KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117022968
Entry
117022968         CDS       T07722                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq01521  EGFR tyrosine kinase inhibitor resistance
rfq01522  Endocrine resistance
rfq04010  MAPK signaling pathway
rfq04012  ErbB signaling pathway
rfq04014  Ras signaling pathway
rfq04015  Rap1 signaling pathway
rfq04022  cGMP-PKG signaling pathway
rfq04024  cAMP signaling pathway
rfq04062  Chemokine signaling pathway
rfq04066  HIF-1 signaling pathway
rfq04068  FoxO signaling pathway
rfq04071  Sphingolipid signaling pathway
rfq04072  Phospholipase D signaling pathway
rfq04114  Oocyte meiosis
rfq04140  Autophagy - animal
rfq04148  Efferocytosis
rfq04150  mTOR signaling pathway
rfq04151  PI3K-Akt signaling pathway
rfq04210  Apoptosis
rfq04218  Cellular senescence
rfq04270  Vascular smooth muscle contraction
rfq04370  VEGF signaling pathway
rfq04371  Apelin signaling pathway
rfq04380  Osteoclast differentiation
rfq04510  Focal adhesion
rfq04540  Gap junction
rfq04550  Signaling pathways regulating pluripotency of stem cells
rfq04613  Neutrophil extracellular trap formation
rfq04620  Toll-like receptor signaling pathway
rfq04650  Natural killer cell mediated cytotoxicity
rfq04660  T cell receptor signaling pathway
rfq04662  B cell receptor signaling pathway
rfq04664  Fc epsilon RI signaling pathway
rfq04666  Fc gamma R-mediated phagocytosis
rfq04668  TNF signaling pathway
rfq04720  Long-term potentiation
rfq04722  Neurotrophin signaling pathway
rfq04725  Cholinergic synapse
rfq04726  Serotonergic synapse
rfq04730  Long-term depression
rfq04810  Regulation of actin cytoskeleton
rfq04910  Insulin signaling pathway
rfq04912  GnRH signaling pathway
rfq04914  Progesterone-mediated oocyte maturation
rfq04915  Estrogen signaling pathway
rfq04916  Melanogenesis
rfq04917  Prolactin signaling pathway
rfq04919  Thyroid hormone signaling pathway
rfq04921  Oxytocin signaling pathway
rfq04926  Relaxin signaling pathway
rfq04928  Parathyroid hormone synthesis, secretion and action
rfq04929  GnRH secretion
rfq04934  Cushing syndrome
rfq04935  Growth hormone synthesis, secretion and action
rfq05010  Alzheimer disease
rfq05022  Pathways of neurodegeneration - multiple diseases
rfq05034  Alcoholism
rfq05132  Salmonella infection
rfq05135  Yersinia infection
rfq05160  Hepatitis C
rfq05161  Hepatitis B
rfq05163  Human cytomegalovirus infection
rfq05164  Influenza A
rfq05165  Human papillomavirus infection
rfq05166  Human T-cell leukemia virus 1 infection
rfq05167  Kaposi sarcoma-associated herpesvirus infection
rfq05170  Human immunodeficiency virus 1 infection
rfq05200  Pathways in cancer
rfq05205  Proteoglycans in cancer
rfq05206  MicroRNAs in cancer
rfq05207  Chemical carcinogenesis - receptor activation
rfq05208  Chemical carcinogenesis - reactive oxygen species
rfq05210  Colorectal cancer
rfq05211  Renal cell carcinoma
rfq05212  Pancreatic cancer
rfq05213  Endometrial cancer
rfq05214  Glioma
rfq05215  Prostate cancer
rfq05216  Thyroid cancer
rfq05218  Melanoma
rfq05219  Bladder cancer
rfq05220  Chronic myeloid leukemia
rfq05221  Acute myeloid leukemia
rfq05223  Non-small cell lung cancer
rfq05224  Breast cancer
rfq05225  Hepatocellular carcinoma
rfq05226  Gastric cancer
rfq05230  Central carbon metabolism in cancer
rfq05231  Choline metabolism in cancer
rfq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    117022968 (MAP2K1)
   04012 ErbB signaling pathway
    117022968 (MAP2K1)
   04014 Ras signaling pathway
    117022968 (MAP2K1)
   04015 Rap1 signaling pathway
    117022968 (MAP2K1)
   04370 VEGF signaling pathway
    117022968 (MAP2K1)
   04371 Apelin signaling pathway
    117022968 (MAP2K1)
   04668 TNF signaling pathway
    117022968 (MAP2K1)
   04066 HIF-1 signaling pathway
    117022968 (MAP2K1)
   04068 FoxO signaling pathway
    117022968 (MAP2K1)
   04072 Phospholipase D signaling pathway
    117022968 (MAP2K1)
   04071 Sphingolipid signaling pathway
    117022968 (MAP2K1)
   04024 cAMP signaling pathway
    117022968 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    117022968 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    117022968 (MAP2K1)
   04150 mTOR signaling pathway
    117022968 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    117022968 (MAP2K1)
   04148 Efferocytosis
    117022968 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    117022968 (MAP2K1)
   04210 Apoptosis
    117022968 (MAP2K1)
   04218 Cellular senescence
    117022968 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    117022968 (MAP2K1)
   04540 Gap junction
    117022968 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    117022968 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    117022968 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    117022968 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    117022968 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    117022968 (MAP2K1)
   04660 T cell receptor signaling pathway
    117022968 (MAP2K1)
   04662 B cell receptor signaling pathway
    117022968 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    117022968 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    117022968 (MAP2K1)
   04062 Chemokine signaling pathway
    117022968 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    117022968 (MAP2K1)
   04929 GnRH secretion
    117022968 (MAP2K1)
   04912 GnRH signaling pathway
    117022968 (MAP2K1)
   04915 Estrogen signaling pathway
    117022968 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    117022968 (MAP2K1)
   04917 Prolactin signaling pathway
    117022968 (MAP2K1)
   04921 Oxytocin signaling pathway
    117022968 (MAP2K1)
   04926 Relaxin signaling pathway
    117022968 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    117022968 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    117022968 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    117022968 (MAP2K1)
   04916 Melanogenesis
    117022968 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    117022968 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    117022968 (MAP2K1)
   04726 Serotonergic synapse
    117022968 (MAP2K1)
   04720 Long-term potentiation
    117022968 (MAP2K1)
   04730 Long-term depression
    117022968 (MAP2K1)
   04722 Neurotrophin signaling pathway
    117022968 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    117022968 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117022968 (MAP2K1)
   05206 MicroRNAs in cancer
    117022968 (MAP2K1)
   05205 Proteoglycans in cancer
    117022968 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    117022968 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    117022968 (MAP2K1)
   05230 Central carbon metabolism in cancer
    117022968 (MAP2K1)
   05231 Choline metabolism in cancer
    117022968 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117022968 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    117022968 (MAP2K1)
   05212 Pancreatic cancer
    117022968 (MAP2K1)
   05225 Hepatocellular carcinoma
    117022968 (MAP2K1)
   05226 Gastric cancer
    117022968 (MAP2K1)
   05214 Glioma
    117022968 (MAP2K1)
   05216 Thyroid cancer
    117022968 (MAP2K1)
   05221 Acute myeloid leukemia
    117022968 (MAP2K1)
   05220 Chronic myeloid leukemia
    117022968 (MAP2K1)
   05218 Melanoma
    117022968 (MAP2K1)
   05211 Renal cell carcinoma
    117022968 (MAP2K1)
   05219 Bladder cancer
    117022968 (MAP2K1)
   05215 Prostate cancer
    117022968 (MAP2K1)
   05213 Endometrial cancer
    117022968 (MAP2K1)
   05224 Breast cancer
    117022968 (MAP2K1)
   05223 Non-small cell lung cancer
    117022968 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    117022968 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    117022968 (MAP2K1)
   05161 Hepatitis B
    117022968 (MAP2K1)
   05160 Hepatitis C
    117022968 (MAP2K1)
   05164 Influenza A
    117022968 (MAP2K1)
   05163 Human cytomegalovirus infection
    117022968 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117022968 (MAP2K1)
   05165 Human papillomavirus infection
    117022968 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    117022968 (MAP2K1)
   05135 Yersinia infection
    117022968 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117022968 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    117022968 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    117022968 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    117022968 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117022968 (MAP2K1)
   01522 Endocrine resistance
    117022968 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rfq01001]
    117022968 (MAP2K1)
Enzymes [BR:rfq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     117022968 (MAP2K1)
Protein kinases [BR:rfq01001]
 Serine/threonine kinases: STE group
  STE7 family
   117022968 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 117022968
NCBI-ProteinID: XP_032963154
Ensembl: ENSRFEG00010004010
UniProt: A0A671DXJ1
LinkDB
Position
6:complement(44513735..44584807)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEINLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccagacggctccgcggtt
aacggcaccagctcggcggagaccaacctggaggctttgcagaagaagctggaggagctg
gagctggacgagcagcagcggaagcgcctggaggcctttcttacccagaagcagaaggtg
ggggaactgaaggacgatgacttcgagaagatcagtgagctgggcgctggcaatggcggg
gtcgtgttcaaggtctcccacaagccatccggcctggtcatggccaggaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctccatgag
tgtaactccccatacatcgtgggcttctacggtgccttctacagtgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatttg
agggagaagcacaagattatgcatagagatgtcaagccttccaacatcttagtgaactct
cgtggggagatcaacctgtgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacgaggtcctacatgtcgccggaaagactccaggggactcactac
tcggtgcagtcggacatctggagcatggggctctcgctggttgagatggcgattgggagg
taccccatcccccctcccgatgccaaggagctggagctgctgttcgggtgccaggtggag
ggagatgcggctgagacaccgccgaggccaaggacccctgggaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaatcctgcagagagagcagatttgaagcagctcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcgggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgcggctggtgtgtga

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