KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108535077
Entry
108535077         CDS       T04641                                 
Symbol
CHUK
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb01523  Antifolate resistance
rbb04010  MAPK signaling pathway
rbb04014  Ras signaling pathway
rbb04062  Chemokine signaling pathway
rbb04064  NF-kappa B signaling pathway
rbb04068  FoxO signaling pathway
rbb04150  mTOR signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04210  Apoptosis
rbb04380  Osteoclast differentiation
rbb04620  Toll-like receptor signaling pathway
rbb04621  NOD-like receptor signaling pathway
rbb04622  RIG-I-like receptor signaling pathway
rbb04623  Cytosolic DNA-sensing pathway
rbb04625  C-type lectin receptor signaling pathway
rbb04657  IL-17 signaling pathway
rbb04658  Th1 and Th2 cell differentiation
rbb04659  Th17 cell differentiation
rbb04660  T cell receptor signaling pathway
rbb04662  B cell receptor signaling pathway
rbb04668  TNF signaling pathway
rbb04920  Adipocytokine signaling pathway
rbb04936  Alcoholic liver disease
rbb05010  Alzheimer disease
rbb05132  Salmonella infection
rbb05135  Yersinia infection
rbb05142  Chagas disease
rbb05145  Toxoplasmosis
rbb05160  Hepatitis C
rbb05161  Hepatitis B
rbb05162  Measles
rbb05163  Human cytomegalovirus infection
rbb05164  Influenza A
rbb05165  Human papillomavirus infection
rbb05166  Human T-cell leukemia virus 1 infection
rbb05167  Kaposi sarcoma-associated herpesvirus infection
rbb05168  Herpes simplex virus 1 infection
rbb05169  Epstein-Barr virus infection
rbb05170  Human immunodeficiency virus 1 infection
rbb05171  Coronavirus disease - COVID-19
rbb05200  Pathways in cancer
rbb05208  Chemical carcinogenesis - reactive oxygen species
rbb05212  Pancreatic cancer
rbb05215  Prostate cancer
rbb05220  Chronic myeloid leukemia
rbb05221  Acute myeloid leukemia
rbb05222  Small cell lung cancer
rbb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rbb05417  Lipid and atherosclerosis
rbb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108535077 (CHUK)
   04014 Ras signaling pathway
    108535077 (CHUK)
   04064 NF-kappa B signaling pathway
    108535077 (CHUK)
   04668 TNF signaling pathway
    108535077 (CHUK)
   04068 FoxO signaling pathway
    108535077 (CHUK)
   04151 PI3K-Akt signaling pathway
    108535077 (CHUK)
   04150 mTOR signaling pathway
    108535077 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    108535077 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    108535077 (CHUK)
   04621 NOD-like receptor signaling pathway
    108535077 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    108535077 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    108535077 (CHUK)
   04625 C-type lectin receptor signaling pathway
    108535077 (CHUK)
   04660 T cell receptor signaling pathway
    108535077 (CHUK)
   04658 Th1 and Th2 cell differentiation
    108535077 (CHUK)
   04659 Th17 cell differentiation
    108535077 (CHUK)
   04657 IL-17 signaling pathway
    108535077 (CHUK)
   04662 B cell receptor signaling pathway
    108535077 (CHUK)
   04062 Chemokine signaling pathway
    108535077 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    108535077 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108535077 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108535077 (CHUK)
   05208 Chemical carcinogenesis - reactive oxygen species
    108535077 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108535077 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    108535077 (CHUK)
   05221 Acute myeloid leukemia
    108535077 (CHUK)
   05220 Chronic myeloid leukemia
    108535077 (CHUK)
   05215 Prostate cancer
    108535077 (CHUK)
   05222 Small cell lung cancer
    108535077 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108535077 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    108535077 (CHUK)
   05161 Hepatitis B
    108535077 (CHUK)
   05160 Hepatitis C
    108535077 (CHUK)
   05171 Coronavirus disease - COVID-19
    108535077 (CHUK)
   05164 Influenza A
    108535077 (CHUK)
   05162 Measles
    108535077 (CHUK)
   05168 Herpes simplex virus 1 infection
    108535077 (CHUK)
   05163 Human cytomegalovirus infection
    108535077 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108535077 (CHUK)
   05169 Epstein-Barr virus infection
    108535077 (CHUK)
   05165 Human papillomavirus infection
    108535077 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108535077 (CHUK)
   05135 Yersinia infection
    108535077 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    108535077 (CHUK)
   05142 Chagas disease
    108535077 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108535077 (CHUK)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108535077 (CHUK)
   05418 Fluid shear stress and atherosclerosis
    108535077 (CHUK)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    108535077 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    108535077 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rbb01001]
    108535077 (CHUK)
Enzymes [BR:rbb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     108535077 (CHUK)
Protein kinases [BR:rbb01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   108535077 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 108535077
NCBI-ProteinID: XP_017736264
UniProt: A0A2K6LKA1
LinkDB
Position
Unknown
AA seq 745 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLSWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSVWLPPTSAEHDHSLSCVVTPPDGDTSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ttgggcaccggcggcttcgggaacgtctgtctgtaccagcatcgggaacttgatctcaaa
atagcaattaagtcttgtcgcctagagctaagtaccaaaaatagagaacgatggtgccac
gaaatccagattatgaagaagttgaaccatgccaacgttgtaaaggcctgtgatgttcct
gaagaactgaatattttgattcatgatgtgcctcttctagcaatggaatactgttctgga
ggagatctccgaaagctgctaaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactaagtgatatagggtctgggattcgatatttgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaacatagttcttcaggacgttggtggaaagataata
cataaaataattgatctgggatatgccaaagatgttgatcaaggaagtctgtgtacatct
tttgtgggaacactgcagtatctggccccagagctctttgagaataagccttacacagcc
actgttgattattggagctttgggaccatggtatttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagagatgtcaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagaacccatggaaaactggctacagctgatgttg
agttgggaccctcagcagagaggaggacctgttgaccttactttgaagcagccgagatgt
tttgtactaatggatcacattttgaatttgaagatagtacacatcctaaatatgacttct
gcaaagataatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatactggttctcaagaacttctttcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagttagaggctgtgat
agctatatggtttatttgtttgataaaagtaaaactgtgtatgaagggccatttgcttcc
agaagtttatctgattgtgtaaattatattgtacaggatagcaaaatacagcttccaatt
atacagctgcgtaaagtgtgggctgaagcagtgcactatgtgtctggactaaaagaagac
tacagcaggctctttcagggacaaagggcagcaatgttaagtcttcttagatataatgct
aacttaacaaaaatgaagaacactttgatctcagcatcacaacaactgaaagctaaattg
gagttttttcacaaaagcattcagcttgacttggagagatacagtgagcagatgacgtat
gggatatcttcagaaaaaatgctaaaagcatggaaagaaatggaagaaaaggccatccac
tatgctgaggtcggtgtcattggatacctggaggatcagattatgtctttgcatgctgaa
atcatggagctacagaagagcccctatggaagacgtcagggagacttgatggaatctctg
gaacagcgtgccattgatctatataagcagttaaaacacagaccttcagatcactcctac
agtgacagcacagagatggtgaaaatcattgtgcacactgtgcagagtcaggaccgtgtg
ctcaaggagctgtttggtcatttgagcaagttgttgggctgtaagcagaagattattgat
ctactccctaaggtggaagtggccctcagtaacatcaaagaagctgataatactgtcatg
ttcatgcagggaaaaaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccggtcccttgtaggatccagtctagaaggtgcagtaacccctcagacgtca
gtatggctgcccccgacttcagcagaacatgatcattctctgtcatgtgtggtaactcct
ccagatggagatacttcagcacaaatgatagaagaaaatttgaactgccttggccattta
agcactattattcatgaggcaaatgaggaacagggcaatagtatgatgaatcttgattgg
agttggttaacagaatga

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