KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117023560
Entry
117023560         CDS       T07722                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq01521  EGFR tyrosine kinase inhibitor resistance
rfq01522  Endocrine resistance
rfq01524  Platinum drug resistance
rfq04010  MAPK signaling pathway
rfq04012  ErbB signaling pathway
rfq04014  Ras signaling pathway
rfq04015  Rap1 signaling pathway
rfq04022  cGMP-PKG signaling pathway
rfq04024  cAMP signaling pathway
rfq04062  Chemokine signaling pathway
rfq04066  HIF-1 signaling pathway
rfq04068  FoxO signaling pathway
rfq04071  Sphingolipid signaling pathway
rfq04072  Phospholipase D signaling pathway
rfq04140  Autophagy - animal
rfq04150  mTOR signaling pathway
rfq04151  PI3K-Akt signaling pathway
rfq04152  AMPK signaling pathway
rfq04210  Apoptosis
rfq04211  Longevity regulating pathway
rfq04213  Longevity regulating pathway - multiple species
rfq04218  Cellular senescence
rfq04261  Adrenergic signaling in cardiomyocytes
rfq04370  VEGF signaling pathway
rfq04371  Apelin signaling pathway
rfq04380  Osteoclast differentiation
rfq04510  Focal adhesion
rfq04517  IgSF CAM signaling
rfq04518  Integrin signaling
rfq04550  Signaling pathways regulating pluripotency of stem cells
rfq04611  Platelet activation
rfq04613  Neutrophil extracellular trap formation
rfq04620  Toll-like receptor signaling pathway
rfq04625  C-type lectin receptor signaling pathway
rfq04630  JAK-STAT signaling pathway
rfq04660  T cell receptor signaling pathway
rfq04662  B cell receptor signaling pathway
rfq04664  Fc epsilon RI signaling pathway
rfq04666  Fc gamma R-mediated phagocytosis
rfq04668  TNF signaling pathway
rfq04722  Neurotrophin signaling pathway
rfq04725  Cholinergic synapse
rfq04728  Dopaminergic synapse
rfq04810  Regulation of actin cytoskeleton
rfq04910  Insulin signaling pathway
rfq04914  Progesterone-mediated oocyte maturation
rfq04915  Estrogen signaling pathway
rfq04917  Prolactin signaling pathway
rfq04919  Thyroid hormone signaling pathway
rfq04920  Adipocytokine signaling pathway
rfq04922  Glucagon signaling pathway
rfq04923  Regulation of lipolysis in adipocytes
rfq04926  Relaxin signaling pathway
rfq04929  GnRH secretion
rfq04931  Insulin resistance
rfq04932  Non-alcoholic fatty liver disease
rfq04933  AGE-RAGE signaling pathway in diabetic complications
rfq04935  Growth hormone synthesis, secretion and action
rfq04936  Alcoholic liver disease
rfq04973  Carbohydrate digestion and absorption
rfq05010  Alzheimer disease
rfq05017  Spinocerebellar ataxia
rfq05132  Salmonella infection
rfq05135  Yersinia infection
rfq05142  Chagas disease
rfq05145  Toxoplasmosis
rfq05152  Tuberculosis
rfq05160  Hepatitis C
rfq05161  Hepatitis B
rfq05162  Measles
rfq05163  Human cytomegalovirus infection
rfq05164  Influenza A
rfq05165  Human papillomavirus infection
rfq05166  Human T-cell leukemia virus 1 infection
rfq05167  Kaposi sarcoma-associated herpesvirus infection
rfq05168  Herpes simplex virus 1 infection
rfq05169  Epstein-Barr virus infection
rfq05170  Human immunodeficiency virus 1 infection
rfq05200  Pathways in cancer
rfq05205  Proteoglycans in cancer
rfq05207  Chemical carcinogenesis - receptor activation
rfq05208  Chemical carcinogenesis - reactive oxygen species
rfq05210  Colorectal cancer
rfq05211  Renal cell carcinoma
rfq05212  Pancreatic cancer
rfq05213  Endometrial cancer
rfq05214  Glioma
rfq05215  Prostate cancer
rfq05218  Melanoma
rfq05220  Chronic myeloid leukemia
rfq05221  Acute myeloid leukemia
rfq05222  Small cell lung cancer
rfq05223  Non-small cell lung cancer
rfq05224  Breast cancer
rfq05225  Hepatocellular carcinoma
rfq05226  Gastric cancer
rfq05230  Central carbon metabolism in cancer
rfq05231  Choline metabolism in cancer
rfq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rfq05415  Diabetic cardiomyopathy
rfq05417  Lipid and atherosclerosis
rfq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    117023560 (AKT1)
   04012 ErbB signaling pathway
    117023560 (AKT1)
   04014 Ras signaling pathway
    117023560 (AKT1)
   04015 Rap1 signaling pathway
    117023560 (AKT1)
   04370 VEGF signaling pathway
    117023560 (AKT1)
   04371 Apelin signaling pathway
    117023560 (AKT1)
   04630 JAK-STAT signaling pathway
    117023560 (AKT1)
   04668 TNF signaling pathway
    117023560 (AKT1)
   04066 HIF-1 signaling pathway
    117023560 (AKT1)
   04068 FoxO signaling pathway
    117023560 (AKT1)
   04072 Phospholipase D signaling pathway
    117023560 (AKT1)
   04071 Sphingolipid signaling pathway
    117023560 (AKT1)
   04024 cAMP signaling pathway
    117023560 (AKT1)
   04022 cGMP-PKG signaling pathway
    117023560 (AKT1)
   04151 PI3K-Akt signaling pathway
    117023560 (AKT1)
   04152 AMPK signaling pathway
    117023560 (AKT1)
   04150 mTOR signaling pathway
    117023560 (AKT1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    117023560 (AKT1)
   04518 Integrin signaling
    117023560 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    117023560 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    117023560 (AKT1)
   04218 Cellular senescence
    117023560 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    117023560 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    117023560 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    117023560 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    117023560 (AKT1)
   04613 Neutrophil extracellular trap formation
    117023560 (AKT1)
   04620 Toll-like receptor signaling pathway
    117023560 (AKT1)
   04625 C-type lectin receptor signaling pathway
    117023560 (AKT1)
   04660 T cell receptor signaling pathway
    117023560 (AKT1)
   04662 B cell receptor signaling pathway
    117023560 (AKT1)
   04664 Fc epsilon RI signaling pathway
    117023560 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    117023560 (AKT1)
   04062 Chemokine signaling pathway
    117023560 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    117023560 (AKT1)
   04922 Glucagon signaling pathway
    117023560 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    117023560 (AKT1)
   04920 Adipocytokine signaling pathway
    117023560 (AKT1)
   04929 GnRH secretion
    117023560 (AKT1)
   04915 Estrogen signaling pathway
    117023560 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    117023560 (AKT1)
   04917 Prolactin signaling pathway
    117023560 (AKT1)
   04926 Relaxin signaling pathway
    117023560 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    117023560 (AKT1)
   04919 Thyroid hormone signaling pathway
    117023560 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    117023560 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    117023560 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    117023560 (AKT1)
   04728 Dopaminergic synapse
    117023560 (AKT1)
   04722 Neurotrophin signaling pathway
    117023560 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    117023560 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    117023560 (AKT1)
   04213 Longevity regulating pathway - multiple species
    117023560 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117023560 (AKT1)
   05205 Proteoglycans in cancer
    117023560 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    117023560 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    117023560 (AKT1)
   05230 Central carbon metabolism in cancer
    117023560 (AKT1)
   05231 Choline metabolism in cancer
    117023560 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117023560 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    117023560 (AKT1)
   05212 Pancreatic cancer
    117023560 (AKT1)
   05225 Hepatocellular carcinoma
    117023560 (AKT1)
   05226 Gastric cancer
    117023560 (AKT1)
   05214 Glioma
    117023560 (AKT1)
   05221 Acute myeloid leukemia
    117023560 (AKT1)
   05220 Chronic myeloid leukemia
    117023560 (AKT1)
   05218 Melanoma
    117023560 (AKT1)
   05211 Renal cell carcinoma
    117023560 (AKT1)
   05215 Prostate cancer
    117023560 (AKT1)
   05213 Endometrial cancer
    117023560 (AKT1)
   05224 Breast cancer
    117023560 (AKT1)
   05222 Small cell lung cancer
    117023560 (AKT1)
   05223 Non-small cell lung cancer
    117023560 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    117023560 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    117023560 (AKT1)
   05161 Hepatitis B
    117023560 (AKT1)
   05160 Hepatitis C
    117023560 (AKT1)
   05164 Influenza A
    117023560 (AKT1)
   05162 Measles
    117023560 (AKT1)
   05168 Herpes simplex virus 1 infection
    117023560 (AKT1)
   05163 Human cytomegalovirus infection
    117023560 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117023560 (AKT1)
   05169 Epstein-Barr virus infection
    117023560 (AKT1)
   05165 Human papillomavirus infection
    117023560 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    117023560 (AKT1)
   05135 Yersinia infection
    117023560 (AKT1)
   05152 Tuberculosis
    117023560 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    117023560 (AKT1)
   05142 Chagas disease
    117023560 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117023560 (AKT1)
   05017 Spinocerebellar ataxia
    117023560 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    117023560 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    117023560 (AKT1)
   05415 Diabetic cardiomyopathy
    117023560 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    117023560 (AKT1)
   04932 Non-alcoholic fatty liver disease
    117023560 (AKT1)
   04931 Insulin resistance
    117023560 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    117023560 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117023560 (AKT1)
   01524 Platinum drug resistance
    117023560 (AKT1)
   01522 Endocrine resistance
    117023560 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rfq01001]
    117023560 (AKT1)
Enzymes [BR:rfq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     117023560 (AKT1)
Protein kinases [BR:rfq01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   117023560 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like Seadorna_VP7
Other DBs
NCBI-GeneID: 117023560
NCBI-ProteinID: XP_032964391
Ensembl: ENSRFEG00010001809
LinkDB
Position
6:828397..850114
AA seq 616 aa
MTDVAIVKEGWLHKRAAGPRALSRQEVTAGKPCSCLAAGGPHHVSLSHPAIPEGPTSLPL
SEKLPQAALSRLPPLAPGCGLRFCPQAVCSELSLQARVWAAVLRSSLRLPSPPTFPTPDG
LAVPRLLPSSWRAALAEPLLCPQPMDRPAAPGEYIKTWRPRYFLLKNDGTFIGYKERPQD
VEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQ
TVADGLKRQEEEMMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKV
ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC
FVMEYANGGELFFHLSRERVFPEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK
DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMLC
GRLPFYNQDHEKLFELILMEEIRFPRSLSPDAKALLSGLLKKDPKQRLGGGPEDAKEIMQ
HRFFASIVWQDVYEKKLCPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDNMECVDSE
RRPHFPQFSYSASGTA
NT seq 1851 nt   +upstreamnt  +downstreamnt
atgaccgacgtggccatcgtgaaagagggctggctgcacaaaagagctgcaggtccccgt
gcactgagcagacaggaggtgacggctggaaaaccgtgctcatgcctggcagcggggggc
cctcaccacgtttccttgtctcacccagccattccagaaggtcctacctccctgccactc
tccgagaagctgccccaagctgccctgtcacgtcttcctcctctggctcctggctgtggc
ctccggttttgtcctcaggctgtgtgctctgagctaagtctgcaggcccgagtctgggca
gctgttctgaggtcctccctgaggctgccatccccgcccactttccctacgcctgatggg
ctggcagtgcctaggctattgcccagctcgtggagagctgctctggcagagccgctgctg
tgtccccagcccatggacaggccggccgcaccaggggagtacatcaaaacctggcggccc
cggtactttctgctcaagaatgacggcaccttcattggctacaaggagcggccgcaggac
gtggagcagcgcgagtcacccctcaacaacttctcggtggcgcaatgccagctgatgaag
accgagcggccccggcccaacaccttcatcatccgctgcctgcagtggaccacggtcatc
gagcgcaccttccacgtggagacgcccgaggaacgggaggagtggacgaccgccatccag
acggtggccgacgggctcaagaggcaggaagaggagatgatggacttccgatcaggctcg
cccagtgacaactcaggggccgaggaaatggaggtgtccctggccaagcccaagcaccgt
gtgaccatgaacgagtttgagtacctgaagctgctgggcaaaggcacgtttgggaaggtc
atcctggtgaaggagaaggccacaggccgctactacgccatgaagatcctaaagaaggag
gtcatcgtggccaaggatgaggtggcacacacacttacagagaaccgcgtcctccagaac
tcccggcaccccttcctgacggccctgaaatactccttccagacccacgaccgcctgtgc
ttcgtcatggagtacgccaacggtggcgagctcttcttccacttgtcgcgggagcgggtg
ttccctgaggaccgggcacgcttctatggggcagagatcgtctcggccctggactacttg
cactcggagaagaatgtggtttaccgtgacctcaagctggagaacctcatgctggacaag
gacggacacatcaagatcaccgactttgggctctgcaaggagggcatcaaggatggtgcc
accatgaagaccttctgcgggacacccgagtacctagcccctgaggtgttggaggacaac
gactacggccgcgctgtggactggtggggactgggcgtggtcatgtacgagatgctgtgc
ggccggctgcccttttacaaccaggaccacgagaagctgttcgagctcatcctcatggag
gagattcgcttcccgcgctcgctcagccctgacgccaaggccctgctctcagggctgctc
aagaaggaccccaagcagcggcttggagggggccccgaggacgccaaggagatcatgcag
caccgcttctttgccagcatcgtgtggcaggatgtgtacgagaagaagctctgtccaccc
ttcaagccccaggtcacgtcggagacggacaccaggtattttgacgaggagttcacggcc
cagatgatcaccatcacgccacccgaccaagacgacaacatggagtgcgtggacagcgag
cggaggccccacttcccccagttctcctactcggccagcggcacggcctga

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