling pathway
rbb04070  Phosphatidylinositol signaling system
rbb04071  Sphingolipid signaling pathway
rbb04072  Phospholipase D signaling pathway
rbb04081  Hormone signaling
rbb04082  Neuroactive ligand signaling
rbb04261  Adrenergic signaling in cardiomyocytes
rbb04270  Vascular smooth muscle contraction
rbb04310  Wnt signaling pathway
rbb04371  Apelin signaling pathway
rbb04540  Gap junction
rbb04611  Platelet activation
rbb04613  Neutrophil extracellular trap formation
rbb04621  NOD-like receptor signaling pathway
rbb04713  Circadian entrainment
rbb04720  Long-term potentiation
rbb04723  Retrograde endocannabinoid signaling
rbb04724  Glutamatergic synapse
rbb04725  Cholinergic synapse
rbb04726  Serotonergic synapse
rbb04728  Dopaminergic synapse
rbb04730  Long-term depression
rbb04742  Taste transduction
rbb04750  Inflammatory mediator regulation of TRP channels
rbb04911  Insulin secretion
rbb04912  GnRH signaling pathway
rbb04915  Estrogen signaling pathway
rbb04916  Melanogenesis
rbb04918  Thyroid hormone synthesis
rbb04919  Thyroid hormone signaling pathway
rbb04921  Oxytocin signaling pathway
rbb04922  Glucagon signaling pathway
rbb04924  Renin secretion
rbb04925  Aldosterone synthesis and secretion
rbb04926  Relaxin signaling pathway
rbb04927  Cortisol synthesis and secretion
rbb04928  Parathyroid hormone synthesis, secretion and action
rbb04929  GnRH secretion
rbb04933  AGE-RAGE signaling pathway in diabetic complications
rbb04934  Cushing syndrome
rbb04935  Growth hormone synthesis, secretion and action
rbb04961  Endocrine and other factor-regulated calcium reabsorption
rbb04970  Salivary secretion
rbb04971  Gastric acid secretion
rbb04972  Pancreatic secretion
rbb04973  Carbohydrate digestion and absorption
rbb05010  Alzheimer disease
rbb05016  Huntington disease
rbb05017  Spinocerebellar ataxia
rbb05022  Pathways of neurodegeneration - multiple diseases
rbb05142  Chagas disease
rbb05143  African trypanosomiasis
rbb05146  Amoebiasis
rbb05163  Human cytomegalovirus infection
rbb05200  Pathways in cancer
rbb05415  Diabetic cardiomyopathy
rbb05417  Lipid and atherosclerosis
Module
rbb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    108527553 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    108527553 (PLCB1)
   04310 Wnt signaling pathway
    108527553 (PLCB1)
   04371 Apelin signaling pathway
    108527553 (PLCB1)
   04020 Calcium signaling pathway
    108527553 (PLCB1)
   04070 Phosphatidylinositol signaling system
    108527553 (PLCB1)
   04072 Phospholipase D signaling pathway
    108527553 (PLCB1)
   04071 Sphingolipid signaling pathway
    108527553 (PLCB1)
   04022 cGMP-PKG signaling pathway
    108527553 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    108527553 (PLCB1)
   04081 Hormone signaling
    108527553 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    108527553 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108527553 (PLCB1)
   04613 Neutrophil extracellular trap formation
    108527553 (PLCB1)
   04621 NOD-like receptor signaling pathway
    108527553 (PLCB1)
   04062 Chemokine signaling pathway
    108527553 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    108527553 (PLCB1)
   04922 Glucagon signaling pathway
    108527553 (PLCB1)
   04929 GnRH secretion
    108527553 (PLCB1)
   04912 GnRH signaling pathway
    108527553 (PLCB1)
   04915 Estrogen signaling pathway
    108527553 (PLCB1)
   04921 Oxytocin signaling pathway
    108527553 (PLCB1)
   04926 Relaxin signaling pathway
    108527553 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    108527553 (PLCB1)
   04918 Thyroid hormone synthesis
    108527553 (PLCB1)
   04919 Thyroid hormone signaling pathway
    108527553 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    108527553 (PLCB1)
   04916 Melanogenesis
    108527553 (PLCB1)
   04924 Renin secretion
    108527553 (PLCB1)
   04925 Aldosterone synthesis and secretion
    108527553 (PLCB1)
   04927 Cortisol synthesis and secretion
    108527553 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    108527553 (PLCB1)
   04270 Vascular smooth muscle contraction
    108527553 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    108527553 (PLCB1)
   04971 Gastric acid secretion
    108527553 (PLCB1)
   04972 Pancreatic secretion
    108527553 (PLCB1)
   04973 Carbohydrate digestion and absorption
    108527553 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    108527553 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    108527553 (PLCB1)
   04725 Cholinergic synapse
    108527553 (PLCB1)
   04728 Dopaminergic synapse
    108527553 (PLCB1)
   04726 Serotonergic synapse
    108527553 (PLCB1)
   04720 Long-term potentiation
    108527553 (PLCB1)
   04730 Long-term depression
    108527553 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    108527553 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    108527553 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    108527553 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    108527553 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108527553 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    108527553 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108527553 (PLCB1)
   05142 Chagas disease
    108527553 (PLCB1)
   05143 African trypanosomiasis
    108527553 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108527553 (PLCB1)
   05016 Huntington disease
    108527553 (PLCB1)
   05017 Spinocerebellar ataxia
    108527553 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    108527553 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108527553 (PLCB1)
   05415 Diabetic cardiomyopathy
    108527553 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    108527553 (PLCB1)
   04934 Cushing syndrome
    108527553 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rbb04131]
    108527553 (PLCB1)
Enzymes [BR:rbb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     108527553 (PLCB1)
Membrane trafficking [BR:rbb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    108527553 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    108527553 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PLCB1-4-like_EFh PI-PLC-Y EF-hand_like PH_14 DUF6158
Other DBs
NCBI-GeneID: 108527553
NCBI-ProteinID: XP_017724367
LinkDB
Position
Unknown
AA seq 1081 aa
MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL
QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP
RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN
NSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA
GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK
TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK
ILVKNKKKSHKSSEGSGKKKLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCK
KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK
SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMVIRLTWNYKLID
AAFFVVIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK
KVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV
KDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSETPSEV
RTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQ
QKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKRTVR
KKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHI
KLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEK
TEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFK
RLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTP
L
NT seq 3246 nt   +upstreamnt  +downstreamnt
atgatcacggtggtgtatggacctgacctcgtgaacatctcccatttgaatctcgtggct
ttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctg
ctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaagctg
caagtcactccagaggggcgtattcctctcaaaaacatatatcgcttgttttcagcagac
cggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgattca
atacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgccct
cgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatcttacc
gttgaccagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaaata
ctttatccaccgctaaaacaagagcaagtccaagtattgattgagaagtatgaacccaac
aacagcctcgccaaaaaaggacaaatatcagtggatgggttcatgcgctatctgagtgga
gaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcagccc
ctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactggct
ggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtggag
ctggactgctggaagggacgaactgcagaagaggaacctgtcatcacccatggcttcacc
atgacaactgaaatatctttcaaggaagtgatagaagcaatagcggagtgtgcatttaag
acttcaccttttccaattctcctttcatttgagaaccatgtggattccccaaagcagcaa
gccaagatggcggagtactgccgactgatcttcggggatgcccttctcatggagcccctg
gaaaaatatccactggaatctggagttcctcttccaagccctatggatttaatgtataaa
attttggtgaaaaataagaagaaatcacacaagtcatcagaaggaagcggcaaaaagaag
ctctcagaacaagcctccaacacctgcagtgactcctccagcatgttcgagccctcatcc
ccaggagccggagaagctgatacggaaagtgacgacgatgatgatgatgatgactgtaaa
aaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaagaaatgtct
aacctggtgaactacattcagccggtcaagtttgagtcatttgaaatttcaaaaaaaaga
aataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcaccaag
tctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaagga
acacgtgtggattcatccaactatatgcctcagctcttctggaatgcaggttgtcagatg
gtggcacttaatttccagacaatggtcatccgactgacctggaattacaagttaatagat
gcagccttttttgttgtgattatttcaggtcagtttctttctgataagaaagtcgggact
tatgtggaagtggatatgtttggtttgcctgtggatacaaggaggaaggcatttaagacc
aagacatcccaaggaaatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaa
aaggtggttcttcctactctggcctgtttgagaatagcagtttatgaagaaggaggtaaa
ttcattggccaccgtatcttgccagtgcaagccattcggccaggctatcactatatatgt
ctaaggaatgaaaggaaccagcctctgacactgcctgctgtctttgtctacatagaagtg
aaagactatgtgccagacacatatgcagatgtcattgaagctttatcaaacccaatccgg
tatgtgaacctgatggagcagagagctaagcaattggctgctttgacactggaagatgaa
gaagaagtaaagaaagaggctgatcctggagaaacaccatcagagactccaagtgaagtg
agaacgactccagcagaaaacggggtgaatcacactacatccctgacacccaagccaccc
tcccaggctctccacagccaaccagctccaggttctgtaaaggcacctgccaaaacagaa
gatcttattcagagtgtcttaacagaagtggaagcacagaccatcgaagagctaaagcaa
cagaaatcgtttgtgaaacttcaaaagaagcactacaaagaaatgaaagacctggttaag
agacaccacaagaaaaccactgacctgatcaaagaacacactaccaagtataatgaaatt
cagaatgactacttgagaaggagagcagctttggaaaagtccgccaaaaggacagtaaga
aaaaaatcggaacccagcagccctgatcatggttcatcaacgattgagcaagacctcgct
gccctggatgctgaaatgacccaaaaattaatagacttgaaggacaaacaacagcagcag
ctgcttaatcttcgacaagaacagtattatagtgaaaaataccagaagcgagaacatatt
aaactgcttattcaaaagttgacggatgtcgcagaagagtgtcagaacaatcagttaaag
aagctcaaagaaatctgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaag
aggcaggagaagataacagaagctaaatctaaagacaaaagtcagatggaagaggagaag
acagagatgatccggtcatatatccaggaagtggtgcagtacatcaagaggctagaagag
gcgcaaagtaaacggcaagaaaaactcgtagagaaacacaaggaaatacgtcagcagatc
ctggatgaaaagcccaagctgcaggtggagctggagcaagaataccaagacaaattcaaa
agactgcccctcgagattttggaatttgtgcaggaagccatgaaaggaaagatcagtgaa
gacagcaatcacggttctgcccctctctccctgtcctcagaccctggaaaagtgaaccac
aagactccctccagtgaggagctgggaggagacatcccaggaaaagaatttgatactcct
ctgtga

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