KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117026596
Entry
117026596         CDS       T07722                                 
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq01521  EGFR tyrosine kinase inhibitor resistance
rfq04151  PI3K-Akt signaling pathway
rfq04217  Necroptosis
rfq04380  Osteoclast differentiation
rfq04550  Signaling pathways regulating pluripotency of stem cells
rfq04620  Toll-like receptor signaling pathway
rfq04621  NOD-like receptor signaling pathway
rfq04630  JAK-STAT signaling pathway
rfq04658  Th1 and Th2 cell differentiation
rfq04659  Th17 cell differentiation
rfq05140  Leishmaniasis
rfq05145  Toxoplasmosis
rfq05152  Tuberculosis
rfq05160  Hepatitis C
rfq05161  Hepatitis B
rfq05162  Measles
rfq05163  Human cytomegalovirus infection
rfq05164  Influenza A
rfq05165  Human papillomavirus infection
rfq05166  Human T-cell leukemia virus 1 infection
rfq05167  Kaposi sarcoma-associated herpesvirus infection
rfq05168  Herpes simplex virus 1 infection
rfq05169  Epstein-Barr virus infection
rfq05171  Coronavirus disease - COVID-19
rfq05200  Pathways in cancer
rfq05203  Viral carcinogenesis
rfq05212  Pancreatic cancer
rfq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    117026596 (JAK1)
   04151 PI3K-Akt signaling pathway
    117026596 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    117026596 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    117026596 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    117026596 (JAK1)
   04621 NOD-like receptor signaling pathway
    117026596 (JAK1)
   04658 Th1 and Th2 cell differentiation
    117026596 (JAK1)
   04659 Th17 cell differentiation
    117026596 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    117026596 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117026596 (JAK1)
   05203 Viral carcinogenesis
    117026596 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117026596 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    117026596 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    117026596 (JAK1)
   05161 Hepatitis B
    117026596 (JAK1)
   05160 Hepatitis C
    117026596 (JAK1)
   05171 Coronavirus disease - COVID-19
    117026596 (JAK1)
   05164 Influenza A
    117026596 (JAK1)
   05162 Measles
    117026596 (JAK1)
   05168 Herpes simplex virus 1 infection
    117026596 (JAK1)
   05163 Human cytomegalovirus infection
    117026596 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117026596 (JAK1)
   05169 Epstein-Barr virus infection
    117026596 (JAK1)
   05165 Human papillomavirus infection
    117026596 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    117026596 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    117026596 (JAK1)
   05140 Leishmaniasis
    117026596 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117026596 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rfq01001]
    117026596 (JAK1)
Enzymes [BR:rfq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     117026596 (JAK1)
Protein kinases [BR:rfq01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   117026596 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1
Other DBs
NCBI-GeneID: 117026596
NCBI-ProteinID: XP_032969299
Ensembl: ENSRFEG00010003864
LinkDB
Position
9:complement(47612851..47737566)
AA seq 1153 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLPDREPLRLSGGEYTAEEL
CIRAAQACCISPLCHNLFALYDENTKLWYAPNHTITVDDKTSVRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMIKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVIPVEKEKNKLKRKKLENKHKKDEERNKIR
EEWSNFSYFPEITHIVIKESVVSINKQDNKKMELKLASHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDHSFPSLGDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHLGRGTRTHIYSGT
LVDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
SSPMTLFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPSNCPEEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgcagtatctaaacataaaagaggactgcaatgctatggctttctgtgctaaaatgcgg
agctccaagaagaccgaggtgaatctggaggcccccgagccaggggtggaagtgctcttc
tacctgccggatagggagcccctccgactgagcggtggggagtacacggccgaggagctt
tgcatcagggcagcgcaagcgtgctgtatctctcctctgtgtcacaacctctttgccctg
tatgatgagaacaccaagctctggtatgctccaaatcacaccatcactgttgacgacaag
acatcggtccggctccactaccggatgaggttctatttcaccaactggcatgggactaat
gataacgagcagtcggtgtggcgacattctccaaagaagcagaaaaatggctacgagaaa
aaaaaagttccagatgcaacccctctccttgacgccagctccctggagtatctgtttgct
cagggccagtatgatttggtcaaatgcctggctcccatccgagaccccaagactgagcag
gacgggcatgacatcgagaacgagtgcctggggatggccgtcctggccatctcccactac
gccatgataaagaagatgcagttgccagaactccccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcaggcagaggaaccttctcaccaggatgcggata
aataacgtcttcaaggatttcctcaaggaatttaacaacaagaccatttgtgacagcagt
gtgtccacacatgacctgaaggtgaaatacctggctacgttggagactttgacaaaacat
tatggtgctgaaatatttgagacctccatgttactgatttcatcagaaaatgagatgaat
tggtttcatccaaacgacagtggaaatgttctctactatgaagtgatggtgactggaaat
cttggaatccagtggagacagaaaccaaatgttatccctgttgaaaaggaaaaaaataaa
ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggagagaaacaaaatccgg
gaagagtggagcaatttttcttacttccccgaaatcacccacatcgtaataaaggaatct
gttgtcagcattaataagcaggacaacaaaaaaatggaactgaagctcgcttcccacgag
gaggccttgtcctttgtgtccctggtagatggctattttcggctcacagcagacgcccat
cattacctctgcaccgatgtggctccccccttgatcgtccacaacatacagaacggctgt
cacggtccaatctgcacagaatacgccatcaataaattgcggcaagaaggaagcgaggag
gggatgtacgtcctgcggtggagctgcaccgactttgacaacatcctcatgaccgtcacc
tgctttgaaaagtctgaggtactgggtggccagaaacagttcaagaactttcagatcgag
gtgcagaagggtcgctacagcctgcacggctcggaccacagcttccccagcctgggggac
ctcatgagccacctcaagaagcagattctgcgcacagacaacatcagcttcgtgctgaag
cgctgctgccagcccaagccccgagaaatctccaatctgctggtggctactaagaaagcc
caggagtggcagcccgtctaccccatgagtcagctgagtttcgatcggatcctcaagaaa
gacattatgcagggcgagcaccttgggagaggcacgcggacacacatctactctgggacc
ctggtggattacaaggatgacgaaggaacttcggaagagaagaggataaaagtgatcctc
aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg
atgagacaggtctcccacaaacacatcgtttacctctatggcgtctgtgtccgagacgtg
gagaatatcatggtggaagagtttgtggagggggggccgctggatctcttcatgcaccgg
aaaagtgatgtcctcaccacaccatggaaattcaaagttgctaaacagctggccagtgcc
ctgagttacttggaggataaagacctggtccatggaaacgtgtgcactaaaaacctcctc
ctggcccgcgagggcatcgacagcgagtgcggcccattcatcaagctcagcgaccccggc
atccccatcactgtgttgtccagacaagaatgcatagaacgaatcccatggattgctccc
gagtgtgtggaagactccaaaaacctgagtgtggccgctgataaatggagctttggaact
acactctgggaaatctgctataatggcgagatccccctgaaagacaagacgctgattgag
aaagaaagattctatgaaagccggtgcaggccagtgacaccatcttgtaaggagctggct
gacctgatgactcgctgcatgaactatgaccccaatcagagaccctttttccgagccatc
atgagagacatcaataagctggaagagcagaatccagacattgtttcagaaaaaaagcca
gccaccgaagtggatcccacgcatttcgaaaagcggttcttaaagcggatccgtgacttg
ggagagggccactttgggaaagtcgagctctgcaggtatgaccctgaaggggacaacaca
ggggagcaggtggcggtcaaatccctgaagcctgagagtggaggcaaccacatagctgat
ctgaagaaggaaatcgaaatcttaaggaacctctatcacgagaacattgtgaagtacaaa
ggcatctgcacagaagatggaggaaatggtattaagctcatcatggaatttctaccttcg
ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta
aaatacgctgttcagatttgtaagggcatggactatttgggttcacgacaatacgttcac
cgggacttagcagcaagaaatgtccttgttgagagtgaacaccaagtaaaaattggagac
tttggtttaaccaaagcaattgaaactgataaggagtactacacagtcaaggacgatcgg
gacagccctgtgttttggtatgctccagaatgtttaatccagtgtaaattttatatcgcc
tctgacgtctggtctttcggagtgactctgcatgagctgctcacttactgtgattcagat
tccagtcccatgacgttgttcctgaaaatgataggcccaactcacggccagatgacggtc
accagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccatctaactgtcca
gaagaggtttatcaacttatgagaaaatgctgggaatttcaaccatctaaccggacgact
tttcagaacctcattgaaggatttgaagcacttttaaaataa

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