KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108539069
Entry
108539069         CDS       T04641                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb01521  EGFR tyrosine kinase inhibitor resistance
rbb01522  Endocrine resistance
rbb01524  Platinum drug resistance
rbb04010  MAPK signaling pathway
rbb04012  ErbB signaling pathway
rbb04014  Ras signaling pathway
rbb04015  Rap1 signaling pathway
rbb04022  cGMP-PKG signaling pathway
rbb04024  cAMP signaling pathway
rbb04062  Chemokine signaling pathway
rbb04066  HIF-1 signaling pathway
rbb04068  FoxO signaling pathway
rbb04071  Sphingolipid signaling pathway
rbb04072  Phospholipase D signaling pathway
rbb04140  Autophagy - animal
rbb04150  mTOR signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04152  AMPK signaling pathway
rbb04210  Apoptosis
rbb04211  Longevity regulating pathway
rbb04213  Longevity regulating pathway - multiple species
rbb04218  Cellular senescence
rbb04261  Adrenergic signaling in cardiomyocytes
rbb04370  VEGF signaling pathway
rbb04371  Apelin signaling pathway
rbb04380  Osteoclast differentiation
rbb04510  Focal adhesion
rbb04517  IgSF CAM signaling
rbb04518  Integrin signaling
rbb04550  Signaling pathways regulating pluripotency of stem cells
rbb04611  Platelet activation
rbb04613  Neutrophil extracellular trap formation
rbb04620  Toll-like receptor signaling pathway
rbb04625  C-type lectin receptor signaling pathway
rbb04630  JAK-STAT signaling pathway
rbb04660  T cell receptor signaling pathway
rbb04662  B cell receptor signaling pathway
rbb04664  Fc epsilon RI signaling pathway
rbb04666  Fc gamma R-mediated phagocytosis
rbb04668  TNF signaling pathway
rbb04722  Neurotrophin signaling pathway
rbb04725  Cholinergic synapse
rbb04728  Dopaminergic synapse
rbb04810  Regulation of actin cytoskeleton
rbb04910  Insulin signaling pathway
rbb04914  Progesterone-mediated oocyte maturation
rbb04915  Estrogen signaling pathway
rbb04917  Prolactin signaling pathway
rbb04919  Thyroid hormone signaling pathway
rbb04920  Adipocytokine signaling pathway
rbb04922  Glucagon signaling pathway
rbb04923  Regulation of lipolysis in adipocytes
rbb04926  Relaxin signaling pathway
rbb04929  GnRH secretion
rbb04931  Insulin resistance
rbb04932  Non-alcoholic fatty liver disease
rbb04933  AGE-RAGE signaling pathway in diabetic complications
rbb04935  Growth hormone synthesis, secretion and action
rbb04936  Alcoholic liver disease
rbb04973  Carbohydrate digestion and absorption
rbb05010  Alzheimer disease
rbb05017  Spinocerebellar ataxia
rbb05132  Salmonella infection
rbb05135  Yersinia infection
rbb05142  Chagas disease
rbb05145  Toxoplasmosis
rbb05152  Tuberculosis
rbb05160  Hepatitis C
rbb05161  Hepatitis B
rbb05162  Measles
rbb05163  Human cytomegalovirus infection
rbb05164  Influenza A
rbb05165  Human papillomavirus infection
rbb05166  Human T-cell leukemia virus 1 infection
rbb05167  Kaposi sarcoma-associated herpesvirus infection
rbb05168  Herpes simplex virus 1 infection
rbb05169  Epstein-Barr virus infection
rbb05170  Human immunodeficiency virus 1 infection
rbb05200  Pathways in cancer
rbb05205  Proteoglycans in cancer
rbb05207  Chemical carcinogenesis - receptor activation
rbb05208  Chemical carcinogenesis - reactive oxygen species
rbb05210  Colorectal cancer
rbb05211  Renal cell carcinoma
rbb05212  Pancreatic cancer
rbb05213  Endometrial cancer
rbb05214  Glioma
rbb05215  Prostate cancer
rbb05218  Melanoma
rbb05220  Chronic myeloid leukemia
rbb05221  Acute myeloid leukemia
rbb05222  Small cell lung cancer
rbb05223  Non-small cell lung cancer
rbb05224  Breast cancer
rbb05225  Hepatocellular carcinoma
rbb05226  Gastric cancer
rbb05230  Central carbon metabolism in cancer
rbb05231  Choline metabolism in cancer
rbb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rbb05415  Diabetic cardiomyopathy
rbb05417  Lipid and atherosclerosis
rbb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108539069 (AKT2)
   04012 ErbB signaling pathway
    108539069 (AKT2)
   04014 Ras signaling pathway
    108539069 (AKT2)
   04015 Rap1 signaling pathway
    108539069 (AKT2)
   04370 VEGF signaling pathway
    108539069 (AKT2)
   04371 Apelin signaling pathway
    108539069 (AKT2)
   04630 JAK-STAT signaling pathway
    108539069 (AKT2)
   04668 TNF signaling pathway
    108539069 (AKT2)
   04066 HIF-1 signaling pathway
    108539069 (AKT2)
   04068 FoxO signaling pathway
    108539069 (AKT2)
   04072 Phospholipase D signaling pathway
    108539069 (AKT2)
   04071 Sphingolipid signaling pathway
    108539069 (AKT2)
   04024 cAMP signaling pathway
    108539069 (AKT2)
   04022 cGMP-PKG signaling pathway
    108539069 (AKT2)
   04151 PI3K-Akt signaling pathway
    108539069 (AKT2)
   04152 AMPK signaling pathway
    108539069 (AKT2)
   04150 mTOR signaling pathway
    108539069 (AKT2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    108539069 (AKT2)
   04518 Integrin signaling
    108539069 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108539069 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    108539069 (AKT2)
   04218 Cellular senescence
    108539069 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108539069 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    108539069 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108539069 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108539069 (AKT2)
   04613 Neutrophil extracellular trap formation
    108539069 (AKT2)
   04620 Toll-like receptor signaling pathway
    108539069 (AKT2)
   04625 C-type lectin receptor signaling pathway
    108539069 (AKT2)
   04660 T cell receptor signaling pathway
    108539069 (AKT2)
   04662 B cell receptor signaling pathway
    108539069 (AKT2)
   04664 Fc epsilon RI signaling pathway
    108539069 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    108539069 (AKT2)
   04062 Chemokine signaling pathway
    108539069 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108539069 (AKT2)
   04922 Glucagon signaling pathway
    108539069 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    108539069 (AKT2)
   04920 Adipocytokine signaling pathway
    108539069 (AKT2)
   04929 GnRH secretion
    108539069 (AKT2)
   04915 Estrogen signaling pathway
    108539069 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    108539069 (AKT2)
   04917 Prolactin signaling pathway
    108539069 (AKT2)
   04926 Relaxin signaling pathway
    108539069 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    108539069 (AKT2)
   04919 Thyroid hormone signaling pathway
    108539069 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    108539069 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    108539069 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    108539069 (AKT2)
   04728 Dopaminergic synapse
    108539069 (AKT2)
   04722 Neurotrophin signaling pathway
    108539069 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108539069 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    108539069 (AKT2)
   04213 Longevity regulating pathway - multiple species
    108539069 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108539069 (AKT2)
   05205 Proteoglycans in cancer
    108539069 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    108539069 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    108539069 (AKT2)
   05230 Central carbon metabolism in cancer
    108539069 (AKT2)
   05231 Choline metabolism in cancer
    108539069 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108539069 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108539069 (AKT2)
   05212 Pancreatic cancer
    108539069 (AKT2)
   05225 Hepatocellular carcinoma
    108539069 (AKT2)
   05226 Gastric cancer
    108539069 (AKT2)
   05214 Glioma
    108539069 (AKT2)
   05221 Acute myeloid leukemia
    108539069 (AKT2)
   05220 Chronic myeloid leukemia
    108539069 (AKT2)
   05218 Melanoma
    108539069 (AKT2)
   05211 Renal cell carcinoma
    108539069 (AKT2)
   05215 Prostate cancer
    108539069 (AKT2)
   05213 Endometrial cancer
    108539069 (AKT2)
   05224 Breast cancer
    108539069 (AKT2)
   05222 Small cell lung cancer
    108539069 (AKT2)
   05223 Non-small cell lung cancer
    108539069 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108539069 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    108539069 (AKT2)
   05161 Hepatitis B
    108539069 (AKT2)
   05160 Hepatitis C
    108539069 (AKT2)
   05164 Influenza A
    108539069 (AKT2)
   05162 Measles
    108539069 (AKT2)
   05168 Herpes simplex virus 1 infection
    108539069 (AKT2)
   05163 Human cytomegalovirus infection
    108539069 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108539069 (AKT2)
   05169 Epstein-Barr virus infection
    108539069 (AKT2)
   05165 Human papillomavirus infection
    108539069 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108539069 (AKT2)
   05135 Yersinia infection
    108539069 (AKT2)
   05152 Tuberculosis
    108539069 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    108539069 (AKT2)
   05142 Chagas disease
    108539069 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108539069 (AKT2)
   05017 Spinocerebellar ataxia
    108539069 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108539069 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    108539069 (AKT2)
   05415 Diabetic cardiomyopathy
    108539069 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    108539069 (AKT2)
   04932 Non-alcoholic fatty liver disease
    108539069 (AKT2)
   04931 Insulin resistance
    108539069 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108539069 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108539069 (AKT2)
   01524 Platinum drug resistance
    108539069 (AKT2)
   01522 Endocrine resistance
    108539069 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rbb01001]
    108539069 (AKT2)
Enzymes [BR:rbb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     108539069 (AKT2)
Protein kinases [BR:rbb01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   108539069 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 108539069
NCBI-ProteinID: XP_017742994
UniProt: A0AAJ7I8U8
LinkDB
Position
Unknown
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRTPGEDPM
DYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVIQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgcggtgaatacatcaag
acctggaggccacggtacttccttctgaagagcgatggctccttcattgggtacaaggag
aggcctgaggcccctgatcagacccttccccccttaaacaacttctctgtcgcagaatgc
cagctgatgaagaccgagaggccacggcccaacacattcgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagacgagagggaggaatggatg
cgggccatccagatggtcgccaacagcctcaagcagcggaccccaggtgaggaccccatg
gactacaagtgtggctcccccagtgactcctccgcggccgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgattttgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtacgccttccag
acccacgaccgcctgtgcttcgtgatggagtacgcaaacggtggcgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtc
tcggctcttgagtacttgcactcacgggacgtggtgtaccgtgacatcaagctggaaaac
ctcatgctggataaagacggccacatcaagatcactgactttggcctctgcaaagaaggc
atcagtgacggggctaccatgaaaaccttctgtgggaccccagagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggttgggtgtggtcatg
tacgagatgatgtgcggccgcctgcctttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgccgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtgatccagaag
aagctcctgccgcccttcaaacctcaggtcacgtccgaggtcgacacaaggtactttgat
gatgaattcaccgcccagtccatcacaatcacaccccccgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga

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