KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108532960
Entry
108532960         CDS       T04641                                 
Symbol
PIK3CA
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb00562  Inositol phosphate metabolism
rbb01100  Metabolic pathways
rbb01521  EGFR tyrosine kinase inhibitor resistance
rbb01522  Endocrine resistance
rbb01524  Platinum drug resistance
rbb04012  ErbB signaling pathway
rbb04014  Ras signaling pathway
rbb04015  Rap1 signaling pathway
rbb04024  cAMP signaling pathway
rbb04062  Chemokine signaling pathway
rbb04066  HIF-1 signaling pathway
rbb04068  FoxO signaling pathway
rbb04070  Phosphatidylinositol signaling system
rbb04071  Sphingolipid signaling pathway
rbb04072  Phospholipase D signaling pathway
rbb04081  Hormone signaling
rbb04140  Autophagy - animal
rbb04150  mTOR signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04152  AMPK signaling pathway
rbb04210  Apoptosis
rbb04211  Longevity regulating pathway
rbb04213  Longevity regulating pathway - multiple species
rbb04218  Cellular senescence
rbb04360  Axon guidance
rbb04370  VEGF signaling pathway
rbb04380  Osteoclast differentiation
rbb04510  Focal adhesion
rbb04550  Signaling pathways regulating pluripotency of stem cells
rbb04611  Platelet activation
rbb04613  Neutrophil extracellular trap formation
rbb04620  Toll-like receptor signaling pathway
rbb04625  C-type lectin receptor signaling pathway
rbb04630  JAK-STAT signaling pathway
rbb04650  Natural killer cell mediated cytotoxicity
rbb04660  T cell receptor signaling pathway
rbb04662  B cell receptor signaling pathway
rbb04664  Fc epsilon RI signaling pathway
rbb04666  Fc gamma R-mediated phagocytosis
rbb04668  TNF signaling pathway
rbb04670  Leukocyte transendothelial migration
rbb04722  Neurotrophin signaling pathway
rbb04725  Cholinergic synapse
rbb04750  Inflammatory mediator regulation of TRP channels
rbb04810  Regulation of actin cytoskeleton
rbb04910  Insulin signaling pathway
rbb04914  Progesterone-mediated oocyte maturation
rbb04915  Estrogen signaling pathway
rbb04917  Prolactin signaling pathway
rbb04919  Thyroid hormone signaling pathway
rbb04923  Regulation of lipolysis in adipocytes
rbb04926  Relaxin signaling pathway
rbb04929  GnRH secretion
rbb04930  Type II diabetes mellitus
rbb04931  Insulin resistance
rbb04932  Non-alcoholic fatty liver disease
rbb04933  AGE-RAGE signaling pathway in diabetic complications
rbb04935  Growth hormone synthesis, secretion and action
rbb04960  Aldosterone-regulated sodium reabsorption
rbb04973  Carbohydrate digestion and absorption
rbb05010  Alzheimer disease
rbb05017  Spinocerebellar ataxia
rbb05020  Prion disease
rbb05100  Bacterial invasion of epithelial cells
rbb05132  Salmonella infection
rbb05135  Yersinia infection
rbb05142  Chagas disease
rbb05146  Amoebiasis
rbb05160  Hepatitis C
rbb05161  Hepatitis B
rbb05162  Measles
rbb05163  Human cytomegalovirus infection
rbb05164  Influenza A
rbb05165  Human papillomavirus infection
rbb05166  Human T-cell leukemia virus 1 infection
rbb05167  Kaposi sarcoma-associated herpesvirus infection
rbb05168  Herpes simplex virus 1 infection
rbb05169  Epstein-Barr virus infection
rbb05170  Human immunodeficiency virus 1 infection
rbb05171  Coronavirus disease - COVID-19
rbb05200  Pathways in cancer
rbb05203  Viral carcinogenesis
rbb05205  Proteoglycans in cancer
rbb05206  MicroRNAs in cancer
rbb05207  Chemical carcinogenesis - receptor activation
rbb05208  Chemical carcinogenesis - reactive oxygen species
rbb05210  Colorectal cancer
rbb05211  Renal cell carcinoma
rbb05212  Pancreatic cancer
rbb05213  Endometrial cancer
rbb05214  Glioma
rbb05215  Prostate cancer
rbb05218  Melanoma
rbb05220  Chronic myeloid leukemia
rbb05221  Acute myeloid leukemia
rbb05222  Small cell lung cancer
rbb05223  Non-small cell lung cancer
rbb05224  Breast cancer
rbb05225  Hepatocellular carcinoma
rbb05226  Gastric cancer
rbb05230  Central carbon metabolism in cancer
rbb05231  Choline metabolism in cancer
rbb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rbb05415  Diabetic cardiomyopathy
rbb05417  Lipid and atherosclerosis
rbb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    108532960 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    108532960 (PIK3CA)
   04014 Ras signaling pathway
    108532960 (PIK3CA)
   04015 Rap1 signaling pathway
    108532960 (PIK3CA)
   04370 VEGF signaling pathway
    108532960 (PIK3CA)
   04630 JAK-STAT signaling pathway
    108532960 (PIK3CA)
   04668 TNF signaling pathway
    108532960 (PIK3CA)
   04066 HIF-1 signaling pathway
    108532960 (PIK3CA)
   04068 FoxO signaling pathway
    108532960 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    108532960 (PIK3CA)
   04072 Phospholipase D signaling pathway
    108532960 (PIK3CA)
   04071 Sphingolipid signaling pathway
    108532960 (PIK3CA)
   04024 cAMP signaling pathway
    108532960 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    108532960 (PIK3CA)
   04152 AMPK signaling pathway
    108532960 (PIK3CA)
   04150 mTOR signaling pathway
    108532960 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    108532960 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108532960 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    108532960 (PIK3CA)
   04218 Cellular senescence
    108532960 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108532960 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    108532960 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108532960 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108532960 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    108532960 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    108532960 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    108532960 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    108532960 (PIK3CA)
   04660 T cell receptor signaling pathway
    108532960 (PIK3CA)
   04662 B cell receptor signaling pathway
    108532960 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    108532960 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    108532960 (PIK3CA)
   04670 Leukocyte transendothelial migration
    108532960 (PIK3CA)
   04062 Chemokine signaling pathway
    108532960 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108532960 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    108532960 (PIK3CA)
   04929 GnRH secretion
    108532960 (PIK3CA)
   04915 Estrogen signaling pathway
    108532960 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    108532960 (PIK3CA)
   04917 Prolactin signaling pathway
    108532960 (PIK3CA)
   04926 Relaxin signaling pathway
    108532960 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    108532960 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    108532960 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    108532960 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    108532960 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    108532960 (PIK3CA)
   04722 Neurotrophin signaling pathway
    108532960 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    108532960 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    108532960 (PIK3CA)
   04380 Osteoclast differentiation
    108532960 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    108532960 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    108532960 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108532960 (PIK3CA)
   05206 MicroRNAs in cancer
    108532960 (PIK3CA)
   05205 Proteoglycans in cancer
    108532960 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    108532960 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    108532960 (PIK3CA)
   05203 Viral carcinogenesis
    108532960 (PIK3CA)
   05230 Central carbon metabolism in cancer
    108532960 (PIK3CA)
   05231 Choline metabolism in cancer
    108532960 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108532960 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108532960 (PIK3CA)
   05212 Pancreatic cancer
    108532960 (PIK3CA)
   05225 Hepatocellular carcinoma
    108532960 (PIK3CA)
   05226 Gastric cancer
    108532960 (PIK3CA)
   05214 Glioma
    108532960 (PIK3CA)
   05221 Acute myeloid leukemia
    108532960 (PIK3CA)
   05220 Chronic myeloid leukemia
    108532960 (PIK3CA)
   05218 Melanoma
    108532960 (PIK3CA)
   05211 Renal cell carcinoma
    108532960 (PIK3CA)
   05215 Prostate cancer
    108532960 (PIK3CA)
   05213 Endometrial cancer
    108532960 (PIK3CA)
   05224 Breast cancer
    108532960 (PIK3CA)
   05222 Small cell lung cancer
    108532960 (PIK3CA)
   05223 Non-small cell lung cancer
    108532960 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108532960 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    108532960 (PIK3CA)
   05161 Hepatitis B
    108532960 (PIK3CA)
   05160 Hepatitis C
    108532960 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    108532960 (PIK3CA)
   05164 Influenza A
    108532960 (PIK3CA)
   05162 Measles
    108532960 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    108532960 (PIK3CA)
   05163 Human cytomegalovirus infection
    108532960 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108532960 (PIK3CA)
   05169 Epstein-Barr virus infection
    108532960 (PIK3CA)
   05165 Human papillomavirus infection
    108532960 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108532960 (PIK3CA)
   05135 Yersinia infection
    108532960 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    108532960 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108532960 (PIK3CA)
   05142 Chagas disease
    108532960 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108532960 (PIK3CA)
   05017 Spinocerebellar ataxia
    108532960 (PIK3CA)
   05020 Prion disease
    108532960 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108532960 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    108532960 (PIK3CA)
   05415 Diabetic cardiomyopathy
    108532960 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    108532960 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    108532960 (PIK3CA)
   04931 Insulin resistance
    108532960 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108532960 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108532960 (PIK3CA)
   01524 Platinum drug resistance
    108532960 (PIK3CA)
   01522 Endocrine resistance
    108532960 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rbb04131]
    108532960 (PIK3CA)
Enzymes [BR:rbb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     108532960 (PIK3CA)
Membrane trafficking [BR:rbb04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    108532960 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1
Other DBs
NCBI-GeneID: 108532960
NCBI-ProteinID: XP_017732771
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVSQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEXKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcgccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgccgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacagctaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgaccttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
tcccagatgtattgcttggtaaaagactggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagnaaaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacactctacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatattgtgtcgctaccttcattctgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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